GB201506389D0 - Site-specific antibody-drug conjugates - Google Patents
Site-specific antibody-drug conjugatesInfo
- Publication number
- GB201506389D0 GB201506389D0 GBGB1506389.4A GB201506389A GB201506389D0 GB 201506389 D0 GB201506389 D0 GB 201506389D0 GB 201506389 A GB201506389 A GB 201506389A GB 201506389 D0 GB201506389 D0 GB 201506389D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- site
- specific antibody
- drug conjugates
- conjugates
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000611 antibody drug conjugate Substances 0.000 title 1
- 229940049595 antibody-drug conjugate Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1506389.4A GB201506389D0 (en) | 2015-04-15 | 2015-04-15 | Site-specific antibody-drug conjugates |
| PCT/EP2016/058373 WO2016166301A1 (en) | 2015-04-15 | 2016-04-15 | Site-specific antibody-drug conjugates |
| PCT/EP2016/058376 WO2016166304A1 (en) | 2015-04-15 | 2016-04-15 | Site-specific antibody-drug conjugates |
| EP16716585.1A EP3283120A1 (en) | 2015-04-15 | 2016-04-15 | Site-specific antibody-drug conjugates |
| CN201680021976.4A CN107530442A (zh) | 2015-04-15 | 2016-04-15 | 位点特异性抗体‑药物缀合物 |
| US15/566,391 US20180092985A1 (en) | 2015-04-15 | 2016-04-15 | Site-specific antibody-drug conjugates |
| JP2017553874A JP2018516860A (ja) | 2015-04-15 | 2016-04-15 | 部位特異的な抗体−薬物複合体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1506389.4A GB201506389D0 (en) | 2015-04-15 | 2015-04-15 | Site-specific antibody-drug conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201506389D0 true GB201506389D0 (en) | 2015-05-27 |
Family
ID=53333821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB1506389.4A Ceased GB201506389D0 (en) | 2015-04-15 | 2015-04-15 | Site-specific antibody-drug conjugates |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180092985A1 (enExample) |
| EP (1) | EP3283120A1 (enExample) |
| JP (1) | JP2018516860A (enExample) |
| CN (1) | CN107530442A (enExample) |
| GB (1) | GB201506389D0 (enExample) |
| WO (2) | WO2016166301A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11384098B2 (en) | 2017-02-08 | 2022-07-12 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| EP3612236A1 (en) | 2017-04-20 | 2020-02-26 | ADC Therapeutics SA | Combination therapy with an anti-cd25 antibody-drug conjugate |
| WO2018224683A1 (en) | 2017-06-08 | 2018-12-13 | Tusk Therapeutics Ltd | Cd38 modulating antibody |
| WO2018224682A1 (en) | 2017-06-08 | 2018-12-13 | Tusk Therapeutics Ltd | Cd38 modulating antibody |
| JP2020523384A (ja) | 2017-06-14 | 2020-08-06 | アーデーセー セラピューティクス ソシエテ アノニム | 抗ｃｄ２５ ａｄｃを投与するための投与レジメ |
| US11236173B2 (en) | 2017-08-16 | 2022-02-01 | Black Belt Therapeutics Limited | CD38 antibody |
| AU2018316521B2 (en) | 2017-08-16 | 2025-01-30 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| EP3801630A1 (en) * | 2018-05-25 | 2021-04-14 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
| GB201820725D0 (en) | 2018-12-19 | 2019-01-30 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine resistance |
| EP3899048A1 (en) | 2018-12-19 | 2021-10-27 | ADC Therapeutics SA | Pyrrolobenzodiazepine resistance |
| GB201908128D0 (en) | 2019-06-07 | 2019-07-24 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| JP2022544393A (ja) | 2019-08-12 | 2022-10-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | マクロファージ刺激１受容体（ｍｓｔ１ｒ）バリアント及びその使用 |
| CN111560078A (zh) * | 2020-06-19 | 2020-08-21 | 联宁（苏州）生物制药有限公司 | 具有马来酰亚胺接头的双臂中间体及其合成方法 |
| GB202011993D0 (en) | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
| CN118215685A (zh) * | 2021-12-27 | 2024-06-18 | 山东先声生物制药有限公司 | 抗gucy2c抗体及其应用 |
| WO2024046455A1 (en) * | 2022-09-01 | 2024-03-07 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Methods for preparing antibody-drug conjugates |
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| JP6392765B2 (ja) * | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ | ピロロベンゾジアゼピン−抗体結合体 |
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| BR112016004073A8 (pt) * | 2013-08-28 | 2018-06-12 | Stemcentrx Inc | Anticorpos criados por engenharia, conjugados de anticorpo fármaco, seu método de preparação e seu uso, composição farmacêutica e seu uso, kits, e métodos para administrar uma pirrolobenzodiazepina (pbd) a uma célula de câncer que expressa dll3 e para determinar a citotoxicidade de um conjugado de anticorpo fármaco anti-dll3 |
-
2015
- 2015-04-15 GB GBGB1506389.4A patent/GB201506389D0/en not_active Ceased
-
2016
- 2016-04-15 WO PCT/EP2016/058373 patent/WO2016166301A1/en not_active Ceased
- 2016-04-15 US US15/566,391 patent/US20180092985A1/en not_active Abandoned
- 2016-04-15 JP JP2017553874A patent/JP2018516860A/ja active Pending
- 2016-04-15 CN CN201680021976.4A patent/CN107530442A/zh active Pending
- 2016-04-15 EP EP16716585.1A patent/EP3283120A1/en not_active Withdrawn
- 2016-04-15 WO PCT/EP2016/058376 patent/WO2016166304A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016166304A1 (en) | 2016-10-20 |
| WO2016166301A1 (en) | 2016-10-20 |
| CN107530442A (zh) | 2018-01-02 |
| EP3283120A1 (en) | 2018-02-21 |
| JP2018516860A (ja) | 2018-06-28 |
| US20180092985A1 (en) | 2018-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AT | Applications terminated before publication under section 16(1) |