JP2018529720A - 乳酸菌由来の細胞外小胞を含む脱毛防止又は育毛促進用組成物 - Google Patents
乳酸菌由来の細胞外小胞を含む脱毛防止又は育毛促進用組成物 Download PDFInfo
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- JP2018529720A JP2018529720A JP2018516427A JP2018516427A JP2018529720A JP 2018529720 A JP2018529720 A JP 2018529720A JP 2018516427 A JP2018516427 A JP 2018516427A JP 2018516427 A JP2018516427 A JP 2018516427A JP 2018529720 A JP2018529720 A JP 2018529720A
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- lactic acid
- acid bacteria
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- hair
- hair growth
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Abstract
Description
本実施例では、乳酸菌としてラクトバチルス属菌株を用い、これからエクソソーム様小胞を含む細胞外小胞を分離した。ラクトバチルス属菌株としては、ラクトバチルス・ロイテリ(L. reuteri、KCTC 3594)、ラクトバチルス・ラムノサス(L. rhamnosus、KCTC 5033)、ラクトバチルス・サケイ(L. sakei、KCTC 3603)を韓国生命工学研究院の微生物資源センターから購入して用いた。
前記実施例1で収得したラクトバチルス属菌株から分離したエクソソーム様小胞を、Dynamic light scattering方法によってその大きさを分析し、図2に示した。
前記実施例1で分離したラクトバチルス属菌株から排出されたエクソソーム様小胞を、毛嚢毛乳頭細胞(primary human dermal papilla cell、hDPC)に多様な濃度で処理して、乳酸菌由来の細胞外小胞の毛嚢細胞増殖効果を確認した。
前記実施例1で分離したラクトバチルス属菌株から排出されたエクソソーム様小胞を、毛嚢器官培養(hair follicle organ culture)に多様な濃度で処理して、乳酸菌由来の細胞外小胞の毛髪成長長さ増加(hair shaft elongation)効果を確認した。
実施例1の乳酸菌由来のエクソソーム様小胞50mg、L−カルニチン80〜140mg、大豆油180mg、パーム油2mg、植物性硬化油8mg、黄蝋4mg、及びレシチン6mgを混合し、通常の方法に従って、1カプセル当たり400mgずつ充填して軟質カプセル剤を製造した。
実施例1の乳酸菌由来のエクソソーム様小胞50mg、ガラクトオリゴ糖200mg、乳糖60mg、及び麦芽糖140mgを混合し、流動層乾燥機を利用して顆粒化した後、糖エステル(sugar ester)6mgを添加して、打錠機で打錠して錠剤を製造した。
実施例1の乳酸菌由来のエクソソーム様小胞50mg、無水結晶ブドウ糖250mg、及び澱粉550mgを混合し、流動層造粒機を使用して顆粒に成形した後、砲に充填して顆粒剤を製造した。
実施例1の乳酸菌由来のエクソソーム様小胞50mg、ブドウ糖10g、クエン酸0.6g、及び液状オリゴ糖25gを混合した後、精製水300mlを加えて各瓶に200mlずつ充填した。瓶に充填した後、130℃で4〜5秒間殺菌して、ドリンク剤飲料を製造した。
下記の表1に記載された組成にて通常の方法により軟膏を製造した。
下記の表2に記載された組成にて通常の方法により美容液型製剤を製造した。
下記の表3に記載された組成にて通常の方法によりシャンプーを製造した。
下記表4に記載された組成にて通常の方法によりリンスを製造した。
Claims (13)
- 乳酸菌由来の細胞外小胞(extracellular vesicle)を有効成分として含む、脱毛防止又は育毛促進用組成物。
- 前記乳酸菌は、ビフィドバクテリウム(Bifidobacterium spp.)、ラクトバチルス(Latobacillus spp.)、ストレプトコッカス(Streptocuccus spp.)、リュウコノストク(Leuconostoc spp.)、ペディオコッカス(Pediococcus spp.)、及びラクトコッカス(Lactococcus spp.)属菌株からなる群から選択される一つ以上を含む、請求項1に記載の脱毛防止又は育毛促進用組成物。
- 前記乳酸菌は、ラクトバチルス(Latobacillus spp.)属菌株を含む、請求項2に記載の脱毛防止又は育毛促進用組成物。
- 前記ラクトバチルス属菌株は、ラクトバチルス・ロイテリ(L. reuteri)、ラクトバチルス・ラムノサス(L. rhamnosus)、及びラクトバチルス・サケイ(L. sakei)からなる群から選択される一つ以上を含む、請求項3に記載の脱毛防止又は育毛促進用組成物。
- 前記細胞外小胞は、乳酸菌培養液から分離したものである、請求項1に記載の脱毛防止又は育毛促進用組成物。
