JP2018528773A5 - - Google Patents
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- JP2018528773A5 JP2018528773A5 JP2018512167A JP2018512167A JP2018528773A5 JP 2018528773 A5 JP2018528773 A5 JP 2018528773A5 JP 2018512167 A JP2018512167 A JP 2018512167A JP 2018512167 A JP2018512167 A JP 2018512167A JP 2018528773 A5 JP2018528773 A5 JP 2018528773A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 75
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 102000008166 Member 25 Tumor Necrosis Factor Receptors Human genes 0.000 claims 3
- 108010060408 Member 25 Tumor Necrosis Factor Receptors Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000003651 pulmonary sarcoidosis Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022005039A JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220442P | 2015-09-18 | 2015-09-18 | |
| US62/220,442 | 2015-09-18 | ||
| PCT/US2016/052040 WO2017049024A1 (en) | 2015-09-18 | 2016-09-16 | Antibodies that specifically bind to tl1a |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022005039A Division JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528773A JP2018528773A (ja) | 2018-10-04 |
| JP2018528773A5 true JP2018528773A5 (enExample) | 2019-10-24 |
| JP7013366B2 JP7013366B2 (ja) | 2022-02-15 |
Family
ID=57043002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512167A Active JP7013366B2 (ja) | 2015-09-18 | 2016-09-16 | Ｔｌ１ａに特異的に結合する抗体 |
| JP2022005039A Active JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022005039A Active JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Country Status (33)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| EP3495389A1 (en) | 2011-09-30 | 2019-06-12 | Teva Pharmaceuticals Australia Pty Ltd | Antibodies against tl1a and uses thereof |
| KR20240122922A (ko) | 2013-03-27 | 2024-08-13 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| JP7240789B2 (ja) * | 2015-12-04 | 2023-03-16 | ユニバーシティー オブ アイオワ リサーチ ファンデーション | 脳症／せん妄のスクリーニングおよびモニタリングのためのシステム |
| CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
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| MY191324A (en) | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
| CA3061467A1 (en) * | 2017-04-28 | 2019-10-24 | Ajinomoto Co., Inc. | Compound having affinity substance to soluble protein, cleavable portionand reactive group, or salt thereof |
| CN119735681A (zh) | 2018-04-25 | 2025-04-01 | 普罗米修斯生物科学公司 | 优化的抗tl1a抗体 |
| EP3969621A4 (en) | 2019-05-14 | 2023-01-25 | Prometheus Biosciences, Inc. | TL1A PATIENT SELECTION METHODS, SYSTEMS AND DEVICES |
| TW202600603A (zh) | 2019-10-24 | 2026-01-01 | 美商普羅米修斯生物科學股份有限公司 | 針對類-tnf配體1a (tl1a)之人類化抗體及其用途 |
| CA3190012A1 (en) * | 2020-08-19 | 2022-02-24 | Adam ZWOLAK | Materials and methods of using engineered ligands |
| KR20230158494A (ko) * | 2021-02-18 | 2023-11-20 | 프로메테우스 바이오사이언시즈, 인크. | 항-tl1a 항체 조성물 및 폐에서의 치료 방법 |
| CN117202932A (zh) * | 2021-02-18 | 2023-12-08 | 普罗米修斯生物科学公司 | 治疗肺部的抗tl1a抗体组合物和方法 |
| AR130041A1 (es) | 2022-07-27 | 2024-10-30 | Cephalon Llc | Formulaciones de anticuerpos anti-tl1a |
| CN119894931A (zh) | 2022-07-27 | 2025-04-25 | 赛福伦有限责任公司 | 用于治疗溃疡性结肠炎和克罗恩病的抗tl1a抗体 |
| AU2024273758A1 (en) | 2023-05-17 | 2025-12-04 | Genentech, Inc. | Anti-tl1a antibody therapeutic methods |
