|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6641809B1
(en)
|
1990-03-26 |
2003-11-04 |
Bristol-Myers Squibb Company |
Method of regulating cellular processes mediated by B7 and CD28
|
|
US7070776B1
(en)
|
1990-03-26 |
2006-07-04 |
Bristol-Myers Squibb Company |
Methods for blocking binding of CD28 receptor to B7
|
|
US6071716A
(en)
|
1990-10-01 |
2000-06-06 |
Dana-Farber Cancer Institute |
DNA encoding, B7, a new member of the IG superfamily with unique expression on activated and neoplastic B cells
|
|
US6887471B1
(en)
|
1991-06-27 |
2005-05-03 |
Bristol-Myers Squibb Company |
Method to inhibit T cell interactions with soluble B7
|
|
US5858776A
(en)
|
1993-11-03 |
1999-01-12 |
Repligen Corporation |
Tumor cells with increased immunogenicity and uses therefor
|
|
US6130316A
(en)
|
1993-07-26 |
2000-10-10 |
Dana Farber Cancer Institute |
Fusion proteins of novel CTLA4/CD28 ligands and uses therefore
|
|
US6824779B1
(en)
|
1993-07-26 |
2004-11-30 |
Dana-Farber Cancer Institute, Inc. |
Methods for inhibiting the interaction of B7-2 with its natural ligand
|
|
US6218510B1
(en)
|
1994-03-02 |
2001-04-17 |
Brigham & Woman's Hospital |
B7-1 and B7-2 polypeptides
|
|
WO1995024217A1
(en)
|
1994-03-08 |
1995-09-14 |
Dana-Farber Cancer Institute |
Methods for modulating t cell unresponsiveness
|
|
US6030815A
(en)
*
|
1995-04-11 |
2000-02-29 |
Neose Technologies, Inc. |
Enzymatic synthesis of oligosaccharides
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
|
US6491925B2
(en)
|
1996-08-15 |
2002-12-10 |
Emory University |
Compositions and methods for cancer prophylaxis and/or treatment
|
|
CA2292415A1
(en)
|
1997-06-20 |
1998-12-30 |
Innogenetics N.V. |
B7-binding molecules for treating immune diseases
|
|
CA2348292A1
(en)
|
1998-10-30 |
2000-05-11 |
Takeda Chemical Industries, Ltd. |
Betacellulin protein-containing preparation
|
|
US7011833B1
(en)
|
1999-05-06 |
2006-03-14 |
Genetics Institute, Inc. |
Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
|
|
EP1210428B1
(en)
|
1999-08-23 |
2015-03-18 |
Dana-Farber Cancer Institute, Inc. |
Pd-1, a receptor for b7-4, and uses therefor
|
|
US6429303B1
(en)
|
1999-09-03 |
2002-08-06 |
Curagen Corporation |
Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same
|
|
US7064111B1
(en)
|
1999-10-05 |
2006-06-20 |
Georgetown University |
Use of soluble costimulatory factor for tumor immuno-gene therapy
|
|
WO2004029197A2
(en)
|
2001-06-22 |
2004-04-08 |
Maxygen, Inc. |
Co-stimulatory molecules
|
|
US7183376B2
(en)
|
2000-06-23 |
2007-02-27 |
Maxygen, Inc. |
Variant B7 co-stimulatory molecules
|
|
US6503914B1
(en)
|
2000-10-23 |
2003-01-07 |
Board Of Regents, The University Of Texas System |
Thienopyrimidine-based inhibitors of the Src family
|
|
US20040236091A1
(en)
|
2001-03-28 |
2004-11-25 |
Chicz Roman M. |
Translational profiling
|
|
AU2002346373A1
(en)
|
2001-11-09 |
2003-05-19 |
