JP2016538313A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016538313A5 JP2016538313A5 JP2016535053A JP2016535053A JP2016538313A5 JP 2016538313 A5 JP2016538313 A5 JP 2016538313A5 JP 2016535053 A JP2016535053 A JP 2016535053A JP 2016535053 A JP2016535053 A JP 2016535053A JP 2016538313 A5 JP2016538313 A5 JP 2016538313A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- halogen
- hydrogen
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 120
- 229910052736 halogen Chemical group 0.000 claims description 102
- 239000001257 hydrogen Substances 0.000 claims description 92
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 92
- 150000002367 halogens Chemical group 0.000 claims description 75
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 54
- 150000001875 compounds Chemical class 0.000 claims description 40
- 229910052799 carbon Inorganic materials 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 30
- 125000003545 alkoxy group Chemical group 0.000 claims description 28
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 28
- -1 cyano, hydroxyl Chemical group 0.000 claims description 27
- 125000004429 atom Chemical group 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 12
- 125000002837 carbocyclic group Chemical group 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 6
- 125000001153 fluoro group Chemical group F* 0.000 claims description 6
- 230000001404 mediated effect Effects 0.000 claims description 6
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 claims description 6
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- NUJVYNDJMXNZNK-NRFANRHFSA-N 2-[3-[6-amino-5-[[(2S)-1-prop-2-enoylazetidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-(hydroxymethyl)phenyl]-6-cyclopropyl-3,4-dihydroisoquinolin-1-one Chemical compound Nc1ncnc(c1OC[C@@H]1CCN1C(=O)C=C)-c1cc(F)cc(N2CCc3cc(ccc3C2=O)C2CC2)c1CO NUJVYNDJMXNZNK-NRFANRHFSA-N 0.000 claims description 2
- JJMARAVUCXEXPI-QFIPXVFZSA-N 2-[3-[6-amino-5-[[(2S)-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-(hydroxymethyl)phenyl]-6-cyclopropyl-3,4-dihydroisoquinolin-1-one Chemical compound Nc1ncnc(c1OC[C@@H]1CCCN1C(=O)C=C)-c1cc(F)cc(N2CCc3cc(ccc3C2=O)C2CC2)c1CO JJMARAVUCXEXPI-QFIPXVFZSA-N 0.000 claims description 2
- HMNGHDQWQAJIPP-XZOQPEGZSA-N 2-[3-[6-amino-5-[[(2S,4R)-4-methoxy-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-(hydroxymethyl)phenyl]-6-cyclopropyl-3,4-dihydroisoquinolin-1-one Chemical compound CO[C@@H]1C[C@@H](COc2c(N)ncnc2-c2cc(F)cc(N3CCc4cc(ccc4C3=O)C3CC3)c2CO)N(C1)C(=O)C=C HMNGHDQWQAJIPP-XZOQPEGZSA-N 0.000 claims description 2
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims description 2
- PBCHDYZOFFYTSM-RBUKOAKNSA-N C(C=C)(=O)N1[C@@H](C[C@H](C1)OC)COC=1C(=NC=NC=1N)C=1C(=C(C=C(C=1)F)C=1C(=C(C(=O)N)C=CC=1C1CC1)F)C Chemical compound C(C=C)(=O)N1[C@@H](C[C@H](C1)OC)COC=1C(=NC=NC=1N)C=1C(=C(C=C(C=1)F)C=1C(=C(C(=O)N)C=CC=1C1CC1)F)C PBCHDYZOFFYTSM-RBUKOAKNSA-N 0.000 claims description 2
- GOGOVJFVUIFNDX-UHFFFAOYSA-N C(C=C)(=O)NCCOC1=NC(=CC(=N1)C1(CC=C(C(=C1)C=1C(=C(C(=O)N)C=CC1C1CC1)F)C)F)N Chemical compound C(C=C)(=O)NCCOC1=NC(=CC(=N1)C1(CC=C(C(=C1)C=1C(=C(C(=O)N)C=CC1C1CC1)F)C)F)N GOGOVJFVUIFNDX-UHFFFAOYSA-N 0.000 claims description 2
- ROYGBUGGEVOCCJ-UHFFFAOYSA-N N-[2-[4-amino-6-[3-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2-yl)phenyl]pyrimidin-5-yl]oxyethyl]-N-methylprop-2-enamide Chemical compound CN(CCOc1c(N)ncnc1-c1cccc(c1)-n1ccc2cc(cc(F)c2c1=O)C1CC1)C(=O)C=C ROYGBUGGEVOCCJ-UHFFFAOYSA-N 0.000 claims description 2
