JP2018536431A5 - - Google Patents
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- JP2018536431A5 JP2018536431A5 JP2018538064A JP2018538064A JP2018536431A5 JP 2018536431 A5 JP2018536431 A5 JP 2018536431A5 JP 2018538064 A JP2018538064 A JP 2018538064A JP 2018538064 A JP2018538064 A JP 2018538064A JP 2018536431 A5 JP2018536431 A5 JP 2018536431A5
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- nucleic acid
- pharmaceutical composition
- Prior art date
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- 239000013598 vector Substances 0.000 claims 12
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 230000002489 hematologic effect Effects 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000000244 kidney pelvis Anatomy 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 claims 1
- 206010010144 Completed suicide Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000004458 Myoma Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 241000520310 Rhabdomys Species 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000032383 Soft tissue cancer Diseases 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 230000005809 anti-tumor immunity Effects 0.000 claims 1
- 210000000436 anus Anatomy 0.000 claims 1
- 208000003373 basosquamous carcinoma Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- 208000012191 childhood neoplasm Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000013601 cosmid vector Substances 0.000 claims 1
- 208000024558 digestive system cancer Diseases 0.000 claims 1
- 210000000750 endocrine system Anatomy 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 201000010231 gastrointestinal system cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000003228 intrahepatic bile duct Anatomy 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000003899 penis Anatomy 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000004994 reproductive system Anatomy 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 210000000626 ureter Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 210000003905 vulva Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239509P | 2015-10-09 | 2015-10-09 | |
| US62/239,509 | 2015-10-09 | ||
| PCT/US2016/056073 WO2017062820A1 (en) | 2015-10-09 | 2016-10-07 | Chimeric antigen receptors and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536431A JP2018536431A (ja) | 2018-12-13 |
| JP2018536431A5 true JP2018536431A5 (cg-RX-API-DMAC7.html) | 2019-11-07 |
| JP6821688B2 JP6821688B2 (ja) | 2021-01-27 |
Family
ID=57145073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538064A Active JP6821688B2 (ja) | 2015-10-09 | 2016-10-07 | キメラ抗原受容体および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10421810B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3359562B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6821688B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN114181960B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016335848B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3001306C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2778651T3 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2017062820A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20191468T1 (hr) | 2014-09-15 | 2019-11-29 | Molmed Spa | Kimerni antigenski receptori |
| US10639329B2 (en) * | 2015-06-12 | 2020-05-05 | Lentigen Technology, Inc. | Method to treat cancer with engineered T-cells |
| US10421810B2 (en) | 2015-10-09 | 2019-09-24 | Lentigen Technology, Inc. | Chimeric antigen receptors and methods of use |
| EP3184548A1 (en) | 2015-12-23 | 2017-06-28 | Miltenyi Biotec GmbH | Chimeric antigen receptor with cytokine receptor activating or blocking domain |
| ES2981703T3 (es) | 2016-09-02 | 2024-10-10 | Lentigen Tech Inc | Composiciones y métodos para tratar cáncer con DuoCars |
| US11021537B2 (en) * | 2017-05-01 | 2021-06-01 | Agenus Inc. | Anti-TIGIT antibodies and methods of use thereof |
| CN107245500B (zh) * | 2017-05-27 | 2019-05-17 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的淋系白血病car-t治疗载体及其构建方法和应用 |
