JP2017507945A5 - - Google Patents
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- JP2017507945A5 JP2017507945A5 JP2016554212A JP2016554212A JP2017507945A5 JP 2017507945 A5 JP2017507945 A5 JP 2017507945A5 JP 2016554212 A JP2016554212 A JP 2016554212A JP 2016554212 A JP2016554212 A JP 2016554212A JP 2017507945 A5 JP2017507945 A5 JP 2017507945A5
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- Prior art keywords
- amino acid
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- acid sequence
- hvr
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 182
- 238000000034 method Methods 0.000 claims description 94
- 101000863884 Homo sapiens Sialic acid-binding Ig-like lectin 8 Proteins 0.000 claims description 86
- 102000051056 human SIGLEC8 Human genes 0.000 claims description 69
- 239000000203 mixture Substances 0.000 claims description 51
- 208000024891 symptom Diseases 0.000 claims description 51
- 206010009137 Chronic sinusitis Diseases 0.000 claims description 39
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims description 39
- 239000000556 agonist Substances 0.000 claims description 35
- 208000038004 exacerbated respiratory disease Diseases 0.000 claims description 30
- 230000001771 impaired effect Effects 0.000 claims description 25
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 21
- 229930182474 N-glycoside Natural products 0.000 claims description 21
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 21
- 206010011224 Cough Diseases 0.000 claims description 20
- 150000001720 carbohydrates Chemical group 0.000 claims description 20
- 230000007794 irritation Effects 0.000 claims description 20
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 19
- 208000006673 asthma Diseases 0.000 claims description 19
- 102100029964 Sialic acid-binding Ig-like lectin 8 Human genes 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 206010003645 Atopy Diseases 0.000 claims description 16
- 230000003915 cell function Effects 0.000 claims description 16
- 208000000592 Nasal Polyps Diseases 0.000 claims description 15
- 206010036790 Productive cough Diseases 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 208000024794 sputum Diseases 0.000 claims description 15
- 210000003802 sputum Anatomy 0.000 claims description 15
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 210000003979 eosinophil Anatomy 0.000 claims description 13
- 208000015768 polyposis Diseases 0.000 claims description 13
- 206010039101 Rhinorrhoea Diseases 0.000 claims description 12
- 208000010753 nasal discharge Diseases 0.000 claims description 12
- 208000028347 Sinus disease Diseases 0.000 claims description 11
- 201000010659 intrinsic asthma Diseases 0.000 claims description 11
- 206010014950 Eosinophilia Diseases 0.000 claims description 9
- 210000000822 natural killer cell Anatomy 0.000 claims description 9
- 230000002085 persistent effect Effects 0.000 claims description 9
- 206010006326 Breath odour Diseases 0.000 claims description 8
- 206010016059 Facial pain Diseases 0.000 claims description 8
- 206010061218 Inflammation Diseases 0.000 claims description 8
- 206010028735 Nasal congestion Diseases 0.000 claims description 8
- 206010052437 Nasal discomfort Diseases 0.000 claims description 8
- 206010028748 Nasal obstruction Diseases 0.000 claims description 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 8
- 208000032140 Sleepiness Diseases 0.000 claims description 8
- 206010041349 Somnolence Diseases 0.000 claims description 8
- 208000027744 congestion Diseases 0.000 claims description 8
- 208000002173 dizziness Diseases 0.000 claims description 8
- 230000004054 inflammatory process Effects 0.000 claims description 8
- 208000004371 toothache Diseases 0.000 claims description 8
- 208000037874 Asthma exacerbation Diseases 0.000 claims description 7
- 102000003886 Glycoproteins Human genes 0.000 claims description 7
- 108090000288 Glycoproteins Proteins 0.000 claims description 7
- 239000003937 drug carrier Substances 0.000 claims description 7
- 239000003446 ligand Substances 0.000 claims description 7
- 208000016366 nasal cavity polyp Diseases 0.000 claims description 7
- 229920001542 oligosaccharide Polymers 0.000 claims description 7
- 150000002482 oligosaccharides Chemical class 0.000 claims description 7
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 150000003431 steroids Chemical class 0.000 claims description 7
- 230000009885 systemic effect Effects 0.000 claims description 7
- 208000032139 Halitosis Diseases 0.000 claims description 6
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 6
- 206010025482 malaise Diseases 0.000 claims description 6
- 230000035945 sensitivity Effects 0.000 claims description 6
- 208000019116 sleep disease Diseases 0.000 claims description 6
- 208000020685 sleep-wake disease Diseases 0.000 claims description 6
- 206010011703 Cyanosis Diseases 0.000 claims description 4
- 208000000059 Dyspnea Diseases 0.000 claims description 4
- 206010013975 Dyspnoeas Diseases 0.000 claims description 4
- 208000037656 Respiratory Sounds Diseases 0.000 claims description 4
- 206010057190 Respiratory tract infections Diseases 0.000 claims description 4
- 206010047924 Wheezing Diseases 0.000 claims description 4
- 208000013116 chronic cough Diseases 0.000 claims description 4
- 208000013220 shortness of breath Diseases 0.000 claims description 4
