JP2018513691A5 - - Google Patents
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- JP2018513691A5 JP2018513691A5 JP2017555599A JP2017555599A JP2018513691A5 JP 2018513691 A5 JP2018513691 A5 JP 2018513691A5 JP 2017555599 A JP2017555599 A JP 2017555599A JP 2017555599 A JP2017555599 A JP 2017555599A JP 2018513691 A5 JP2018513691 A5 JP 2018513691A5
- Authority
- JP
- Japan
- Prior art keywords
- product
- seq
- brox
- ambrox
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 239000000047 product Substances 0.000 claims 11
- YPZUZOLGGMJZJO-UHFFFAOYSA-N ambrofix Natural products C1CC2C(C)(C)CCCC2(C)C2C1(C)OCC2 YPZUZOLGGMJZJO-UHFFFAOYSA-N 0.000 claims 7
- YPZUZOLGGMJZJO-LQKXBSAESA-N ambroxan Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)[C@@H]1[C@]2(C)OCC1 YPZUZOLGGMJZJO-LQKXBSAESA-N 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 5
- 108090000790 Enzymes Proteins 0.000 claims 5
- 101150083127 brox gene Proteins 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 5
- 239000002537 cosmetic Substances 0.000 claims 4
- 239000003205 fragrance Substances 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- KOICZDDAVPYKKX-UHFFFAOYSA-N (3E,7Z)-4,8,12-trimethyltrideca-3,7,11-trien-1-ol Chemical compound CC(=C/CCO)CCC=C(/CCC=C(C)C)C KOICZDDAVPYKKX-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101710095468 Cyclase Proteins 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 238000004140 cleaning Methods 0.000 claims 2
- 238000004821 distillation Methods 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- HHXYJYBYNZMZKX-PYQRSULMSA-N 22(29)-Hopene Chemical compound C([C@]1(C)[C@H]2CC[C@H]34)CCC(C)(C)[C@@H]1CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@@H]1C(=C)C HHXYJYBYNZMZKX-PYQRSULMSA-N 0.000 claims 1
- HHXYJYBYNZMZKX-UHFFFAOYSA-N 3,4:15,16-diepoxy-7-oxo-13(16),14-clerodadien-20,12-olide-(3alpha,4alpha)-form Natural products C12CCC3C4(C)CCCC(C)(C)C4CCC3(C)C1(C)CCC1C2(C)CCC1C(=C)C HHXYJYBYNZMZKX-UHFFFAOYSA-N 0.000 claims 1
- 229930186351 Hopene Natural products 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229940095696 soap product Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1507207.7A GB201507207D0 (en) | 2015-04-24 | 2015-04-24 | Enzymes and applications thereof |
| GB1507207.7 | 2015-04-24 | ||
| PCT/EP2016/058987 WO2016170099A1 (en) | 2015-04-24 | 2016-04-22 | Enzymes and applications thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019202017A Division JP7213167B2 (ja) | 2015-04-24 | 2019-11-07 | 酵素およびその適用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513691A JP2018513691A (ja) | 2018-05-31 |
| JP2018513691A5 true JP2018513691A5 (enExample) | 2019-06-06 |
| JP6616426B2 JP6616426B2 (ja) | 2019-12-04 |
Family
ID=53488772
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555599A Active JP6616426B2 (ja) | 2015-04-24 | 2016-04-22 | 酵素およびその適用 |
| JP2019202017A Active JP7213167B2 (ja) | 2015-04-24 | 2019-11-07 | 酵素およびその適用 |
| JP2022170342A Active JP7603041B2 (ja) | 2015-04-24 | 2022-10-25 | 酵素およびその適用 |
| JP2024193741A Pending JP2025032090A (ja) | 2015-04-24 | 2024-11-05 | 酵素およびその適用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019202017A Active JP7213167B2 (ja) | 2015-04-24 | 2019-11-07 | 酵素およびその適用 |
| JP2022170342A Active JP7603041B2 (ja) | 2015-04-24 | 2022-10-25 | 酵素およびその適用 |
| JP2024193741A Pending JP2025032090A (ja) | 2015-04-24 | 2024-11-05 | 酵素およびその適用 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US10472655B2 (enExample) |
| EP (2) | EP3760716A1 (enExample) |
| JP (4) | JP6616426B2 (enExample) |
| CN (3) | CN107567500A (enExample) |
| CO (1) | CO2017010807A2 (enExample) |
| ES (1) | ES2838691T3 (enExample) |
| GB (1) | GB201507207D0 (enExample) |
| IL (5) | IL315274A (enExample) |
| MX (3) | MX394537B (enExample) |
| RU (1) | RU2727641C2 (enExample) |
