JP2020521458A5 - - Google Patents

Info

Publication number

JP2020521458A5

JP2020521458A5 JP2019564951A JP2019564951A JP2020521458A5 JP 2020521458 A5 JP2020521458 A5 JP 2020521458A5 JP 2019564951 A JP2019564951 A JP 2019564951A JP 2019564951 A JP2019564951 A JP 2019564951A JP 2020521458 A5 JP2020521458 A5 JP 2020521458A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

tyr

antibody polypeptide

Prior art date

2018-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229920001184 polypeptide Polymers 0.000 claims 19
• 102000004196 processed proteins & peptides Human genes 0.000 claims 19
• 108090000765 processed proteins & peptides Proteins 0.000 claims 19
• 150000001413 amino acids Chemical group 0.000 claims 14
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 6
• 239000004472 Lysine Substances 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 230000028993 immune response Effects 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 101150013553 CD40 gene Proteins 0.000 claims 2
• 206010020751 Hypersensitivity Diseases 0.000 claims 2
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
• 230000007815 allergy Effects 0.000 claims 2
• 235000001014 amino acid Nutrition 0.000 claims 2
• 208000006673 asthma Diseases 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 208000026278 immune system disease Diseases 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
• 208000026872 Addison Disease Diseases 0.000 claims 1
• 206010002198 Anaphylactic reaction Diseases 0.000 claims 1
• 239000004475 Arginine Substances 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 206010003645 Atopy Diseases 0.000 claims 1
• 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
• 208000023328 Basedow disease Diseases 0.000 claims 1
• 102100023804 Coagulation factor VII Human genes 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 108010023321 Factor VII Proteins 0.000 claims 1
• 206010018364 Glomerulonephritis Diseases 0.000 claims 1
• 208000015023 Graves' disease Diseases 0.000 claims 1
• 208000001204 Hashimoto Disease Diseases 0.000 claims 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
• 208000031220 Hemophilia Diseases 0.000 claims 1
• 208000009292 Hemophilia A Diseases 0.000 claims 1
• 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
• 102000009490 IgG Receptors Human genes 0.000 claims 1
• 108010073807 IgG Receptors Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
• 206010028372 Muscular weakness Diseases 0.000 claims 1
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 206010037660 Pyrexia Diseases 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
• 201000002661 Spondylitis Diseases 0.000 claims 1
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• 230000036783 anaphylactic response Effects 0.000 claims 1
• 208000003455 anaphylaxis Diseases 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 206010003246 arthritis Diseases 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
• 208000029078 coronary artery disease Diseases 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 229940012413 factor vii Drugs 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 208000007475 hemolytic anemia Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
• 201000003265 lymphadenitis Diseases 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 230000036473 myasthenia Effects 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 201000000306 sarcoidosis Diseases 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1
• 206010043778 thyroiditis Diseases 0.000 claims 1
• 230000001256 tonic effect Effects 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1