JP2018535701A5 - - Google Patents
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- JP2018535701A5 JP2018535701A5 JP2018546725A JP2018546725A JP2018535701A5 JP 2018535701 A5 JP2018535701 A5 JP 2018535701A5 JP 2018546725 A JP2018546725 A JP 2018546725A JP 2018546725 A JP2018546725 A JP 2018546725A JP 2018535701 A5 JP2018535701 A5 JP 2018535701A5
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- 210000001744 T-lymphocyte Anatomy 0.000 claims description 100
- 239000000427 antigen Substances 0.000 claims description 54
- 102000036639 antigens Human genes 0.000 claims description 54
- 108091007433 antigens Proteins 0.000 claims description 54
- 230000000890 antigenic effect Effects 0.000 claims description 46
- 210000004027 cell Anatomy 0.000 claims description 32
- 108091008874 T cell receptors Proteins 0.000 claims description 31
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 31
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 28
- 150000007523 nucleic acids Chemical class 0.000 claims description 27
- 108020004707 nucleic acids Proteins 0.000 claims description 26
- 102000039446 nucleic acids Human genes 0.000 claims description 26
- 210000000130 stem cell Anatomy 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 108020003175 receptors Proteins 0.000 claims description 23
- 102000005962 receptors Human genes 0.000 claims description 23
- 230000003213 activating effect Effects 0.000 claims description 15
- 230000011664 signaling Effects 0.000 claims description 14
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 12
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 12
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- -1 for example Proteins 0.000 claims description 11
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 8
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 8
- 102000054766 genetic haplotypes Human genes 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 5
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims description 4
- 238000006471 dimerization reaction Methods 0.000 claims description 4
- 230000000813 microbial effect Effects 0.000 claims description 4
- 101150047061 tag-72 gene Proteins 0.000 claims description 4
- 230000006044 T cell activation Effects 0.000 claims description 3
- 235000018417 cysteine Nutrition 0.000 claims description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 3
- 230000001613 neoplastic effect Effects 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 230000001363 autoimmune Effects 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 13
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 7
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 5
- 102100038080 B-cell receptor CD22 Human genes 0.000 description 4
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 4
- 108700010039 chimeric receptor Proteins 0.000 description 4
- 230000004068 intracellular signaling Effects 0.000 description 4
- 102100023990 60S ribosomal protein L17 Human genes 0.000 description 2
- 101710145634 Antigen 1 Proteins 0.000 description 2
- 102000006306 Antigen Receptors Human genes 0.000 description 2
- 108010083359 Antigen Receptors Proteins 0.000 description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 2
- 102100027207 CD27 antigen Human genes 0.000 description 2
- 102100038078 CD276 antigen Human genes 0.000 description 2
- 101710185679 CD276 antigen Proteins 0.000 description 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 2
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 2
- 101150013553 CD40 gene Proteins 0.000 description 2
- 102100035793 CD83 antigen Human genes 0.000 description 2
- 102100037904 CD9 antigen Human genes 0.000 description 2
- 102100025466 Carcinoembryonic antigen-related cell adhesion molecule 3 Human genes 0.000 description 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 2
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 2
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 description 2
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 description 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 description 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 description 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 description 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 2
