JP2018519804A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018519804A5 JP2018519804A5 JP2017560539A JP2017560539A JP2018519804A5 JP 2018519804 A5 JP2018519804 A5 JP 2018519804A5 JP 2017560539 A JP2017560539 A JP 2017560539A JP 2017560539 A JP2017560539 A JP 2017560539A JP 2018519804 A5 JP2018519804 A5 JP 2018519804A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- chain variable
- variable region
- sequence shown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- 208000037262 Hepatitis delta Diseases 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000008485 antagonism Effects 0.000 claims description 2
- 210000004748 cultured cell Anatomy 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims 176
- 239000012634 fragment Substances 0.000 claims 14
- 241000700721 Hepatitis B virus Species 0.000 claims 8
- 241000724709 Hepatitis delta virus Species 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 230000009227 antibody-mediated cytotoxicity Effects 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000029570 hepatitis D virus infection Diseases 0.000 description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020116317A JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2015/079534 | 2015-05-22 | ||
| CN2015079534 | 2015-05-22 | ||
| PCT/CN2016/082985 WO2016188386A1 (en) | 2015-05-22 | 2016-05-23 | Anti-Pre-S1 HBV Antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116317A Division JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519804A JP2018519804A (ja) | 2018-07-26 |
| JP2018519804A5 true JP2018519804A5 (enExample) | 2019-06-27 |
| JP6820278B2 JP6820278B2 (ja) | 2021-01-27 |
Family
ID=57392535
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560539A Active JP6820278B2 (ja) | 2015-05-22 | 2016-05-23 | 抗Ｐｒｅ−Ｓ１ ＨＢＶ抗体 |
| JP2020116317A Active JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116317A Active JP7304320B2 (ja) | 2015-05-22 | 2020-07-06 | 抗Ｐｒｅ－Ｓ１ ＨＢＶ抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20180094047A1 (enExample) |
| EP (2) | EP3298038B1 (enExample) |
| JP (2) | JP6820278B2 (enExample) |
| KR (1) | KR102770671B1 (enExample) |
| CN (3) | CN107614525B (enExample) |
| ES (1) | ES2896275T3 (enExample) |
| HK (1) | HK1243429A1 (enExample) |
| MA (1) | MA42137A (enExample) |
| RU (1) | RU2739955C2 (enExample) |
| WO (1) | WO2016188386A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6820278B2 (ja) | 2015-05-22 | 2021-01-27 | フアフイ ヘルス リミテッドＨｕａｈｕｉ Ｈｅａｌｔｈ Ｌｔｄ． | 抗Ｐｒｅ−Ｓ１ ＨＢＶ抗体 |
| JP7466459B2 (ja) | 2018-04-17 | 2024-04-12 | セルデックス セラピューティクス インコーポレイテッド | 抗ｃｄ２７および抗ｐｄ－ｌ１抗体ならびに二重特異性構築物 |
| JP7454855B2 (ja) * | 2018-12-21 | 2024-03-25 | 国立大学法人広島大学 | 抗ｐｒｅＳ１抗体およびその用途 |
| JP2022542035A (ja) * | 2019-07-20 | 2022-09-29 | フアフイ ヘルス リミテッド | 抗ｐｒｅ－ｓ１ ｈｂｖ抗体を用いるｈｂｖ感染症の治療方法 |
| WO2022265264A1 (ko) * | 2021-06-15 | 2022-12-22 | 에이피트바이오 주식회사 | B형 간염바이러스 pres1항원의 간세포 수용체 결합부위에 특이적으로 결합하는 인간 항체 및 이의 용도 |