- ZFUQKYYJMUPMTI-UHFFFAOYSA-N N-[2-[4-amino-6-[3-[(4-cyclopropyl-2-fluorobenzoyl)amino]-5-fluoro-2-methylphenyl]pyrimidin-5-yl]oxyethyl]-N-methyloxirane-2-carboxamide Chemical compound CN(CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C)C(=O)C1CO1 ZFUQKYYJMUPMTI-UHFFFAOYSA-N 0.000 claims description 2
- OSLWRSOLKHYZCC-UHFFFAOYSA-N N-[3-[6-amino-5-(1-prop-2-enoylazetidin-3-yl)oxypyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound Cc1c(NC(=O)c2ccc(cc2F)C2CC2)cc(F)cc1-c1ncnc(N)c1OC1CN(C1)C(=O)C=C OSLWRSOLKHYZCC-UHFFFAOYSA-N 0.000 claims description 2
- WWPRHRSBBBVQRE-HNNXBMFYSA-N N-[3-[6-amino-5-[(2S)-2-(but-2-ynoylamino)propoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound NC1=C(C(=NC=N1)C=1C(=C(C=C(C1)F)NC(C1=C(C=C(C=C1)C1CC1)F)=O)C)OC[C@H](C)NC(C#CC)=O WWPRHRSBBBVQRE-HNNXBMFYSA-N 0.000 claims description 2
- DTUJVUIDYMFIAW-AWEZNQCLSA-N N-[3-[6-amino-5-[(2S)-2-(prop-2-enoylamino)propoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound C(C=C)(=O)N[C@H](COC=1C(=NC=NC1N)C=1C(=C(C=C(C1)F)NC(C1=C(C=C(C=C1)C1CC1)F)=O)C)C DTUJVUIDYMFIAW-AWEZNQCLSA-N 0.000 claims description 2
- CLFDGAFGHVOAPE-ONEGZZNKSA-N N-[3-[6-amino-5-[1-[(E)-but-2-enoyl]azetidin-3-yl]oxypyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound C1N(C(=O)/C=C/C)CC1Oc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C CLFDGAFGHVOAPE-ONEGZZNKSA-N 0.000 claims description 2
- LBPYBURZJMWWDQ-SNAWJCMRSA-N N-[3-[6-amino-5-[2-[[(E)-4-methoxybut-2-enoyl]-methylamino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound COC\C=C\C(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C LBPYBURZJMWWDQ-SNAWJCMRSA-N 0.000 claims description 2
- MAEVSXHQLPMRFL-SNAWJCMRSA-N N-[3-[6-amino-5-[2-[[(E)-but-2-enoyl]-methylamino]ethoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound C\C=C\C(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C MAEVSXHQLPMRFL-SNAWJCMRSA-N 0.000 claims description 2
- VNHKOUCVWYOOAC-LJQANCHMSA-N N-[3-[6-amino-5-[[(2R)-1-prop-2-enoylazetidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound C(C=C)(=O)N1[C@H](CC1)COC=1C(=NC=NC1N)C=1C(=C(C=C(C1)F)NC(C1=C(C=C(C=C1)C1CC1)F)=O)C VNHKOUCVWYOOAC-LJQANCHMSA-N 0.000 claims description 2
- MRMUBBWFULSDKQ-RPBOFIJWSA-N N-[3-[6-amino-5-[[(2R,3S)-3-methoxy-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound CO[C@H]1CCN([C@@H]1COc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C)C(=O)C=C MRMUBBWFULSDKQ-RPBOFIJWSA-N 0.000 claims description 2
- VNHKOUCVWYOOAC-IBGZPJMESA-N N-[3-[6-amino-5-[[(2S)-1-prop-2-enoylazetidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound C(C=C)(=O)N1[C@@H](CC1)COC=1C(=NC=NC1N)C=1C(=C(C=C(C1)F)NC(C1=C(C=C(C=C1)C1CC1)F)=O)C VNHKOUCVWYOOAC-IBGZPJMESA-N 0.000 claims description 2
- ZVHBHHORKZBNIT-UWJYYQICSA-N N-[3-[6-amino-5-[[(2S,4R)-4-cyano-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound Cc1c(NC(=O)c2ccc(cc2F)C2CC2)cc(F)cc1-c1ncnc(N)c1OC[C@@H]1C[C@H](CN1C(=O)C=C)C#N ZVHBHHORKZBNIT-UWJYYQICSA-N 0.000 claims description 2
- MYNSOSQDEAAOFJ-UXHICEINSA-N N-[3-[6-amino-5-[[(2S,4R)-4-fluoro-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound Cc1c(NC(=O)c2ccc(cc2F)C2CC2)cc(F)cc1-c1ncnc(N)c1OC[C@@H]1C[C@@H](F)CN1C(=O)C=C MYNSOSQDEAAOFJ-UXHICEINSA-N 0.000 claims description 2
- NOBVNQWDJSXGNG-SFTDATJTSA-N N-[3-[6-amino-5-[[(2S,4S)-4-methoxy-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound CO[C@H]1C[C@@H](COc2c(N)ncnc2-c2cc(F)cc(NC(=O)c3ccc(cc3F)C3CC3)c2C)N(C1)C(=O)C=C NOBVNQWDJSXGNG-SFTDATJTSA-N 0.000 claims description 2
