|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US7070776B1
(en)
|
1990-03-26 |
2006-07-04 |
Bristol-Myers Squibb Company |
Methods for blocking binding of CD28 receptor to B7
|
|
US6641809B1
(en)
|
1990-03-26 |
2003-11-04 |
Bristol-Myers Squibb Company |
Method of regulating cellular processes mediated by B7 and CD28
|
|
US6071716A
(en)
|
1990-10-01 |
2000-06-06 |
Dana-Farber Cancer Institute |
DNA encoding, B7, a new member of the IG superfamily with unique expression on activated and neoplastic B cells
|
|
US6887471B1
(en)
|
1991-06-27 |
2005-05-03 |
Bristol-Myers Squibb Company |
Method to inhibit T cell interactions with soluble B7
|
|
US5858776A
(en)
|
1993-11-03 |
1999-01-12 |
Repligen Corporation |
Tumor cells with increased immunogenicity and uses therefor
|
|
US6130316A
(en)
|
1993-07-26 |
2000-10-10 |
Dana Farber Cancer Institute |
Fusion proteins of novel CTLA4/CD28 ligands and uses therefore
|
|
US6824779B1
(en)
|
1993-07-26 |
2004-11-30 |
Dana-Farber Cancer Institute, Inc. |
Methods for inhibiting the interaction of B7-2 with its natural ligand
|
|
US6218510B1
(en)
|
1994-03-02 |
2001-04-17 |
Brigham & Woman's Hospital |
B7-1 and B7-2 polypeptides
|
|
EP1025856A3
(en)
|
1994-03-08 |
2002-10-16 |
Dana-Farber Cancer Institute |
Methods for modulating T Cell unresponsiveness
|
|
US6030815A
(en)
*
|
1995-04-11 |
2000-02-29 |
Neose Technologies, Inc. |
Enzymatic synthesis of oligosaccharides
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
|
US6491925B2
(en)
|
1996-08-15 |
2002-12-10 |
Emory University |
Compositions and methods for cancer prophylaxis and/or treatment
|
|
EP0988321A2
(en)
|
1997-06-20 |
2000-03-29 |
Innogenetics N.V. |
B7-binding molecules for treating immune diseases
|
|
AU6366999A
(en)
|
1998-10-30 |
2000-05-22 |
Takeda Chemical Industries Ltd. |
Betacellulin protein-containing preparations
|
|
US7011833B1
(en)
|
1999-05-06 |
2006-03-14 |
Genetics Institute, Inc. |
Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
|
|
ES2539411T3
(es)
|
1999-08-23 |
2015-06-30 |
Dana-Farber Cancer Institute, Inc. |
PD-1, receptor para la B7-4 y su utilización
|
|
US6429303B1
(en)
|
1999-09-03 |
2002-08-06 |
Curagen Corporation |
Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same
|
|
US7064111B1
(en)
|
1999-10-05 |
2006-06-20 |
Georgetown University |
Use of soluble costimulatory factor for tumor immuno-gene therapy
|
|
US7183376B2
(en)
|
2000-06-23 |
2007-02-27 |
Maxygen, Inc. |
Variant B7 co-stimulatory molecules
|
|
US6503914B1
(en)
|
2000-10-23 |
2003-01-07 |
Board Of Regents, The University Of Texas System |
Thienopyrimidine-based inhibitors of the Src family
|
|
US20040236091A1
(en)
|
2001-03-28 |
2004-11-25 |
Chicz Roman M. |
Translational profiling
|
|
AU2002368044A1
(en)
|
2001-06-22 |
2004-04-19 |
Maxygen, Inc. |
Co-stimulatory molecules
|
|
WO2003039486A2
(en)
|
2001-11-09 |
2003-05-15 |
Idec Pharmaceuticals Corporation |
Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies
|
|
ES2367430T3
(es)
|
2002-12-23 |
2011-11-03 |
Wyeth Llc |
Anticuerpos contra pd-1 y sus usos.
