JP2018521308A5 - - Google Patents
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- JP2018521308A5 JP2018521308A5 JP2017560260A JP2017560260A JP2018521308A5 JP 2018521308 A5 JP2018521308 A5 JP 2018521308A5 JP 2017560260 A JP2017560260 A JP 2017560260A JP 2017560260 A JP2017560260 A JP 2017560260A JP 2018521308 A5 JP2018521308 A5 JP 2018521308A5
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- JP
- Japan
- Prior art keywords
- series
- labeled
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- single molecule
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 claims 18
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 230000005284 excitation Effects 0.000 claims 5
- 238000004020 luminiscence type Methods 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- 229930024421 Adenine Natural products 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021138498A JP7339302B2 (ja) | 2015-05-20 | 2021-08-27 | 時間分解発光を使用して核酸の配列を決定するための方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562164482P | 2015-05-20 | 2015-05-20 | |
| US201562164506P | 2015-05-20 | 2015-05-20 | |
| US201562164485P | 2015-05-20 | 2015-05-20 | |
| US201562164464P | 2015-05-20 | 2015-05-20 | |
| US62/164,485 | 2015-05-20 | ||
| US62/164,506 | 2015-05-20 | ||
| US62/164,464 | 2015-05-20 | ||
| US62/164,482 | 2015-05-20 | ||
| US14/821,688 US9885657B2 (en) | 2014-08-08 | 2015-08-07 | Integrated device with external light source for probing detecting and analyzing molecules |
| US14/821,688 | 2015-08-07 | ||
| PCT/US2016/033616 WO2016187580A1 (en) | 2015-05-20 | 2016-05-20 | Method of determining the sequence of a nuclear acid using time resolved luminescence |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138498A Division JP7339302B2 (ja) | 2015-05-20 | 2021-08-27 | 時間分解発光を使用して核酸の配列を決定するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521308A JP2018521308A (ja) | 2018-08-02 |
| JP2018521308A5 true JP2018521308A5 (enExample) | 2019-06-20 |
| JP6936736B2 JP6936736B2 (ja) | 2021-09-22 |
Family
ID=57320962
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560260A Active JP6936736B2 (ja) | 2015-05-20 | 2016-05-20 | 時間分解発光を使用して核酸の配列を決定するための方法 |
| JP2021138498A Active JP7339302B2 (ja) | 2015-05-20 | 2021-08-27 | 時間分解発光を使用して核酸の配列を決定するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138498A Active JP7339302B2 (ja) | 2015-05-20 | 2021-08-27 | 時間分解発光を使用して核酸の配列を決定するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP3298389B1 (enExample) |
| JP (2) | JP6936736B2 (enExample) |
| KR (1) | KR20180008779A (enExample) |
| CN (1) | CN108027325A (enExample) |
| AU (2) | AU2016264753B2 (enExample) |
| BR (1) | BR112017024573B1 (enExample) |
| CA (1) | CA2986237A1 (enExample) |
| MX (2) | MX2022001187A (enExample) |
| TW (1) | TWI704229B (enExample) |
| WO (1) | WO2016187580A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3194935B1 (en) | 2014-08-08 | 2018-10-31 | Quantum-si Incorporated | Integrated device for temporal binning of received photons |
| PE20181167A1 (es) | 2015-10-25 | 2018-07-19 | Sanofi Sa | Proteinas de union triespecificas y/o trivalentes para la prevencion o el tratamiento de la infeccion por vih |