- 前記細胞外小胞は、エクソソーム様小胞(exosome−like vesicle)である、請求項1に記載の脱毛防止又は育毛促進用組成物。
- 前記細胞外小胞は、20〜500nmの直径を有するものである、請求項1に記載の脱毛防止又は育毛促進用組成物。
- 前記細胞外小胞は、乳酸菌培養液の100,000×g以上の超遠心分離で沈降するものである、請求項1に記載の脱毛防止又は育毛促進用組成物。
- 前記有効成分は、毛乳頭細胞(dermal papilla cells、DPCs)を活性化して毛髪成長を誘導するものである、請求項1に記載の脱毛防止又は育毛促進用組成物。
- 請求項1〜9のいずれか一項に記載の乳酸菌由来の細胞外小胞(extracellular vesicle)を製造する方法であって、
(1)乳酸菌培養液を遠心分離して上澄液を収得する段階;
(2)前記収得された上澄液を濾過する段階;及び
(3)前記収得された濾過物を超遠心分離して沈殿物を収得する段階;を含む、乳酸菌由来の細胞外小胞の製造方法。 - 前記段階(1)における遠心分離は、1,000〜20,000×gで実施する、請求項10に記載の乳酸菌由来の細胞外小胞の製造方法。
- 前記段階(3)における超遠心分離は、100,000×g以上で実施する、請求項10に記載の乳酸菌由来の細胞外小胞の製造方法。
- 前記段階(3)の後、(4)前記収得された沈殿物を懸濁する段階をさらに含む、請求項10に記載の乳酸菌由来の細胞外小胞の製造方法。
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- 2016-09-26 CN CN201680058245.7A patent/CN108367032A/zh active Pending
- 2016-09-26 EP EP16852028.6A patent/EP3357500B1/en active Active
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JP2019524835A (ja) * | 2016-08-16 | 2019-09-05 | エムディー ヘルスケア インコーポレイテッドMd Healthcare Inc. | ラクトバチルス属細菌由来小胞を含む精神疾患の予防または治療用組成物 |
WO2020096059A1 (ja) * | 2018-11-09 | 2020-05-14 | ニチニチ製薬株式会社 | 育毛用又は脱毛防止用外用剤 |
JP7426100B2 (ja) | 2018-11-09 | 2024-02-01 | ニチニチ製薬株式会社 | 育毛用又は脱毛防止用外用剤 |
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WO2020226022A1 (ja) * | 2019-05-07 | 2020-11-12 | 一般社団法人夢源 | 育毛・発毛用外用剤 |
JP7170357B2 (ja) | 2019-05-07 | 2022-11-14 | 一般社団法人夢源 | 育毛・発毛用外用剤 |
KR20210055901A (ko) * | 2019-11-08 | 2021-05-18 | 주식회사 에치와이 | 모발 성장 촉진 효능을 가지는 락토바실러스 파라카제이 hy7015 및 이를 유효성분으로 함유하는 모발 성장 촉진을 위한 조성물 |
KR102254553B1 (ko) * | 2019-11-08 | 2021-05-21 | 주식회사 에치와이 | 모발 성장 촉진 효능을 가지는 락토바실러스 파라카제이 hy7015 및 이를 유효성분으로 함유하는 모발 성장 촉진을 위한 조성물 |
JP7449520B2 (ja) | 2020-03-04 | 2024-03-14 | エムディー ヘルスケア インコーポレイテッド | ラクトバチルス属細菌由来細胞外小胞を有効成分として含む幹細胞機能調節用組成物 |
WO2022085738A1 (ja) * | 2020-10-21 | 2022-04-28 | 日清食品ホールディングス株式会社 | 乳酸菌を含有する発毛・育毛効果を有する飲食品、化粧品、医薬部外品又は医薬品 |
Also Published As
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HK1251147A1 (zh) | 2019-01-25 |
EP3357500B1 (en) | 2023-05-24 |
US20180256490A1 (en) | 2018-09-13 |
EP3357500A4 (en) | 2019-04-10 |
TWI755362B (zh) | 2022-02-21 |
CN108367032A (zh) | 2018-08-03 |
US10765623B2 (en) | 2020-09-08 |
TW201711692A (zh) | 2017-04-01 |
JP6890121B2 (ja) | 2021-06-18 |
EP3357500A1 (en) | 2018-08-08 |
WO2017057882A1 (ko) | 2017-04-06 |
KR102394638B1 (ko) | 2022-05-09 |
KR20170038462A (ko) | 2017-04-07 |
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