| SG (2) | SG11201707963YA (enExample) |
| WO (1) | WO2016170099A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201507170D0 (en) * | 2015-04-24 | 2015-06-10 | Givaudan Sa | Process |
| GB201507207D0 (en) | 2015-04-24 | 2015-06-10 | Givaudan Sa | Enzymes and applications thereof |
| GB201618090D0 (en) | 2016-10-26 | 2016-12-07 | Givaudan Sa | Product |
| WO2018157021A1 (en) * | 2017-02-24 | 2018-08-30 | International Flavors & Fragrances Inc. | Squalene hopene cyclase and use thereof for producing ambroxan |
| US11136611B2 (en) | 2017-02-24 | 2021-10-05 | Basf Se | Method for the preparation of (3E,7E)-homofarnesic acid or (3E,7E)-homofarnesic acid ester |
| EP3476822A1 (en) | 2017-10-31 | 2019-05-01 | Givaudan SA | Process of making organic compounds |
| JP2019170350A (ja) * | 2018-03-30 | 2019-10-10 | 国立大学法人千葉大学 | スクアレン消費酵素のスクリーニング方法及びスクアレン−ホペン環化酵素 |
| BR112021009807A2 (pt) * | 2018-11-20 | 2021-08-17 | Unilever Ip Holdings B.V. | composição detergente, método de tratamento de um substrato de tecido e uso de uma enzima isomerase |
| GB201902646D0 (en) * | 2019-02-27 | 2019-04-10 | Givaudan Sa | Process |
| CN110577961B (zh) * | 2019-09-23 | 2021-05-04 | 安徽师范大学 | 一种热稳定性苹果酸脱氢酶基因的构建方法、编码蛋白及其应用 |
| GB201917688D0 (en) | 2019-12-04 | 2020-01-15 | Givaudan Sa | SHC enzymes and enzyme variants |
| GB201917694D0 (en) | 2019-12-04 | 2020-01-15 | Givaudan Sa | Enzyme mediated process |
| GB202005468D0 (en) | 2020-04-15 | 2020-05-27 | Givaudan Sa | Enzyme-media process |
| GB202011823D0 (en) * | 2020-07-30 | 2020-09-16 | Givaudan Sa | Method |
| ES3037793T3 (en) * | 2020-09-02 | 2025-10-06 | Int Flavors & Fragrances Inc | Squalene hopene cyclase derivatives and use thereof for producing ambrox |
| MX2024011115A (es) | 2022-03-17 | 2024-09-18 | Givaudan Sa | Enzimas escualeno-hopeno-ciclasa (shc) y variantes de enzimas. |
| US20250368978A1 (en) | 2022-06-15 | 2025-12-04 | International Flavors & Fragrances Inc. | Squalene hopene cyclase variants for producing sclareolide |
| WO2024112870A1 (en) * | 2022-11-23 | 2024-05-30 | Conagen Inc. | Conversion of homofarnesol to ambroxide |
| WO2024256472A2 (en) | 2023-06-12 | 2024-12-19 | Firmenich Sa | Preparation of terpenoid compounds |
| CN118995880A (zh) * | 2024-09-05 | 2024-11-22 | 北京国科星联科技有限公司 | 一种检测唾液酸的方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU910561A1 (ru) * | 1980-08-19 | 1982-03-07 | Всесоюзный научно-исследовательский институт синтетических и натуральных душистых веществ | Способ получени смеси душистых веществ дитерпеноидного р да |
| JPS6133184A (ja) * | 1984-07-24 | 1986-02-17 | Takasago Corp | ｌ−アンブロツクスの製造方法 |
| SU1498767A1 (ru) * | 1987-06-04 | 1989-08-07 | Институт Химии Ан Мсср | Способ получени ( @ ) 3 @ ,6,6,9 @ -тетраметилпергидронафто [2,1-в]фурана |
| JPH05186452A (ja) * | 1991-12-29 | 1993-07-27 | Kuraray Co Ltd | Ｌ−アンブロックスの製造方法 |
| DE19524584A1 (de) * | 1995-07-06 | 1997-01-09 | Basf Ag | Verfahren zur stereoselektiven Herstellung von (-)3a,6,6,9a-Tetramethyl-perhydronaphtho[2,1-b]furan |
| DE19649655A1 (de) | 1996-11-29 | 1998-06-04 | Haarmann & Reimer Gmbh | Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung |
| DE19960106A1 (de) | 1999-12-14 | 2001-06-21 | Haarmann & Reimer Gmbh | Enzyme und Gene für die Herstellung von Vanillin |
| CN1308442C (zh) * | 2001-07-02 | 2007-04-04 | 诺尔玛克药物有限责任及股份两合公司 | 纯化酶的方法和按此产生出的经纯化的酶以及该酶的用途 |
| AU2003302326A1 (en) | 2002-12-02 | 2004-08-10 | The Ohio State University Research Foundation | Rapid detection of microorganisms |
| US20040265850A1 (en) | 2002-12-02 | 2004-12-30 | Hua Wang | Rapid detection of microorganisms |
| CN1874749A (zh) | 2003-11-04 | 2006-12-06 | 宝洁公司 | 包含残留谐香剂的芳香剂 |
| CN100488940C (zh) * | 2004-06-11 | 2009-05-20 | 湖南中烟工业有限责任公司 | 用于制备降龙涎醚或向卷烟烟气释放降龙涎醚的草酸酯及应用 |