- 230000004580 weight loss Effects 0.000 claims description 4
- 206010008469 Chest discomfort Diseases 0.000 claims description 3
- 230000000779 depleting effect Effects 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- 230000020279 natural killer cell cytokine production Effects 0.000 claims description 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 206010014020 Ear pain Diseases 0.000 claims 4
- 206010070488 Upper-airway cough syndrome Diseases 0.000 claims 4
- 230000037418 vocal dysfunction Effects 0.000 claims 4
- 238000013313 FeNO test Methods 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- 206010003497 Asphyxia Diseases 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 230000004199 lung function Effects 0.000 claims 1
- 238000013123 lung function test Methods 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000013125 spirometry Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 230000001270 agonistic effect Effects 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461946407P | 2014-02-28 | 2014-02-28 | |
| US61/946,407 | 2014-02-28 | ||
| PCT/US2015/018188 WO2015131155A1 (en) | 2014-02-28 | 2015-02-27 | Methods and compositions for treating siglec-8 associated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021003944A Division JP2021054866A (ja) | 2014-02-28 | 2021-01-14 | シグレック−８関連疾患を処置するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507945A JP2017507945A (ja) | 2017-03-23 |
| JP2017507945A5 true JP2017507945A5 (enExample) | 2018-04-12 |
| JP6825909B2 JP6825909B2 (ja) | 2021-02-03 |
Family
ID=54009691
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554212A Active JP6825909B2 (ja) | 2014-02-28 | 2015-02-27 | シグレック−８関連疾患を処置するための方法および組成物 |
| JP2021003944A Pending JP2021054866A (ja) | 2014-02-28 | 2021-01-14 | シグレック−８関連疾患を処置するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021003944A Pending JP2021054866A (ja) | 2014-02-28 | 2021-01-14 | シグレック−８関連疾患を処置するための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10183996B2 (enExample) |
| EP (2) | EP4014995A1 (enExample) |
| JP (2) | JP6825909B2 (enExample) |
| AU (2) | AU2015222757B2 (enExample) |
| CA (1) | CA2939931C (enExample) |
| DK (1) | DK3110446T3 (enExample) |
| WO (1) | WO2015131155A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201900714T1 (it) * | 2013-12-09 | 2020-01-14 | Allakos Inc | Anticorpi anti-siglec-8 e loro metodi d'impiego |
| EP4014995A1 (en) | 2014-02-28 | 2022-06-22 | Allakos Inc. | Methods and compositions for treating siglec-8 associated diseases |
| US10774145B2 (en) * | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| US10604577B2 (en) * | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| EP3565597A4 (en) * | 2017-01-06 | 2021-01-13 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISORDER |
| EA201992626A1 (ru) * | 2017-05-05 | 2020-04-24 | Аллакос Инк. | Способы и композиции для лечения аллергических заболеваний глаз |
| SG10202112259VA (en) * | 2017-05-05 | 2021-12-30 | Allakos Inc | Methods and compositions for treating inflammatory gastrointestinal disorders |
| EP3732194A1 (en) * | 2017-12-29 | 2020-11-04 | Cornell University | Gene therapy for eosinophilic disorders |
| PE20211304A1 (es) * | 2018-02-09 | 2021-07-20 | Genentech Inc | Metodos terapeuticos y diagnosticos para enfermedades inflamatorias mediadas por mastocitos |
| AU2019262167A1 (en) * | 2018-05-04 | 2020-12-10 | Allakos Inc. | Methods and compositions for treating chronic urticaria |
| WO2020179700A1 (ja) * | 2019-03-01 | 2020-09-10 | 国立大学法人筑波大学 | アレルギー疾患を処置することに用いるための組成物 |
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| EP2465873A1 (en) | 2010-12-16 | 2012-06-20 | Deutsches Rheuma-Forschungszentrum Berlin | Eosinophils as a therapeutic target |
| CA2865154A1 (en) | 2012-02-24 | 2013-08-29 | Children's Hospital Medical Center | Esophageal microrna expression profiles in eosinophilic esophagitis |
| KR101567758B1 (ko) | 2013-10-17 | 2015-11-11 | 인하대학교 산학협력단 | 항-Siglec-8 항체 또는 항-Siglec-F 항체, 및 항-IL-33 항체를 포함하는 알러지 질환의 예방 또는 치료용 조성물 |
| KR20150044680A (ko) | 2013-10-17 | 2015-04-27 | 인하대학교 산학협력단 | 항-Siglec-8 항체 또는 항-Siglec-F 항체를 포함하는 알러지 질환의 예방 또는 치료용 조성물 |
| SMT201900714T1 (it) | 2013-12-09 | 2020-01-14 | Allakos Inc | Anticorpi anti-siglec-8 e loro metodi d'impiego |
| EP4014995A1 (en) | 2014-02-28 | 2022-06-22 | Allakos Inc. | Methods and compositions for treating siglec-8 associated diseases |
| US10774145B2 (en) | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| EP3565597A4 (en) | 2017-01-06 | 2021-01-13 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISORDER |
-
2015
- 2015-02-27 EP EP21204280.8A patent/EP4014995A1/en not_active Withdrawn
- 2015-02-27 DK DK15755175.5T patent/DK3110446T3/da active
- 2015-02-27 WO PCT/US2015/018188 patent/WO2015131155A1/en not_active Ceased
- 2015-02-27 CA CA2939931A patent/CA2939931C/en active Active
- 2015-02-27 EP EP15755175.5A patent/EP3110446B1/en active Active
- 2015-02-27 JP JP2016554212A patent/JP6825909B2/ja active Active
- 2015-02-27 US US15/121,756 patent/US10183996B2/en active Active
- 2015-02-27 AU AU2015222757A patent/AU2015222757B2/en active Active
-
2021
- 2021-01-07 AU AU2021200075A patent/AU2021200075A1/en not_active Abandoned
- 2021-01-14 JP JP2021003944A patent/JP2021054866A/ja active Pending
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