MX2022001187A - Método para determinar la secuencia de un ácido nucleico usando luminiscencia resuelta por tiempo. - Google Patents
Método para determinar la secuencia de un ácido nucleico usando luminiscencia resuelta por tiempo.Info
- Publication number
- MX2022001187A MX2022001187A MX2022001187A MX2022001187A MX2022001187A MX 2022001187 A MX2022001187 A MX 2022001187A MX 2022001187 A MX2022001187 A MX 2022001187A MX 2022001187 A MX2022001187 A MX 2022001187A MX 2022001187 A MX2022001187 A MX 2022001187A
- Authority
- MX
- Mexico
- Prior art keywords
- determining
- sequence
- time resolved
- luminescence
- nuclear acid
- Prior art date
Links
- 238000004020 luminiscence type Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 238000012163 sequencing technique Methods 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6482—Sample cells, cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/064—Stray light conditioning
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562164482P | 2015-05-20 | 2015-05-20 | |
| US201562164506P | 2015-05-20 | 2015-05-20 | |
| US201562164485P | 2015-05-20 | 2015-05-20 | |
| US201562164464P | 2015-05-20 | 2015-05-20 | |
| US14/821,688 US9885657B2 (en) | 2014-08-08 | 2015-08-07 | Integrated device with external light source for probing detecting and analyzing molecules |
| PCT/US2016/033616 WO2016187580A1 (en) | 2015-05-20 | 2016-05-20 | Method of determining the sequence of a nuclear acid using time resolved luminescence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022001187A true MX2022001187A (es) | 2023-01-04 |
Family
ID=57320962
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022001187A MX2022001187A (es) | 2015-05-20 | 2016-05-20 | Método para determinar la secuencia de un ácido nucleico usando luminiscencia resuelta por tiempo. |
| MX2017014821A MX392170B (es) | 2015-05-20 | 2016-05-20 | Método para determinar la secuencia de un acido nucleico usando luminiscencia resuelta por tiempo. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017014821A MX392170B (es) | 2015-05-20 | 2016-05-20 | Método para determinar la secuencia de un acido nucleico usando luminiscencia resuelta por tiempo. |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP3298389B1 (enExample) |
| JP (2) | JP6936736B2 (enExample) |
| KR (1) | KR20180008779A (enExample) |
| CN (1) | CN108027325A (enExample) |
| AU (2) | AU2016264753B2 (enExample) |
| BR (1) | BR112017024573B1 (enExample) |
| CA (1) | CA2986237A1 (enExample) |
| MX (2) | MX2022001187A (enExample) |
| TW (1) | TWI704229B (enExample) |
| WO (1) | WO2016187580A1 (enExample) |
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| EP3194935B1 (en) | 2014-08-08 | 2018-10-31 | Quantum-si Incorporated | Integrated device for temporal binning of received photons |
| PE20181167A1 (es) | 2015-10-25 | 2018-07-19 | Sanofi Sa | Proteinas de union triespecificas y/o trivalentes para la prevencion o el tratamiento de la infeccion por vih |
| KR20180111999A (ko) | 2016-02-17 | 2018-10-11 | 테서렉트 헬스, 인코포레이티드 | 수명 촬상 및 검출 응용을 위한 센서 및 디바이스 |
| HUE063824T2 (hu) | 2016-04-13 | 2024-02-28 | Sanofi Sa | Trispecifikus és/vagy trivalens kötõfehérjék |
| KR102627237B1 (ko) | 2016-06-01 | 2024-01-23 | 퀀텀-에스아이 인코포레이티드 | 분자들을 검출 및 분석하기 위한 통합 디바이스 |
| JP7189874B2 (ja) * | 2016-12-16 | 2022-12-14 | クアンタム－エスアイ インコーポレイテッド | 光カプラおよび導波路システム |