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 description 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 description 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 description 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 2
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000000139 costimulatory effect Effects 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000012737 microarray-based gene expression Methods 0.000 description 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 1
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 description 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 description 1
- 210000003995 blood forming stem cell Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021183110A JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
| JP2024010098A JP2024028648A (ja) | 2015-11-27 | 2024-01-26 | 遺伝子改変された細胞およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015904933A AU2015904933A0 (en) | 2015-11-27 | Genetically modified cells and uses thereof | |
| AU2015904933 | 2015-11-27 | ||
| AU2016901328 | 2016-04-11 | ||
| AU2016901328A AU2016901328A0 (en) | 2016-04-11 | Genetically modified cells and uses thereof - III | |
| PCT/AU2016/051141 WO2017088012A1 (en) | 2015-11-27 | 2016-11-23 | Genetically modified cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183110A Division JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535701A JP2018535701A (ja) | 2018-12-06 |
| JP2018535701A5 true JP2018535701A5 (enExample) | 2019-12-26 |
| JP6976960B2 JP6976960B2 (ja) | 2021-12-08 |
Family
ID=58762790
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546725A Active JP6976960B2 (ja) | 2015-11-27 | 2016-11-23 | 遺伝子改変された細胞およびその使用 |
| JP2021183110A Pending JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
| JP2024010098A Pending JP2024028648A (ja) | 2015-11-27 | 2024-01-26 | 遺伝子改変された細胞およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183110A Pending JP2022027762A (ja) | 2015-11-27 | 2021-11-10 | 遺伝子改変された細胞およびその使用 |
| JP2024010098A Pending JP2024028648A (ja) | 2015-11-27 | 2024-01-26 | 遺伝子改変された細胞およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11400145B2 (enExample) |
| EP (3) | EP3380117B1 (enExample) |
| JP (3) | JP6976960B2 (enExample) |
| CN (2) | CN116121281B (enExample) |
| AU (2) | AU2016361451B2 (enExample) |
| CA (1) | CA3004120A1 (enExample) |
| ES (2) | ES2862907T3 (enExample) |
| IL (2) | IL296410A (enExample) |
| MY (1) | MY189819A (enExample) |
| SG (2) | SG10201912825XA (enExample) |
| WO (1) | WO2017088012A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4406604A3 (en) | 2015-03-05 | 2024-10-23 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| EP4353750A3 (en) * | 2016-06-24 | 2024-07-24 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
| US12350349B2 (en) | 2016-08-03 | 2025-07-08 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| US11525119B2 (en) | 2016-09-06 | 2022-12-13 | The Children's Medical Center Corporation | Immune cells derived from induced pluripotent stem cell |
| CN119409836A (zh) | 2017-03-17 | 2025-02-11 | 弗雷德哈钦森癌症中心 | 免疫调节融合蛋白及其用途 |
| CA3058807A1 (en) | 2017-04-03 | 2018-10-11 | Neon Therapeutics, Inc. | Protein antigens and uses thereof |
| EP4083063A3 (en) * | 2017-04-18 | 2023-01-04 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| JP2021500882A (ja) * | 2017-10-18 | 2021-01-14 | プレシゲン，インコーポレイテッド | スペーサーを含むポリペプチド組成物 |
| US11793867B2 (en) | 2017-12-18 | 2023-10-24 | Biontech Us Inc. | Neoantigens and uses thereof |
| CN109971716B (zh) * | 2017-12-28 | 2023-08-01 | 上海细胞治疗研究院 | 自分泌cd47抗体的egfr特异性car-t细胞及其用途 |
| CN109971721B (zh) * | 2017-12-28 | 2023-10-31 | 上海细胞治疗研究院 | 自表达cd47抗体的间皮素特异性car-t细胞及其用途 |
| WO2019157454A1 (en) * | 2018-02-11 | 2019-08-15 | Memorial Sloan-Kettering Cancer Center | Non-hla restricted t cell receptors and uses thereof |
| JP2021514360A (ja) | 2018-02-23 | 2021-06-10 | カーサリクス プロプライエタリー リミテッド | Ｔａｇ−７２を標的化するｔ細胞疾患処置 |
| GB201804701D0 (en) * | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| GB201807945D0 (en) * | 2018-05-16 | 2018-06-27 | Ospedale San Raffaele Srl | Vector production |