- YLXWLGWXHPGIMD-GOSISDBHSA-N N-[3-[6-amino-5-[[(3R)-1-prop-2-enoylpiperidin-3-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound C(C=C)(=O)N1C[C@@H](CCC1)COC=1C(=NC=NC1N)C=1C(=C(C=C(C1)F)NC(C1=C(C=C(C=C1)C1CC1)F)=O)C YLXWLGWXHPGIMD-GOSISDBHSA-N 0.000 claims description 2
- YYRLWYMBOAJKGR-UHFFFAOYSA-N N-[3-[6-amino-5-[[1-(prop-2-enoylamino)cyclopropyl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound Cc1c(NC(=O)c2ccc(cc2F)C2CC2)cc(F)cc1-c1ncnc(N)c1OCC1(CC1)NC(=O)C=C YYRLWYMBOAJKGR-UHFFFAOYSA-N 0.000 claims description 2
- 125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- QTZCKDFHDJVFRD-UHFFFAOYSA-N n-(2-fluoroethyl)prop-2-enamide Chemical compound FCCNC(=O)C=C QTZCKDFHDJVFRD-UHFFFAOYSA-N 0.000 claims description 2
- ZJMZNFQDSWTHLP-FQEVSTJZSA-N n-[3-[6-amino-5-[[(2s)-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound C1=C(F)C=C(C=2C(=C(N)N=CN=2)OC[C@H]2N(CCC2)C(=O)C=C)C(C)=C1NC(=O)C(C(=C1)F)=CC=C1C1CC1 ZJMZNFQDSWTHLP-FQEVSTJZSA-N 0.000 claims description 2
- SWPMNMYLORDLJE-UHFFFAOYSA-N n-ethylprop-2-enamide Chemical compound CCNC(=O)C=C SWPMNMYLORDLJE-UHFFFAOYSA-N 0.000 claims description 2
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims 27
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 63
- 125000003342 alkenyl group Chemical group 0.000 description 10
- 125000000753 cycloalkyl group Chemical group 0.000 description 10
- 125000000304 alkynyl group Chemical group 0.000 description 8
- 125000005466 alkylenyl group Chemical group 0.000 description 7
- 229940124597 therapeutic agent Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- ZVHBHHORKZBNIT-UTKZUKDTSA-N N-[3-[6-amino-5-[[(2S,4S)-4-cyano-1-prop-2-enoylpyrrolidin-2-yl]methoxy]pyrimidin-4-yl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide Chemical compound Cc1c(NC(=O)c2ccc(cc2F)C2CC2)cc(F)cc1-c1ncnc(N)c1OC[C@@H]1C[C@@H](CN1C(=O)C=C)C#N ZVHBHHORKZBNIT-UTKZUKDTSA-N 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13195081 | 2013-11-29 | ||
| EP13195081.8 | 2013-11-29 | ||
| PCT/IB2014/066422 WO2015079417A1 (en) | 2013-11-29 | 2014-11-28 | Novel amino pyrimidine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018094772A Division JP6667573B2 (ja) | 2013-11-29 | 2018-05-16 | 新規なアミノピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016538313A JP2016538313A (ja) | 2016-12-08 |
| JP2016538313A5 true JP2016538313A5 (OSRAM) | 2017-10-26 |
| JP6342495B2 JP6342495B2 (ja) | 2018-06-13 |
Family
ID=49674216
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535053A Active JP6342495B2 (ja) | 2013-11-29 | 2014-11-28 | 新規なアミノピリミジン誘導体 |
| JP2018094772A Active JP6667573B2 (ja) | 2013-11-29 | 2018-05-16 | 新規なアミノピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018094772A Active JP6667573B2 (ja) | 2013-11-29 | 2018-05-16 | 新規なアミノピリミジン誘導体 |
Country Status (42)
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
| FI3888674T3 (fi) | 2014-04-07 | 2024-07-02 | Novartis Ag | Syövän hoito käyttäen kimeeristä anti-cd19-antigeenireseptoria |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のｍＴＯＲ阻害剤とＣＡＲの組み合わせ |
| WO2016014565A2 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| BR112017001242A2 (pt) | 2014-07-21 | 2017-12-05 | Novartis Ag | tratamento de câncer usando um receptor antigênico quimérico a cd33 |
| US20170209492A1 (en) | 2014-07-31 | 2017-07-27 | Novartis Ag | Subset-optimized chimeric antigen receptor-containing t-cells |
| JP6919118B2 (ja) | 2014-08-14 | 2021-08-18 | ノバルティス アーゲー | ＧＦＲα−４キメラ抗原受容体を用いる癌の治療 |