| CN110168732B (zh) | 2016-12-22 | 2024-03-08 | 宽腾矽公司 | 具有直接合并像素的整合式光电侦测器 |
| WO2018204810A1 (en) | 2017-05-05 | 2018-11-08 | Quantum-Si Incorporated | Substrates having modified surface reactivity and antifouling properties in biological reactions |
| WO2018210394A1 (en) * | 2017-05-19 | 2018-11-22 | Københavns Universitet | Coherent single photon source |
| ES2908748T3 (es) * | 2017-06-23 | 2022-05-03 | Nanotemper Tech Gmbh | Métodos para medir interacciones inter- y/o intramoleculares |
| KR102786367B1 (ko) * | 2017-07-24 | 2025-03-26 | 퀀텀-에스아이 인코포레이티드 | 광학 거부 광자 구조체들 |
| AU2018308098B2 (en) * | 2017-07-24 | 2025-04-03 | Quantum-Si Incorporated | High intensity labeled reactant compositions and methods for sequencing |
| US11162138B2 (en) | 2017-10-30 | 2021-11-02 | Pacific Biosciences Of California, Inc. | Multi-amplitude modular labeled compounds |
| CA3108295A1 (en) | 2018-06-22 | 2019-12-26 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
| WO2020010589A1 (en) * | 2018-07-12 | 2020-01-16 | Shenzhen Genorivision Technology Co., Ltd. | An apparatus for biopolymer sequencing |
| EP3820943A1 (en) | 2018-07-13 | 2021-05-19 | Quantum-si Incorporated | Biconjugatable labels and methods of use |
| CA3109866A1 (en) * | 2018-08-29 | 2020-03-05 | Quantum-Si Incorporated | Sample well fabrication techniques and structures for integrated sensor devices |
| EP3844486A1 (en) * | 2018-08-29 | 2021-07-07 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
| US12179204B2 (en) | 2018-12-03 | 2024-12-31 | Quantum-Si Incorporated | Sample well fabrication techniques and structures for integrated sensor |
| CN111333605B (zh) * | 2018-12-18 | 2022-07-15 | 中国科学院大连化学物理研究所 | 一种高亮度、高稳定性的细胞膜碳酸酐酶ⅸ荧光探针 |
| CN113424047A (zh) * | 2019-01-03 | 2021-09-21 | 宽腾矽公司 | 用于将光传送到光子元件阵列的光波导及耦合器 |
| BR112021013787A2 (pt) | 2019-01-23 | 2021-10-05 | Quantum-Si Incorporated | Composições reagentes marcadas com alta densidade e métodos para sequenciamento |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN110066723A (zh) * | 2019-05-05 | 2019-07-30 | 京东方科技集团股份有限公司 | 基因测序芯片、设备、制造方法 |
| CN114514420A (zh) * | 2019-08-08 | 2022-05-17 | 宽腾矽公司 | 集成光学装置中的增加的发射收集效率 |
| AU2020364058A1 (en) | 2019-10-11 | 2022-05-26 | Quantum-Si Incorporated | Surface modification in the vapor phase |
| US20210123921A1 (en) * | 2019-10-17 | 2021-04-29 | C2Sense, Inc. | Diagnostic assays and related methods |
| US11726037B2 (en) * | 2019-10-17 | 2023-08-15 | C2Sense, Inc. | Luminescence imaging for sensing and/or authentication |
| US11869917B2 (en) | 2020-01-14 | 2024-01-09 | Quantum-Si Incorporated | Integrated sensor for lifetime characterization |
| EP4088319A1 (en) | 2020-01-14 | 2022-11-16 | Quantum-si Incorporated | Sensor for lifetime plus spectral characterization |
| US11719639B2 (en) | 2020-03-02 | 2023-08-08 | Quantum-Si Incorporated | Integrated sensor for multi-dimensional signal analysis |
| WO2021207400A2 (en) | 2020-04-08 | 2021-10-14 | Quantum-Si Incorporated | Integrated sensor with reduced skew |
| US20220049298A1 (en) * | 2020-08-14 | 2022-02-17 | Siphox, Inc. | Tagged-base dna sequencing readout on waveguide surfaces |
| GB2599729A (en) * | 2020-10-12 | 2022-04-13 | Sumitomo Chemical Co | Method comprising light emitting marker |
| CA3199745A1 (en) * | 2020-10-27 | 2022-05-05 | Quantum-Si Incorporated | Calibration of single-molecule detection system |
