JP2018537962A5 - - Google Patents

Info

Publication number

JP2018537962A5

JP2018537962A5 JP2018520536A JP2018520536A JP2018537962A5 JP 2018537962 A5 JP2018537962 A5 JP 2018537962A5 JP 2018520536 A JP2018520536 A JP 2018520536A JP 2018520536 A JP2018520536 A JP 2018520536A JP 2018537962 A5 JP2018537962 A5 JP 2018537962A5

Authority

JP

Japan

Prior art keywords

seq

antibody

antigen

binding portion

heavy chain

Prior art date

2016-10-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 102000036639 antigens Human genes 0.000 claims description 52
• 108091007433 antigens Proteins 0.000 claims description 52
• 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims description 33
• 210000004027 cell Anatomy 0.000 claims description 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 13
• 108020004707 nucleic acids Proteins 0.000 claims description 12
• 102000039446 nucleic acids Human genes 0.000 claims description 12
• 150000007523 nucleic acids Chemical class 0.000 claims description 12
• 238000000034 method Methods 0.000 claims description 9
• 102000055277 human IL2 Human genes 0.000 claims description 7
• 239000002773 nucleotide Substances 0.000 claims description 7
• 125000003729 nucleotide group Chemical group 0.000 claims description 7
• 206010062016 Immunosuppression Diseases 0.000 claims description 6
• 230000001506 immunosuppresive effect Effects 0.000 claims description 6
• 230000004968 inflammatory condition Effects 0.000 claims description 6
• 238000012258 culturing Methods 0.000 claims description 4
• 239000003937 drug carrier Substances 0.000 claims description 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
• 239000008194 pharmaceutical composition Substances 0.000 claims description 3
• 208000023275 Autoimmune disease Diseases 0.000 claims description 2
• 208000009329 Graft vs Host Disease Diseases 0.000 claims description 2
• 108010002350 Interleukin-2 Proteins 0.000 claims description 2
• 102000000588 Interleukin-2 Human genes 0.000 claims description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
• 239000004472 Lysine Substances 0.000 claims description 2
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
• 210000004899 c-terminal region Anatomy 0.000 claims description 2
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• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
• 210000004962 mammalian cell Anatomy 0.000 claims description 2
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• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 5
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• 210000001744 T-lymphocyte Anatomy 0.000 description 3
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• 102100027581 Forkhead box protein P3 Human genes 0.000 description 1
• 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 description 1
• 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
• 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
• 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 1
• 102000001712 STAT5 Transcription Factor Human genes 0.000 description 1
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