| CN107299110B (zh) | 2017-05-27 | 2019-11-22 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的胰腺癌、恶性间皮瘤car-t治疗载体及其构建方法和应用 |
| CN107267555B (zh) * | 2017-05-27 | 2020-03-20 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用 |
| CN107177632B (zh) * | 2017-05-27 | 2020-02-07 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用 |
| CN107164410B (zh) * | 2017-05-27 | 2019-09-03 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的前列腺癌car-t治疗载体及其构建方法和应用 |
| US10428141B2 (en) * | 2017-11-03 | 2019-10-01 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-ROR1 immunotherapy |
| JP7546553B2 (ja) | 2018-09-20 | 2024-09-06 | レンティジェン・テクノロジー・インコーポレイテッド | 抗ｃｄ１２３免疫療法によりがんを処置するための組成物および方法 |
| CN111454909B (zh) * | 2019-01-22 | 2024-12-10 | 北京大学深圳研究生院 | 天然配体介导的多靶点识别可调控基因工程化免疫细胞的制备方法 |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| AU2020232789A1 (en) * | 2019-03-06 | 2021-10-07 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with self-driving chimeric antigen receptors |
| EP3715368A1 (en) | 2019-03-28 | 2020-09-30 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors, vectors coding for such receptors and their use in the modification of t cells |
| JP2022526187A (ja) * | 2019-04-12 | 2022-05-23 | エモリー ユニバーシティー | 造血細胞の細胞傷害性を促進するための組成物及び方法 |
| EP3965897A4 (en) * | 2019-05-07 | 2023-01-04 | The Board of Trustees of the Leland Stanford Junior University | CHEMERA ANTIGEN RECEPTORS TARGETING GLYPICAN-2 |
| US20220249565A1 (en) * | 2019-06-27 | 2022-08-11 | Eutilex Co., Ltd. | Chimeric antigen receptor with 4-ibb costimulatory domain |
| JP2022538425A (ja) * | 2019-06-27 | 2022-09-02 | ユーティレックス カンパニー リミテッド | ４－１ｂｂ共刺激性ドメインを有するキメラ抗原受容体 |
| CN112812182B (zh) * | 2019-11-15 | 2023-01-06 | 深圳宾德生物技术有限公司 | 一种靶向fgfr4的单链抗体、嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用 |
| WO2021164959A1 (en) * | 2020-02-17 | 2021-08-26 | Miltenyi Biotec B.V. & Co. KG | Method for providing personalized cells with chimeric antigen receptors (car) against tumor microenvironment cells |
| US20220169694A1 (en) * | 2020-02-20 | 2022-06-02 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
| CN112159818B (zh) * | 2020-08-20 | 2023-02-21 | 山东兴瑞生物科技有限公司 | 用于治疗hcc的核酸、其制备方法、具有该核酸的car-t细胞及细胞的制备方法 |
| US20230364139A1 (en) * | 2020-08-26 | 2023-11-16 | The Regents Of The University Of California | Methods and compositions for treating glioblastoma |
| CN117062611A (zh) | 2021-01-26 | 2023-11-14 | 惠和生物技术(上海)有限公司 | 嵌合抗原受体（car）构建体和表达car构建体的nk细胞 |
| CN112851794B (zh) * | 2021-02-04 | 2023-05-23 | 苏州铂维生物科技有限公司 | 一种基于cd271的抗原表位及其应用 |
| TW202304965A (zh) | 2021-05-04 | 2023-02-01 | 美商艾吉納斯公司 | 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法 |
| WO2023076811A1 (en) * | 2021-10-26 | 2023-05-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Combination therapies with chimeric antigen receptors |
| CA3245638A1 (en) * | 2022-03-15 | 2023-09-21 | New York University | PROCESSES AND COMPOSITIONS COMPRISING FUSION PROTEINS FOR ENHANCED IMMUNOTHERAPIES |
| CA3263188A1 (en) | 2022-07-28 | 2024-02-01 | Lentigen Technology, Inc. | Chimeric Antigen Receptor Therapies for the Treatment of Solid Tumors |
| AU2024240255A1 (en) * | 2023-03-17 | 2025-10-02 | Cartesian Therapeutics, Inc. | Intracellular signaling and costimulatory domains adapted for prolonged expression of chimeric antigen receptors |
| WO2025006499A2 (en) * | 2023-06-26 | 2025-01-02 | Atara Biotherapeutics, Inc. | Gpc3-targeted molecules and uses thereof |
| CN121045391A (zh) * | 2024-05-27 | 2025-12-02 | 清华大学 | 用于降解炎症细胞因子的嵌合抗原受体及包含其的重组免疫细胞 |
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- 2016-10-07 JP JP2018538064A patent/JP6821688B2/ja active Active
- 2016-10-07 CA CA3001306A patent/CA3001306C/en active Active
- 2016-10-07 ES ES16782384T patent/ES2778651T3/es active Active
- 2016-10-07 WO PCT/US2016/056073 patent/WO2017062820A1/en not_active Ceased
- 2016-10-07 EP EP16782384.8A patent/EP3359562B1/en active Active
- 2016-10-07 EP EP19213308.0A patent/EP3660044A1/en active Pending
- 2016-10-07 CN CN202111359062.8A patent/CN114181960B/zh active Active
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