JP2021137024A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021137024A5 JP2021137024A5 JP2021095192A JP2021095192A JP2021137024A5 JP 2021137024 A5 JP2021137024 A5 JP 2021137024A5 JP 2021095192 A JP2021095192 A JP 2021095192A JP 2021095192 A JP2021095192 A JP 2021095192A JP 2021137024 A5 JP2021137024 A5 JP 2021137024A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- antibody
- engineered
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023119584A JP7719128B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
| JP2023119583A JP7717762B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
| JP2025124172A JP2025169264A (ja) | 2015-02-06 | 2025-07-24 | 治療免疫細胞の有効性を改良するための方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562112765P | 2015-02-06 | 2015-02-06 | |
| US62/112,765 | 2015-02-06 | ||
| US201562130970P | 2015-03-10 | 2015-03-10 | |
| US62/130,970 | 2015-03-10 | ||
| JP2017541243A JP6895380B2 (ja) | 2015-02-06 | 2016-02-05 | 治療免疫細胞の有効性を改良するための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541243A Division JP6895380B2 (ja) | 2015-02-06 | 2016-02-05 | 治療免疫細胞の有効性を改良するための方法 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023119584A Division JP7719128B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
| JP2023119583A Division JP7717762B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021137024A JP2021137024A (ja) | 2021-09-16 |
| JP2021137024A5 true JP2021137024A5 (enExample) | 2022-06-02 |
| JP7320560B2 JP7320560B2 (ja) | 2023-08-03 |
Family
ID=56564429
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541243A Active JP6895380B2 (ja) | 2015-02-06 | 2016-02-05 | 治療免疫細胞の有効性を改良するための方法 |
| JP2021095192A Active JP7320560B2 (ja) | 2015-02-06 | 2021-06-07 | 治療免疫細胞の有効性を改良するための方法 |
| JP2023119583A Active JP7717762B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
| JP2023119584A Active JP7719128B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
| JP2025124172A Pending JP2025169264A (ja) | 2015-02-06 | 2025-07-24 | 治療免疫細胞の有効性を改良するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541243A Active JP6895380B2 (ja) | 2015-02-06 | 2016-02-05 | 治療免疫細胞の有効性を改良するための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023119583A Active JP7717762B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
| JP2023119584A Active JP7719128B2 (ja) | 2015-02-06 | 2023-07-24 | 治療免疫細胞の有効性を改良するための方法 |
| JP2025124172A Pending JP2025169264A (ja) | 2015-02-06 | 2025-07-24 | 治療免疫細胞の有効性を改良するための方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US10765699B2 (enExample) |
| EP (2) | EP3253865B1 (enExample) |
| JP (5) | JP6895380B2 (enExample) |
| KR (2) | KR20250022235A (enExample) |
| CN (4) | CN115029362A (enExample) |
| AU (3) | AU2016216149B2 (enExample) |
| CA (1) | CA2975851A1 (enExample) |
| DK (1) | DK3253865T3 (enExample) |
| ES (1) | ES2926384T3 (enExample) |
| HR (1) | HRP20220890T1 (enExample) |
| HU (1) | HUE059662T2 (enExample) |
| LT (1) | LT3253865T (enExample) |
| PL (1) | PL3253865T3 (enExample) |
| PT (1) | PT3253865T (enExample) |
| RS (1) | RS63574B1 (enExample) |
| SG (2) | SG11201706236SA (enExample) |
| SI (1) | SI3253865T1 (enExample) |
| SM (1) | SMT202200353T1 (enExample) |