|
|
WO2004060911A2
(en)
|
2002-12-30 |
2004-07-22 |
Amgen Inc. |
Combination therapy with co-stimulatory factors
|
|
KR100976076B1
(ko)
|
2003-05-22 |
2010-08-17 |
아보트 러보러터리즈 |
인다졸, 벤즈이속사졸 및 벤즈이소티아졸 키나제 억제제
|
|
JP2007506442A
(ja)
|
2003-05-30 |
2007-03-22 |
ゲノミック ヘルス， インコーポレイテッド |
Ｅｇｆｒ阻害薬への応答に関する遺伝子発現マーカー
|
|
NZ545314A
(en)
|
2003-08-04 |
2009-03-31 |
Bristol Myers Squibb Co |
Methods for treating cardiovascular disease using a soluble CTLA4 molecule
|
|
EP2439284B1
(en)
|
2004-03-31 |
2019-05-08 |
The General Hospital Corporation |
Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
|
|
AU2005250484B2
(en)
|
2004-06-04 |
2011-08-11 |
Genentech, Inc. |
EGFR mutations
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
CA2585025A1
(en)
|
2004-10-22 |
2006-05-04 |
Redpath Integrated Pathology, Inc. |
Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and purefluid specimens
|
|
CN101072578A
(zh)
|
2004-10-29 |
2007-11-14 |
南加州大学 |
用共刺激分子的联合癌症免疫疗法
|
|
JP5238936B2
(ja)
|
2005-03-25 |
2013-07-17 |
ジーアイティーアール，インク． |
Ｇｉｔｒ結合分子およびその使用
|
|
US7635570B2
(en)
|
2005-04-01 |
2009-12-22 |
Salvatore Siena |
Epidermal growth factor receptor gene copy number
|
|
AU2006233675A1
(en)
|
2005-04-14 |
2006-10-19 |
Merck Patent Gmbh |
Anti-EGFR antibody therapy based on an increased copy number of the EGFR gene in tumor tissues
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
DK1879573T3
(da)
|
2005-05-10 |
2013-02-25 |
Incyte Corp |
Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf
|
|
SI1913157T2
(sl)
|
2005-06-28 |
2017-02-28 |
Genentech, Inc. |
EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjem
|
|
WO2007011702A2
(en)
|
2005-07-15 |
2007-01-25 |
The University Of North Carolina At Chapel Hill |
Use of egfr inhibitors to prevent or treat obesity
|
|
NZ565511A
(en)
*
|
2005-07-22 |
2011-03-31 |
Five Prime Therapeutics Inc |
Compositions and methods of treating disease with FGFR fusion proteins
|
|
WO2007025044A2
(en)
|
2005-08-24 |
2007-03-01 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
|
|
ES2540561T3
(es)
|
2005-12-20 |
2015-07-10 |
Incyte Corporation |
N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa
|
|
US7908091B2
(en)
|
2006-03-17 |
2011-03-15 |
Prometheus Laboratories Inc. |
Methods of predicting and monitoring tyrosine kinase inhibitor therapy
|
|
WO2007123737A2
(en)
|
2006-03-30 |
2007-11-01 |
University Of California |
Methods and compositions for localized secretion of anti-ctla-4 antibodies
|
|
WO2008033442A2
(en)
|
2006-09-12 |
2008-03-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for performing low background multiplex nucleic acid amplification reactions
|
|
CL2007002650A1
(es)
|
2006-09-19 |
2008-02-08 |
Incyte Corp |
Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
|
|
CA2663057C
(en)
|
2006-09-19 |
2015-12-08 |
Incyte Corporation |
N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
|
|
WO2008037080A1
(en)
|
2006-09-29 |
2008-04-03 |
Universite De Montreal |
Methods and compositions for immune response modulation and uses thereof
|
|
PL2412828T3
(pl)
|
2007-03-13 |
2013-11-29 |
Amgen Inc |
Mutacje K-ras i B-raf i terapia przeciwciałami anty-EGFr
|
|
CA2682027A1
(en)
|
2007-03-28 |
2008-10-02 |
Biogen Idec Inc. |
Modulation of tumor microenvironment
|
|
US20100189716A1
(en)
|
2007-03-28 |
2010-07-29 |
Biogen Idec Inc. |
Treatment of hodgkins lymphoma
|
|
US8389282B2
(en)
|
2007-03-30 |
2013-03-05 |
Memorial Sloan-Kettering Cancer Center |
Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
|
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
PT2170959E
(pt)
|
2007-06-18 |
2014-01-07 |
Merck Sharp & Dohme |
Anticorpos para o receptor humano de morte programada pd-1
|
|
PT2175884T
(pt)
|
2007-07-12 |
2016-09-21 |
Gitr Inc |
Terapias de combinação empregando moléculas de ligação a gitr
|
|
CN101358225B
(zh)
*
|
2007-07-30 |
2012-02-01 |
厦门大学 |
高唾液酸含量的免疫球蛋白抗体的制备方法与应用
|
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
|
CA2703263C
(en)
*
|
2007-11-01 |
2014-03-18 |
Perseid Therapeutics Llc |
Immunosuppressive polypeptides and nucleic acids
|
|
WO2009073620A2
(en)
|
2007-11-30 |
2009-06-11 |
Newlink Genetics |
Ido inhibitors
|
|
WO2009089149A1
(en)
|
2008-01-03 |
2009-07-16 |
The Johns Hopkins University |
B7-h1 (cd274) antagonists induce apoptosis of tumor cells
|
|
MX2010008578A
(es)
*
|
2008-02-08 |
2010-11-10 |
Medimmune Llc |
Anticuerpos anti-receptor 1 de interferon alfa con afinidad reducida al ligando fc.
