JP2017510627A5 - - Google Patents
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- Publication number
- JP2017510627A5 JP2017510627A5 JP2016574516A JP2016574516A JP2017510627A5 JP 2017510627 A5 JP2017510627 A5 JP 2017510627A5 JP 2016574516 A JP2016574516 A JP 2016574516A JP 2016574516 A JP2016574516 A JP 2016574516A JP 2017510627 A5 JP2017510627 A5 JP 2017510627A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antagonist
- mcam
- composition according
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- PJOHVEQSYPOERL-SHEAVXILSA-N (e)-n-[(4r,4as,7ar,12br)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N[C@]1(CCC(=O)[C@@H]2O3)[C@H]4CC5=CC=C(O)C3=C5[C@]12CCN4CC1CC1 PJOHVEQSYPOERL-SHEAVXILSA-N 0.000 claims 18
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 18
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 18
- 239000005557 antagonist Substances 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 229940122414 Alpha4 integrin antagonist Drugs 0.000 claims 9
- 108010041012 Integrin alpha4 Proteins 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 229960005027 natalizumab Drugs 0.000 claims 2
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952835P | 2014-03-13 | 2014-03-13 | |
| US61/952,835 | 2014-03-13 | ||
| US201462023577P | 2014-07-11 | 2014-07-11 | |
| US62/023,577 | 2014-07-11 | ||
| PCT/IB2015/051785 WO2015136468A1 (en) | 2014-03-13 | 2015-03-12 | Combination treatment for multiple sclerosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020019355A Division JP2020100631A (ja) | 2014-03-13 | 2020-02-07 | 多発性硬化症の併用治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017510627A JP2017510627A (ja) | 2017-04-13 |
| JP2017510627A5 true JP2017510627A5 (enExample) | 2018-04-19 |
Family
ID=52737375
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574516A Pending JP2017510627A (ja) | 2014-03-13 | 2015-03-12 | 多発性硬化症の併用治療 |
| JP2020019355A Pending JP2020100631A (ja) | 2014-03-13 | 2020-02-07 | 多発性硬化症の併用治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020019355A Pending JP2020100631A (ja) | 2014-03-13 | 2020-02-07 | 多発性硬化症の併用治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20170002077A1 (enExample) |
| EP (1) | EP3116910A1 (enExample) |
| JP (2) | JP2017510627A (enExample) |
| KR (1) | KR20170052526A (enExample) |
| CA (1) | CA2938945A1 (enExample) |
| WO (1) | WO2015136468A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI660972B (zh) | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
| PT3116911T (pt) | 2014-03-12 | 2019-09-04 | Prothena Biosciences Ltd | Anticorpos anti-mcam e métodos de utilização associados |
| US10059761B2 (en) | 2014-03-12 | 2018-08-28 | Prothena Biosciences Limited | Anti-Laminin4 antibodies specific for LG4-5 |
| WO2017134178A1 (en) * | 2016-02-05 | 2017-08-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Imaging method for predicting the onset of multiple sclerosis |
| WO2017149513A1 (en) * | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2017153955A1 (en) * | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| EP3708175A4 (en) * | 2017-11-09 | 2021-07-28 | Sapporo Medical University | MEDICINAL PRODUCT FOR TISSUE REGENERATION, AND ITS PREPARATION PROCESS |
| CN114401741A (zh) | 2019-07-11 | 2022-04-26 | 拓维创新生物科技(香港)有限公司 | 干扰胸腺基质淋巴细胞生成素(tslp)受体信号传导的药剂 |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| CA2291762A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
| CA2291473A1 (en) | 1997-07-31 | 1999-02-11 | Elan Pharmaceuticals, Inc. | Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4 |
| WO1999006432A1 (en) | 1997-07-31 | 1999-02-11 | Elan Pharmaceuticals, Inc. | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4 |
| HUP0004259A3 (en) | 1997-07-31 | 2001-05-28 | Wyeth Corp | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof |
| NZ502813A (en) | 1997-08-22 | 2002-10-25 | F | N-aroylphenylalanine derivatives as inhibitors of the interaction between a4 containing integrins and VCAM-1 |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| SK15592000A3 (sk) | 1998-04-16 | 2001-12-03 | Texas Biotechnology Corporation | N,n-disubstituované amidy, ktoré inhibujú viazanie integrínov na ich receptory |
| GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821406D0 (en) | 1998-10-01 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| CN100405399C (zh) | 1999-02-05 | 2008-07-23 | 三星电子株式会社 | 图像纹理恢复方法及其装置 |
| RO122246B1 (ro) | 1999-05-07 | 2009-03-30 | Texas Biotechnology Corporation | Derivaţi de acid propionic ce inhibă legarea integrinelor de receptorii acestora, compoziţie farmaceutică ce îi conţine şi utilizare |
| AU6909300A (en) | 1999-08-20 | 2001-03-19 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
| US6689781B2 (en) | 2000-07-21 | 2004-02-10 | Elan Pharmaceuticals, Inc. | Phenylalanine derivatives as alpha 4 integrin inhibitors |
| US7192931B2 (en) * | 2000-10-12 | 2007-03-20 | Neuren Pharmaceuticals Ltd. | Treatment of demyelinating diseases |
| KR20040074587A (ko) * | 2001-02-19 | 2004-08-25 | 메르크 파텐트 게엠베하 | 감소된 면역원성을 갖는 인공 단백질 |
| WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
| JPWO2003024933A1 (ja) | 2001-09-12 | 2004-12-24 | 科研製薬株式会社 | ２−フェニル−３−ヘテロアリールプロピオン酸誘導体またはその塩、それを用いた医薬 |
| WO2004066932A2 (en) * | 2003-01-24 | 2004-08-12 | Elan Pharmaceuticals Inc. | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
| PT2170390T (pt) * | 2007-06-14 | 2019-02-12 | Biogen Ma Inc | Formulações com anticorpo natalizumab |
| WO2012001647A2 (en) * | 2010-06-30 | 2012-01-05 | Compugen Ltd. | Polypeptides and uses thereof as a drug for treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders |
| US20140314744A1 (en) | 2011-06-06 | 2014-10-23 | Neotope Biosciences Limited | Mcam antagonists and methods of treatment |
| TWI660972B (zh) * | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
-
2015
- 2015-03-12 US US15/125,568 patent/US20170002077A1/en not_active Abandoned
- 2015-03-12 EP EP15712195.5A patent/EP3116910A1/en not_active Withdrawn
- 2015-03-12 WO PCT/IB2015/051785 patent/WO2015136468A1/en not_active Ceased
- 2015-03-12 JP JP2016574516A patent/JP2017510627A/ja active Pending
- 2015-03-12 KR KR1020167027876A patent/KR20170052526A/ko not_active Abandoned
- 2015-03-12 CA CA2938945A patent/CA2938945A1/en active Pending
-
2020
- 2020-02-07 JP JP2020019355A patent/JP2020100631A/ja active Pending
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