| US20200040056A1 (en) * | 2018-05-31 | 2020-02-06 | Washington University | Genome-edited invariant natural killer t (inkt) cells for the treatment of hematologic malignancies |
| TW202015719A (zh) | 2018-06-19 | 2020-05-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
| EP3830133A1 (en) * | 2018-08-01 | 2021-06-09 | City of Hope | Tag72 targeted chimeric antigen receptor modified t cells for treatment of tag72-positive tumors |
| AU2020291457B2 (en) * | 2019-06-12 | 2024-11-14 | The Regents Of The University Of California | Engineered off-the-shelf immune cells and methods of use thereof |
| BR112022009181A2 (pt) * | 2019-11-25 | 2022-07-26 | Univ Kyoto | Sistema para prover um produto de célula t, métodos para produzir um produto de célula t, para construir um banco celular e uma coleção de produto de célula t e para prover um produto de célula t, banco celular, coleções de banco celular e de produto de célula t, e, produto de célula t |
| KR20230013257A (ko) * | 2020-05-22 | 2023-01-26 | 충칭 프리시젼 바이오테크 컴퍼니 리미티드 | 종양 미세환경의 역전을 위한 융합 단백질 및 이의 응용 |
| WO2021248061A1 (en) | 2020-06-04 | 2021-12-09 | Carisma Therapeutics Inc. | Novel constructs for chimeric antigen receptors |
| WO2022061837A1 (en) * | 2020-09-27 | 2022-03-31 | Jiangsu Cell Tech Medical Research Institute Co., Ltd. | Fibronectin extra domain b (edb) -specific car-t for cancer |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| CA3214473A1 (en) * | 2021-04-07 | 2022-10-13 | Century Therapeutics, Inc. | Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells |
| EP4320227A1 (en) * | 2021-04-07 | 2024-02-14 | Century Therapeutics, Inc. | Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells |
| WO2023110824A1 (en) * | 2021-12-15 | 2023-06-22 | Novo Nordisk A/S | Novel integrin associated protein (iap) |
| CN114573710A (zh) * | 2022-02-16 | 2022-06-03 | 南方医科大学珠江医院 | 一种靶向抗原同时外泌cd47抗体的免疫细胞及其应用 |
| WO2024036214A2 (en) * | 2022-08-10 | 2024-02-15 | Jasper Therapeutics, Inc. | Modified stem cell compositions and methods for use |
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| CA2929087A1 (en) * | 2013-10-31 | 2015-05-07 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| EP3105333B1 (en) * | 2014-02-10 | 2020-04-08 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
| US20180214527A1 (en) * | 2015-03-26 | 2018-08-02 | City Of Hope | Bi-specific targeted chimeric antigen receptor t cells |
| CN108368520B (zh) * | 2015-11-04 | 2023-01-17 | 菲特治疗公司 | 多能细胞的基因组工程改造 |
| CN105331586B (zh) * | 2015-11-20 | 2020-09-15 | 上海细胞治疗研究院 | 一种包含高效杀伤启动机制的肿瘤精准t细胞及其用途 |
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2016
- 2016-11-23 JP JP2018546725A patent/JP6976960B2/ja active Active
- 2016-11-23 EP EP16867445.5A patent/EP3380117B1/en active Active
- 2016-11-23 SG SG10201912825XA patent/SG10201912825XA/en unknown
- 2016-11-23 ES ES16867445T patent/ES2862907T3/es active Active
- 2016-11-23 EP EP20169648.1A patent/EP3708588A1/en active Pending
- 2016-11-23 MY MYPI2018701648A patent/MY189819A/en unknown
- 2016-11-23 CA CA3004120A patent/CA3004120A1/en active Pending
- 2016-11-23 ES ES20169645T patent/ES2988976T3/es active Active
- 2016-11-23 IL IL296410A patent/IL296410A/en unknown
- 2016-11-23 CN CN202211541314.3A patent/CN116121281B/zh active Active
- 2016-11-23 WO PCT/AU2016/051141 patent/WO2017088012A1/en not_active Ceased
- 2016-11-23 EP EP20169645.7A patent/EP3708587B1/en active Active
- 2016-11-23 CN CN201680069543.6A patent/CN109152824B/zh active Active
- 2016-11-23 US US15/778,836 patent/US11400145B2/en active Active
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2018
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2021
- 2021-11-10 JP JP2021183110A patent/JP2022027762A/ja active Pending
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2022
- 2022-06-09 US US17/836,052 patent/US20220305106A1/en not_active Abandoned
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2024
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- 2024-01-26 JP JP2024010098A patent/JP2024028648A/ja active Pending
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2025
- 2025-07-17 US US19/271,861 patent/US20250340612A1/en active Pending
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