| WO2007015481A1 (ja) * | 2005-08-04 | 2007-02-08 | Shiseido Co., Ltd. | 香料成分の選定方法及び調香方法、嗜好性向上剤 |
| JP5236233B2 (ja) * | 2007-09-04 | 2013-07-17 | 花王株式会社 | （−）−アンブロキサンの製造方法 |
| KR101752514B1 (ko) | 2009-06-05 | 2017-06-29 | 바스프 에스이 | 소성 변형성 강성 폴리우레탄 발포체, 접착제 및 피복재를 함유하는 복합 부품 |
| EP2438182B1 (de) | 2009-06-05 | 2018-10-10 | Basf Se | Biokatalytische herstellung von ambroxan |
| US8932839B2 (en) * | 2010-11-17 | 2015-01-13 | Basf Se | Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein |
| ES2925777T3 (es) | 2010-11-17 | 2022-10-19 | Basf Se | Procedimiento para la ciclación biocatalítica de terpenos y mutantes de ciclasa que pueden usarse en el mismo |
| KR101251793B1 (ko) | 2010-11-26 | 2013-04-08 | 현대자동차주식회사 | 차량내 운전자 실제 얼굴 인증 방법 |
| JP2013132226A (ja) | 2011-12-26 | 2013-07-08 | Kao Corp | （−）−３ａ，６，６，９ａ−テトラメチルドデカヒドロナフト［２，１−ｂ］フランの製造方法 |
| US20130273619A1 (en) * | 2012-04-16 | 2013-10-17 | Basf Se | Process for the Preparation of (3E, 7E)-Homofarnesol |
| WO2013156398A1 (de) * | 2012-04-16 | 2013-10-24 | Basf Se | Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol |
| JP6429243B2 (ja) | 2013-09-05 | 2018-11-28 | 国立大学法人 新潟大学 | アンブレインの製造方法 |
| GB201318886D0 (en) | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements i or relating to organic compounds |
| GB201318894D0 (en) | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements in or relating to organic compounds |
| GB201507207D0 (en) * | 2015-04-24 | 2015-06-10 | Givaudan Sa | Enzymes and applications thereof |
| GB201507170D0 (en) | 2015-04-24 | 2015-06-10 | Givaudan Sa | Process |
| CN105037308B (zh) | 2015-07-06 | 2017-06-06 | 四川中烟工业有限责任公司 | 一种制备降龙涎香醚的方法 |
| WO2018157021A1 (en) | 2017-02-24 | 2018-08-30 | International Flavors & Fragrances Inc. | Squalene hopene cyclase and use thereof for producing ambroxan |
-
2015
- 2015-04-24 GB GBGB1507207.7A patent/GB201507207D0/en not_active Ceased
-
2016
- 2016-04-22 WO PCT/EP2016/058987 patent/WO2016170099A1/en not_active Ceased
- 2016-04-22 US US15/568,945 patent/US10472655B2/en active Active
- 2016-04-22 RU RU2017134449A patent/RU2727641C2/ru active
- 2016-04-22 CN CN201680023646.9A patent/CN107567500A/zh active Pending
- 2016-04-22 JP JP2017555599A patent/JP6616426B2/ja active Active
- 2016-04-22 CN CN202210270202.2A patent/CN114438147A/zh active Pending
- 2016-04-22 ES ES16718331T patent/ES2838691T3/es active Active
- 2016-04-22 SG SG11201707963YA patent/SG11201707963YA/en unknown
- 2016-04-22 IL IL315274A patent/IL315274A/en unknown
- 2016-04-22 IL IL296713A patent/IL296713B2/en unknown
- 2016-04-22 EP EP20188563.9A patent/EP3760716A1/en active Pending
- 2016-04-22 EP EP16718331.8A patent/EP3286308B1/en active Active
- 2016-04-22 CN CN202511277250.4A patent/CN121065287A/zh active Pending
- 2016-04-22 MX MX2017013098A patent/MX394537B/es unknown
- 2016-04-22 SG SG10202104954XA patent/SG10202104954XA/en unknown
-
2017
- 2017-10-09 IL IL254938A patent/IL254938B/en active IP Right Grant
- 2017-10-11 MX MX2022003908A patent/MX2022003908A/es unknown
- 2017-10-11 MX MX2022008508A patent/MX2022008508A/es unknown
- 2017-10-24 CO CONC2017/0010807A patent/CO2017010807A2/es unknown
-
2019
- 2019-10-10 US US16/598,317 patent/US11021722B2/en active Active
- 2019-11-07 JP JP2019202017A patent/JP7213167B2/ja active Active
-
2020
- 2020-07-26 IL IL276291A patent/IL276291B/en unknown
-
2021
- 2021-04-26 US US17/240,262 patent/US11466299B2/en active Active
- 2021-09-29 IL IL286785A patent/IL286785B2/en unknown
-
2022
- 2022-08-31 US US17/900,590 patent/US12071645B2/en active Active
- 2022-10-25 JP JP2022170342A patent/JP7603041B2/ja active Active
-
2024
- 2024-07-15 US US18/772,512 patent/US20240368647A1/en active Pending
- 2024-11-05 JP JP2024193741A patent/JP2025032090A/ja active Pending
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