JP2018534316A5 - - Google Patents
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- Publication number
- JP2018534316A5 JP2018534316A5 JP2018525743A JP2018525743A JP2018534316A5 JP 2018534316 A5 JP2018534316 A5 JP 2018534316A5 JP 2018525743 A JP2018525743 A JP 2018525743A JP 2018525743 A JP2018525743 A JP 2018525743A JP 2018534316 A5 JP2018534316 A5 JP 2018534316A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- substituted
- tumors
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1520499.3 | 2015-11-20 | ||
| GBGB1520499.3A GB201520499D0 (en) | 2015-11-20 | 2015-11-20 | Compounds |
| PCT/GB2016/053579 WO2017085483A1 (en) | 2015-11-20 | 2016-11-16 | Pyrropyrimidine compounds as mnks inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534316A JP2018534316A (ja) | 2018-11-22 |
| JP2018534316A5 true JP2018534316A5 (enExample) | 2019-12-26 |
| JP6946290B2 JP6946290B2 (ja) | 2021-10-06 |
Family
ID=55133105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525743A Expired - Fee Related JP6946290B2 (ja) | 2015-11-20 | 2016-11-16 | Ｍｎｋ阻害剤としてのピロロピリミジン化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10604524B2 (enExample) |
| EP (2) | EP3377494B1 (enExample) |
| JP (1) | JP6946290B2 (enExample) |
| CN (1) | CN108368114B (enExample) |
| AU (1) | AU2016355103B2 (enExample) |
| CA (1) | CA3003554C (enExample) |
| ES (2) | ES2972862T3 (enExample) |
| GB (1) | GB201520499D0 (enExample) |
| WO (1) | WO2017085483A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | ＭｎＫ抑制劑及其相關方法 |
| ES2969988T3 (es) | 2017-02-14 | 2024-05-23 | Effector Therapeutics Inc | Inhibidores de Mnk sustituidos con piperidina y métodos relacionados con los mismos |
| CN109020957B (zh) * | 2017-06-12 | 2023-01-13 | 南京天印健华医药科技有限公司 | 作为mnk抑制剂的杂环化合物 |
| WO2020086713A1 (en) | 2018-10-24 | 2020-04-30 | Effector Therapeutics, Inc. | Crystalline forms of mnk inhibitors |
| CN110903286B (zh) * | 2019-12-16 | 2021-09-24 | 沈阳药科大学 | 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| SK72996A3 (en) * | 1995-06-07 | 1997-04-09 | Pfizer | Heterocyclic ring-fused pyrimidine derivatives and pharmaceutical compositions on their base |
| KR20000057228A (ko) * | 1996-11-27 | 2000-09-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 축합된 비사이클릭 피리미딘 유도체 |
| JP2004509059A (ja) | 1999-06-03 | 2004-03-25 | アボット・ラボラトリーズ | 細胞接着抑制性抗炎症化合物 |
| US20050165029A1 (en) | 2004-01-13 | 2005-07-28 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| EP1773826A4 (en) | 2004-07-02 | 2009-06-03 | Exelixis Inc | MODULATORS OF C-MET AND THEIR METHOD OF USE |
| TW200730527A (en) * | 2005-12-02 | 2007-08-16 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| US8633201B2 (en) * | 2006-04-07 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Thienopyrimidines having Mnk1/Mnk2 inhibiting activity for pharmaceutical compositions |
| EP1889847A1 (en) * | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| EP2219649A2 (en) * | 2007-11-22 | 2010-08-25 | Boehringer Ingelheim International Gmbh | Use of mnk inhibitors for the treatment of alzheimer's disease |
| JP5626748B2 (ja) * | 2008-07-02 | 2014-11-19 | キッコーマン株式会社 | ペプチド含有調味料 |
| JP5575274B2 (ja) * | 2010-02-26 | 2014-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物のためのｍｎｋｌ／ｍｎｋ２阻害活性を有する４−［シクロアルキルオキシ（ヘテロ）アリールアミノ］チエノ「２，３−ｄ］ピリミジン |
| EP2539343B1 (en) | 2010-02-26 | 2015-12-30 | Evotec International GmbH | Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions |
| ES2653419T3 (es) | 2013-02-01 | 2018-02-07 | Bayer Pharma Aktiengesellschaft | Pirazolopirimidinilamino-indazoles sustituidos |
| US9675612B2 (en) | 2013-03-06 | 2017-06-13 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
| CN104744446B (zh) * | 2013-12-30 | 2019-06-25 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
-
2015
- 2015-11-20 GB GBGB1520499.3A patent/GB201520499D0/en not_active Ceased
-
2016
- 2016-11-16 ES ES20204385T patent/ES2972862T3/es active Active
- 2016-11-16 EP EP16801015.5A patent/EP3377494B1/en active Active
- 2016-11-16 CA CA3003554A patent/CA3003554C/en active Active
- 2016-11-16 AU AU2016355103A patent/AU2016355103B2/en not_active Ceased
- 2016-11-16 CN CN201680067666.6A patent/CN108368114B/zh not_active Expired - Fee Related
- 2016-11-16 JP JP2018525743A patent/JP6946290B2/ja not_active Expired - Fee Related
- 2016-11-16 WO PCT/GB2016/053579 patent/WO2017085483A1/en not_active Ceased
- 2016-11-16 ES ES16801015T patent/ES2872775T3/es active Active
- 2016-11-16 EP EP20204385.7A patent/EP3792264B1/en active Active
- 2016-11-16 US US15/776,574 patent/US10604524B2/en active Active