Idec Pharmaceuticals Corporation |
Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies
|
|
CN1753912B
(zh)
|
2002-12-23 |
2011-11-02 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
AU2003299971A1
(en)
|
2002-12-30 |
2004-07-29 |
Amgen Inc. |
Combination therapy with co-stimulatory factors
|
|
JP4810427B2
(ja)
|
2003-05-22 |
2011-11-09 |
アボット・ラボラトリーズ |
インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤
|
|
EP1636380A2
(en)
|
2003-05-30 |
2006-03-22 |
Genomic Health, Inc. |
Gene expression markers for response to egfr inhibitor drugs
|
|
CA2762015A1
(en)
|
2003-08-04 |
2005-02-24 |
Bristol-Myers Squibb Company |
Methods for treating cardiovascular disease using a soluble ctla4 molecule
|
|
CN101501211A
(zh)
|
2004-03-31 |
2009-08-05 |
综合医院公司 |
测定癌症对表皮生长因子受体靶向性治疗反应性的方法
|
|
EP1766068A4
(en)
|
2004-06-04 |
2010-03-03 |
Genentech Inc |
EGFR Mutations
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
WO2006047483A2
(en)
|
2004-10-22 |
2006-05-04 |
Redpath Integrated Pathology, Inc. |
Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and pure fluid specimens
|
|
AU2005302459A1
(en)
|
2004-10-29 |
2006-05-11 |
University Of Southern California |
Combination cancer immunotherapy with co-stimulatory molecules
|
|
AU2006230099B2
(en)
|
2005-03-25 |
2012-04-19 |
Gitr, Inc. |
GITR binding molecules and uses therefor
|
|
US7635570B2
(en)
|
2005-04-01 |
2009-12-22 |
Salvatore Siena |
Epidermal growth factor receptor gene copy number
|
|
KR20080003422A
(ko)
|
2005-04-14 |
2008-01-07 |
메르크 파텐트 게엠베하 |
종양 조직 내의 egfr 유전자의 증가된 복제수에 기초한항-egfr 항체 치료
|
|
RU2494107C2
(ru)
|
2005-05-09 |
2013-09-27 |
Оно Фармасьютикал Ко., Лтд. |
Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
|
|
PL1879573T3
(pl)
|
2005-05-10 |
2013-05-31 |
Incyte Holdings Corp |
Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
|
|
PL1913157T5
(pl)
|
2005-06-28 |
2017-09-29 |
Genentech Inc |
Mutacje EGFR i KRAS do prognozowania reakcji pacjenta na leczenie inhibitorem EGFR
|
|
US8703769B2
(en)
|
2005-07-15 |
2014-04-22 |
The University Of North Carolina At Chapel Hill |
Use of EGFR inhibitors to prevent or treat obesity
|
|
EP1910542B1
(en)
*
|
2005-07-22 |
2009-12-02 |
Five Prime Therapeutics, Inc. |
Compositions and methods of treating disease with fgfr fusion proteins
|
|
ATE520979T1
(de)
|
2005-08-24 |
2011-09-15 |
Bristol Myers Squibb Co |
Biomarker und verfahren zur bestimmung der empfindlichkeit gegenüber modulatoren des egf(epidermal growth factor)-rezeptors
|
|
CA2634198C
(en)
|
2005-12-20 |
2014-06-03 |
Incyte Corporation |
N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
|
|
US7908091B2
(en)
|
2006-03-17 |
2011-03-15 |
Prometheus Laboratories Inc. |
Methods of predicting and monitoring tyrosine kinase inhibitor therapy
|
|
JP6092497B2
(ja)
|
2006-03-30 |
2017-03-08 |
ユニバーシティー オブ カリフォルニア |
抗ctla−4抗体の限局性分泌のための方法および組成物
|
|
WO2008033442A2
(en)
|
2006-09-12 |
