JP2018516860A5 - - Google Patents
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- JP2018516860A5 JP2018516860A5 JP2017553874A JP2017553874A JP2018516860A5 JP 2018516860 A5 JP2018516860 A5 JP 2018516860A5 JP 2017553874 A JP2017553874 A JP 2017553874A JP 2017553874 A JP2017553874 A JP 2017553874A JP 2018516860 A5 JP2018516860 A5 JP 2018516860A5
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- 125000000217 alkyl group Chemical group 0.000 claims 18
- 229910052799 carbon Inorganic materials 0.000 claims 13
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 150000001413 amino acids Chemical group 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- 235000018417 cysteine Nutrition 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000005647 linker group Chemical group 0.000 claims 8
- 235000001014 amino acid Nutrition 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- -1 methoxy, pyridyl Chemical group 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 229940024606 amino acid Drugs 0.000 claims 5
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
- 125000005907 alkyl ester group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 108010016626 Dipeptides Proteins 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 150000002825 nitriles Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 102000000412 Annexin Human genes 0.000 claims 1
- 108050008874 Annexin Proteins 0.000 claims 1
- 102100027052 Bone morphogenetic protein receptor type-1B Human genes 0.000 claims 1
- 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 claims 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
- 108010065524 CD52 Antigen Proteins 0.000 claims 1
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102100032768 Complement receptor type 2 Human genes 0.000 claims 1
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims 1
- 101710099518 Dickkopf-related protein 1 Proteins 0.000 claims 1
- 101150076616 EPHA2 gene Proteins 0.000 claims 1
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims 1
- 102100031517 Fc receptor-like protein 1 Human genes 0.000 claims 1
- 101710120224 Fc receptor-like protein 1 Proteins 0.000 claims 1
- 102100031511 Fc receptor-like protein 2 Human genes 0.000 claims 1
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims 1
- 102100035139 Folate receptor alpha Human genes 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 1
- 102100031546 HLA class II histocompatibility antigen, DO beta chain Human genes 0.000 claims 1
- 101000984546 Homo sapiens Bone morphogenetic protein receptor type-1B Proteins 0.000 claims 1
- 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 claims 1
- 101000846911 Homo sapiens Fc receptor-like protein 2 Proteins 0.000 claims 1
- 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims 1
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 claims 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 1
- 101000866281 Homo sapiens HLA class II histocompatibility antigen, DO beta chain Proteins 0.000 claims 1
- 101000606465 Homo sapiens Inactive tyrosine-protein kinase 7 Proteins 0.000 claims 1
- 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 claims 1
- 101000628535 Homo sapiens Metalloreductase STEAP2 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101001023705 Homo sapiens Nectin-4 Proteins 0.000 claims 1
- 101000897042 Homo sapiens Nucleotide pyrophosphatase Proteins 0.000 claims 1
- 101000610548 Homo sapiens Proline-rich protein 4 Proteins 0.000 claims 1
- 101000829127 Homo sapiens Somatostatin receptor type 2 Proteins 0.000 claims 1
- 101000829138 Homo sapiens Somatostatin receptor type 3 Proteins 0.000 claims 1
- 101000829153 Homo sapiens Somatostatin receptor type 5 Proteins 0.000 claims 1
- 101000835745 Homo sapiens Teratocarcinoma-derived growth factor 1 Proteins 0.000 claims 1
- 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100039813 Inactive tyrosine-protein kinase 7 Human genes 0.000 claims 1
- 102100022337 Integrin alpha-V Human genes 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 claims 1
- 102100026711 Metalloreductase STEAP2 Human genes 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100035486 Nectin-4 Human genes 0.000 claims 1
- 102100021969 Nucleotide pyrophosphatase Human genes 0.000 claims 1