| MY189028A (en) | 2014-08-19 | 2022-01-20 | Novartis Ag | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
| CA2961636A1 (en) | 2014-09-17 | 2016-03-24 | Boris ENGELS | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| CN106973568B (zh) | 2014-10-08 | 2021-07-23 | 诺华股份有限公司 | 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途 |
| MX389663B (es) | 2014-10-14 | 2025-03-20 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas. |
| US20180334490A1 (en) | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
| ES2876974T3 (es) * | 2015-04-07 | 2021-11-15 | Novartis Ag | Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina |
| IL254817B2 (en) | 2015-04-08 | 2023-12-01 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
| DK3317301T3 (da) | 2015-07-29 | 2021-06-28 | Immutep Sas | Kombinationsterapier omfattende antistofmolekyler mod lag-3 |
| US20180222982A1 (en) | 2015-07-29 | 2018-08-09 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| EP3389712B1 (en) | 2015-12-17 | 2024-04-10 | Novartis AG | Antibody molecules to pd-1 and uses thereof |
| MA44140A (fr) | 2015-12-22 | 2021-05-19 | Dana Farber Cancer Inst Inc | Récepteur d'antigène chimérique (car) contre la mésothéline et anticorps contre l'inhibiteur de pd-l1 pour une utilisation combinée dans une thérapie anticancéreuse |
| CA3016287A1 (en) | 2016-03-04 | 2017-09-08 | Novartis Ag | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore |
| US11365252B2 (en) | 2016-07-20 | 2022-06-21 | University Of Utah Research Foundation | CD229 CAR T cells and methods of use thereof |
| EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
| RU2019120398A (ru) | 2016-12-03 | 2021-01-12 | Джуно Терапьютикс, Инк. | Способы определения дозировки cart-клеток |
| WO2018201051A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| KR20200054160A (ko) | 2017-06-02 | 2020-05-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법을 사용한 치료를 위한 물품 제조 및 방법 |
| AU2018291032A1 (en) | 2017-06-29 | 2020-01-16 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| CA3080904A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
| BR112020008638A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma) |
| TWI694995B (zh) * | 2017-11-06 | 2020-06-01 | 美商美國禮來大藥廠 | Btk抑制劑化合物 |
| WO2019109053A1 (en) | 2017-12-01 | 2019-06-06 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| CN108069911A (zh) * | 2017-12-14 | 2018-05-25 | 中国药科大学 | 6－氨基－2－苯基嘧啶类化合物、制备方法和医药用途 |
| WO2019118937A1 (en) | 2017-12-15 | 2019-06-20 | Juno Therapeutics, Inc. | Anti-cct5 binding molecules and methods of use thereof |
| US20210396739A1 (en) | 2018-05-01 | 2021-12-23 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| US20210213063A1 (en) | 2018-05-25 | 2021-07-15 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
| AU2019284911A1 (en) | 2018-06-13 | 2020-12-17 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
| CN112424207B (zh) | 2018-07-25 | 2024-03-19 | 诺华股份有限公司 | Nlrp3炎性小体抑制剂 |
| IL312413B1 (en) | 2018-08-29 | 2025-09-01 | Acerta Pharma Bv | Processes for the preparation of 4-{8-amino-3-[(2s)-1-(but-2-enol)-pyrrolidin-2-yl]imidazo[1,5-a]-pyrazin-1-yl}n-(pyridin-2-yl)-benzamide |
| AU2019372331A1 (en) | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| AU2019374103A1 (en) | 2018-11-01 | 2021-05-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) |
| CA3120118A1 (en) | 2018-11-16 | 2020-05-22 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
| WO2020113194A2 (en) | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