2008-03-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for performing low background multiplex nucleic acid amplification reactions
|
|
CL2007002650A1
(es)
|
2006-09-19 |
2008-02-08 |
Incyte Corp |
Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
|
|
ES2444574T3
(es)
|
2006-09-19 |
2014-02-25 |
Incyte Corporation |
N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa
|
|
WO2008037080A1
(en)
|
2006-09-29 |
2008-04-03 |
Universite De Montreal |
Methods and compositions for immune response modulation and uses thereof
|
|
ES2426814T3
(es)
|
2007-03-13 |
2013-10-25 |
Amgen Inc. |
Mutaciones de K-ras y B-raf y terapia con anticuerpos anti-EGFr
|
|
CA2682027A1
(en)
|
2007-03-28 |
2008-10-02 |
Biogen Idec Inc. |
Modulation of tumor microenvironment
|
|
EP2139922A1
(en)
|
2007-03-28 |
2010-01-06 |
Biogen Idec, Inc. |
Treatment of hodgkins lymphoma
|
|
CA2682527C
(en)
|
2007-03-30 |
2017-07-11 |
Memorial Sloan-Kettering Cancer Center |
Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
|
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
HRP20131167T1
(hr)
|
2007-06-18 |
2014-01-03 |
Merck Sharp & Dohme B.V. |
Antitijela za humani receptor programirane smrti pd-1
|
|
ES2776406T3
(es)
|
2007-07-12 |
2020-07-30 |
Gitr Inc |
Terapias de combinación que emplean moléculas de enlazamiento a GITR
|
|
CN101358225B
(zh)
*
|
2007-07-30 |
2012-02-01 |
厦门大学 |
高唾液酸含量的免疫球蛋白抗体的制备方法与应用
|
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
|
AU2008319053B2
(en)
*
|
2007-11-01 |
2012-04-26 |
Astellas Pharma Inc. |
Immunosuppressive polypeptides and nucleic acids
|
|
JP5583592B2
(ja)
|
2007-11-30 |
2014-09-03 |
ニューリンク ジェネティクス コーポレイション |
Ido阻害剤
|
|
WO2009089149A1
(en)
|
2008-01-03 |
2009-07-16 |
The Johns Hopkins University |
B7-h1 (cd274) antagonists induce apoptosis of tumor cells
|
|
HRP20160855T1
(hr)
|
2008-02-08 |
2016-09-23 |
Medimmune, Llc |
Anti-ifnar1 protutijela sa smanjenim afinitetom fc liganda
|
|
WO2009114335A2
(en)
|
2008-03-12 |
2009-09-17 |
Merck & Co., Inc. |
Pd-1 binding proteins
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
WO2010098788A2
(en)
|
2008-08-25 |
2010-09-02 |
Amplimmune, Inc. |
Pd-i antagonists and methods for treating infectious disease
|
|
CN102203132A
(zh)
|
2008-08-25 |
2011-09-28 |
安普利穆尼股份有限公司 |
Pd-1拮抗剂的组合物和使用方法
|
|
EP2473531A4
(en)
|
2009-09-03 |
2013-05-01 |
Merck Sharp & Dohme |
Anti-gitr antibodies
|
|
US8722720B2
(en)
|
2009-10-28 |
2014-05-13 |
Newlink Genetics Corporation |
Imidazole derivatives as IDO inhibitors
|
|
WO2011066342A2
(en)
|
2009-11-24 |
2011-06-03 |
Amplimmune, Inc. |
Simultaneous inhibition of pd-l1/pd-l2
|
|
JP5998060B2
(ja)
|
2010-03-04 |
2016-09-28 |
マクロジェニクス,インコーポレーテッド |
B7−h3と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
|
|
PT2614082T
(pt)
|
2010-09-09 |
2018-12-03 |
Pfizer |
Moléculas de ligação a 4-1bb
|
|
AR083495A1
(es)
|
2010-10-22 |
2013-02-27 |