- 102100029329 Somatostatin receptor type 1 Human genes 0.000 claims 1
- 102100023802 Somatostatin receptor type 2 Human genes 0.000 claims 1
- 102100023803 Somatostatin receptor type 3 Human genes 0.000 claims 1
- 102100023801 Somatostatin receptor type 4 Human genes 0.000 claims 1
- 102100023806 Somatostatin receptor type 5 Human genes 0.000 claims 1
- 102100038126 Tenascin Human genes 0.000 claims 1
- 108010008125 Tenascin Proteins 0.000 claims 1
- 102100026404 Teratocarcinoma-derived growth factor 1 Human genes 0.000 claims 1
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 150000001945 cysteines Chemical group 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 108010064556 somatostatin receptor subtype-4 Proteins 0.000 claims 1
- 108010082379 somatostatin receptor type 1 Proteins 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 0 CC(C[C@@]1C(C)N(*)c2c3c(*)c(*)c(*)c2*)CN1C3=O Chemical compound CC(C[C@@]1C(C)N(*)c2c3c(*)c(*)c(*)c2*)CN1C3=O 0.000 description 7
- AZYHRETZPPPZQG-UHFFFAOYSA-N CC(NOC(C)O)I Chemical compound CC(NOC(C)O)I AZYHRETZPPPZQG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1506389.4A GB201506389D0 (en) | 2015-04-15 | 2015-04-15 | Site-specific antibody-drug conjugates |
| GB1506389.4 | 2015-04-15 | ||
| PCT/EP2016/058373 WO2016166301A1 (en) | 2015-04-15 | 2016-04-15 | Site-specific antibody-drug conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018516860A JP2018516860A (ja) | 2018-06-28 |
| JP2018516860A5 true JP2018516860A5 (enExample) | 2019-05-16 |
Family
ID=53333821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553874A Pending JP2018516860A (ja) | 2015-04-15 | 2016-04-15 | 部位特異的な抗体−薬物複合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180092985A1 (enExample) |
| EP (1) | EP3283120A1 (enExample) |
| JP (1) | JP2018516860A (enExample) |
| CN (1) | CN107530442A (enExample) |
| GB (1) | GB201506389D0 (enExample) |
| WO (2) | WO2016166301A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6704532B1 (ja) | 2017-02-08 | 2020-06-03 | アーデーセー セラピューティクス ソシエテ アノニム | ピロロベンゾジアゼピン抗体複合体 |
| US11596696B2 (en) | 2017-04-20 | 2023-03-07 | Adc Therapeutics Sa | Combination therapy with an anti-CD25 antibody-drug conjugate |
| KR102719065B1 (ko) | 2017-06-08 | 2024-10-17 | 블랙 벨트 테라퓨틱스 리미티드 | Cd38 조정 항체 |
| NZ759835A (en) | 2017-06-08 | 2025-09-26 | Black Belt Therapeutics Ltd | Cd38 modulating antibody |
| US11426467B2 (en) | 2017-06-14 | 2022-08-30 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-CD25 ADC |
| JP7299873B2 (ja) | 2017-08-16 | 2023-06-28 | ブラック ベルト セラピューティクス リミテッド | Ｃｄ３８抗体 |
| WO2019034752A1 (en) | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | CD38 MODULATOR ANTIBODY |
| EP3801630A1 (en) * | 2018-05-25 | 2021-04-14 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
| GB201820725D0 (en) | 2018-12-19 | 2019-01-30 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine resistance |
| US20220347309A1 (en) | 2018-12-19 | 2022-11-03 | Adc Therapeutics Sa | Pyrrolobenzodiazepine resistance |
| GB201908128D0 (en) | 2019-06-07 | 2019-07-24 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| AU2020329191B2 (en) | 2019-08-12 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Macrophage stimulating 1 receptor (MST1R) variants and uses thereof |
| CN111560078A (zh) * | 2020-06-19 | 2020-08-21 | 联宁（苏州）生物制药有限公司 | 具有马来酰亚胺接头的双臂中间体及其合成方法 |
| GB202011993D0 (en) | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
| WO2023125349A1 (zh) * | 2021-12-27 | 2023-07-06 | 山东先声生物制药有限公司 | 抗gucy2c抗体及其应用 |
| WO2024046455A1 (en) * | 2022-09-01 | 2024-03-07 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Methods for preparing antibody-drug conjugates |
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2015
- 2015-04-15 GB GBGB1506389.4A patent/GB201506389D0/en not_active Ceased
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2016
- 2016-04-15 JP JP2017553874A patent/JP2018516860A/ja active Pending
- 2016-04-15 WO PCT/EP2016/058373 patent/WO2016166301A1/en not_active Ceased
- 2016-04-15 US US15/566,391 patent/US20180092985A1/en not_active Abandoned
- 2016-04-15 EP EP16716585.1A patent/EP3283120A1/en not_active Withdrawn
- 2016-04-15 CN CN201680021976.4A patent/CN107530442A/zh active Pending
- 2016-04-15 WO PCT/EP2016/058376 patent/WO2016166304A1/en not_active Ceased