| WO2022263644A1 (en) * | 2021-06-17 | 2022-12-22 | Roche Diagnostics Gmbh | Thermostable affinity polypeptides |
| WO2023275738A1 (en) * | 2021-06-28 | 2023-01-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method and device for performing spectrally and temporally resolved spectroscopy of single photon emission in a quantum device |
| EP4397673A4 (en) | 2021-08-31 | 2025-02-19 | FUJIFILM Corporation | COMPOUND AND MARKED BIOMATERIAL USING SAME |
| WO2023114209A1 (en) * | 2021-12-14 | 2023-06-22 | Quantum-Si Incorporated | Methods for loading and data acquisition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE152831T1 (de) * | 1991-09-16 | 1997-05-15 | Molecular Probes Inc | Dimere unsymmetrische cyaninfarbstoffe |
| US5597696A (en) * | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| SE506700C2 (sv) * | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| JP3690271B2 (ja) * | 2000-11-29 | 2005-08-31 | 株式会社島津製作所 | 核酸の塩基配列決定のためのマトリックス値を得る方法 |
| US7041812B2 (en) | 2001-08-29 | 2006-05-09 | Amersham Biosciences Corp | Labeled nucleoside polyphosphates |
| JP2007033159A (ja) * | 2005-07-25 | 2007-02-08 | Assay Corp | 蛍光分子で標識された測定対象物質 |
| JP2010066212A (ja) * | 2008-09-12 | 2010-03-25 | Univ Of Tokyo | 測定装置及び観察対象の測定方法 |
| US9670243B2 (en) * | 2010-06-02 | 2017-06-06 | Industrial Technology Research Institute | Compositions and methods for sequencing nucleic acids |
| JP5928906B2 (ja) * | 2013-08-27 | 2016-06-01 | 横河電機株式会社 | 核酸配列計測方法、核酸配列計測用デバイス、核酸配列計測用デバイスの製造方法および核酸配列計測装置 |
-
2016
- 2016-05-20 EP EP16729108.7A patent/EP3298389B1/en active Active
- 2016-05-20 JP JP2017560260A patent/JP6936736B2/ja active Active
- 2016-05-20 WO PCT/US2016/033616 patent/WO2016187580A1/en not_active Ceased
- 2016-05-20 CN CN201680040436.0A patent/CN108027325A/zh active Pending
- 2016-05-20 KR KR1020177036583A patent/KR20180008779A/ko not_active Ceased
- 2016-05-20 AU AU2016264753A patent/AU2016264753B2/en active Active
- 2016-05-20 TW TW105115925A patent/TWI704229B/zh active
- 2016-05-20 BR BR112017024573-6A patent/BR112017024573B1/pt active IP Right Grant
- 2016-05-20 EP EP21199590.7A patent/EP3998471A1/en not_active Withdrawn
- 2016-05-20 CA CA2986237A patent/CA2986237A1/en active Pending
- 2016-05-20 MX MX2022001187A patent/MX2022001187A/es unknown
- 2016-05-20 MX MX2017014821A patent/MX392170B/es unknown
-
2021
- 2021-08-27 JP JP2021138498A patent/JP7339302B2/ja active Active
- 2021-12-08 AU AU2021282471A patent/AU2021282471B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180008779A (ko) | 2018-01-24 |
| JP2021192044A (ja) | 2021-12-16 |
| CA2986237A1 (en) | 2016-11-24 |
| JP6936736B2 (ja) | 2021-09-22 |
| TWI704229B (zh) | 2020-09-11 |
| EP3298389B1 (en) | 2021-09-29 |
| BR112017024573B1 (pt) | 2024-03-05 |
| MX2017014821A (es) | 2018-06-27 |
| AU2016264753A1 (en) | 2017-12-14 |
| AU2021282471A1 (en) | 2022-01-06 |
| TW201708546A (zh) | 2017-03-01 |
| JP2018521308A (ja) | 2018-08-02 |
| JP7339302B2 (ja) | 2023-09-05 |
| BR112017024573A2 (pt) | 2018-07-31 |
| AU2016264753B2 (en) | 2021-09-09 |
| EP3298389A1 (en) | 2018-03-28 |
| EP3998471A1 (en) | 2022-05-18 |
| WO2016187580A1 (en) | 2016-11-24 |
| MX392170B (es) | 2025-03-21 |
| AU2021282471B2 (en) | 2024-01-04 |
| CN108027325A (zh) | 2018-05-11 |
| HK1252483A1 (zh) | 2019-05-24 |
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