Esbatech Alcon Biomed Res Unit |
Anticuerpos estables y solubles
|
|
SG10201602394QA
(en)
|
2011-03-29 |
2016-05-30 |
Roche Glycart Ag |
Antibody FC Variants
|
|
NO2694640T3
(https=)
|
2011-04-15 |
2018-03-17 |
|
|
|
KR101970025B1
(ko)
|
2011-04-20 |
2019-04-17 |
메디뮨 엘엘씨 |
B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들
|
|
MY180616A
(en)
|
2011-06-30 |
2020-12-03 |
Genzyme Corp |
Inhibitors of t-cell activation
|
|
JP6240600B2
(ja)
|
2011-07-24 |
2017-11-29 |
キュアテク リミテッド |
ヒト化免疫モノクローナル抗体の変異体
|
|
JP6238459B2
(ja)
|
2011-08-01 |
2017-11-29 |
ジェネンテック, インコーポレイテッド |
Pd−1軸結合アンタゴニストとmek阻害剤を使用する癌の治療方法
|
|
US8956619B2
(en)
|
2011-10-25 |
2015-02-17 |
University Of Maryland, Baltimore County |
Soluble CD80 as a therapeutic to reverse immune supression in cancer patients
|
|
US9567642B2
(en)
|
2012-02-02 |
2017-02-14 |
Massachusetts Institute Of Technology |
Methods and products related to targeted cancer therapy
|
|
CA2863658C
(en)
|
2012-02-03 |
2023-03-14 |
Emory University |
Immunostimulatory compositions, particles, and uses related thereto
|
|
CN113967253A
(zh)
|
2012-05-15 |
2022-01-25 |
百时美施贵宝公司 |
通过破坏pd-1/pd-l1信号传输的免疫治疗
|
|
AR091649A1
(es)
|
2012-07-02 |
2015-02-18 |
Bristol Myers Squibb Co |
Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
|
|
ES2862950T3
(es)
*
|
2012-12-18 |
2021-10-08 |
Univ Rockefeller |
Anticuerpos anti-CD4 modificados con glicanos para la prevención y terapia del VIH
|
|
US20160024179A1
(en)
|
2013-03-15 |
2016-01-28 |
Pyranose Biotherapeutics, Inc. |
Modified fc fusion proteins
|
|
KR102389677B1
(ko)
|
2013-03-15 |
2022-04-21 |
제넨테크, 인크. |
Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법
|
|
US9308236B2
(en)
|
2013-03-15 |
2016-04-12 |
Bristol-Myers Squibb Company |
Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
|
|
ES2699599T3
(es)
|
2013-03-15 |
2019-02-11 |
Abbvie Biotherapeutics Inc |
Variantes de Fc
|
|
TW201605896A
(zh)
|
2013-08-30 |
2016-02-16 |
安美基股份有限公司 |
Gitr抗原結合蛋白
|
|
ES2714708T3
(es)
|
2013-10-01 |
2019-05-29 |
Mayo Found Medical Education & Res |
Procedimientos para el tratamiento de cáncer en pacientes con niveles elevados de Bim
|
|
WO2015100219A1
(en)
|
2013-12-23 |
2015-07-02 |
Oncomed Pharmaceuticals, Inc. |
Immunotherapy with binding agents
|
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
|
ES2916923T3
(es)
|
2014-07-11 |
2022-07-06 |
Ventana Med Syst Inc |
Anticuerpos anti-PD-L1 y usos diagnósticos de los mismos
|
|
WO2016044189A1
(en)
|
2014-09-15 |
2016-03-24 |
Genentech, Inc. |
Methods of treating cancer using pd-1 axis binding antagonist and il-17 binding antagonists
|
|
UY36390A
(es)
*
|
2014-11-05 |
2016-06-01 |
Flexus Biosciences Inc |
Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
|
|
EP3270943A4
(en)
|
2015-03-16 |
2018-10-17 |
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. |
Isolated peptides derived from the b7 ligand dimer interface and uses thereof
