CN107922322B - 化合物n-(3,5-二甲基苯基)-n′-(2-三氟甲基苯基)胍的制备方法 - Google Patents

化合物n-(3,5-二甲基苯基)-n′-(2-三氟甲基苯基)胍的制备方法 Download PDF

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Publication number
CN107922322B
CN107922322B CN201680045772.4A CN201680045772A CN107922322B CN 107922322 B CN107922322 B CN 107922322B CN 201680045772 A CN201680045772 A CN 201680045772A CN 107922322 B CN107922322 B CN 107922322B
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formula
compound
solid
mixture
dimethylphenyl
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Expired - Fee Related
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CN201680045772.4A
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Chinese (zh)
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CN107922322A (zh
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J·阿马托
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Chemo Research SL
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Chemo Research SL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/02—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/06—Purification or separation of guanidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680045772.4A 2015-08-11 2016-08-10 化合物n-(3,5-二甲基苯基)-n′-(2-三氟甲基苯基)胍的制备方法 Expired - Fee Related CN107922322B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ARP150102582A AR101498A1 (es) 2015-08-11 2015-08-11 Procedimiento para la preparación del compuesto n-(3,5-dimetilfenil)-n-(2-trifluorometilfenil)guanidina y su forma cristalina a
AR20150102582 2015-08-11
EP15382424 2015-08-11
EP15382424.8 2015-08-11
PCT/EP2016/069033 WO2017025560A1 (en) 2015-08-11 2016-08-10 A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine

Publications (2)

Publication Number Publication Date
CN107922322A CN107922322A (zh) 2018-04-17
CN107922322B true CN107922322B (zh) 2023-11-03

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CN201680045772.4A Expired - Fee Related CN107922322B (zh) 2015-08-11 2016-08-10 化合物n-(3,5-二甲基苯基)-n′-(2-三氟甲基苯基)胍的制备方法

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US (1) US10343984B2 (enExample)
EP (1) EP3334707B1 (enExample)
JP (1) JP6748188B2 (enExample)
CN (1) CN107922322B (enExample)
AR (1) AR101498A1 (enExample)
BR (1) BR112018002614B1 (enExample)
CA (1) CA2994781A1 (enExample)
CY (1) CY1122481T1 (enExample)
DK (1) DK3334707T3 (enExample)
ES (1) ES2756580T3 (enExample)
HR (1) HRP20192301T1 (enExample)
HU (1) HUE046959T2 (enExample)
LT (1) LT3334707T (enExample)
MX (1) MX383481B (enExample)
PL (1) PL3334707T3 (enExample)
PT (1) PT3334707T (enExample)
RS (1) RS59759B1 (enExample)
RU (1) RU2737430C2 (enExample)
SI (1) SI3334707T1 (enExample)
SM (1) SMT201900747T1 (enExample)
WO (1) WO2017025560A1 (enExample)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045111A1 (en) * 1996-05-24 1997-12-04 Neurosearch A/S Phenyl derivatives useful as blockers of chloride channels
WO2010051129A2 (en) * 2008-10-03 2010-05-06 The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Materiel Command New imidazolidinedione derivatives as antimalarial agents, preparation thereof, and methods of use
CN103917520A (zh) * 2011-10-11 2014-07-09 基尔梅斯国立大学 苯基胍衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN172842B (enExample) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045111A1 (en) * 1996-05-24 1997-12-04 Neurosearch A/S Phenyl derivatives useful as blockers of chloride channels
WO2010051129A2 (en) * 2008-10-03 2010-05-06 The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Materiel Command New imidazolidinedione derivatives as antimalarial agents, preparation thereof, and methods of use
CN103917520A (zh) * 2011-10-11 2014-07-09 基尔梅斯国立大学 苯基胍衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis,Structure and Biological Activities of Some Novel N-(4,6-Disubstituted-pyrimidin-2-yl)-N’-(trifluoromethylphenyl-guanidine) Derivatives;HE, Feng-Qi等;《Chinese Journal of Chemistry》;20081231;第26卷;第1481-1485页 *

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Publication number Publication date
MX383481B (es) 2025-03-14
US20180244608A1 (en) 2018-08-30
CA2994781A1 (en) 2017-02-16
BR112018002614A2 (enExample) 2018-10-02
SI3334707T1 (sl) 2020-03-31
CY1122481T1 (el) 2021-01-27
RU2018107840A (ru) 2019-09-12
MX2018001548A (es) 2018-06-22
HK1256253A1 (en) 2019-09-20
US10343984B2 (en) 2019-07-09
RS59759B1 (sr) 2020-02-28
WO2017025560A1 (en) 2017-02-16
ES2756580T3 (es) 2020-04-27
EP3334707A1 (en) 2018-06-20
HRP20192301T1 (hr) 2020-03-20
HUE046959T2 (hu) 2020-04-28
JP6748188B2 (ja) 2020-08-26
JP2018525393A (ja) 2018-09-06
AR101498A1 (es) 2016-12-21
CN107922322A (zh) 2018-04-17
RU2018107840A3 (enExample) 2019-12-18
DK3334707T3 (da) 2020-01-06
BR112018002614B1 (pt) 2023-04-11
EP3334707B1 (en) 2019-10-09
PL3334707T3 (pl) 2020-05-18
PT3334707T (pt) 2020-01-14
LT3334707T (lt) 2020-01-27
RU2737430C2 (ru) 2020-11-30
SMT201900747T1 (it) 2020-03-13

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