| WO (1) | WO2016126213A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3143134B1 (en) | 2014-05-15 | 2020-10-28 | National University of Singapore | Modified natural killer cells and uses thereof |
| ES2926384T3 (es) * | 2015-02-06 | 2022-10-25 | Nat Univ Singapore | Métodos para mejorar la eficacia de células inmunitarias terapéuticas |
| EP3261651B1 (en) | 2015-02-27 | 2022-05-04 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| MA45123A (fr) | 2016-05-27 | 2019-04-10 | Agenus Inc | Anticorps anti-tim-3 et leurs méthodes d'utilisation |
| US12350349B2 (en) * | 2016-08-03 | 2025-07-08 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| CN109689693B (zh) * | 2016-11-03 | 2022-06-28 | 深圳华大生命科学研究院 | 提高基因编辑效率的方法和系统 |
| SG10201912387PA (en) * | 2016-11-22 | 2020-02-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
| WO2018156434A1 (en) | 2017-02-22 | 2018-08-30 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Tim3-binding chimeric antigen receptors |
| WO2018169922A2 (en) * | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
| SG11201908492PA (en) | 2017-03-27 | 2019-10-30 | Nat Univ Singapore | Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy |
| EP3601537A4 (en) | 2017-03-27 | 2021-01-13 | National University of Singapore | STIMULATING CELL LINES FOR EX VIVO EXPANSION AND ACTIVATION OF NATURAL KILLER CELLS |
| KR20200035304A (ko) | 2017-08-10 | 2020-04-02 | 싱가포르국립대학교 | T 세포 수용체-결핍 키메라 항원 수용체 t-세포 및 이의 사용 방법 |
| EP3697425A1 (en) * | 2017-10-18 | 2020-08-26 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Methods and compounds for improved immune cell therapy |
| WO2019084258A1 (en) | 2017-10-25 | 2019-05-02 | Actinium Pharmaceuticals, Inc. | METHODS OF CONDITIONING BASED ON ANTI-CD45 AND USES THEREOF IN COMBINATION WITH GENETICALLY MODIFIED CELL THERAPIES |
| US12365733B2 (en) | 2017-12-29 | 2025-07-22 | Cellectis | Method for improving production of car T cells |
| CA3089478A1 (en) * | 2018-01-25 | 2019-08-01 | Pdi Therapeutics, Inc. | Mica/b antibodies and methods of use |
| CN108314739B (zh) * | 2018-02-05 | 2020-07-14 | 深圳市默赛尔生物医学科技发展有限公司 | 多信号嵌合抗原受体及其表达基因、其修饰的nk细胞及应用 |
| CN111801348A (zh) | 2018-02-09 | 2020-10-20 | 新加坡国立大学 | 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| AR114269A1 (es) * | 2018-02-26 | 2020-08-12 | Ablynx Nv | Secuencias nucleotídicas mejoradas que codifican para péptidos de unión |
| KR20200138741A (ko) * | 2018-04-02 | 2020-12-10 | 내셔널 유니버시티 오브 싱가포르 | 면역 세포에서 발현되는 막-결합 항-사이토카인 비-신호전달 결합제를 이용한 인간 사이토카인의 중화 |
| JP7584299B2 (ja) * | 2018-05-23 | 2024-11-15 | ナショナル ユニバーシティ オブ シンガポール | Ｔ細胞悪性腫瘍の免疫療法のためのｃｄ２表面発現の遮断およびキメラ抗原受容体の発現 |
| EP3802578A4 (en) * | 2018-06-01 | 2022-03-23 | Washington University | SUPPRESSION OF CYTOKINE RELEASE SYNDROME IN CHIMERIC ANTIGEN RECEPTOR CELL THERAPY |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| CN109207430A (zh) * | 2018-09-25 | 2019-01-15 | 华东师范大学 | 一种嵌合抗原受体nk细胞及其制备方法和应用 |
| CN109266618B (zh) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | 能够靶向肿瘤细胞的巨噬细胞及其制备方法 |
| KR20200049594A (ko) * | 2018-10-24 | 2020-05-08 | 주식회사 툴젠 | 조작된 면역 세포 |
| AU2019372673A1 (en) | 2018-11-01 | 2021-05-27 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Compositions and methods for T cell engineering |