|
|
US8168757B2
(en)
|
2008-03-12 |
2012-05-01 |
Merck Sharp & Dohme Corp. |
PD-1 binding proteins
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
EA201500417A1
(ru)
|
2008-08-25 |
2015-11-30 |
Эмплиммьюн, Инк. |
Композиции антагонистов pd-1 и способы применения
|
|
WO2010098788A2
(en)
|
2008-08-25 |
2010-09-02 |
Amplimmune, Inc. |
Pd-i antagonists and methods for treating infectious disease
|
|
IN2015DN02826A
(enExample)
|
2009-09-03 |
2015-09-11 |
Merck Sharp & Dohme |
|
|
EP2493862B1
(en)
|
2009-10-28 |
2016-10-05 |
Newlink Genetics Corporation |
Imidazole derivatives as ido inhibitors
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
DK2542256T3
(da)
|
2010-03-04 |
2019-08-26 |
Macrogenics Inc |
Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
|
|
NZ729044A
(en)
|
2010-09-09 |
2020-07-31 |
Pfizer |
4-1bb binding molecules
|
|
UY33679A
(es)
|
2010-10-22 |
2012-03-30 |
Esbatech |
Anticuerpos estables y solubles
|
|
LT2691417T
(lt)
|
2011-03-29 |
2018-10-25 |
Roche Glycart Ag |
Antikūno fc variantai
|
|
NO2694640T3
(enExample)
|
2011-04-15 |
2018-03-17 |
|
|
|
CA2833636A1
(en)
|
2011-04-20 |
2012-10-26 |
Amplimmune, Inc. |
Antibodies and other molecules that bind b7-h1 and pd-1
|
|
RU2657440C2
(ru)
|
2011-06-30 |
2018-06-13 |
Джензим Корпорейшн |
Ингибиторы т-клеточной активации
|
|
US8686119B2
(en)
|
2011-07-24 |
2014-04-01 |
Curetech Ltd. |
Variants of humanized immunomodulatory monoclonal antibodies
|
|
BR112014002353B1
(pt)
|
2011-08-01 |
2022-09-27 |
Genentech, Inc |
Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
|
|
US8956619B2
(en)
|
2011-10-25 |
2015-02-17 |
University Of Maryland, Baltimore County |
Soluble CD80 as a therapeutic to reverse immune supression in cancer patients
|
|
WO2013116686A1
(en)
|
2012-02-02 |
2013-08-08 |
Massachusetts Institute Of Technology |
Methods and products related to targeted cancer therapy
|
|
EP2809345A4
(en)
|
2012-02-03 |
2015-11-25 |
Univ Emory |
IMMUNOSTIMULATING COMPOSITIONS, PARTICLES THEREFOR, AND USES THEREFOR
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
AR091649A1
(es)
|
2012-07-02 |
2015-02-18 |
Bristol Myers Squibb Co |
Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
|
|
JP6408487B2
(ja)
*
|
2012-12-18 |
2018-10-24 |
ザ ロックフェラー ユニバーシティ |
Ｈｉｖの防止および療法のためのグリカン修飾された抗ｃｄ４抗体
|
|
ES2699599T3
(es)
|
2013-03-15 |
2019-02-11 |
Abbvie Biotherapeutics Inc |
Variantes de Fc
|
|
KR20150131269A
(ko)
|
2013-03-15 |
2015-11-24 |
제넨테크, 인크. |
Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법
|
|
EP2969009B1
(en)
|
2013-03-15 |
2018-11-28 |
Pyranose Biotherapeutics, Inc. |
Modified fc fusion proteins
|
|
US9308236B2
(en)
|
2013-03-15 |
2016-04-12 |
Bristol-Myers Squibb Company |
Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
|
|
TW201605896A
(zh)
|
2013-08-30 |
2016-02-16 |
安美基股份有限公司 |
Gitr抗原結合蛋白
|
|
EP3470081A1
(en)
|
2013-10-01 |
2019-04-17 |
Mayo Foundation for Medical Education and Research |
Methods for treating cancer in patients with elevated levels of bim
|
|
EP3087099A4
(en)
|
2013-12-23 |
2017-07-19 |
Oncomed Pharmaceuticals, Inc. |
Immunotherapy with binding agents
|
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
|
CN106604933B
(zh)
|
2014-07-11 |
2021-08-10 |
文塔纳医疗系统公司 |
抗pd-l1抗体及其诊断用途
|
|
WO2016044189A1
(en)
|
2014-09-15 |
2016-03-24 |
