JP2018511626A5 - - Google Patents
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- Publication number
- JP2018511626A5 JP2018511626A5 JP2017553414A JP2017553414A JP2018511626A5 JP 2018511626 A5 JP2018511626 A5 JP 2018511626A5 JP 2017553414 A JP2017553414 A JP 2017553414A JP 2017553414 A JP2017553414 A JP 2017553414A JP 2018511626 A5 JP2018511626 A5 JP 2018511626A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- pharmaceutically acceptable
- acceptable salt
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562148098P | 2015-04-15 | 2015-04-15 | |
| US62/148,098 | 2015-04-15 | ||
| PCT/US2016/027874 WO2016168682A2 (en) | 2015-04-15 | 2016-04-15 | Bromodomain inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018511626A JP2018511626A (ja) | 2018-04-26 |
| JP2018511626A5 true JP2018511626A5 (OSRAM) | 2019-05-23 |
| JP6856543B2 JP6856543B2 (ja) | 2021-04-07 |
Family
ID=57126317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553414A Expired - Fee Related JP6856543B2 (ja) | 2015-04-15 | 2016-04-15 | ブロモドメイン阻害剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9908885B2 (OSRAM) |
| EP (2) | EP3831383A1 (OSRAM) |
| JP (1) | JP6856543B2 (OSRAM) |
| KR (1) | KR20170135938A (OSRAM) |
| CN (1) | CN107635558A (OSRAM) |
| AR (1) | AR104259A1 (OSRAM) |
| AU (1) | AU2016249273B2 (OSRAM) |
| CA (1) | CA2982588A1 (OSRAM) |
| CL (1) | CL2017002606A1 (OSRAM) |
| CO (1) | CO2017011484A2 (OSRAM) |
| EA (1) | EA201792229A1 (OSRAM) |
| EC (1) | ECSP17070706A (OSRAM) |
| ES (1) | ES2868355T3 (OSRAM) |
| HK (1) | HK1243326A1 (OSRAM) |
| IL (1) | IL255006A0 (OSRAM) |
| MX (1) | MX2017013207A (OSRAM) |
| PE (1) | PE20180258A1 (OSRAM) |
| PH (1) | PH12017501888A1 (OSRAM) |
| SG (1) | SG11201708470SA (OSRAM) |
| TW (1) | TW201643153A (OSRAM) |
| WO (1) | WO2016168682A2 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| WO2017024406A1 (en) | 2015-08-11 | 2017-02-16 | Neomed Institute | N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals |
| CN108290856A (zh) | 2015-08-11 | 2018-07-17 | 尼奥迈德研究所 | 芳基-取代的二氢喹诺酮、它们的制备和它们作为药物的用途 |
| AU2016305515A1 (en) | 2015-08-12 | 2018-03-08 | Neomed Institute | Substituted benzimidazoles, their preparation and their use as pharmaceuticals |
| WO2017066876A1 (en) | 2015-10-21 | 2017-04-27 | Neomed Institute | Substituted imidazopyridines, their preparation and their use as pharmaceuticals |
| US10519151B2 (en) | 2016-01-28 | 2019-12-31 | Neomed Institute | Substituted [1,2,4]triazolo[4,3-A]pyridines, their preparation and their use as pharmaceuticals |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| CN108314680A (zh) * | 2017-01-16 | 2018-07-24 | 凯惠科技发展(上海)有限公司 | 一种含芳环化合物、其制备方法、药物组合物及应用 |
| TW202332436A (zh) * | 2017-04-18 | 2023-08-16 | 美商塞爾基因定量細胞研究公司 | 治療用化合物 |
| CN107098844B (zh) * | 2017-05-17 | 2019-07-30 | 许昌学院 | 一种c-5位硝基取代的酰基吲哚啉类化合物的合成方法 |
| IL275478B2 (en) * | 2017-12-20 | 2024-06-01 | Betta Pharmaceuticals Co Ltd | A preparation that functions as a bromodomain protein inhibitor, and the composition |
| WO2019152440A1 (en) | 2018-01-30 | 2019-08-08 | Foghorn Therapeutics Inc. | Methods and compounds for treating disorders |
| CN108516973A (zh) * | 2018-03-30 | 2018-09-11 | 广西师范大学 | 3-苯并噻唑-1-(3-二甲氨基)丙基喹啉-4-酮衍生物及其制备方法和应用 |
| KR20210058817A (ko) * | 2018-07-23 | 2021-05-24 | 셀젠 콴티셀 리서치, 인크. | 브로모도메인 억제제의 제조 방법 |
| LT3860998T (lt) | 2018-10-05 | 2024-06-25 | Annapurna Bio Inc. | Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu |
| AU2019372121A1 (en) | 2018-10-30 | 2021-05-27 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
| WO2020160198A1 (en) | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2020160193A2 (en) * | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| EP3917529A4 (en) | 2019-01-29 | 2022-11-02 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US12391686B2 (en) | 2019-01-29 | 2025-08-19 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| JP2022053557A (ja) * | 2019-02-08 | 2022-04-06 | マルホ株式会社 | ピリドン誘導体 |
| EP4424379A3 (en) * | 2019-04-24 | 2024-10-30 | Convergene Llc | Small molecule bromodomain inhibitors and uses thereof |
| CN112174945B (zh) * | 2019-07-02 | 2022-06-07 | 四川大学 | 具有抗癌作用的吲唑类化合物及其制备方法和用途 |
| US11584756B2 (en) * | 2019-07-02 | 2023-02-21 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