| AU2019378039A1 (en) | 2018-11-14 | 2021-05-27 | Medisix Therapeutics Pte Ltd. | Two-gene vectors for generating CAR-T cells and uses thereof |
| CN109652379B (zh) * | 2018-12-29 | 2022-08-16 | 博生吉医药科技(苏州)有限公司 | Cd7嵌合抗原受体修饰的nk-92mi细胞及其应用 |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| KR102503349B1 (ko) | 2019-05-14 | 2023-02-23 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| GB201914611D0 (en) * | 2019-10-09 | 2019-11-20 | Autolus Ltd | Engineered immune cell |
| WO2021072250A1 (en) * | 2019-10-11 | 2021-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Recombinant polypeptides for regulatable cellular localization |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| CN118562007A (zh) * | 2019-12-19 | 2024-08-30 | 苏州方德门达新药开发有限公司 | 工程改造的t细胞、其制备及应用 |
| CN113088495B (zh) * | 2020-01-09 | 2024-08-16 | 苏州方德门达新药开发有限公司 | 工程改造的t细胞、其制备及应用 |
| BR112022016633A2 (pt) * | 2020-02-27 | 2022-12-13 | Novartis Ag | Métodos para produzir células que expressam receptor de antígeno quimérico |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CN113801238A (zh) * | 2020-06-11 | 2021-12-17 | 南京北恒生物科技有限公司 | 表达nk抑制性分子的工程化免疫细胞及其用途 |
| AU2021294559A1 (en) | 2020-06-22 | 2023-02-23 | Ramot At Tel-Aviv University Ltd. | Multi subunit protein modules, cells expressing same and uses thereof |
| CN112195155A (zh) * | 2020-08-11 | 2021-01-08 | 广东万海细胞生物科技有限公司 | 一种通用car-t细胞及其制备方法 |
| CN114525259B (zh) * | 2020-11-03 | 2025-02-14 | 南京北恒生物科技有限公司 | 靶向cd7的嵌合抗原受体及其用途 |
| AU2021377699A1 (en) | 2020-11-13 | 2023-06-15 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| AU2021401934A1 (en) * | 2020-12-14 | 2023-06-22 | Allogene Therapeutics, Inc. | Methods and reagents for characterizing car t cells for therapies |
| EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN115947852A (zh) * | 2021-01-12 | 2023-04-11 | 上海雅科生物科技有限公司 | 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用 |
| JP2024505955A (ja) * | 2021-02-03 | 2024-02-08 | バイオヘン セラピューティクス リミテッド | 新型キメラ抗原受容体及びその使用 |
| BR112023018832A2 (pt) | 2021-03-17 | 2023-12-26 | Myeloid Therapeutics Inc | Composições de proteínas de fusão quiméricas modificadas e métodos de uso das mesmas |
| EP4337268A4 (en) | 2021-05-11 | 2025-06-04 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| CN113416701B (zh) * | 2021-07-28 | 2023-05-09 | 新疆西部赛澳生物科技有限责任公司 | 一种nk细胞培养基及培养方法 |
| AU2022317972A1 (en) * | 2021-07-30 | 2024-03-21 | St Phi Therapeutics Co., Ltd | Universal t cell and application thereof |
| WO2024151213A2 (en) | 2023-01-12 | 2024-07-18 | National University Of Singapore | Blockade of cd8 expression and chimeric antigen receptors for immunotherapy of t-cell and nk-cell malignancies |
| WO2024154122A1 (en) | 2023-01-18 | 2024-07-25 | Gilboa Therapeutics LTD | Immune cells expressing a complement receptor and uses thereof |
| WO2024236557A1 (en) | 2023-05-12 | 2024-11-21 | Gilboa Therapeutics LTD | Compositions comprising an fc domain for the treatment of medical conditions |
| CN116731205B (zh) * | 2023-05-19 | 2024-02-27 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 一种表达TGFβRII和TIM3胞外区的免疫增强型融合蛋白及其应用 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| CA2018248A1 (en) | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| WO1999014353A2 (en) | 1997-09-19 | 1999-03-25 | Dana-Farber Cancer Institute, Inc. | Intrabody-mediated control of immune reactions |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| EP1343820A4 (en) | 2000-10-13 | 2005-09-14 | Uab Research Foundation | HUMANE SINGLE CHAIN ANTI EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY |
| CA2427858A1 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| AU2002361390A1 (en) | 2001-12-14 | 2003-06-30 | Friedrich-Alexander-Universitaet Erlangen-Nuernberg | Anti-cd7 immunotoxin as fusion protein |
| US20090191213A9 (en) | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| KR20060079180A (ko) | 2003-07-02 | 2006-07-05 | 노보 노르디스크 에이/에스 | Ｎｋ 세포 활성을 조절하기 위한 조성물 및 방법 |
| WO2005017163A2 (en) | 2003-08-15 | 2005-02-24 | Imperial College Innovations Limited | Phenotypic knockout of cell-surface proteins |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| CA2550933A1 (en) | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| DK2287195T3 (da) | 2004-07-01 | 2019-08-19 | Innate Pharma | Pan-kir2dl nk-receptor-antistoffer og anvendelse heraf i diagnostik og terapi |
| AU2005299353A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Use of modulators of EphA2 and EphrinA1 for the treatment and prevention of infections |
| US20090196850A1 (en) | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
| US20070036773A1 (en) * | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| CA2625998C (en) | 2005-10-06 | 2015-12-01 | Xencor, Inc. | Optimized anti-cd30 antibodies |
| JP5174005B2 (ja) * | 2006-03-28 | 2013-04-03 | ハンプトン ユニバーシティ | 適切な生物学的重み付けをしたハドロン治療計画 |
| PL2132229T3 (pl) | 2007-03-01 | 2016-12-30 | Kompozycje rekombinowanych przeciwciał anty-receptor czynnika wzrostu naskórka | |
| PL2185574T3 (pl) | 2007-09-07 | 2013-09-30 | Agensys Inc | Przeciwciała i powiązane cząsteczki, które wiążą się do białek 24P4C12 |
| MX2010007935A (es) * | 2008-01-24 | 2010-08-23 | Novo Nordisk As | Anticuerpo monoclonal humanizado anti-nkg2a humano. |
| US8580714B2 (en) | 2009-10-14 | 2013-11-12 | Janssen Biotech, Inc. | Methods of affinity maturing antibodies |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US9273283B2 (en) * | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CA2863799C (en) | 2012-02-22 | 2020-09-01 | Matthew J. FRIGAULT | Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer |
| FI3597749T3 (fi) | 2012-05-25 | 2023-10-09 | Univ California | Menetelmiä ja koostumuksia rna-ohjattua kohde-dna-modifikaatiota varten ja rna-ohjattua transkription modulaatiota varten |
| ES2778701T3 (es) * | 2012-07-13 | 2020-08-11 | The Trustees Of The Univ Of Pennsylvania Center For Technology Transfer | Gestión de toxicidad para la actividad antitumoral de CAR |
| ES2824024T3 (es) * | 2012-10-10 | 2021-05-11 | Sangamo Therapeutics Inc | Compuestos modificadores de células T y usos de los mismos |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| KR101521224B1 (ko) * | 2012-12-20 | 2015-05-19 | 한양대학교 산학협력단 | T 세포 특이적인 인간화 단일조각항체 전달체 |
| SG10201700916SA (en) * | 2012-12-27 | 2017-03-30 | Aduro Biotech Inc | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
| WO2014124143A1 (en) | 2013-02-06 | 2014-08-14 | Anthrogenesis Corporation | Modified t lymphocytes having improved specificity |
