JP2018515107A5 - - Google Patents
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- JP2018515107A5 JP2018515107A5 JP2017559449A JP2017559449A JP2018515107A5 JP 2018515107 A5 JP2018515107 A5 JP 2018515107A5 JP 2017559449 A JP2017559449 A JP 2017559449A JP 2017559449 A JP2017559449 A JP 2017559449A JP 2018515107 A5 JP2018515107 A5 JP 2018515107A5
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- JP
- Japan
- Prior art keywords
- cells
- host
- strains
- expression
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021034586A JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562160794P | 2015-05-13 | 2015-05-13 | |
| US62/160,794 | 2015-05-13 | ||
| PCT/EP2016/060919 WO2016180982A1 (en) | 2015-05-13 | 2016-05-13 | T cell recruiting polypeptides based on cd3 reactivity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021034586A Division JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515107A JP2018515107A (ja) | 2018-06-14 |
| JP2018515107A5 true JP2018515107A5 (enExample) | 2021-04-30 |
| JP7163028B2 JP7163028B2 (ja) | 2022-10-31 |
Family
ID=55971009
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559449A Active JP7163028B2 (ja) | 2015-05-13 | 2016-05-13 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
| JP2021034586A Active JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
| JP2023068151A Active JP7763804B2 (ja) | 2015-05-13 | 2023-04-18 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
| JP2025151363A Pending JP2025186357A (ja) | 2015-05-13 | 2025-09-11 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021034586A Active JP7465833B2 (ja) | 2015-05-13 | 2021-03-04 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
| JP2023068151A Active JP7763804B2 (ja) | 2015-05-13 | 2023-04-18 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
| JP2025151363A Pending JP2025186357A (ja) | 2015-05-13 | 2025-09-11 | Ｃｄ３反応性に基づくｔ細胞リクルートポリペプチド |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11046767B2 (enExample) |
| EP (2) | EP4345112A3 (enExample) |
| JP (4) | JP7163028B2 (enExample) |
| CN (4) | CN119219778A (enExample) |
| AU (1) | AU2016260909B2 (enExample) |
| CA (2) | CA2985700C (enExample) |
| DK (1) | DK3294319T3 (enExample) |
| ES (1) | ES2984656T3 (enExample) |
| FI (1) | FI3294319T3 (enExample) |
| HR (1) | HRP20240971T1 (enExample) |
| HU (1) | HUE067423T2 (enExample) |
| LT (1) | LT3294319T (enExample) |
| PL (1) | PL3294319T3 (enExample) |
| PT (1) | PT3294319T (enExample) |
| RS (1) | RS65904B1 (enExample) |
| SI (1) | SI3294319T1 (enExample) |
| WO (1) | WO2016180982A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2984656T3 (es) | 2015-05-13 | 2024-10-30 | Ablynx Nv | Polipéptidos que reclutan linfocitos T en función de la reactividad a CD3 |
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| KR102530742B1 (ko) | 2016-05-20 | 2023-05-09 | 하푼 테라퓨틱스, 인크. | 단일 도메인 혈청 알부민 결합 단백질 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| MY200973A (en) | 2017-04-11 | 2024-01-26 | Inhibrx Inc | Multispecific Polypeptide Constructs Having Constrained Cd3 Binding And Methods Of Using The Same |
| SG10202107880XA (en) | 2017-05-12 | 2021-09-29 | Harpoon Therapeutics Inc | Mesothelin binding proteins |
| WO2019000223A1 (en) | 2017-06-27 | 2019-01-03 | Nanjing Legend Biotech Co., Ltd. | ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF |
| CA3078969A1 (en) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| GB201721802D0 (en) * | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| TW202010757A (zh) | 2018-04-11 | 2020-03-16 | 美商英伊布里克斯公司 | 具有經受限cd3結合的多重特異性多肽構築體以及相關方法及用途 |
| CA3102254A1 (en) * | 2018-06-04 | 2019-12-12 | Apo-T B.V. | Methods and means for attracting immune effector cells to tumor cells |
| CN113195544A (zh) * | 2018-06-07 | 2021-07-30 | 库利南肿瘤股份有限公司 | 多特异性结合蛋白及其使用方法 |
| WO2020001344A1 (en) * | 2018-06-29 | 2020-01-02 | Beijing Biocytogen Co., Ltd | ANTI-CD3e ANTIBODIES AND USES THEREOF |