| WO2021022163A2 (en) * | 2019-07-31 | 2021-02-04 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| MX2022009308A (es) | 2020-01-29 | 2022-08-22 | Foghorn Therapeutics Inc | Compuestos y usos de estos. |
| US11787800B2 (en) | 2020-07-29 | 2023-10-17 | Foghorn Therapeutics Inc. | BRD9 degraders and uses thereof |
| CN116322780A (zh) * | 2020-07-29 | 2023-06-23 | 福宏治疗公司 | 化合物及其用途 |
| US11767330B2 (en) | 2021-07-06 | 2023-09-26 | Foghorn Therapeutics Inc. | Citrate salt, pharmaceutical compositions, and methods of making and using the same |
| CN114014842B (zh) * | 2021-11-04 | 2024-03-01 | 中国药科大学 | 一种杂环酮类化合物与其组合物及其制备方法和应用 |
| WO2023090859A1 (ko) * | 2021-11-17 | 2023-05-25 | 일동제약(주) | 아이속사졸 유도체의 제조 방법 및 그의 신규한 중간체 |
| GB202213163D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
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| DE2356005A1 (de) | 1973-11-09 | 1975-05-22 | Boehringer Sohn Ingelheim | Neue 7-amino-imidazo eckige klammer auf 1,2-a eckige klammer zu pyrimidine, diese enthaltende arzneimittel sowie verfahren zu deren herstellung |
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| BRPI0722064A2 (pt) | 2006-12-27 | 2014-04-01 | Sanofi Aventis | Derivados de isoquinolona substituídos por cicloalquilamina |
| US20090054434A1 (en) | 2007-08-23 | 2009-02-26 | Amgen Inc. | Isoquinolone derivatives as phosphodiesterase 10 inhibitors |
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| ES2809535T3 (es) | 2013-12-09 | 2021-03-04 | UCB Biopharma SRL | Derivados de imidazopiridina como moduladores de la actividad de TNF |
| US10173991B2 (en) * | 2014-01-07 | 2019-01-08 | Bristol-Myers Squibb Company | Sulfone amide linked benzothiazole inhibitors of endothelial lipase |
| AU2015209189A1 (en) | 2014-01-24 | 2016-07-28 | Confluence Life Sciences, Inc. | Substituted pyroolopyridines and pyrrolopyrazines for treating cancer or inflammatory diseases |
| SG10201809353TA (en) * | 2014-04-23 | 2018-11-29 | Incyte Corp | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS |
| MA40943A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| MA40940A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| JP6771464B2 (ja) * | 2014-11-27 | 2020-10-21 | ジェネンテック, インコーポレイテッド | Cbpおよび/またはep300インヒビターとしての、4,5,6,7−テトラヒドロ−1h−ピラゾロ[4,3−c]ピリジン−3−アミン化合物 |
| EP3265453B1 (en) * | 2015-03-05 | 2022-06-29 | Boehringer Ingelheim International GmbH | New pyridinones and isoquinolinones as inhibitors of the bromodomain brd9 |
| AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| TW201642860A (zh) * | 2015-04-22 | 2016-12-16 | 塞爾基因定量細胞研究公司 | 布羅莫結構域抑制劑 |
-
2016
- 2016-04-14 AR ARP160101014A patent/AR104259A1/es unknown
- 2016-04-15 MX MX2017013207A patent/MX2017013207A/es unknown
- 2016-04-15 KR KR1020177032364A patent/KR20170135938A/ko not_active Withdrawn
- 2016-04-15 SG SG11201708470SA patent/SG11201708470SA/en unknown
- 2016-04-15 PE PE2017002197A patent/PE20180258A1/es not_active Application Discontinuation
- 2016-04-15 ES ES16780891T patent/ES2868355T3/es active Active
- 2016-04-15 EA EA201792229A patent/EA201792229A1/ru unknown
- 2016-04-15 EP EP20215944.8A patent/EP3831383A1/en not_active Withdrawn
- 2016-04-15 JP JP2017553414A patent/JP6856543B2/ja not_active Expired - Fee Related
- 2016-04-15 WO PCT/US2016/027874 patent/WO2016168682A2/en not_active Ceased
- 2016-04-15 CN CN201680034663.2A patent/CN107635558A/zh active Pending
- 2016-04-15 CA CA2982588A patent/CA2982588A1/en active Pending
- 2016-04-15 HK HK18102785.5A patent/HK1243326A1/zh unknown
- 2016-04-15 US US15/130,503 patent/US9908885B2/en active Active
- 2016-04-15 TW TW105111879A patent/TW201643153A/zh unknown
- 2016-04-15 EP EP16780891.4A patent/EP3283077B1/en active Active
- 2016-04-15 AU AU2016249273A patent/AU2016249273B2/en not_active Ceased
-
2017
- 2017-10-13 CL CL2017002606A patent/CL2017002606A1/es unknown
- 2017-10-15 IL IL255006A patent/IL255006A0/en unknown
- 2017-10-18 PH PH12017501888A patent/PH12017501888A1/en unknown
- 2017-10-24 EC ECIEPI201770706A patent/ECSP17070706A/es unknown
- 2017-11-08 CO CONC2017/0011484A patent/CO2017011484A2/es unknown
-
2018
- 2018-01-12 US US15/870,557 patent/US10494371B2/en active Active
-
2019
- 2019-11-04 US US16/673,839 patent/US10807982B2/en active Active
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