| KR20210108497A (ko) | 2013-02-26 | 2021-09-02 | 메모리얼 슬로안 케터링 캔서 센터 | 면역치료용 조성물 및 방법 |
| ES2882183T3 (es) | 2013-03-14 | 2021-12-01 | Univ Duke | Moléculas biespecíficas que son inmunorreactivas con células efectoras inmunitarias que expresan un receptor activador |
| DK3004337T3 (da) | 2013-05-29 | 2017-11-13 | Cellectis | Fremgangsmåde til konstruktion af T-celler til immunoterapi ved brug af RNA-guidet Cas nuklease-system |
| WO2015075468A1 (en) | 2013-11-21 | 2015-05-28 | Ucl Business Plc | Cell |
| JP6673838B2 (ja) | 2014-02-14 | 2020-04-01 | セレクティスＣｅｌｌｅｃｔｉｓ | 免疫細胞と病的細胞の両方に存在する抗原を標的とするように操作された、免疫療法のための細胞 |
| GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
| MX2017000646A (es) | 2014-07-15 | 2017-04-27 | Juno Therapeutics Inc | Celulas geneticamente modificadas para terapia celular adoptiva. |
| AU2015330017A1 (en) | 2014-10-07 | 2017-04-27 | Cellectis | Method for modulating car-induced immune cells activity |
| EP4427809A3 (en) | 2014-10-31 | 2024-12-04 | The Trustees of The University of Pennsylvania | Altering gene expression in car-t cells and uses thereof |
| HRP20240357T1 (hr) * | 2014-12-24 | 2024-06-07 | Autolus Limited | Stanica |
| WO2016126608A1 (en) * | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| ES2926384T3 (es) | 2015-02-06 | 2022-10-25 | Nat Univ Singapore | Métodos para mejorar la eficacia de células inmunitarias terapéuticas |
| EP3261651B1 (en) | 2015-02-27 | 2022-05-04 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| CA2976684C (en) * | 2015-03-02 | 2024-03-05 | Innovative Cellular Therapeutics CO., LTD. | Reducing immune tolerance induced by pd-l1 |
| AU2016279050A1 (en) | 2015-06-19 | 2018-01-04 | Massachusetts Institute Of Technology | Tumor immunotherapy |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| GB2557123B (en) | 2015-07-31 | 2021-11-03 | Univ Minnesota | Modified cells and methods of therapy |
| CA3001185A1 (en) | 2015-10-06 | 2017-04-13 | Regents Of The University Of Minnesota | Nk engaging compounds and methods |
| WO2017112877A1 (en) | 2015-12-22 | 2017-06-29 | Icell Gene Therapeutics, Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
| US11390658B2 (en) | 2016-06-06 | 2022-07-19 | St. Jude Children's Research Hospital | Anti-CD7 chimeric antigen receptor and method of use thereof |
| EP4353750A3 (en) | 2016-06-24 | 2024-07-24 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
| CA2937157A1 (en) | 2016-07-25 | 2018-01-25 | Ucl Business Plc | Protein-based t-cell receptor knockdown |
| US12350349B2 (en) | 2016-08-03 | 2025-07-08 | Washington University | Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors |
| SG10201912387PA (en) | 2016-11-22 | 2020-02-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
| GB201622044D0 (en) | 2016-12-22 | 2017-02-08 | Ucl Business Plc | T cell-targeted T cells |
| JP7717439B2 (ja) | 2017-01-10 | 2025-08-04 | ザ ジェネラル ホスピタル コーポレイション | 修飾されたｔ細胞及びその使用方法 |
| KR20200035304A (ko) | 2017-08-10 | 2020-04-02 | 싱가포르국립대학교 | T 세포 수용체-결핍 키메라 항원 수용체 t-세포 및 이의 사용 방법 |
| AU2019378039A1 (en) | 2018-11-14 | 2021-05-27 | Medisix Therapeutics Pte Ltd. | Two-gene vectors for generating CAR-T cells and uses thereof |
-
2016
- 2016-02-05 ES ES16746922T patent/ES2926384T3/es active Active
- 2016-02-05 HU HUE16746922A patent/HUE059662T2/hu unknown
