JP2018525393A5 - - Google Patents
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- Publication number
- JP2018525393A5 JP2018525393A5 JP2018506997A JP2018506997A JP2018525393A5 JP 2018525393 A5 JP2018525393 A5 JP 2018525393A5 JP 2018506997 A JP2018506997 A JP 2018506997A JP 2018506997 A JP2018506997 A JP 2018506997A JP 2018525393 A5 JP2018525393 A5 JP 2018525393A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- trifluoromethylphenyl
- dimethylphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 238000000034 method Methods 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 4
- DVIJFJSZZNOTLP-UHFFFAOYSA-N 1-(3,5-dimethylphenyl)-2-[2-(trifluoromethyl)phenyl]guanidine Chemical compound CC1=CC(C)=CC(NC(=N)NC=2C(=CC=CC=2)C(F)(F)F)=C1 DVIJFJSZZNOTLP-UHFFFAOYSA-N 0.000 claims 3
- -1 cyanamide compound Chemical class 0.000 claims 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003495 polar organic solvent Substances 0.000 claims 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000007268 rho GTP-Binding Proteins Human genes 0.000 claims 1
- 108010033674 rho GTP-Binding Proteins Proteins 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP150102582A AR101498A1 (es) | 2015-08-11 | 2015-08-11 | Procedimiento para la preparación del compuesto n-(3,5-dimetilfenil)-n-(2-trifluorometilfenil)guanidina y su forma cristalina a |
| EP15382424 | 2015-08-11 | ||
| EP15382424.8 | 2015-08-11 | ||
| ARP20150102582 | 2015-08-11 | ||
| PCT/EP2016/069033 WO2017025560A1 (en) | 2015-08-11 | 2016-08-10 | A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018525393A JP2018525393A (ja) | 2018-09-06 |
| JP2018525393A5 true JP2018525393A5 (enExample) | 2019-08-15 |
| JP6748188B2 JP6748188B2 (ja) | 2020-08-26 |
Family
ID=56799434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506997A Expired - Fee Related JP6748188B2 (ja) | 2015-08-11 | 2016-08-10 | 化合物ｎ−（３，５−ジメチルフェニル）−ｎ’−（２−トリフルオロメチルフェニル）グアニジンの調製方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10343984B2 (enExample) |
| EP (1) | EP3334707B1 (enExample) |
| JP (1) | JP6748188B2 (enExample) |
| CN (1) | CN107922322B (enExample) |
| AR (1) | AR101498A1 (enExample) |
| BR (1) | BR112018002614B1 (enExample) |
| CA (1) | CA2994781A1 (enExample) |
| CY (1) | CY1122481T1 (enExample) |
| DK (1) | DK3334707T3 (enExample) |
| ES (1) | ES2756580T3 (enExample) |
| HR (1) | HRP20192301T1 (enExample) |
| HU (1) | HUE046959T2 (enExample) |
| LT (1) | LT3334707T (enExample) |
| MX (1) | MX383481B (enExample) |
| PL (1) | PL3334707T3 (enExample) |
| PT (1) | PT3334707T (enExample) |
| RS (1) | RS59759B1 (enExample) |
| RU (1) | RU2737430C2 (enExample) |
| SI (1) | SI3334707T1 (enExample) |
| SM (1) | SMT201900747T1 (enExample) |
| WO (1) | WO2017025560A1 (enExample) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN172842B (enExample) * | 1990-05-17 | 1993-12-11 | Boots Pharmaceuticals Limited | |
| AU2962297A (en) * | 1996-05-24 | 1998-01-05 | Neurosearch A/S | Phenyl derivatives useful as blockers of chloride channels |
| US8283370B2 (en) * | 2008-10-03 | 2012-10-09 | The United States Of America As Represented By The Secretary Of The Army | Imidazolidinedione derivatives as antimalarial agents, preparation thereof, and methods of use |
| BR112014008589B1 (pt) * | 2011-10-11 | 2022-06-14 | Universidad Nacional De Quilmes | Compostos derivados de fenil-guanidina, processo para a preparação destes, uso dos mesmos e composição farmacêutica |
-
2015
- 2015-08-11 AR ARP150102582A patent/AR101498A1/es not_active Application Discontinuation
-
2016
- 2016-08-10 ES ES16756641T patent/ES2756580T3/es active Active
- 2016-08-10 US US15/751,437 patent/US10343984B2/en active Active
- 2016-08-10 JP JP2018506997A patent/JP6748188B2/ja not_active Expired - Fee Related
- 2016-08-10 RU RU2018107840A patent/RU2737430C2/ru active
- 2016-08-10 HU HUE16756641A patent/HUE046959T2/hu unknown
- 2016-08-10 CA CA2994781A patent/CA2994781A1/en active Pending
- 2016-08-10 HR HRP20192301TT patent/HRP20192301T1/hr unknown
- 2016-08-10 PT PT167566413T patent/PT3334707T/pt unknown
- 2016-08-10 EP EP16756641.3A patent/EP3334707B1/en active Active
- 2016-08-10 PL PL16756641T patent/PL3334707T3/pl unknown
- 2016-08-10 DK DK16756641.3T patent/DK3334707T3/da active
- 2016-08-10 BR BR112018002614-0A patent/BR112018002614B1/pt not_active IP Right Cessation
- 2016-08-10 MX MX2018001548A patent/MX383481B/es unknown
- 2016-08-10 WO PCT/EP2016/069033 patent/WO2017025560A1/en not_active Ceased
- 2016-08-10 CN CN201680045772.4A patent/CN107922322B/zh not_active Expired - Fee Related
- 2016-08-10 LT LTEP16756641.3T patent/LT3334707T/lt unknown
- 2016-08-10 SM SM20190747T patent/SMT201900747T1/it unknown
- 2016-08-10 RS RS20191669A patent/RS59759B1/sr unknown
- 2016-08-10 SI SI201630561T patent/SI3334707T1/sl unknown
-
2019
- 2019-12-27 CY CY20191101359T patent/CY1122481T1/el unknown
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