| MX2021009087A (es) | 2019-01-29 | 2021-09-08 | Juno Therapeutics Inc | Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1). |
| UY38687A (es) | 2019-05-17 | 2023-05-15 | Novartis Ag | Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso |
| FI3972604T3 (fi) * | 2019-05-23 | 2025-09-01 | Novartis Ag | Brutonin tyrosiinikinaasin estäjä käytettäväksi kroonisen spontaanin urtikarian hoidossa |
| MX2021014157A (es) | 2019-05-23 | 2022-01-04 | Novartis Ag | Formas cristalinas de un inhibidor btk. |
| WO2020234780A1 (en) | 2019-05-23 | 2020-11-26 | Novartis Ag | Methods of treating asthma using a bruton's tyrosine kinase inhibitor |
| PT3972603T (pt) | 2019-05-23 | 2024-11-26 | Novartis Ag | Métodos de tratamento de síndrome de sjögren com o uso de um inibidor de tirosina quinase de bruton |
| JP7646671B2 (ja) * | 2019-12-23 | 2025-03-17 | バイオジェン・エムエイ・インコーポレイテッド | Ｂｔｋ阻害剤 |
| KR20230009386A (ko) | 2020-04-10 | 2023-01-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｂ-세포 성숙 항원을 표적화하는 키메라 항원 수용체로 조작된 세포 요법 관련 방법 및 용도 |
| KR20230051227A (ko) | 2020-08-14 | 2023-04-17 | 노파르티스 아게 | 헤테로아릴 치환된 스피로피페리디닐 유도체 및 이의 제약 용도 |
| WO2022033569A1 (zh) * | 2020-08-14 | 2022-02-17 | 苏州晶云药物科技股份有限公司 | 苯甲酰胺类化合物的晶型及其制备方法 |
| EP4284344A1 (en) * | 2021-01-26 | 2023-12-06 | Novartis AG | Pharmaceutical composition |
| EP4313023A1 (en) | 2021-04-02 | 2024-02-07 | Biogen MA Inc. | Combination treatment methods of multiple sclerosis |
| AU2022337087A1 (en) * | 2021-09-03 | 2024-03-14 | Novartis Ag | Lou064 for treating multiple sclerosis |
| WO2023111802A1 (en) | 2021-12-14 | 2023-06-22 | Novartis Ag | Methods of treatment using lou064 |
| TW202342048A (zh) | 2022-02-28 | 2023-11-01 | 瑞士商諾華公司 | 使用ｌｏｕ０６４治療化膿性汗腺炎之方法 |
| JP2025521543A (ja) | 2022-06-22 | 2025-07-10 | ジュノー セラピューティクス インコーポレイテッド | Ｃｄ１９標的ｃａｒ ｔ細胞のセカンドライン治療のための処置方法 |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
| EP4565262A2 (en) | 2022-08-05 | 2025-06-11 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| WO2024069507A1 (en) | 2022-09-30 | 2024-04-04 | Novartis Ag | Synthesis methods and intermediates for the production of remibrutinib |
| EP4633664A2 (en) | 2022-12-13 | 2025-10-22 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for baff-r and cd19 and methods and uses thereof |
| TW202515850A (zh) * | 2023-09-22 | 2025-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 雜芳基類化合物、其製備方法及其在醫藥上的應用 |
| CN117024354B (zh) * | 2023-10-08 | 2023-12-08 | 天津凯莱英制药有限公司 | 瑞米布替尼的制备方法 |
| US20250243170A1 (en) | 2024-01-26 | 2025-07-31 | Novartis Ag | Remibrutinib drug substance and drug product substantially free of nitrosamine impurity |
| US20250304538A1 (en) | 2024-04-02 | 2025-10-02 | Novartis Ag | Process of preparing remibrutinib substantially free of nitrosamine impurity |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303652B1 (en) | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
| GB0005345D0 (en) | 2000-03-06 | 2000-04-26 | Mathilda & Terence Kennedy Ins | Methods of treating sepsis septic shock and inflammation |
| WO2002038797A2 (en) | 2000-10-23 | 2002-05-16 | Bristol-Myers Squibb Company | Modulators of bruton's tyrosine kinase, their identification and use |
| PE20020544A1 (es) | 2000-11-07 | 2002-07-30 | Novartis Ag | Derivados de indolilmaleimida |
| AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| AR039209A1 (es) | 2002-04-03 | 2005-02-09 | Novartis Ag | Derivados de indolilmaleimida |
