JP2018535294A5 - - Google Patents
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- Publication number
- JP2018535294A5 JP2018535294A5 JP2018517156A JP2018517156A JP2018535294A5 JP 2018535294 A5 JP2018535294 A5 JP 2018535294A5 JP 2018517156 A JP2018517156 A JP 2018517156A JP 2018517156 A JP2018517156 A JP 2018517156A JP 2018535294 A5 JP2018535294 A5 JP 2018535294A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- hydrogen
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 238000000034 method Methods 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 239000001022 rhodamine dye Substances 0.000 claims 7
- 239000002904 solvent Substances 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- -1 cyano, carboxy Chemical group 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000006227 byproduct Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical class [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical group FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910001882 dioxygen Inorganic materials 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562236488P | 2015-10-02 | 2015-10-02 | |
| US62/236,488 | 2015-10-02 | ||
| PCT/US2016/054898 WO2017059308A1 (en) | 2015-10-02 | 2016-09-30 | Methods for synthesizing rhodamine dyes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535294A JP2018535294A (ja) | 2018-11-29 |
| JP2018535294A5 true JP2018535294A5 (enExample) | 2019-11-07 |
| JP6802841B2 JP6802841B2 (ja) | 2020-12-23 |
Family
ID=57113819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517156A Active JP6802841B2 (ja) | 2015-10-02 | 2016-09-30 | ローダミン色素の合成方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10093806B2 (enExample) |
| EP (1) | EP3356338B1 (enExample) |
| JP (1) | JP6802841B2 (enExample) |
| WO (1) | WO2017059308A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107163017B (zh) * | 2017-05-22 | 2019-01-01 | 北京欧凯纳斯科技有限公司 | 一种四甲基罗丹明的制备工艺 |
| CN109608429A (zh) * | 2018-12-03 | 2019-04-12 | 浙江工业大学 | 一种磺酸基罗丹明化合物的合成工艺 |
| CN110452203B (zh) * | 2019-08-29 | 2021-04-13 | 忻州师范学院 | 一种1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的制备方法 |
| CN110526886B (zh) * | 2019-08-30 | 2021-04-30 | 忻州师范学院 | 一种合成1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5331097A (en) * | 1991-08-13 | 1994-07-19 | Milliken Research Corporation | Poly(oxyalkylene) substituted xanthene colorant and method for making the same |
| US8163910B2 (en) | 2007-10-03 | 2012-04-24 | Elitech Holding B.V. | Amide-substituted xanthene dyes |
| WO2010149190A1 (en) | 2009-06-26 | 2010-12-29 | Max-Planck-Gesellschaft Zur | Novel fluorinated rhodamines as photostable fluorescent dyes for labelling and imaging techniques |
| KR101125057B1 (ko) * | 2009-09-25 | 2012-03-21 | 주식회사 디케이씨코포레이션 | 물질 표지용 화합물 및 그 제조방법 |
| EP2782916B1 (en) | 2011-11-21 | 2018-02-28 | Promega Corporation | Carboxy x rhodamine analogs |
-
2016
- 2016-09-30 JP JP2018517156A patent/JP6802841B2/ja active Active
- 2016-09-30 WO PCT/US2016/054898 patent/WO2017059308A1/en not_active Ceased
- 2016-09-30 US US15/282,590 patent/US10093806B2/en active Active
- 2016-09-30 EP EP16778663.1A patent/EP3356338B1/en active Active
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