JP6802841B2 - ローダミン色素の合成方法 - Google Patents

ローダミン色素の合成方法 Download PDF

Info

Publication number
JP6802841B2
JP6802841B2 JP2018517156A JP2018517156A JP6802841B2 JP 6802841 B2 JP6802841 B2 JP 6802841B2 JP 2018517156 A JP2018517156 A JP 2018517156A JP 2018517156 A JP2018517156 A JP 2018517156A JP 6802841 B2 JP6802841 B2 JP 6802841B2
Authority
JP
Japan
Prior art keywords
compound
formula
alkyl
group
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018517156A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018535294A5 (enExample
JP2018535294A (ja
Inventor
スティーブン ジェイ ドワイト
スティーブン ジェイ ドワイト
セルジー レヴィン
セルジー レヴィン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Publication of JP2018535294A publication Critical patent/JP2018535294A/ja
Publication of JP2018535294A5 publication Critical patent/JP2018535294A5/ja
Application granted granted Critical
Publication of JP6802841B2 publication Critical patent/JP6802841B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2018517156A 2015-10-02 2016-09-30 ローダミン色素の合成方法 Active JP6802841B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562236488P 2015-10-02 2015-10-02
US62/236,488 2015-10-02
PCT/US2016/054898 WO2017059308A1 (en) 2015-10-02 2016-09-30 Methods for synthesizing rhodamine dyes

Publications (3)

Publication Number Publication Date
JP2018535294A JP2018535294A (ja) 2018-11-29
JP2018535294A5 JP2018535294A5 (enExample) 2019-11-07
JP6802841B2 true JP6802841B2 (ja) 2020-12-23

Family

ID=57113819

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018517156A Active JP6802841B2 (ja) 2015-10-02 2016-09-30 ローダミン色素の合成方法

Country Status (4)

Country Link
US (1) US10093806B2 (enExample)
EP (1) EP3356338B1 (enExample)
JP (1) JP6802841B2 (enExample)
WO (1) WO2017059308A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107163017B (zh) * 2017-05-22 2019-01-01 北京欧凯纳斯科技有限公司 一种四甲基罗丹明的制备工艺
CN109608429A (zh) * 2018-12-03 2019-04-12 浙江工业大学 一种磺酸基罗丹明化合物的合成工艺
CN110452203B (zh) * 2019-08-29 2021-04-13 忻州师范学院 一种1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的制备方法
CN110526886B (zh) * 2019-08-30 2021-04-30 忻州师范学院 一种合成1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331097A (en) * 1991-08-13 1994-07-19 Milliken Research Corporation Poly(oxyalkylene) substituted xanthene colorant and method for making the same
US8163910B2 (en) 2007-10-03 2012-04-24 Elitech Holding B.V. Amide-substituted xanthene dyes
WO2010149190A1 (en) 2009-06-26 2010-12-29 Max-Planck-Gesellschaft Zur Novel fluorinated rhodamines as photostable fluorescent dyes for labelling and imaging techniques
KR101125057B1 (ko) * 2009-09-25 2012-03-21 주식회사 디케이씨코포레이션 물질 표지용 화합물 및 그 제조방법
EP2782916B1 (en) 2011-11-21 2018-02-28 Promega Corporation Carboxy x rhodamine analogs

Also Published As

Publication number Publication date
EP3356338B1 (en) 2020-06-17
US20170096560A1 (en) 2017-04-06
US10093806B2 (en) 2018-10-09
EP3356338A1 (en) 2018-08-08
WO2017059308A1 (en) 2017-04-06
JP2018535294A (ja) 2018-11-29

Similar Documents

Publication Publication Date Title
JP6802841B2 (ja) ローダミン色素の合成方法
JP7539451B2 (ja) アミノピリミジン誘導体を調製するための改善されたプロセス
Watanabe et al. One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling
RS59100B1 (sr) Antitela usmerena protiv her-3 i njihove upotrebe
Shen et al. The base-promoted synthesis of multisubstituted benzo [b][1, 4] oxazepines
Sun et al. Selectfluor-induced C (sp 2)–O coupling reaction of N-substituted anilines with hydroxylamine derivatives
Tang et al. Metal-and additive-free radical-triggered nitration/cyclization to construct indolo [2, 1-α] isoquinoline and benzimidazo [2, 1-a] isoquinolin-6 (5 H)-one derivatives using t-BuONO as nitro reagents
Ma et al. Three-component cascade reaction synthesis of polycyclic 1, 4-dihydropyridine derivatives in water
JPWO2019240143A1 (ja) トリアゾリンジオン付加体、トリアゾリンジオン付加体の製造方法、エン化合物の製造方法、およびエン化合物の分析方法
CN102863399A (zh) 一种靛红酸酐衍生物的合成方法
JPS63145284A (ja) イミダゾール誘導体およびその製法
Wen et al. Light-assisted green and efficient construction of thiadiazole/selenadiazole derivatives
CN108218762B (zh) 一种2位季碳吲哚-3-酮类化合物的合成方法
CN109535140A (zh) 一种基于肟酯与吲哚构建双吲哚取代二氢吡咯酮类衍生物的方法
CN107176957B (zh) 手性吡唑啉酮螺[乙烯硫脲]螺羟吲哚类化合物及其衍生物
CN1043644C (zh) 制备(1H－四唑－5－基)四唑并[1,5－a]喹啉和1,8－二氮杂萘的方法
CN118994154B (zh) 一种C3氟烷基化4H-吡啶并[1,2-a]嘧啶-4-酮衍生物及其合成方法
CN119823020A (zh) 一种3-硫氰基吲哚衍生物的制备方法
JPH07109260A (ja) ５−アミノ−２−ニトロピリジン誘導体及び２，５−ジアミノ−３−ヒドロキシピリジン誘導体の製造方法
JP5773123B2 (ja) ５位にイミノ基を有するアジン系化合物の製造方法。
JP2003048873A (ja) ４−フタロニトリル誘導体の製造方法
JPS6263557A (ja) 末端二重結合を有するジアセチレン化合物
JP3882546B2 (ja) ４−フタロニトリル誘導体の製造方法
Yue et al. Synthesis, Crystal Structure and Antitumor Activity of Novel 5-Chloro-β-carboline Derivatives
Zhang et al. Copper-Catalyzed Cascade Bicyclization of o-Alkenylphenyl Isothiocyanates with Sodium Azide Leading to the 5H-Benzo [d] tetrazolo [5, 1-b][1, 3] thiazines

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190926

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190926

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200423

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200615

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200914

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201005

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201029

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201127

R150 Certificate of patent or registration of utility model

Ref document number: 6802841

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250