| EP2322203A3 (en) | 2002-10-29 | 2011-07-27 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US7365096B2 (en) | 2002-12-09 | 2008-04-29 | Board Of Regents, The University Of Texas System | Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3) |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| EP1473039A1 (en) | 2003-05-02 | 2004-11-03 | Centre National De La Recherche Scientifique (Cnrs) | Use of inhibitors and antisense oligonucleotides of BTK for the treatment of proliferative mastocytosis |
| AU2004251146A1 (en) | 2003-05-19 | 2005-01-06 | Irm, Llc | Immunosuppressant compounds and compositions |
| GB2432834A (en) | 2004-01-12 | 2007-06-06 | Cytopia Res Pty Ltd | Selective Kinase Inhibitors |
| CA2601628C (en) | 2005-03-10 | 2014-05-13 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| EP2068849A2 (en) | 2006-09-11 | 2009-06-17 | CGI Pharmaceuticals, Inc. | Kinase inhibitors, and methods of using and identifying kinase inhibitors |
| AR063946A1 (es) * | 2006-09-11 | 2009-03-04 | Cgi Pharmaceuticals Inc | Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. |
| EP2526934B1 (en) | 2006-09-22 | 2015-12-09 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| KR101791981B1 (ko) | 2007-03-14 | 2017-11-01 | 비온실 에스.알.엘. | 화학요법 약물-내성 상피성 종양을 치료하기 위한 ｓｉＲＮＡ-매개 유전자 침묵화 |
| WO2009137596A1 (en) | 2008-05-06 | 2009-11-12 | Cgi Pharmaceuticals, Inc. | Substituted amides, method of making, and use as btk inhibitors |
| PL2300459T3 (pl) | 2008-07-02 | 2013-10-31 | Hoffmann La Roche | Nowe fenylopirazynony jako inhibitory kinazy |
| MX2011000661A (es) | 2008-07-16 | 2011-05-25 | Pharmacyclics Inc | Inhibidores de tirosina cinasa de bruton para el tratamiento de tumores solidos. |
| US20100261776A1 (en) | 2008-11-07 | 2010-10-14 | The Research Foundation Of State University Of New York | Bruton's tyrosine kinase as anti-cancer drug target |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| SG175287A1 (en) | 2009-04-24 | 2011-11-28 | Hoffmann La Roche | Inhibitors of bruton's tyrosine kinase |
| UY33241A (es) * | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| AR080328A1 (es) * | 2010-02-26 | 2012-03-28 | Boehringer Ingelheim Int | Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros |
| US20120071497A1 (en) | 2010-06-03 | 2012-03-22 | Pharmacyclics, Inc. | Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase |
| CN103889962B (zh) | 2011-04-01 | 2017-05-03 | 犹他大学研究基金会 | 作为受体酪氨酸激酶btk抑制剂的取代的n‑(3‑(嘧啶‑4‑基)苯基)丙烯酰胺类似物 |
| DK2710007T3 (da) | 2011-05-17 | 2020-01-27 | Principia Biopharma Inc | Kinasehæmmere |
| KR20180084153A (ko) | 2011-06-10 | 2018-07-24 | 메르크 파텐트 게엠베하 | Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법 |
| US20130178483A1 (en) | 2011-06-28 | 2013-07-11 | Pharmacyclics, Inc. | Methods and Compositions for Inhibition of Bone Resorption |
| CN103732596B (zh) | 2011-07-08 | 2016-06-01 | 诺华股份有限公司 | 吡咯并嘧啶衍生物 |
| US9273317B2 (en) | 2011-08-09 | 2016-03-01 | Fred Hutchinson Cancer Research Center | Methods and compositions for inhibiting the growth and/or proliferation of MYC-driven tumor cells |
| EP2771010A4 (en) | 2011-10-19 | 2015-04-01 | Pharmacyclics Inc | USE OF BRUTON TYROSINE KINASE (BTK) INHIBITORS |
| EP2770830A4 (en) | 2011-10-28 | 2015-05-27 | Celgene Avilomics Res Inc | METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE) |
| JP5832664B2 (ja) | 2011-12-09 | 2015-12-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ブルトン型チロシンキナーゼの阻害剤 |
| EP2824099A4 (en) | 2012-03-09 | 2015-11-11 | Carna Biosciences Inc | NOVEL TRIAZINE DERIVATIVE |
