PL3334707T3 - Sposób wytwarzania związku stanowiącego n-(3,5-dimetylofenylo)-n'-(2-trifluorometylofenylo)guanidynę - Google Patents

Sposób wytwarzania związku stanowiącego n-(3,5-dimetylofenylo)-n'-(2-trifluorometylofenylo)guanidynę

Info

Publication number
PL3334707T3
PL3334707T3 PL16756641T PL16756641T PL3334707T3 PL 3334707 T3 PL3334707 T3 PL 3334707T3 PL 16756641 T PL16756641 T PL 16756641T PL 16756641 T PL16756641 T PL 16756641T PL 3334707 T3 PL3334707 T3 PL 3334707T3
Authority
PL
Poland
Prior art keywords
trifluoromethylphenyl
dimethylphenyl
guanidine
compound
preparation
Prior art date
Application number
PL16756641T
Other languages
English (en)
Inventor
José AMATO
Original Assignee
Chemo Research, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Research, S.L. filed Critical Chemo Research, S.L.
Publication of PL3334707T3 publication Critical patent/PL3334707T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/02Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/06Purification or separation of guanidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL16756641T 2015-08-11 2016-08-10 Sposób wytwarzania związku stanowiącego n-(3,5-dimetylofenylo)-n'-(2-trifluorometylofenylo)guanidynę PL3334707T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ARP150102582A AR101498A1 (es) 2015-08-11 2015-08-11 Procedimiento para la preparación del compuesto n-(3,5-dimetilfenil)-n-(2-trifluorometilfenil)guanidina y su forma cristalina a
EP15382424 2015-08-11
PCT/EP2016/069033 WO2017025560A1 (en) 2015-08-11 2016-08-10 A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine
EP16756641.3A EP3334707B1 (en) 2015-08-11 2016-08-10 A process for the preparation of the compound n-(3,5-dimethylphenyl)-n'-(2-trifluoromethylphenyl) guanidine

Publications (1)

Publication Number Publication Date
PL3334707T3 true PL3334707T3 (pl) 2020-05-18

Family

ID=56799434

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16756641T PL3334707T3 (pl) 2015-08-11 2016-08-10 Sposób wytwarzania związku stanowiącego n-(3,5-dimetylofenylo)-n'-(2-trifluorometylofenylo)guanidynę

Country Status (21)

Country Link
US (1) US10343984B2 (pl)
EP (1) EP3334707B1 (pl)
JP (1) JP6748188B2 (pl)
CN (1) CN107922322B (pl)
AR (1) AR101498A1 (pl)
BR (1) BR112018002614B1 (pl)
CA (1) CA2994781A1 (pl)
CY (1) CY1122481T1 (pl)
DK (1) DK3334707T3 (pl)
ES (1) ES2756580T3 (pl)
HK (1) HK1256253A1 (pl)
HR (1) HRP20192301T1 (pl)
HU (1) HUE046959T2 (pl)
LT (1) LT3334707T (pl)
MX (1) MX2018001548A (pl)
PL (1) PL3334707T3 (pl)
PT (1) PT3334707T (pl)
RS (1) RS59759B1 (pl)
RU (1) RU2737430C2 (pl)
SI (1) SI3334707T1 (pl)
WO (1) WO2017025560A1 (pl)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN172842B (pl) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
AU2962297A (en) * 1996-05-24 1998-01-05 Neurosearch A/S Phenyl derivatives useful as blockers of chloride channels
US8283370B2 (en) * 2008-10-03 2012-10-09 The United States Of America As Represented By The Secretary Of The Army Imidazolidinedione derivatives as antimalarial agents, preparation thereof, and methods of use
DK2766342T3 (en) * 2011-10-11 2016-05-02 Univ Nac Quilmes PHENYL-guanidine derivatives

Also Published As

Publication number Publication date
CN107922322A (zh) 2018-04-17
JP6748188B2 (ja) 2020-08-26
RU2018107840A (ru) 2019-09-12
DK3334707T3 (da) 2020-01-06
US20180244608A1 (en) 2018-08-30
CA2994781A1 (en) 2017-02-16
AR101498A1 (es) 2016-12-21
HRP20192301T1 (hr) 2020-03-20
JP2018525393A (ja) 2018-09-06
PT3334707T (pt) 2020-01-14
EP3334707B1 (en) 2019-10-09
LT3334707T (lt) 2020-01-27
RU2018107840A3 (pl) 2019-12-18
CY1122481T1 (el) 2021-01-27
SI3334707T1 (sl) 2020-03-31
HK1256253A1 (zh) 2019-09-20
CN107922322B (zh) 2023-11-03
US10343984B2 (en) 2019-07-09
BR112018002614A2 (pl) 2018-10-02
RS59759B1 (sr) 2020-02-28
WO2017025560A1 (en) 2017-02-16
HUE046959T2 (hu) 2020-04-28
RU2737430C2 (ru) 2020-11-30
ES2756580T3 (es) 2020-04-27
BR112018002614B1 (pt) 2023-04-11
EP3334707A1 (en) 2018-06-20
MX2018001548A (es) 2018-06-22

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