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
EP3283508B1
(en)
|
2015-04-17 |
2021-03-17 |
Alpine Immune Sciences, Inc. |
Immunomodulatory proteins with tunable affinities
|
|
PE20180241A1
(es)
|
2015-04-30 |
2018-01-31 |
Psioxus Therapeutics Ltd |
Adenovirus oncolitico que codifica una proteina b7
|
|
WO2017019846A1
(en)
|
2015-07-30 |
2017-02-02 |
Macrogenics, Inc. |
Pd-1-binding molecules and methods use thereof
|
|
CN106397592A
(zh)
|
2015-07-31 |
2017-02-15 |
苏州康宁杰瑞生物科技有限公司 |
针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白
|
|
WO2017042814A1
(en)
|
2015-09-10 |
2017-03-16 |
Yeda Research And Development Co. Ltd. |
Use of perforin positive immature dendritic cells in disease treatment
|
|
JP2018534245A
(ja)
|
2015-09-14 |
2018-11-22 |
アルパイン イミューン サイエンシズ インコーポレイテッド |
調整可能なバリアント免疫グロブリンスーパーファミリードメインおよび改変細胞療法
|
|
AU2016350701B2
(en)
|
2015-11-02 |
2021-08-19 |
Five Prime Therapeutics, Inc. |
CD80 extracellular domain polypeptides and their use in cancer treatment
|
|
EA201891022A1
(ru)
|
2015-12-17 |
2019-01-31 |
Псайоксус Терапьютикс Лимитед |
Вирус, кодирующий антитело к комплексу tcr или фрагмент указанного антитела
|
|
KR102844773B1
(ko)
|
2015-12-23 |
2025-08-13 |
암젠 인크 |
위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법
|
|
KR20190003938A
(ko)
|
2016-02-25 |
2019-01-10 |
셀 메디카 스위처란트 아게 |
면역치료를 위한 변형된 세포
|
|
CA3014458A1
(en)
|
2016-03-02 |
2017-09-08 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
DK3423087T3
(da)
|
2016-03-04 |
2023-12-18 |
Io Biotech Aps |
Kombinationsterapi mod cancer
|
|
IL262365B2
(en)
|
2016-04-15 |
2024-11-01 |
Alpine Immune Sciences Inc |
Immunomodulatory proteins ICOS ligand variants and uses thereof
|
|
EP4706777A2
(en)
|
2016-04-15 |
2026-03-11 |
Alpine Immune Sciences, Inc. |
Cd80 variant immunomodulatory proteins and uses thereof
|
|
WO2017201352A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Mrna combination therapy for the treatment of cancer
|
|
CA3019005A1
(en)
|
2016-05-18 |
2017-11-23 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
CN118307682A
(zh)
|
2016-09-27 |
2024-07-09 |
埃皮辛特瑞柯斯公司 |
免疫调节性融合蛋白
|
|
CA3040296A1
(en)
|
2016-10-20 |
2018-04-26 |
Alpine Immune Sciences, Inc. |
Secretable variant immunomodulatory proteins and engineered cell therapy
|
|
WO2018201014A1
(en)
|
2017-04-28 |
2018-11-01 |
Five Prime Therapeutics, Inc. |
Methods of treatment with cd80 extracellular domain polypeptides
|
|
SG11202100642UA
(en)
|
2018-08-29 |
2021-03-30 |
Five Prime Therapeutics Inc |
Cd80 extracellular domain fc fusion protein dosing regimens
|
|
US12589132B2
(en)
|
2019-02-22 |
2026-03-31 |
Five Prime Therapeutics, Inc. |
CD80 extracellular domain Fc fusion proteins for treating PD-L1 negative tumors
|
|
EP3963079A1
(en)
|
2019-05-03 |
2022-03-09 |
Five Prime Therapeutics, Inc. |
Pharmaceutical formulations containing cd80 extracellular domain-fc fusion proteins
|