| CA2869954C (en) | 2012-04-20 | 2023-01-03 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof in medical conditions related to modulation of bruton's tyrosine kinase activity |
| WO2013157021A1 (en) | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| US9133134B2 (en) | 2012-05-16 | 2015-09-15 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| EP2882741B1 (en) | 2012-08-10 | 2018-10-24 | Boehringer Ingelheim International GmbH | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| EP2903972B1 (en) | 2012-10-04 | 2019-12-04 | University of Utah Research Foundation | Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors |
| US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
-
2014
- 2014-11-13 US US14/540,140 patent/US9512084B2/en active Active
- 2014-11-27 UY UY0001035858A patent/UY35858A/es active IP Right Grant
- 2014-11-27 JO JOP/2014/0341A patent/JO3314B1/ar active
- 2014-11-27 AR ARP140104439A patent/AR098549A1/es active IP Right Grant
- 2014-11-28 PL PL14821285T patent/PL3074386T3/pl unknown
- 2014-11-28 PT PT148212855T patent/PT3074386T/pt unknown
- 2014-11-28 DK DK17191467.4T patent/DK3299368T3/da active
- 2014-11-28 HU HUE20158961A patent/HUE062248T2/hu unknown
- 2014-11-28 CA CA2926908A patent/CA2926908C/en active Active
- 2014-11-28 AP AP2016009158A patent/AP2016009158A0/en unknown
- 2014-11-28 HU HUE14821285A patent/HUE037588T2/hu unknown
- 2014-11-28 MY MYPI2016701223A patent/MY179059A/en unknown
- 2014-11-28 PL PL17191467T patent/PL3299368T3/pl unknown
- 2014-11-28 LT LTEP20158961.1T patent/LT3689865T/lt unknown
- 2014-11-28 JP JP2016535053A patent/JP6342495B2/ja active Active
- 2014-11-28 ES ES17191467T patent/ES2791525T3/es active Active
- 2014-11-28 WO PCT/IB2014/066422 patent/WO2015079417A1/en not_active Ceased
- 2014-11-28 ES ES14821285.5T patent/ES2655527T3/es active Active
- 2014-11-28 PE PE2016000683A patent/PE20160869A1/es unknown
- 2014-11-28 RS RS20230437A patent/RS64275B1/sr unknown
- 2014-11-28 RS RS20171206A patent/RS56657B1/sr unknown
- 2014-11-28 NO NO14821285A patent/NO3074386T3/no unknown
- 2014-11-28 HR HRP20230585TT patent/HRP20230585T1/hr unknown
- 2014-11-28 SI SI201430536T patent/SI3074386T1/en unknown
- 2014-11-28 NZ NZ718835A patent/NZ718835A/en unknown
- 2014-11-28 HR HRP20171999TT patent/HRP20171999T1/hr unknown
- 2014-11-28 EP EP14821285.5A patent/EP3074386B1/en active Active
- 2014-11-28 EP EP23161775.4A patent/EP4219478B1/en active Active
- 2014-11-28 ES ES20158961T patent/ES2947770T3/es active Active
- 2014-11-28 LT LTEP17191467.4T patent/LT3299368T/lt unknown
- 2014-11-28 SI SI201432031T patent/SI3689865T1/sl unknown
- 2014-11-28 HU HUE17191467A patent/HUE049794T2/hu unknown
- 2014-11-28 CU CU2016000078A patent/CU24384B1/es unknown
- 2014-11-28 MA MA39055A patent/MA39055B1/fr unknown
- 2014-11-28 CN CN201480058515.5A patent/CN105683181B/zh active Active
- 2014-11-28 MY MYPI2020002915A patent/MY191381A/en unknown
- 2014-11-28 PL PL20158961.1T patent/PL3689865T3/pl unknown
- 2014-11-28 AU AU2014356069A patent/AU2014356069B2/en active Active
- 2014-11-28 PT PT171914674T patent/PT3299368T/pt unknown
- 2014-11-28 EA EA201691125A patent/EA031218B1/ru not_active IP Right Cessation
- 2014-11-28 DK DK14821285.5T patent/DK3074386T3/en active
- 2014-11-28 RS RS20200550A patent/RS60251B1/sr unknown
- 2014-11-28 KR KR1020227009823A patent/KR102421388B1/ko active Active
- 2014-11-28 LT LTEP14821285.5T patent/LT3074386T/lt unknown
- 2014-11-28 FI FIEP20158961.1T patent/FI3689865T3/fi active
- 2014-11-28 PT PT201589611T patent/PT3689865T/pt unknown
