JP2018525332A5 - - Google Patents
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- JP2018525332A5 JP2018525332A5 JP2017565185A JP2017565185A JP2018525332A5 JP 2018525332 A5 JP2018525332 A5 JP 2018525332A5 JP 2017565185 A JP2017565185 A JP 2017565185A JP 2017565185 A JP2017565185 A JP 2017565185A JP 2018525332 A5 JP2018525332 A5 JP 2018525332A5
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- Prior art keywords
- amino acid
- seq
- acid sequence
- antibody
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 259
- 239000000203 mixture Substances 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 51
- 238000004519 manufacturing process Methods 0.000 claims description 46
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 33
- 206010016654 Fibrosis Diseases 0.000 claims description 32
- 201000010099 disease Diseases 0.000 claims description 32
- 230000004761 fibrosis Effects 0.000 claims description 32
- 230000003176 fibrotic effect Effects 0.000 claims description 29
- 101000863884 Homo sapiens Sialic acid-binding Ig-like lectin 8 Proteins 0.000 claims description 25
- 102000051056 human SIGLEC8 Human genes 0.000 claims description 25
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 16
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 15
- 239000000556 agonist Substances 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 9
- 206010039710 Scleroderma Diseases 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 210000002950 fibroblast Anatomy 0.000 claims description 8
- 230000003434 inspiratory effect Effects 0.000 claims description 8
- 230000004199 lung function Effects 0.000 claims description 8
- 230000001575 pathological effect Effects 0.000 claims description 8
- 210000003630 histaminocyte Anatomy 0.000 claims description 7
- 230000008595 infiltration Effects 0.000 claims description 7
- 238000001764 infiltration Methods 0.000 claims description 7
- 108010006654 Bleomycin Proteins 0.000 claims description 6
- 229960001561 bleomycin Drugs 0.000 claims description 6
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims description 6
- 210000004072 lung Anatomy 0.000 claims description 5
- 208000024891 symptom Diseases 0.000 claims description 5
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 4
- 201000001320 Atherosclerosis Diseases 0.000 claims description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 206010019668 Hepatic fibrosis Diseases 0.000 claims description 4
- 208000024934 IgG4-related mediastinitis Diseases 0.000 claims description 4
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 4
- 208000002805 Mediastinal fibrosis Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 claims description 4
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims description 4
- 206010072207 Splenic fibrosis Diseases 0.000 claims description 4
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 4
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000009787 cardiac fibrosis Effects 0.000 claims description 4
- 229920001436 collagen Polymers 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- 230000004941 influx Effects 0.000 claims description 4
- 206010028537 myelofibrosis Diseases 0.000 claims description 4
- 210000000651 myofibroblast Anatomy 0.000 claims description 4
- 210000000440 neutrophil Anatomy 0.000 claims description 4
- 201000002793 renal fibrosis Diseases 0.000 claims description 4
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 3
- 230000020411 cell activation Effects 0.000 claims description 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 description 6
- 230000002206 pro-fibrotic effect Effects 0.000 description 5
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 4
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- 208000032027 Essential Thrombocythemia Diseases 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 206010035742 Pneumonitis Diseases 0.000 description 2
- 206010038933 Retinopathy of prematurity Diseases 0.000 description 2
- 206010038934 Retinopathy proliferative Diseases 0.000 description 2
- 208000036866 Vitreoretinopathy Diseases 0.000 description 2
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 2
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- 201000003142 neovascular glaucoma Diseases 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000006785 proliferative vitreoretinopathy Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562181146P | 2015-06-17 | 2015-06-17 | |