| US20240391979A1 (en) * | 2021-09-13 | 2024-11-28 | Achelois Biopharma, Inc. | Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use |
| CN116568808A (zh) * | 2021-10-19 | 2023-08-08 | 北京三诺佳邑生物技术有限责任公司 | 特异性结合乙型肝炎病毒表面抗原pre-S1的抗体及其应用 |
| CN114685663B (zh) * | 2022-04-07 | 2023-09-08 | 西南大学 | 一种抗胆固醇依赖性细胞溶素的抗体及其应用 |
| CN117304308A (zh) * | 2022-06-20 | 2023-12-29 | 华辉安健（北京）生物科技有限公司 | 抗乙型肝炎病毒的抗体及其制备和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| CA2041772A1 (en) * | 1990-05-11 | 1991-11-12 | Larry T. Mimms | Monoclonal antibodies to pres2 and pres1 polypeptide of the hepatitis b viral envelope |
| JP2002502222A (ja) * | 1992-11-06 | 2002-01-22 | ノバーティス アクチエンゲゼルシャフト | Ｂ型肝炎表面抗原に対して活性なヒトモノクローナル抗体の生産 |
| KR100345463B1 (ko) * | 1998-11-19 | 2003-01-08 | 주)녹십자 | B형간염바이러스의표면항원프리-s1에대한인간화항체및이의제조방법 |
| CN1216914C (zh) * | 2000-05-17 | 2005-08-31 | 韩国科学技术研究院 | 对hbv表面抗原pre－s1具有特异性的人源化抗体 |
| KR100423614B1 (ko) * | 2001-05-16 | 2004-03-22 | 주식회사유한양행 | 비형간염바이러스의 에스-표면항원을 인식하는단일클론항체의 가변영역 및 이를 코딩하는 유전자 |
| EP1281761A1 (en) * | 2001-07-27 | 2003-02-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Hepatitis B virus pre-S1 derived synthetic polypeptides and their use thereof. |
| US7601351B1 (en) * | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
| CN1733798B (zh) * | 2005-08-12 | 2012-07-04 | 上海贺普生物科技有限公司 | 乙型肝炎病毒表面l蛋白相关肽 |
| WO2011045079A1 (en) * | 2009-10-15 | 2011-04-21 | Intercell Ag | Hepatitis b virus specific human antibodies |
| WO2013159243A1 (en) | 2012-04-25 | 2013-10-31 | National Institute Of Biological Sciences, Beijing | Compositions and uses of functional receptor for hbv/hdv virus |
| JP6820278B2 (ja) | 2015-05-22 | 2021-01-27 | フアフイ ヘルス リミテッドＨｕａｈｕｉ Ｈｅａｌｔｈ Ｌｔｄ． | 抗Ｐｒｅ−Ｓ１ ＨＢＶ抗体 |
-
2016
- 2016-05-23 JP JP2017560539A patent/JP6820278B2/ja active Active
- 2016-05-23 WO PCT/CN2016/082985 patent/WO2016188386A1/en not_active Ceased
- 2016-05-23 CN CN201680029377.7A patent/CN107614525B/zh active Active
- 2016-05-23 CN CN202110657776.0A patent/CN113527470B/zh active Active
- 2016-05-23 ES ES16799274T patent/ES2896275T3/es active Active
- 2016-05-23 EP EP16799274.2A patent/EP3298038B1/en active Active
- 2016-05-23 MA MA042137A patent/MA42137A/fr unknown
- 2016-05-23 CN CN202310981391.9A patent/CN117247944A/zh active Pending
- 2016-05-23 RU RU2017145085A patent/RU2739955C2/ru active
- 2016-05-23 US US15/566,555 patent/US20180094047A1/en not_active Abandoned
- 2016-05-23 HK HK18102836.4A patent/HK1243429A1/zh unknown
- 2016-05-23 EP EP21187270.0A patent/EP3978521A1/en active Pending
- 2016-05-23 KR KR1020177036711A patent/KR102770671B1/ko active Active
-
2018
- 2018-01-08 US US15/864,494 patent/US10544205B2/en active Active
-
2019
- 2019-12-12 US US16/711,861 patent/US11485774B2/en active Active
-
2020
- 2020-07-06 JP JP2020116317A patent/JP7304320B2/ja active Active