| KR20180111999A (ko) | 2016-02-17 | 2018-10-11 | 테서렉트 헬스, 인코포레이티드 | 수명 촬상 및 검출 응용을 위한 센서 및 디바이스 |
| HUE063824T2 (hu) | 2016-04-13 | 2024-02-28 | Sanofi Sa | Trispecifikus és/vagy trivalens kötõfehérjék |
| KR102627237B1 (ko) | 2016-06-01 | 2024-01-23 | 퀀텀-에스아이 인코포레이티드 | 분자들을 검출 및 분석하기 위한 통합 디바이스 |
| JP7189874B2 (ja) * | 2016-12-16 | 2022-12-14 | クアンタム－エスアイ インコーポレイテッド | 光カプラおよび導波路システム |
| CN110168732B (zh) | 2016-12-22 | 2024-03-08 | 宽腾矽公司 | 具有直接合并像素的整合式光电侦测器 |
| WO2018204810A1 (en) | 2017-05-05 | 2018-11-08 | Quantum-Si Incorporated | Substrates having modified surface reactivity and antifouling properties in biological reactions |
| WO2018210394A1 (en) * | 2017-05-19 | 2018-11-22 | Københavns Universitet | Coherent single photon source |
| ES2908748T3 (es) * | 2017-06-23 | 2022-05-03 | Nanotemper Tech Gmbh | Métodos para medir interacciones inter- y/o intramoleculares |
| KR102786367B1 (ko) * | 2017-07-24 | 2025-03-26 | 퀀텀-에스아이 인코포레이티드 | 광학 거부 광자 구조체들 |
| AU2018308098B2 (en) * | 2017-07-24 | 2025-04-03 | Quantum-Si Incorporated | High intensity labeled reactant compositions and methods for sequencing |
| US11162138B2 (en) | 2017-10-30 | 2021-11-02 | Pacific Biosciences Of California, Inc. | Multi-amplitude modular labeled compounds |
| CA3108295A1 (en) | 2018-06-22 | 2019-12-26 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
| WO2020010589A1 (en) * | 2018-07-12 | 2020-01-16 | Shenzhen Genorivision Technology Co., Ltd. | An apparatus for biopolymer sequencing |
| EP3820943A1 (en) | 2018-07-13 | 2021-05-19 | Quantum-si Incorporated | Biconjugatable labels and methods of use |
| CA3109866A1 (en) * | 2018-08-29 | 2020-03-05 | Quantum-Si Incorporated | Sample well fabrication techniques and structures for integrated sensor devices |
| EP3844486A1 (en) * | 2018-08-29 | 2021-07-07 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
| US12179204B2 (en) | 2018-12-03 | 2024-12-31 | Quantum-Si Incorporated | Sample well fabrication techniques and structures for integrated sensor |
| CN111333605B (zh) * | 2018-12-18 | 2022-07-15 | 中国科学院大连化学物理研究所 | 一种高亮度、高稳定性的细胞膜碳酸酐酶ⅸ荧光探针 |
| CN113424047A (zh) * | 2019-01-03 | 2021-09-21 | 宽腾矽公司 | 用于将光传送到光子元件阵列的光波导及耦合器 |
| BR112021013787A2 (pt) | 2019-01-23 | 2021-10-05 | Quantum-Si Incorporated | Composições reagentes marcadas com alta densidade e métodos para sequenciamento |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN110066723A (zh) * | 2019-05-05 | 2019-07-30 | 京东方科技集团股份有限公司 | 基因测序芯片、设备、制造方法 |
| CN114514420A (zh) * | 2019-08-08 | 2022-05-17 | 宽腾矽公司 | 集成光学装置中的增加的发射收集效率 |
| AU2020364058A1 (en) | 2019-10-11 | 2022-05-26 | Quantum-Si Incorporated | Surface modification in the vapor phase |
| US20210123921A1 (en) * | 2019-10-17 | 2021-04-29 | C2Sense, Inc. | Diagnostic assays and related methods |
| US11726037B2 (en) * | 2019-10-17 | 2023-08-15 | C2Sense, Inc. | Luminescence imaging for sensing and/or authentication |
| US11869917B2 (en) | 2020-01-14 | 2024-01-09 | Quantum-Si Incorporated | Integrated sensor for lifetime characterization |
| EP4088319A1 (en) | 2020-01-14 | 2022-11-16 | Quantum-si Incorporated | Sensor for lifetime plus spectral characterization |