| US62/181,146 | 2015-06-17 | ||
| US201662296482P | 2016-02-17 | 2016-02-17 | |
| US62/296,482 | 2016-02-17 | ||
| US201662344357P | 2016-06-01 | 2016-06-01 | |
| US62/344,357 | 2016-06-01 | ||
| PCT/US2016/037935 WO2016205567A1 (en) | 2015-06-17 | 2016-06-16 | Methods and compositions for treating fibrotic diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021031966A Division JP2021080289A (ja) | 2015-06-17 | 2021-03-01 | 線維性疾患を処置するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018525332A JP2018525332A (ja) | 2018-09-06 |
| JP2018525332A5 true JP2018525332A5 (enExample) | 2019-07-18 |
| JP6846362B2 JP6846362B2 (ja) | 2021-03-24 |
Family
ID=57546275
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565185A Active JP6846362B2 (ja) | 2015-06-17 | 2016-06-16 | 線維性疾患を処置するための方法および組成物 |
| JP2021031966A Withdrawn JP2021080289A (ja) | 2015-06-17 | 2021-03-01 | 線維性疾患を処置するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021031966A Withdrawn JP2021080289A (ja) | 2015-06-17 | 2021-03-01 | 線維性疾患を処置するための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10774145B2 (enExample) |
| EP (1) | EP3310385A4 (enExample) |
| JP (2) | JP6846362B2 (enExample) |
| AU (1) | AU2016278239B9 (enExample) |
| CA (1) | CA2987797A1 (enExample) |
| HK (1) | HK1254432A1 (enExample) |
| WO (1) | WO2016205567A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4014995A1 (en) | 2014-02-28 | 2022-06-22 | Allakos Inc. | Methods and compositions for treating siglec-8 associated diseases |
| US10774145B2 (en) * | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| EP3565597A4 (en) * | 2017-01-06 | 2021-01-13 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISORDER |
| EA201992626A1 (ru) | 2017-05-05 | 2020-04-24 | Аллакос Инк. | Способы и композиции для лечения аллергических заболеваний глаз |
| SG10202112259VA (en) * | 2017-05-05 | 2021-12-30 | Allakos Inc | Methods and compositions for treating inflammatory gastrointestinal disorders |
| WO2020163529A1 (en) * | 2019-02-06 | 2020-08-13 | Oncoimmune, Inc. | Targeting cd24-siglec interactions for the treatment and prevention of nonalcoholic steatohepatitis |
| WO2022061032A1 (en) * | 2020-09-17 | 2022-03-24 | Allakos Inc. | Methods and compositions for treating viral infection |
| WO2022204045A1 (en) * | 2021-03-22 | 2022-09-29 | Spiritus Therapeutics, Inc. | Diagnostic and therapeutic uses of purified potent exosomes containing disease-based and therapy based signature cargo |
| US11935238B2 (en) * | 2021-12-22 | 2024-03-19 | RealizeMD Ltd. | Systems and methods for generating clinically relevant images that preserve physical attributes of humans while protecting personal identity |
| US11631208B1 (en) * | 2021-12-22 | 2023-04-18 | RealizeMD Ltd. | Systems and methods for generating clinically relevant images that preserve physical attributes of humans while protecting personal identity |
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| SMT201900714T1 (it) | 2013-12-09 | 2020-01-14 | Allakos Inc | Anticorpi anti-siglec-8 e loro metodi d'impiego |
| EP4014995A1 (en) | 2014-02-28 | 2022-06-22 | Allakos Inc. | Methods and compositions for treating siglec-8 associated diseases |
| US10774145B2 (en) * | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| US10604577B2 (en) * | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| EP3565597A4 (en) | 2017-01-06 | 2021-01-13 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISORDER |
| SG10202112259VA (en) | 2017-05-05 | 2021-12-30 | Allakos Inc | Methods and compositions for treating inflammatory gastrointestinal disorders |
| EA201992626A1 (ru) | 2017-05-05 | 2020-04-24 | Аллакос Инк. | Способы и композиции для лечения аллергических заболеваний глаз |
-
2016
- 2016-06-16 US US15/737,270 patent/US10774145B2/en active Active
- 2016-06-16 AU AU2016278239A patent/AU2016278239B9/en not_active Ceased
- 2016-06-16 WO PCT/US2016/037935 patent/WO2016205567A1/en not_active Ceased
- 2016-06-16 CA CA2987797A patent/CA2987797A1/en active Pending
- 2016-06-16 JP JP2017565185A patent/JP6846362B2/ja active Active
- 2016-06-16 HK HK18113516.8A patent/HK1254432A1/zh unknown
- 2016-06-16 EP EP16812473.3A patent/EP3310385A4/en not_active Withdrawn
-
2020
- 2020-07-31 US US16/945,490 patent/US20210107977A1/en not_active Abandoned
-
2021
- 2021-03-01 JP JP2021031966A patent/JP2021080289A/ja not_active Withdrawn
-
2022
- 2022-10-21 US US17/971,520 patent/US20230303686A1/en not_active Abandoned
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