| WO2020023553A1 (en) | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| WO2020052543A1 (en) | 2018-09-10 | 2020-03-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies against cd33 and constructs thereof |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN119306844A (zh) * | 2018-09-25 | 2025-01-14 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| JP7611820B2 (ja) | 2018-10-11 | 2025-01-10 | インヒブルクス バイオサイエンシズ インコーポレイテッド | Ｄｌｌ３シングルドメイン抗体およびその治療用組成物 |
| US12590169B2 (en) | 2018-10-11 | 2026-03-31 | Inhibrx Biosciences, Inc. | 5T4 single domain antibodies and therapeutic compositions thereof |
| CN114106183B (zh) | 2019-01-15 | 2023-06-23 | 浙江道尔生物科技有限公司 | 抗cld18a2纳米抗体及其应用 |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| WO2020232303A1 (en) | 2019-05-14 | 2020-11-19 | Harpoon Therapeutics, Inc. | EpCAM BINDING PROTEINS AND METHODS OF USE |
| NL2024375B1 (en) * | 2019-12-04 | 2021-08-31 | Apo T B V | Methods and means for attracting immune effector cells to tumor cells. |
| CN115916818A (zh) | 2019-12-11 | 2023-04-04 | 库利南肿瘤股份有限公司 | 抗cd19抗体和多特异性结合蛋白 |
| EP4097129A1 (en) | 2020-01-29 | 2022-12-07 | Inhibrx, Inc. | Cd28 single domain antibodies and multivalent and multispecific constructs thereof |
| CN113527497B (zh) * | 2020-04-16 | 2022-06-10 | 上海洛启生物医药技术有限公司 | 抗Trop2纳米抗体及其应用 |
| CN111548390B (zh) * | 2020-06-17 | 2022-09-06 | 清华大学深圳国际研究生院 | 一种cd133拮抗多肽及其衍生物与应用 |
| JP2023550148A (ja) | 2020-11-20 | 2023-11-30 | シンシア・イノベーション・インコーポレイテッド | がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法 |
| US11795224B2 (en) * | 2021-03-24 | 2023-10-24 | China Medical University Hospital | Anti-T-cell nanobody and nucleic acid encoding sequence thereof, and uses of the same |
| US11795227B2 (en) * | 2021-03-24 | 2023-10-24 | Shine-On Biomedical Co., Ltd. | Immunomodulation and anti-tumor-related nanobody and nucleic acid encoding sequence thereof, and uses of the same |
| KR20240004937A (ko) | 2021-05-05 | 2024-01-11 | 이매틱스 바이오테크놀로지스 게엠베하 | Bma031 항원 결합 폴리펩타이드 |
| TW202330594A (zh) | 2021-09-29 | 2023-08-01 | 美商莫德斯醫療公司 | 抗原結合多肽、抗原結合多肽複合物及其使用方法 |
| US20230322996A1 (en) * | 2021-11-08 | 2023-10-12 | Life Technologies As | Polymer-interaction molecule conjugates and methods of use |
| WO2023141856A1 (zh) * | 2022-01-27 | 2023-08-03 | 岩唐生物科技(杭州)有限责任公司 | 靶向cd3的多特异性抗体及其应用 |
| US20240415974A1 (en) | 2022-12-23 | 2024-12-19 | Ablynx N.V. | Protein-based conjugation carriers |
| IL322519A (en) | 2023-02-17 | 2025-10-01 | Ablynx Nv | Polypeptides that bind to the neonatal fc receptor |
| WO2025251924A1 (zh) * | 2024-06-07 | 2025-12-11 | 广东菲鹏制药股份有限公司 | 特异性结合cd3/tcr复合物的纳米抗体或其抗原结合片段及其应用 |
| WO2026021698A1 (en) | 2024-07-23 | 2026-01-29 | BioNTech SE | Nucleic acid particle |
| WO2026078159A1 (en) | 2024-10-10 | 2026-04-16 | Ablynx Nv | Immune cell engagers and methods comprising the same |
| EP4729542A1 (en) | 2024-10-16 | 2026-04-22 | Universitätsklinikum Hamburg-Eppendorf | Antigen-binding polypeptides against cd229 |
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| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| WO1994002610A1 (en) | 1992-07-17 | 1994-02-03 | Dana-Farber Cancer Institute | Method of intracellular binding of target molecules |
| DE69334275D1 (de) | 1992-08-21 | 2009-05-20 | Univ Bruxelles | Immunoglobuline ohne Leichtkette |
| CA2162878A1 (en) | 1993-06-09 | 1994-12-22 | Leon Gerardus Joseph Frenken | Process for producing fusion proteins comprising scfv fragments by a transformed mould |
| JPH10501681A (ja) | 1994-02-22 | 1998-02-17 | ダナ−ファーバー キャンサー インスティチュート | 核酸送達システムならびにその合成および使用方法 |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| DK1027439T3 (da) | 1997-10-27 | 2010-05-10 | Bac Ip Bv | Multivalente antigenbindende proteiner |
| ID26964A (id) * | 1998-02-19 | 2001-02-22 | Xcyte Therapies Inc | Komposisi dan metode untuk pengaturan pengaktifan limfosit |
| CA2326389C (en) | 1998-04-21 | 2007-01-23 | Micromet Gesellschaft Fur Biomedizinische Forschung Mbh | Novel cd19xcd3 specific polypeptides and uses thereof |
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| US7211395B2 (en) | 2001-03-09 | 2007-05-01 | Dyax Corp. | Serum albumin binding moieties |
