HRP20192301T1 - Postupak dobivanja spoja n-(3,5-dimetilfenil)-n'-(2-trifluormetilfenil)gvanidina - Google Patents

Postupak dobivanja spoja n-(3,5-dimetilfenil)-n'-(2-trifluormetilfenil)gvanidina Download PDF

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Publication number
HRP20192301T1
HRP20192301T1 HRP20192301TT HRP20192301T HRP20192301T1 HR P20192301 T1 HRP20192301 T1 HR P20192301T1 HR P20192301T T HRP20192301T T HR P20192301TT HR P20192301 T HRP20192301 T HR P20192301T HR P20192301 T1 HRP20192301 T1 HR P20192301T1
Authority
HR
Croatia
Prior art keywords
compound
formula
trifluoromethylphenyl
dimethylphenyl
guanidine
Prior art date
Application number
HRP20192301TT
Other languages
English (en)
Croatian (hr)
Inventor
José AMATO
Original Assignee
Chemo Research, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Research, S.L. filed Critical Chemo Research, S.L.
Publication of HRP20192301T1 publication Critical patent/HRP20192301T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/02—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/06—Purification or separation of guanidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HRP20192301TT 2015-08-11 2016-08-10 Postupak dobivanja spoja n-(3,5-dimetilfenil)-n'-(2-trifluormetilfenil)gvanidina HRP20192301T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15382424 2015-08-11
ARP150102582A AR101498A1 (es) 2015-08-11 2015-08-11 Procedimiento para la preparación del compuesto n-(3,5-dimetilfenil)-n-(2-trifluorometilfenil)guanidina y su forma cristalina a
EP16756641.3A EP3334707B1 (en) 2015-08-11 2016-08-10 A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine
PCT/EP2016/069033 WO2017025560A1 (en) 2015-08-11 2016-08-10 A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine

Publications (1)

Publication Number Publication Date
HRP20192301T1 true HRP20192301T1 (hr) 2020-03-20

Family

ID=56799434

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20192301TT HRP20192301T1 (hr) 2015-08-11 2016-08-10 Postupak dobivanja spoja n-(3,5-dimetilfenil)-n'-(2-trifluormetilfenil)gvanidina

Country Status (21)

Country Link
US (1) US10343984B2 (enExample)
EP (1) EP3334707B1 (enExample)
JP (1) JP6748188B2 (enExample)
CN (1) CN107922322B (enExample)
AR (1) AR101498A1 (enExample)
BR (1) BR112018002614B1 (enExample)
CA (1) CA2994781A1 (enExample)
CY (1) CY1122481T1 (enExample)
DK (1) DK3334707T3 (enExample)
ES (1) ES2756580T3 (enExample)
HR (1) HRP20192301T1 (enExample)
HU (1) HUE046959T2 (enExample)
LT (1) LT3334707T (enExample)
MX (1) MX383481B (enExample)
PL (1) PL3334707T3 (enExample)
PT (1) PT3334707T (enExample)
RS (1) RS59759B1 (enExample)
RU (1) RU2737430C2 (enExample)
SI (1) SI3334707T1 (enExample)
SM (1) SMT201900747T1 (enExample)
WO (1) WO2017025560A1 (enExample)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN172842B (enExample) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
JP2000510862A (ja) * 1996-05-24 2000-08-22 ニューロサーチ・アクティーゼルスカブ クロライドチャンネル遮断剤として有用なフエニル誘導体
US8283370B2 (en) * 2008-10-03 2012-10-09 The United States Of America As Represented By The Secretary Of The Army Imidazolidinedione derivatives as antimalarial agents, preparation thereof, and methods of use
AR088291A1 (es) * 2011-10-11 2014-05-21 Univ Nac Quilmes Derivados de fenil-guanidina

Also Published As

Publication number Publication date
WO2017025560A1 (en) 2017-02-16
RU2737430C2 (ru) 2020-11-30
LT3334707T (lt) 2020-01-27
US10343984B2 (en) 2019-07-09
SMT201900747T1 (it) 2020-03-13
EP3334707B1 (en) 2019-10-09
HK1256253A1 (en) 2019-09-20
AR101498A1 (es) 2016-12-21
CY1122481T1 (el) 2021-01-27
MX2018001548A (es) 2018-06-22
SI3334707T1 (sl) 2020-03-31
RU2018107840A3 (enExample) 2019-12-18
CN107922322A (zh) 2018-04-17
RS59759B1 (sr) 2020-02-28
CN107922322B (zh) 2023-11-03
HUE046959T2 (hu) 2020-04-28
MX383481B (es) 2025-03-14
BR112018002614A2 (enExample) 2018-10-02
CA2994781A1 (en) 2017-02-16
JP2018525393A (ja) 2018-09-06
US20180244608A1 (en) 2018-08-30
PL3334707T3 (pl) 2020-05-18
PT3334707T (pt) 2020-01-14
RU2018107840A (ru) 2019-09-12
BR112018002614B1 (pt) 2023-04-11
JP6748188B2 (ja) 2020-08-26
ES2756580T3 (es) 2020-04-27
DK3334707T3 (da) 2020-01-06
EP3334707A1 (en) 2018-06-20

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