CN109311852A - 作为egfr抑制剂的苯胺嘧啶化合物的结晶 - Google Patents
作为egfr抑制剂的苯胺嘧啶化合物的结晶 Download PDFInfo
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- CN109311852A CN109311852A CN201780037239.8A CN201780037239A CN109311852A CN 109311852 A CN109311852 A CN 109311852A CN 201780037239 A CN201780037239 A CN 201780037239A CN 109311852 A CN109311852 A CN 109311852A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
本申请属于医药化学领域,涉及作为EGFR抑制剂的苯胺嘧啶化合物的结晶,具体而言,本申请涉及N‑(2‑((2‑(二甲基氨基)乙基)(甲基)氨基)‑4‑甲氧基‑5‑(4‑(3‑甲基‑2‑氧代‑2,3‑二氢‑1H‑苯并[d]咪唑‑1‑基)嘧啶‑2‑基氨基)苯基)丙烯酰胺(式I)盐酸盐的结晶A、结晶B和结晶C,还涉及结晶A、结晶B和结晶C的制备方法、包含该结晶A、结晶B或结晶C的结晶组合物、包含该结晶A、结晶B和结晶C或其结晶组合物的药物组合物以及它们的医药用途。本申请的结晶A、结晶B和结晶C具有纯度高、结晶度高、稳定性好等优点。
Description
PCT国内申请,说明书已公开。
Claims (18)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610470835.2A CN107540661A (zh) | 2016-06-24 | 2016-06-24 | 作为egfr抑制剂的苯胺嘧啶化合物的结晶 |
CN2016104708352 | 2016-06-24 | ||
PCT/CN2017/089693 WO2017220007A1 (zh) | 2016-06-24 | 2017-06-23 | 作为egfr抑制剂的苯胺嘧啶化合物的结晶 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109311852A true CN109311852A (zh) | 2019-02-05 |
CN109311852B CN109311852B (zh) | 2021-04-02 |
Family
ID=60783319
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610470835.2A Pending CN107540661A (zh) | 2016-06-24 | 2016-06-24 | 作为egfr抑制剂的苯胺嘧啶化合物的结晶 |
CN201780037239.8A Active CN109311852B (zh) | 2016-06-24 | 2017-06-23 | 作为egfr抑制剂的苯胺嘧啶化合物的结晶 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610470835.2A Pending CN107540661A (zh) | 2016-06-24 | 2016-06-24 | 作为egfr抑制剂的苯胺嘧啶化合物的结晶 |
Country Status (9)
Country | Link |
---|---|
US (2) | US20190256497A1 (zh) |
EP (1) | EP3476841A4 (zh) |
JP (1) | JP2019518776A (zh) |
KR (1) | KR20190021345A (zh) |
CN (2) | CN107540661A (zh) |
AU (1) | AU2017282903B2 (zh) |
CA (1) | CA3028015A1 (zh) |
RU (1) | RU2019100065A (zh) |
WO (1) | WO2017220007A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105085489B (zh) | 2014-11-05 | 2019-03-01 | 益方生物科技(上海)有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
CN110698461B (zh) * | 2018-07-09 | 2024-04-05 | 上海翰森生物医药科技有限公司 | 第三代egfr抑制剂的制备方法 |
CN113521074A (zh) * | 2020-04-17 | 2021-10-22 | 南京圣和药业股份有限公司 | 一种包含喹啉类TGF-β1抑制剂的组合物及其用途 |
WO2023061433A1 (zh) * | 2021-10-14 | 2023-04-20 | 齐鲁制药有限公司 | 一种egfr抑制剂的多晶型 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103702990A (zh) * | 2011-07-27 | 2014-04-02 | 阿斯利康(瑞典)有限公司 | 2-(2,4,5-取代苯胺)嘧啶衍生物作为egfr调谐子用于治疗癌症 |
CN105085489A (zh) * | 2014-11-05 | 2015-11-25 | 上海页岩科技有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ710636A (en) * | 2010-11-01 | 2017-02-24 | Celgene Avilomics Res Inc | Heterocyclic compounds and uses thereof |
JP6215938B2 (ja) * | 2012-08-06 | 2017-10-18 | エイシア バイオサイエンシーズ インコーポレイテッド | プロテインキナーゼの阻害剤としての新規ピロロピリミジン化合物 |
CA2992317A1 (en) * | 2015-07-16 | 2017-01-19 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Aniline pyrimidine derivatives and uses thereof |
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2016
- 2016-06-24 CN CN201610470835.2A patent/CN107540661A/zh active Pending
-
2017
- 2017-06-23 RU RU2019100065A patent/RU2019100065A/ru unknown
- 2017-06-23 CN CN201780037239.8A patent/CN109311852B/zh active Active
- 2017-06-23 US US16/311,623 patent/US20190256497A1/en not_active Abandoned
- 2017-06-23 CA CA3028015A patent/CA3028015A1/en active Pending
- 2017-06-23 WO PCT/CN2017/089693 patent/WO2017220007A1/zh unknown
- 2017-06-23 AU AU2017282903A patent/AU2017282903B2/en active Active
- 2017-06-23 EP EP17814745.0A patent/EP3476841A4/en active Pending
- 2017-06-23 JP JP2018567240A patent/JP2019518776A/ja active Pending
- 2017-06-23 KR KR1020197001682A patent/KR20190021345A/ko not_active Application Discontinuation
-
2020
- 2020-08-05 US US16/985,615 patent/US20200361908A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103702990A (zh) * | 2011-07-27 | 2014-04-02 | 阿斯利康(瑞典)有限公司 | 2-(2,4,5-取代苯胺)嘧啶衍生物作为egfr调谐子用于治疗癌症 |
CN105085489A (zh) * | 2014-11-05 | 2015-11-25 | 上海页岩科技有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
Also Published As
Publication number | Publication date |
---|---|
AU2017282903B2 (en) | 2021-03-25 |
US20200361908A1 (en) | 2020-11-19 |
EP3476841A4 (en) | 2020-01-22 |
CA3028015A1 (en) | 2017-12-28 |
JP2019518776A (ja) | 2019-07-04 |
CN107540661A (zh) | 2018-01-05 |
WO2017220007A1 (zh) | 2017-12-28 |
KR20190021345A (ko) | 2019-03-05 |
CN109311852B (zh) | 2021-04-02 |
RU2019100065A (ru) | 2020-07-24 |
RU2019100065A3 (zh) | 2020-09-25 |
AU2017282903A1 (en) | 2019-02-07 |
EP3476841A1 (en) | 2019-05-01 |
US20190256497A1 (en) | 2019-08-22 |
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