Genentech, Inc. |
Methods of treating cancer using pd-1 axis binding antagonist and il-17 binding antagonists
|
|
UY36390A
(es)
*
|
2014-11-05 |
2016-06-01 |
Flexus Biosciences Inc |
Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
|
|
WO2016147182A1
(en)
|
2015-03-16 |
2016-09-22 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Isolated peptides derived from the b7 ligand dimer interface and uses thereof
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
SMT202100467T1
(it)
|
2015-04-17 |
2021-09-14 |
Alpine Immune Sciences Inc |
Proteine immunomodulatorie con affinità regolabili
|
|
DK3288573T3
(da)
|
2015-04-30 |
2020-03-16 |
Psioxus Therapeutics Ltd |
Onkolytisk adenovirus, der koder for et b7-protein
|
|
PE20231958A1
(es)
|
2015-07-30 |
2023-12-06 |
Macrogenics Inc |
Moleculas de union a pd-1 y metodos de uso de las mismas
|
|
CN106397592A
(zh)
|
2015-07-31 |
2017-02-15 |
苏州康宁杰瑞生物科技有限公司 |
针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白
|
|
WO2017042816A1
(en)
|
2015-09-10 |
2017-03-16 |
Yeda Research And Development Co. Ltd. |
Ablation of perforin positive dendritic cells in cancer treatment
|
|
EP3350206A1
(en)
|
2015-09-14 |
2018-07-25 |
Alpine Immune Sciences, Inc. |
Tunable variant immunoglobulin superfamily domains and engineered cell therapy
|
|
CA3001131A1
(en)
|
2015-11-02 |
2017-05-11 |
Five Prime Therapeutics, Inc. |
Cd80 extracellular domain polypeptides and their use in cancer treatment
|
|
US11155622B2
(en)
|
2015-12-17 |
2021-10-26 |
Psioxus Therapeutics Limited |
Virus encoding an anti-TCR-complex antibody or fragment
|
|
CN117106085A
(zh)
|
2015-12-23 |
2023-11-24 |
美国安进公司 |
使用gipr结合蛋白与glp-1激动剂的组合来治疗或改善代谢病症的方法
|
|
EP4086285A1
(en)
|
2016-02-25 |
2022-11-09 |
Cell Medica Switzerland AG |
Binding members to pd-l1
|
|
CA3014458A1
(en)
|
2016-03-02 |
2017-09-08 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
HUE064857T2
(hu)
|
2016-03-04 |
2024-04-28 |
Io Biotech Aps |
Kombinációs terápia a rák ellen
|
|
AU2017248830B2
(en)
|
2016-04-15 |
2023-03-09 |
Alpine Immune Sciences, Inc. |
CD80 variant immunomodulatory proteins and uses thereof
|
|
SG11201808457PA
(en)
|
2016-04-15 |
2018-10-30 |
Alpine Immune Sciences Inc |
Icos ligand variant immunomodulatory proteins and uses thereof
|
|
SG11201808552XA
(en)
|
2016-05-18 |
2018-10-30 |
Cue Biopharma Inc |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
CA3024509A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Mrna combination therapy for the treatment of cancer
|
|
US10906957B2
(en)
|
2016-09-27 |
2021-02-02 |
Epicentrx, Inc. |
Immunomodulatory fusion proteins
|
|
EP3872180A1
(en)
|
2016-10-20 |
2021-09-01 |
Alpine Immune Sciences, Inc. |
Secretable variant immunomodulatory proteins and engineered cell therapy
|
|
CN110546509A
(zh)
|
2017-04-28 |
2019-12-06 |
戊瑞治疗有限公司 |
用cd80细胞外结构域多肽进行治疗的方法
|
|
KR20210049814A
(ko)
|
2018-08-29 |
2021-05-06 |
파이브 프라임 테라퓨틱스, 인크. |
Cd80 세포외 도메인 fc 융합 단백질 투약 요법
|
|
AU2020224137B2
(en)
|
2019-02-22 |
2026-01-08 |
Five Prime Therapeutics, Inc. |
CD80 extracellular domain-Fc fusion proteins for treating PD-L1 negative tumors
|
|
MX2021013272A
(es)
|
2019-05-03 |
2021-11-17 |
Five Prime Therapeutics Inc |
Formulaciones farmaceuticas que contienen proteinas de fusion fc de dominio extracelular de cd80.
|