| US11719639B2 (en) | 2020-03-02 | 2023-08-08 | Quantum-Si Incorporated | Integrated sensor for multi-dimensional signal analysis |
| WO2021207400A2 (en) | 2020-04-08 | 2021-10-14 | Quantum-Si Incorporated | Integrated sensor with reduced skew |
| US20220049298A1 (en) * | 2020-08-14 | 2022-02-17 | Siphox, Inc. | Tagged-base dna sequencing readout on waveguide surfaces |
| GB2599729A (en) * | 2020-10-12 | 2022-04-13 | Sumitomo Chemical Co | Method comprising light emitting marker |
| CA3199745A1 (en) * | 2020-10-27 | 2022-05-05 | Quantum-Si Incorporated | Calibration of single-molecule detection system |
| WO2022263644A1 (en) * | 2021-06-17 | 2022-12-22 | Roche Diagnostics Gmbh | Thermostable affinity polypeptides |
| WO2023275738A1 (en) * | 2021-06-28 | 2023-01-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method and device for performing spectrally and temporally resolved spectroscopy of single photon emission in a quantum device |
| EP4397673A4 (en) | 2021-08-31 | 2025-02-19 | FUJIFILM Corporation | COMPOUND AND MARKED BIOMATERIAL USING SAME |
| WO2023114209A1 (en) * | 2021-12-14 | 2023-06-22 | Quantum-Si Incorporated | Methods for loading and data acquisition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE152831T1 (de) * | 1991-09-16 | 1997-05-15 | Molecular Probes Inc | Dimere unsymmetrische cyaninfarbstoffe |
| US5597696A (en) * | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| SE506700C2 (sv) * | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| JP3690271B2 (ja) * | 2000-11-29 | 2005-08-31 | 株式会社島津製作所 | 核酸の塩基配列決定のためのマトリックス値を得る方法 |
| US7041812B2 (en) | 2001-08-29 | 2006-05-09 | Amersham Biosciences Corp | Labeled nucleoside polyphosphates |
| JP2007033159A (ja) * | 2005-07-25 | 2007-02-08 | Assay Corp | 蛍光分子で標識された測定対象物質 |
| JP2010066212A (ja) * | 2008-09-12 | 2010-03-25 | Univ Of Tokyo | 測定装置及び観察対象の測定方法 |
| US9670243B2 (en) * | 2010-06-02 | 2017-06-06 | Industrial Technology Research Institute | Compositions and methods for sequencing nucleic acids |
| JP5928906B2 (ja) * | 2013-08-27 | 2016-06-01 | 横河電機株式会社 | 核酸配列計測方法、核酸配列計測用デバイス、核酸配列計測用デバイスの製造方法および核酸配列計測装置 |
-
2016
- 2016-05-20 EP EP16729108.7A patent/EP3298389B1/en active Active
- 2016-05-20 JP JP2017560260A patent/JP6936736B2/ja active Active
- 2016-05-20 WO PCT/US2016/033616 patent/WO2016187580A1/en not_active Ceased
- 2016-05-20 CN CN201680040436.0A patent/CN108027325A/zh active Pending
- 2016-05-20 KR KR1020177036583A patent/KR20180008779A/ko not_active Ceased
- 2016-05-20 AU AU2016264753A patent/AU2016264753B2/en active Active
- 2016-05-20 TW TW105115925A patent/TWI704229B/zh active
- 2016-05-20 BR BR112017024573-6A patent/BR112017024573B1/pt active IP Right Grant
- 2016-05-20 EP EP21199590.7A patent/EP3998471A1/en not_active Withdrawn
- 2016-05-20 CA CA2986237A patent/CA2986237A1/en active Pending
- 2016-05-20 MX MX2022001187A patent/MX2022001187A/es unknown
- 2016-05-20 MX MX2017014821A patent/MX392170B/es unknown
-
2021
- 2021-08-27 JP JP2021138498A patent/JP7339302B2/ja active Active
- 2021-12-08 AU AU2021282471A patent/AU2021282471B2/en active Active
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