RS59759B1 - Postupak za pripremanje jedinjenja n-(3,5-dimetilfenil)-n'-(2-trifluorometilfenil) gvanidina - Google Patents

Postupak za pripremanje jedinjenja n-(3,5-dimetilfenil)-n'-(2-trifluorometilfenil) gvanidina

Info

Publication number
RS59759B1
RS59759B1 RS20191669A RSP20191669A RS59759B1 RS 59759 B1 RS59759 B1 RS 59759B1 RS 20191669 A RS20191669 A RS 20191669A RS P20191669 A RSP20191669 A RS P20191669A RS 59759 B1 RS59759 B1 RS 59759B1
Authority
RS
Serbia
Prior art keywords
compound
formula
solid form
crystalline solid
dimethylphenyl
Prior art date
Application number
RS20191669A
Other languages
English (en)
Serbian (sr)
Inventor
José Amato
Original Assignee
Chemo Research S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Research S L filed Critical Chemo Research S L
Publication of RS59759B1 publication Critical patent/RS59759B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/02—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/06—Purification or separation of guanidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RS20191669A 2015-08-11 2016-08-10 Postupak za pripremanje jedinjenja n-(3,5-dimetilfenil)-n'-(2-trifluorometilfenil) gvanidina RS59759B1 (sr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ARP150102582A AR101498A1 (es) 2015-08-11 2015-08-11 Procedimiento para la preparación del compuesto n-(3,5-dimetilfenil)-n-(2-trifluorometilfenil)guanidina y su forma cristalina a
EP15382424 2015-08-11
EP16756641.3A EP3334707B1 (en) 2015-08-11 2016-08-10 A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine
PCT/EP2016/069033 WO2017025560A1 (en) 2015-08-11 2016-08-10 A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine

Publications (1)

Publication Number Publication Date
RS59759B1 true RS59759B1 (sr) 2020-02-28

Family

ID=56799434

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20191669A RS59759B1 (sr) 2015-08-11 2016-08-10 Postupak za pripremanje jedinjenja n-(3,5-dimetilfenil)-n'-(2-trifluorometilfenil) gvanidina

Country Status (21)

Country Link
US (1) US10343984B2 (enExample)
EP (1) EP3334707B1 (enExample)
JP (1) JP6748188B2 (enExample)
CN (1) CN107922322B (enExample)
AR (1) AR101498A1 (enExample)
BR (1) BR112018002614B1 (enExample)
CA (1) CA2994781A1 (enExample)
CY (1) CY1122481T1 (enExample)
DK (1) DK3334707T3 (enExample)
ES (1) ES2756580T3 (enExample)
HR (1) HRP20192301T1 (enExample)
HU (1) HUE046959T2 (enExample)
LT (1) LT3334707T (enExample)
MX (1) MX383481B (enExample)
PL (1) PL3334707T3 (enExample)
PT (1) PT3334707T (enExample)
RS (1) RS59759B1 (enExample)
RU (1) RU2737430C2 (enExample)
SI (1) SI3334707T1 (enExample)
SM (1) SMT201900747T1 (enExample)
WO (1) WO2017025560A1 (enExample)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN172842B (enExample) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
AU2962297A (en) * 1996-05-24 1998-01-05 Neurosearch A/S Phenyl derivatives useful as blockers of chloride channels
US8283370B2 (en) * 2008-10-03 2012-10-09 The United States Of America As Represented By The Secretary Of The Army Imidazolidinedione derivatives as antimalarial agents, preparation thereof, and methods of use
EP2766342B1 (en) * 2011-10-11 2016-02-10 Universidad Nacional de Quilmes Phenyl-guanidine derivatives

Also Published As

Publication number Publication date
ES2756580T3 (es) 2020-04-27
HK1256253A1 (en) 2019-09-20
DK3334707T3 (da) 2020-01-06
HUE046959T2 (hu) 2020-04-28
MX2018001548A (es) 2018-06-22
JP6748188B2 (ja) 2020-08-26
RU2737430C2 (ru) 2020-11-30
HRP20192301T1 (hr) 2020-03-20
SMT201900747T1 (it) 2020-03-13
JP2018525393A (ja) 2018-09-06
US10343984B2 (en) 2019-07-09
LT3334707T (lt) 2020-01-27
RU2018107840A3 (enExample) 2019-12-18
CY1122481T1 (el) 2021-01-27
BR112018002614A2 (enExample) 2018-10-02
MX383481B (es) 2025-03-14
CN107922322A (zh) 2018-04-17
EP3334707B1 (en) 2019-10-09
BR112018002614B1 (pt) 2023-04-11
EP3334707A1 (en) 2018-06-20
SI3334707T1 (sl) 2020-03-31
US20180244608A1 (en) 2018-08-30
WO2017025560A1 (en) 2017-02-16
PL3334707T3 (pl) 2020-05-18
PT3334707T (pt) 2020-01-14
RU2018107840A (ru) 2019-09-12
CN107922322B (zh) 2023-11-03
CA2994781A1 (en) 2017-02-16
AR101498A1 (es) 2016-12-21

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RS59759B1 (sr) Postupak za pripremanje jedinjenja n-(3,5-dimetilfenil)-n'-(2-trifluorometilfenil) gvanidina
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