| WO2024263868A2 (en) * | 2023-06-21 | 2024-12-26 | Paragon Therapeutics, Inc. | Tl1a antibody compositions and methods of use |
| TW202515910A (zh) * | 2023-06-22 | 2025-04-16 | 美商派拉岡醫療公司 | Il-17抗體組合物及使用方法 |
| JP2026522632A (ja) * | 2023-06-22 | 2026-07-08 | パラゴン セラピューティクス、インコーポレイテッド | Ｉｌ－２３抗体組成物および使用法 |
| IL325993A (en) | 2023-08-11 | 2026-03-01 | Paragon Therapeutics Inc | TL1A binding proteins and methods of use |
| US12473370B2 (en) | 2023-10-03 | 2025-11-18 | Absci Corporation | TL1A associated antibody compositions and methods of use |
| CN121851173A (zh) * | 2023-11-30 | 2026-04-14 | 北京智仁美博生物科技有限公司 | 抗肿瘤坏死因子样配体1a的抗体及其用途 |
| AU2024406222A1 (en) | 2023-12-20 | 2026-06-04 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rβ) and related methods |
| CN120424214A (zh) * | 2024-02-05 | 2025-08-05 | 三生国健药业（上海）股份有限公司 | 一种抗tl1a抗体及其制备方法和用途 |
| AU2025218720A1 (en) | 2024-02-06 | 2026-05-21 | Paragon Therapeutics, Inc. | Il-23 antibody compositions and methods of use |
| WO2025171006A1 (en) | 2024-02-06 | 2025-08-14 | Paragon Therapeutics, Inc. | Il-23 binding protein compositions and methods of use |
| CN120590530A (zh) * | 2024-03-05 | 2025-09-05 | 帆礼生物技术(武汉)有限公司 | 靶向tl1a的抗体及其应用 |
| TW202613167A (zh) | 2024-05-17 | 2026-04-01 | 美商建南德克公司 | 使用抗ｔｌ１ａ抗體治療發炎性腸病之方法 |
| WO2026072993A1 (en) | 2024-09-27 | 2026-04-02 | Genentech, Inc. | Methods for treatment of metabolic dysfunction-associated steatohepatitis with an anti-tl1a antibody |
| WO2026072983A1 (en) | 2024-09-27 | 2026-04-02 | Genentech, Inc. | Methods for treatment of atopic dermatitis with an anti-tl1a antibody |
| WO2026080698A1 (en) * | 2024-10-11 | 2026-04-16 | Spyre Therapeutics, Inc. | Methods of treatment of gastrointestinal inflammatory diseases using α4β7 binding antibody and tl1a binding antibody |
| CN119552252B (zh) * | 2025-01-16 | 2025-11-25 | 华润生物医药有限公司 | 抗tl1a抗体及其制备方法和应用 |
| WO2026158530A1 (zh) * | 2025-01-24 | 2026-07-30 | 信立泰(成都)生物技术有限公司 | 一种抗tl1a抗体或其抗原结合片段及用途 |
| WO2026165337A1 (en) | 2025-01-31 | 2026-08-06 | Genentech, Inc. | Methods for treatment of pediatric inflammatory bowel disease with an anti-tl1a antibody |
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-
2016
- 2016-09-14 TW TW105130075A patent/TWI703158B/zh active
- 2016-09-16 AU AU2016323460A patent/AU2016323460B2/en active Active
- 2016-09-16 SM SM20200500T patent/SMT202000500T1/it unknown
- 2016-09-16 MA MA42825A patent/MA42825B1/fr unknown
- 2016-09-16 EP EP20151834.7A patent/EP3693393A1/en active Pending
- 2016-09-16 CA CA3306751A patent/CA3306751A1/en active Pending
- 2016-09-16 PH PH1/2018/500580A patent/PH12018500580B1/en unknown
- 2016-09-16 IL IL257761A patent/IL257761B2/en unknown
- 2016-09-16 PE PE2018000398A patent/PE20181080A1/es unknown
- 2016-09-16 PL PL16774750T patent/PL3350223T3/pl unknown
- 2016-09-16 ES ES16774750T patent/ES2810751T3/es active Active
- 2016-09-16 EP EP16774750.0A patent/EP3350223B1/en active Active
- 2016-09-16 UA UAA201804192A patent/UA125284C2/uk unknown
- 2016-09-16 PT PT167747500T patent/PT3350223T/pt unknown
- 2016-09-16 EA EA201890756A patent/EA201890756A1/ru unknown
- 2016-09-16 HU HUE16774750A patent/HUE051496T2/hu unknown
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