JP2018512174A5 - - Google Patents
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- Publication number
- JP2018512174A5 JP2018512174A5 JP2018502307A JP2018502307A JP2018512174A5 JP 2018512174 A5 JP2018512174 A5 JP 2018512174A5 JP 2018502307 A JP2018502307 A JP 2018502307A JP 2018502307 A JP2018502307 A JP 2018502307A JP 2018512174 A5 JP2018512174 A5 JP 2018512174A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- candida
- subject
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 7
- 206010007134 Candida infections Diseases 0.000 claims 6
- 201000003984 candidiasis Diseases 0.000 claims 6
- 229960004884 fluconazole Drugs 0.000 claims 5
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 241000222122 Candida albicans Species 0.000 claims 4
- 241000191940 Staphylococcus Species 0.000 claims 4
- 241000194017 Streptococcus Species 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 230000001032 anti-candidal effect Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960004125 ketoconazole Drugs 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
- 108010064760 Anidulafungin Proteins 0.000 claims 1
- 108010020326 Caspofungin Proteins 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 208000027244 Dysbiosis Diseases 0.000 claims 1
- 108010049047 Echinocandins Proteins 0.000 claims 1
- 241001496375 Iris albicans Species 0.000 claims 1
- 108010021062 Micafungin Proteins 0.000 claims 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims 1
- 208000010195 Onychomycosis Diseases 0.000 claims 1
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 1
- 206010042938 Systemic candida Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
- 229960003942 amphotericin b Drugs 0.000 claims 1
- 229960003348 anidulafungin Drugs 0.000 claims 1
- JHVAMHSQVVQIOT-MFAJLEFUSA-N anidulafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@@H](C)O)[C@H](O)[C@@H](O)C=2C=CC(O)=CC=2)[C@@H](C)O)=O)C=C1 JHVAMHSQVVQIOT-MFAJLEFUSA-N 0.000 claims 1
- 230000000941 anti-staphylcoccal effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000032770 biofilm formation Effects 0.000 claims 1
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 claims 1
- 229960003034 caspofungin Drugs 0.000 claims 1
- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 claims 1
- 229960003749 ciclopirox Drugs 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 208000005035 cutaneous candidiasis Diseases 0.000 claims 1
- 229960003913 econazole Drugs 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 208000036732 invasive candidiasis Diseases 0.000 claims 1
- 229960004130 itraconazole Drugs 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229960002159 micafungin Drugs 0.000 claims 1
- PIEUQSKUWLMALL-YABMTYFHSA-N micafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS(O)(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 PIEUQSKUWLMALL-YABMTYFHSA-N 0.000 claims 1
- 229960002509 miconazole Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960000988 nystatin Drugs 0.000 claims 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims 1
- 229960001589 posaconazole Drugs 0.000 claims 1
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims 1
- 201000005882 tinea unguium Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
- 229960004740 voriconazole Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562141412P | 2015-04-01 | 2015-04-01 | |
| US62/141,412 | 2015-04-01 | ||
| PCT/CN2016/078238 WO2016155652A1 (en) | 2015-04-01 | 2016-04-01 | Antibodies against infectious diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512174A JP2018512174A (ja) | 2018-05-17 |
| JP2018512174A5 true JP2018512174A5 (enExample) | 2019-05-09 |
| JP6924745B2 JP6924745B2 (ja) | 2021-08-25 |
Family
ID=57004560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502307A Active JP6924745B2 (ja) | 2015-04-01 | 2016-04-01 | 感染性疾患に対する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10766951B2 (enExample) |
| EP (1) | EP3277707A4 (enExample) |
| JP (1) | JP6924745B2 (enExample) |
| CN (1) | CN107614517B (enExample) |
| TW (1) | TWI708784B (enExample) |
| WO (1) | WO2016155652A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102822827B1 (ko) * | 2019-07-29 | 2025-06-19 | 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 | 칸디다에 대한 항체 및 이의 용도 |
| CN111249444B (zh) * | 2020-03-10 | 2023-04-07 | 西北大学 | 一种用于抑制白色念珠菌的制剂 |
| CN113791216A (zh) * | 2021-08-31 | 2021-12-14 | 石家庄和亚生物技术有限公司 | 一种检测人血清光滑念珠菌烯醇化酶IgG抗体的ELISA检测方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58198758A (ja) * | 1982-05-15 | 1983-11-18 | Amano Pharmaceut Co Ltd | ヒトエノラーゼの定量方法 |
| US20100119533A1 (en) * | 2007-03-07 | 2010-05-13 | Cornelius Joseph Clancy | Polynucleotides and Polypeptides Identified by IVIAT Screening and Methods of Use |
| US8449881B2 (en) * | 2010-01-28 | 2013-05-28 | Taipei Medical University | Anti-α-enolase I antibodies for diagnosis and treatment of α-enolase I-associated diseases |
| CN103204929A (zh) * | 2012-01-16 | 2013-07-17 | 天津贻诺琦生物工程有限公司 | 一种白色念珠菌多克隆抗体的制备方法 |
| EP2680002A1 (en) * | 2012-06-29 | 2014-01-01 | Bio-Rad Innovations | Method for diagnosing invasive Candida infections |
-
2016
- 2016-04-01 US US15/563,614 patent/US10766951B2/en active Active
- 2016-04-01 WO PCT/CN2016/078238 patent/WO2016155652A1/en not_active Ceased
- 2016-04-01 TW TW105110703A patent/TWI708784B/zh active
- 2016-04-01 CN CN201680020951.2A patent/CN107614517B/zh active Active
- 2016-04-01 JP JP2018502307A patent/JP6924745B2/ja active Active
- 2016-04-01 EP EP16771407.0A patent/EP3277707A4/en not_active Ceased
-
2020
- 2020-07-23 US US16/937,447 patent/US11485776B2/en active Active
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