ES2872775T3 - Compuestos de pirropirimidina como inhibidores de MNK - Google Patents
Compuestos de pirropirimidina como inhibidores de MNK Download PDFInfo
- Publication number
- ES2872775T3 ES2872775T3 ES16801015T ES16801015T ES2872775T3 ES 2872775 T3 ES2872775 T3 ES 2872775T3 ES 16801015 T ES16801015 T ES 16801015T ES 16801015 T ES16801015 T ES 16801015T ES 2872775 T3 ES2872775 T3 ES 2872775T3
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- alkyl
- compound according
- heterocycloalkyl
- tumors
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- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1520499.3A GB201520499D0 (en) | 2015-11-20 | 2015-11-20 | Compounds |
| PCT/GB2016/053579 WO2017085483A1 (en) | 2015-11-20 | 2016-11-16 | Pyrropyrimidine compounds as mnks inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2872775T3 true ES2872775T3 (es) | 2021-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16801015T Active ES2872775T3 (es) | 2015-11-20 | 2016-11-16 | Compuestos de pirropirimidina como inhibidores de MNK |
| ES20204385T Active ES2972862T3 (es) | 2015-11-20 | 2016-11-16 | Compuestos de pirropirimidina como inhibidores de MNK |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES20204385T Active ES2972862T3 (es) | 2015-11-20 | 2016-11-16 | Compuestos de pirropirimidina como inhibidores de MNK |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10604524B2 (enExample) |
| EP (2) | EP3377494B1 (enExample) |
| JP (1) | JP6946290B2 (enExample) |
| CN (1) | CN108368114B (enExample) |
| AU (1) | AU2016355103B2 (enExample) |
| CA (1) | CA3003554C (enExample) |
| ES (2) | ES2872775T3 (enExample) |
| GB (1) | GB201520499D0 (enExample) |
| WO (1) | WO2017085483A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | ＭｎＫ抑制劑及其相關方法 |
| PE20191349A1 (es) | 2017-02-14 | 2019-09-30 | Effector Therapeutics Inc | Inhibidores de mnk sustituidos con piperidina y metodos relacionados con los mismos |
| CN109020957B (zh) * | 2017-06-12 | 2023-01-13 | 南京天印健华医药科技有限公司 | 作为mnk抑制剂的杂环化合物 |
| CA3117169A1 (en) | 2018-10-24 | 2020-04-30 | Effector Therapeutics, Inc. | Crystalline forms of mnk inhibitors |
| CN110903286B (zh) * | 2019-12-16 | 2021-09-24 | 沈阳药科大学 | 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| ES2203642T3 (es) * | 1995-06-07 | 2004-04-16 | Pfizer Inc. | Derivados de pirimidina heterociclicos con anillos condensados. |
| IL129825A0 (en) | 1996-11-27 | 2000-02-29 | Pfizer | Fused bicyclic pyrimidine derivatives |
| BR9916746A (pt) | 1999-06-03 | 2005-01-11 | Abbott Lab | Compostos anti-inflamatórios que inibem adesão de célula |
| US20050153989A1 (en) | 2004-01-13 | 2005-07-14 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| CA2572331A1 (en) | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
| TW200730527A (en) * | 2005-12-02 | 2007-08-16 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| WO2007115822A1 (en) * | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having mnkl /mnk2 inhibiting activity for pharmaceutical compositions |
| EP1889847A1 (en) * | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| EP2219649A2 (en) * | 2007-11-22 | 2010-08-25 | Boehringer Ingelheim International Gmbh | Use of mnk inhibitors for the treatment of alzheimer's disease |
| JP5626748B2 (ja) * | 2008-07-02 | 2014-11-19 | キッコーマン株式会社 | ペプチド含有調味料 |
| MX2012009735A (es) | 2010-02-26 | 2012-09-12 | Boehringer Ingelheim Int | 4-[cicloalquiloxi (hetero) arilamino] tieno [2,3-d] pirimidinas que tienen actividad inhibitoria de mnk1/mnk2 para composiciones farmaceuticas. |
| EA201201192A1 (ru) | 2010-02-26 | 2013-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Тиенопиримидины, содержащие замещенную алкильную группу, предназначенные для фармацевтических композиций |
| HK1222173A1 (zh) | 2013-02-01 | 2017-06-23 | Bayer Pharma Aktiengesellschaft | 取代的吡唑并嘧啶基氨基-吲唑类 |
| EP2964656A1 (en) | 2013-03-06 | 2016-01-13 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
| CN104744446B (zh) * | 2013-12-30 | 2019-06-25 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
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2015
- 2015-11-20 GB GBGB1520499.3A patent/GB201520499D0/en not_active Ceased
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2016
- 2016-11-16 ES ES16801015T patent/ES2872775T3/es active Active
- 2016-11-16 EP EP16801015.5A patent/EP3377494B1/en active Active
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- 2016-11-16 AU AU2016355103A patent/AU2016355103B2/en not_active Ceased
- 2016-11-16 CA CA3003554A patent/CA3003554C/en active Active
- 2016-11-16 CN CN201680067666.6A patent/CN108368114B/zh not_active Expired - Fee Related
- 2016-11-16 JP JP2018525743A patent/JP6946290B2/ja not_active Expired - Fee Related
- 2016-11-16 US US15/776,574 patent/US10604524B2/en active Active
- 2016-11-16 WO PCT/GB2016/053579 patent/WO2017085483A1/en not_active Ceased
- 2016-11-16 EP EP20204385.7A patent/EP3792264B1/en active Active
Also Published As
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|---|---|
| HK1253576A1 (en) | 2019-06-21 |
| AU2016355103B2 (en) | 2021-07-08 |
| EP3792264A1 (en) | 2021-03-17 |
| JP2018534316A (ja) | 2018-11-22 |
| CA3003554A1 (en) | 2017-05-26 |
| JP6946290B2 (ja) | 2021-10-06 |
| EP3377494B1 (en) | 2021-03-03 |
| GB201520499D0 (en) | 2016-01-06 |
| AU2016355103A1 (en) | 2018-05-31 |
| WO2017085483A1 (en) | 2017-05-26 |
| CN108368114A (zh) | 2018-08-03 |
| US20180346469A1 (en) | 2018-12-06 |
| CN108368114B (zh) | 2023-10-24 |
| EP3377494A1 (en) | 2018-09-26 |
| ES2972862T3 (es) | 2024-06-17 |
| US10604524B2 (en) | 2020-03-31 |
| CA3003554C (en) | 2023-08-29 |
| EP3792264B1 (en) | 2024-01-03 |
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