- 2016-02-05 CA CA2975851A patent/CA2975851A1/en active Pending
- 2016-02-05 SM SM20220353T patent/SMT202200353T1/it unknown
- 2016-02-05 EP EP16746922.0A patent/EP3253865B1/en active Active
- 2016-02-05 SG SG11201706236SA patent/SG11201706236SA/en unknown
- 2016-02-05 CN CN202210667502.4A patent/CN115029362A/zh active Pending
- 2016-02-05 HR HRP20220890TT patent/HRP20220890T1/hr unknown
- 2016-02-05 EP EP22180254.9A patent/EP4134430A1/en active Pending
- 2016-02-05 RS RS20220680A patent/RS63574B1/sr unknown
- 2016-02-05 JP JP2017541243A patent/JP6895380B2/ja active Active
- 2016-02-05 PL PL16746922.0T patent/PL3253865T3/pl unknown
- 2016-02-05 KR KR1020257003185A patent/KR20250022235A/ko active Pending
- 2016-02-05 US US15/548,577 patent/US10765699B2/en active Active
- 2016-02-05 KR KR1020177024662A patent/KR102763121B1/ko active Active
- 2016-02-05 AU AU2016216149A patent/AU2016216149B2/en active Active
- 2016-02-05 CN CN201680018962.7A patent/CN107709548B/zh active Active
- 2016-02-05 CN CN202210661143.1A patent/CN114891816B/zh active Active
- 2016-02-05 PT PT167469220T patent/PT3253865T/pt unknown
- 2016-02-05 SG SG10201913124RA patent/SG10201913124RA/en unknown
- 2016-02-05 LT LTEPPCT/SG2016/050063T patent/LT3253865T/lt unknown
- 2016-02-05 DK DK16746922.0T patent/DK3253865T3/da active
- 2016-02-05 SI SI201631593T patent/SI3253865T1/sl unknown
- 2016-02-05 WO PCT/SG2016/050063 patent/WO2016126213A1/en not_active Ceased
- 2016-02-05 CN CN202111064400.5A patent/CN113713091A/zh active Pending
-
2020
- 2020-07-30 US US16/943,400 patent/US12404491B2/en active Active
-
2021
- 2021-06-07 JP JP2021095192A patent/JP7320560B2/ja active Active
-
2022
- 2022-06-29 AU AU2022204601A patent/AU2022204601B2/en active Active
- 2022-07-12 US US17/862,797 patent/US12404492B2/en active Active
- 2022-07-12 US US17/862,721 patent/US11679132B2/en active Active
-
2023
- 2023-07-24 JP JP2023119583A patent/JP7717762B2/ja active Active
- 2023-07-24 JP JP2023119584A patent/JP7719128B2/ja active Active
-
2025
- 2025-07-03 AU AU2025205077A patent/AU2025205077A1/en active Pending
- 2025-07-24 JP JP2025124172A patent/JP2025169264A/ja active Pending
- 2025-07-30 US US19/285,735 patent/US20250354119A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021137024A5 (enExample) | ||
| JP7719128B2 (ja) | 治療免疫細胞の有効性を改良するための方法 | |
| JP2023059873A5 (enExample) | ||
| JP2025065142A5 (enExample) | ||
| Geldres et al. | Chimeric antigen receptor-redirected T cells return to the bench | |
| IL264104B1 (en) | Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof | |
| JP2019509764A (ja) | 初代細胞のためのトランスポゾンに基づく転移システム | |
| CN110616191B (zh) | 共刺激配体联合的car t疗法 | |
| JPWO2021173995A5 (enExample) | ||
| JP2023541132A (ja) | 免疫細胞におけるアダプターの誘導性発現のための系 | |
| JPWO2021205172A5 (enExample) | ||
| JP2025524457A (ja) | 哺乳動物におけるキメラ抗原受容体介在性の免疫応答を刺激するための方法において使用するためのｃｄ１２３に対する標的化モジュール | |
| WO2025140540A1 (zh) | 特异性靶向肿瘤的转基因重组免疫细胞及其应用 | |
| KR20250111218A (ko) | 혈액학적 암의 치료에 사용하기 위한 키트 | |
| HK40086170A (en) | Methods for enhancing efficacy of therapeutic immune cells | |
| Debets et al. | TCR-Engineered T cells | |
| NZ734107B2 (en) | Methods for enhancing efficacy of therapeutic immune cells | |
| JPWO2022243565A5 (enExample) |