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| JP2010500876A (ja) | 2006-08-18 | 2010-01-14 | アブリンクス エン．ヴェー． | Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド |
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| CA2706425A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| CA2721202A1 (en) | 2008-04-17 | 2009-10-22 | Hilde Adi Pierrette Revets | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| CA2759370C (en) | 2009-04-30 | 2020-02-11 | Peter Schotte | Method for the production of domain antibodies |
| ES2804450T3 (es) | 2009-07-10 | 2021-02-08 | Ablynx Nv | Método para la producción de dominios variables |
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| EP2632946B1 (en) | 2010-10-29 | 2017-12-06 | Ablynx N.V. | Method for the production of immunoglobulin single variable domains |
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| TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| JP6407726B2 (ja) | 2012-03-01 | 2018-10-24 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハーＡＭＧＥＮ Ｒｅｓｅａｒｃｈ（Ｍｕｎｉｃｈ）ＧｍｂＨ | 長寿命ポリペプチド結合分子 |
| BR112015000798A2 (pt) * | 2012-07-13 | 2017-06-27 | Zymeworks Inc | heterodímeros assimétricos biespecíficos compreendendo construtos anti-cd3 |
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| EP2887960A2 (en) * | 2012-08-21 | 2015-07-01 | Glaxo Group Limited | Compositions comprising a single variable domain and camostat mesylate (cm) |
| JO3519B1 (ar) * | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| EP2769989A1 (en) * | 2013-02-21 | 2014-08-27 | Universitätsklinikum Freiburg | Recombinant bispecific antibody that binds to the CD133 antigen on tumor cells and to the human CD3 T cell receptor |
| CN105073128A (zh) * | 2013-04-03 | 2015-11-18 | Ibc药品公司 | 用于诱导对疾病的免疫应答的组合疗法 |
| US20160251440A1 (en) * | 2013-09-26 | 2016-09-01 | Ablynx N.V. | Bispecific nanobodies |
| KR102093343B1 (ko) | 2013-10-23 | 2020-03-25 | 삼성전자주식회사 | 이미지 센서 및 이미지 센서를 구동하는 방법 |
| WO2015095412A1 (en) * | 2013-12-19 | 2015-06-25 | Zhong Wang | Bispecific antibody with two single-domain antigen-binding fragments |
| ES2984656T3 (es) | 2015-05-13 | 2024-10-30 | Ablynx Nv | Polipéptidos que reclutan linfocitos T en función de la reactividad a CD3 |
-
2016
- 2016-05-13 ES ES16722891T patent/ES2984656T3/es active Active
- 2016-05-13 LT LTEPPCT/EP2016/060919T patent/LT3294319T/lt unknown
- 2016-05-13 HR HRP20240971TT patent/HRP20240971T1/hr unknown
- 2016-05-13 PT PT167228915T patent/PT3294319T/pt unknown
- 2016-05-13 PL PL16722891.5T patent/PL3294319T3/pl unknown
- 2016-05-13 CA CA2985700A patent/CA2985700C/en active Active
- 2016-05-13 SI SI201631835T patent/SI3294319T1/sl unknown
- 2016-05-13 CN CN202411292391.9A patent/CN119219778A/zh active Pending
- 2016-05-13 EP EP24155492.2A patent/EP4345112A3/en active Pending
- 2016-05-13 AU AU2016260909A patent/AU2016260909B2/en active Active
- 2016-05-13 JP JP2017559449A patent/JP7163028B2/ja active Active
- 2016-05-13 CA CA3155409A patent/CA3155409A1/en active Pending
- 2016-05-13 US US15/573,298 patent/US11046767B2/en active Active
- 2016-05-13 FI FIEP16722891.5T patent/FI3294319T3/fi active
- 2016-05-13 RS RS20240804A patent/RS65904B1/sr unknown
- 2016-05-13 WO PCT/EP2016/060919 patent/WO2016180982A1/en not_active Ceased
- 2016-05-13 CN CN201680040586.1A patent/CN107847559B/zh active Active
- 2016-05-13 HU HUE16722891A patent/HUE067423T2/hu unknown
- 2016-05-13 CN CN202210664220.9A patent/CN114920848B/zh active Active
- 2016-05-13 EP EP16722891.5A patent/EP3294319B1/en active Active
- 2016-05-13 CN CN202210164018.XA patent/CN114920847B/zh active Active
- 2016-05-13 DK DK16722891.5T patent/DK3294319T3/da active
-
2021
- 2021-03-04 JP JP2021034586A patent/JP7465833B2/ja active Active
- 2021-05-03 US US17/246,771 patent/US12371496B2/en active Active
-
2023
- 2023-04-18 JP JP2023068151A patent/JP7763804B2/ja active Active
-
2025
- 2025-06-03 US US19/226,314 patent/US20250388672A1/en active Pending
- 2025-09-11 JP JP2025151363A patent/JP2025186357A/ja active Pending
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