JP2018514794A5 - - Google Patents

Info

Publication number

JP2018514794A5

JP2018514794A5 JP2018509734A JP2018509734A JP2018514794A5 JP 2018514794 A5 JP2018514794 A5 JP 2018514794A5 JP 2018509734 A JP2018509734 A JP 2018509734A JP 2018509734 A JP2018509734 A JP 2018509734A JP 2018514794 A5 JP2018514794 A5 JP 2018514794A5

Authority

JP

Japan

Prior art keywords

particle

optionally

targeted

biomolecule

magnetic core

Prior art date

2016-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000007771 core particle Substances 0.000 claims description 26
• 239000000203 mixture Substances 0.000 claims description 23
• 238000000034 method Methods 0.000 claims description 22
• 230000008685 targeting Effects 0.000 claims description 22
• 235000018102 proteins Nutrition 0.000 claims description 16
• 102000004169 proteins and genes Human genes 0.000 claims description 16
• 108090000623 proteins and genes Proteins 0.000 claims description 16
• 241000894007 species Species 0.000 claims description 16
• 239000002131 composite material Substances 0.000 claims description 14
• 229920000642 polymer Polymers 0.000 claims description 14
• 239000011521 glass Substances 0.000 claims description 12
• 239000012472 biological sample Substances 0.000 claims description 10
• 239000011541 reaction mixture Substances 0.000 claims description 10
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 8
• 108010001857 Cell Surface Receptors Proteins 0.000 claims description 8
• 239000013078 crystal Substances 0.000 claims description 8
• SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 8
• 239000003446 ligand Substances 0.000 claims description 8
• 102000006240 membrane receptors Human genes 0.000 claims description 8
• 239000002122 magnetic nanoparticle Substances 0.000 claims description 5
• 108090001008 Avidin Proteins 0.000 claims description 4
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 4
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 4
• UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 4
• 108010090804 Streptavidin Proteins 0.000 claims description 4
• 239000000427 antigen Substances 0.000 claims description 4
• 102000036639 antigens Human genes 0.000 claims description 4
• 108091007433 antigens Proteins 0.000 claims description 4
• 229960002685 biotin Drugs 0.000 claims description 4
• 235000020958 biotin Nutrition 0.000 claims description 4
• 239000011616 biotin Substances 0.000 claims description 4
• 210000004369 blood Anatomy 0.000 claims description 4
• 239000008280 blood Substances 0.000 claims description 4
• 150000001875 compounds Chemical class 0.000 claims description 4
• 239000007788 liquid Substances 0.000 claims description 4
• 102000039446 nucleic acids Human genes 0.000 claims description 4
• 108020004707 nucleic acids Proteins 0.000 claims description 4
• 150000007523 nucleic acids Chemical class 0.000 claims description 4
• 241000283690 Bos taurus Species 0.000 claims description 2
• 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 2
• 229920002307 Dextran Polymers 0.000 claims description 2
• 229910052692 Dysprosium Inorganic materials 0.000 claims description 2
• 229910052688 Gadolinium Inorganic materials 0.000 claims description 2
• 108091006905 Human Serum Albumin Proteins 0.000 claims description 2
• 102000008100 Human Serum Albumin Human genes 0.000 claims description 2
• PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 2
• 108010071390 Serum Albumin Proteins 0.000 claims description 2
• 102000007562 Serum Albumin Human genes 0.000 claims description 2
• BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 2
• WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 claims description 2
• -1 amino, sulfhydryl Chemical group 0.000 claims description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
• 239000005018 casein Substances 0.000 claims description 2
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
• 235000021240 caseins Nutrition 0.000 claims description 2
• 229910000423 chromium oxide Inorganic materials 0.000 claims description 2
• 230000002939 deleterious effect Effects 0.000 claims description 2
• 238000012377 drug delivery Methods 0.000 claims description 2
• 238000010438 heat treatment Methods 0.000 claims description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
• 238000000338 in vitro Methods 0.000 claims description 2
• 238000001727 in vivo Methods 0.000 claims description 2
• 238000005339 levitation Methods 0.000 claims description 2
• 230000005389 magnetism Effects 0.000 claims description 2
• 229910052748 manganese Inorganic materials 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 229910021645 metal ion Inorganic materials 0.000 claims description 2
• 229910044991 metal oxide Inorganic materials 0.000 claims description 2
• 150000004706 metal oxides Chemical class 0.000 claims description 2
• 239000011859 microparticle Substances 0.000 claims description 2
• 229910052759 nickel Inorganic materials 0.000 claims description 2
• 235000004252 protein component Nutrition 0.000 claims description 2
• 238000000926 separation method Methods 0.000 claims description 2
• 229910000077 silane Inorganic materials 0.000 claims description 2
• 229910052725 zinc Inorganic materials 0.000 claims description 2
• 239000006249 magnetic particle Substances 0.000 claims 1
• 239000002105 nanoparticle Substances 0.000 claims 1
• 230000009257 reactivity Effects 0.000 claims 1
• 238000012986 modification Methods 0.000 description 4
• 230000004048 modification Effects 0.000 description 4
• 230000014509 gene expression Effects 0.000 description 2