- 2014-11-28 KR KR1020167013830A patent/KR102380539B1/ko active Active
- 2014-11-28 CN CN201910288376.XA patent/CN110172056B/zh active Active
- 2014-11-28 TW TW103141506A patent/TWI652261B/zh active
- 2014-11-28 ES ES23161775T patent/ES3040769T3/es active Active
- 2014-11-28 MX MX2016006908A patent/MX367911B/es active IP Right Grant
- 2014-11-28 DK DK20158961.1T patent/DK3689865T3/da active
- 2014-11-28 BR BR112016010397-1A patent/BR112016010397B1/pt active IP Right Grant
- 2014-11-28 EP EP20158961.1A patent/EP3689865B1/en active Active
- 2014-11-28 EP EP17191467.4A patent/EP3299368B1/en active Active
- 2014-11-28 UA UAA201603623A patent/UA117256C2/uk unknown
- 2014-11-28 TN TN2016000128A patent/TN2016000128A1/en unknown
- 2014-11-28 SI SI201431570T patent/SI3299368T1/sl unknown
- 2014-11-28 EP EP25181626.0A patent/EP4606377A3/en active Pending
-
2016
- 2016-04-05 ZA ZA2016/02275A patent/ZA201602275B/en unknown
- 2016-04-06 IL IL244943A patent/IL244943B/en active IP Right Grant
- 2016-04-21 US US15/135,296 patent/US20160235746A1/en not_active Abandoned
- 2016-04-28 PH PH12016500791A patent/PH12016500791A1/en unknown
- 2016-05-03 CL CL2016001055A patent/CL2016001055A1/es unknown
- 2016-05-27 CR CR20160244A patent/CR20160244A/es unknown
- 2016-05-27 SV SV2016005206A patent/SV2016005206A/es unknown
- 2016-06-20 EC ECIEPI201654826A patent/ECSP16054826A/es unknown
-
2017
- 2017-12-22 CY CY20171101345T patent/CY1119705T1/el unknown
-
2018
- 2018-05-08 US US15/974,190 patent/US10457647B2/en active Active
- 2018-05-16 JP JP2018094772A patent/JP6667573B2/ja active Active
-
2019
- 2019-09-16 US US16/571,405 patent/US11180460B2/en active Active
-
2020
- 2020-05-12 HR HRP20200775TT patent/HRP20200775T1/hr unknown
- 2020-05-25 CY CY20201100478T patent/CY1122924T1/el unknown
-
2021
- 2021-10-22 US US17/508,054 patent/US11673868B2/en active Active
-
2023
- 2023-05-01 US US18/309,948 patent/US20230312483A1/en active Pending
- 2023-06-27 CY CY20231100301T patent/CY1126056T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016538313A5 (OSRAM) | ||
| SI3074386T1 (en) | New aminopyrimidine derivatives | |
| JP2014513110A5 (OSRAM) | ||
| JP2015514808A5 (OSRAM) | ||
| RU2014105624A (ru) | Соединения индазола, способ их применения и фармацевтическая композиция | |
| JP2014530900A5 (OSRAM) | ||
| JP2017528487A5 (OSRAM) | ||
| JP2019510796A5 (OSRAM) | ||
| RU2017116196A (ru) | 2-амино-6-(дифторметил)-5,5-дифтор-6-фенил-3,4,5,6-тетрагидропиридины как ингибиторы васе1 | |
| JP2016506962A5 (OSRAM) | ||
| JP2014526549A5 (OSRAM) | ||
| HRP20120144T1 (en) | Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity | |
| RU2017120217A (ru) | 2-амино-5,5-дифтор-6-(фторметил)-6-фенил-3,4,5,6-тетрагидпропиридины в качестве ингибиторов bace1 | |
| JP2012501312A5 (OSRAM) | ||
| HRP20220990T1 (hr) | 3-supstituirane propionske kiseline kao inhibitori alfa v integrina | |
| JP2015517566A5 (OSRAM) | ||
| JP2016517878A5 (OSRAM) | ||
| RU2014135436A (ru) | Комбинация ингибитора rtk с антиэстрогеном и ее применение для лечения рака | |
| RU2014115290A (ru) | Производные 1-фенил 2-пиридинилалкиловых спиртов в качестве ингибиторов | |
| JP2014508804A5 (OSRAM) | ||
| RU2018104868A (ru) | 2-амино-3-фтор-3-(фторметил)-6-метил-6-фенил-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1 | |
| JP2019505595A5 (OSRAM) | ||
| RU2015116816A (ru) | Производное имидазола | |
| RU2014131058A (ru) | Средство, усиливающее действие противоопухолевых средств | |
| JP2017526724A5 (OSRAM) |