JP2018522861A5 - - Google Patents
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- Publication number
- JP2018522861A5 JP2018522861A5 JP2017566742A JP2017566742A JP2018522861A5 JP 2018522861 A5 JP2018522861 A5 JP 2018522861A5 JP 2017566742 A JP2017566742 A JP 2017566742A JP 2017566742 A JP2017566742 A JP 2017566742A JP 2018522861 A5 JP2018522861 A5 JP 2018522861A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazolo
- dimethoxyphenyl
- dimethyl
- methyl
- triazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 26
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- 208000036142 Viral infection Diseases 0.000 claims description 9
- 230000009385 viral infection Effects 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 4
- -1 R 2 O Chemical class 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- SZUXYYIDZMHWDD-UHFFFAOYSA-N pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound NC1=NC=NC2=CC=NN12 SZUXYYIDZMHWDD-UHFFFAOYSA-N 0.000 claims description 3
- JXBSPQSHTHRAGH-UHFFFAOYSA-N 4-[[[8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-yl]amino]methyl]benzenesulfonamide Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)S(=O)(=O)N)C)C JXBSPQSHTHRAGH-UHFFFAOYSA-N 0.000 claims description 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 2
- PRNLFPBWUWLDJV-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(1,3-oxazol-5-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CN=CO1)C)C PRNLFPBWUWLDJV-UHFFFAOYSA-N 0.000 claims description 2
- AYAIKIJARAEZJD-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(pyridazin-4-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CN=NC=C1)C)C AYAIKIJARAEZJD-UHFFFAOYSA-N 0.000 claims description 2
- DCEXCAWOIZVMBX-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(pyridin-2-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=NC=CC=C1)C)C DCEXCAWOIZVMBX-UHFFFAOYSA-N 0.000 claims description 2
- ANMDHEUWJCCQAZ-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC=1C=NC=CC=1)C)C ANMDHEUWJCCQAZ-UHFFFAOYSA-N 0.000 claims description 2
- XVAMGYPWYKSSTH-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=NC=C1)C)C XVAMGYPWYKSSTH-UHFFFAOYSA-N 0.000 claims description 2
- VXBXOHQZDUTAPG-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC=1SC=CC=1)C)C VXBXOHQZDUTAPG-UHFFFAOYSA-N 0.000 claims description 2
- LALVTGVFZZVMLK-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-[(1-methylpyrazol-3-yl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=NN(C=C1)C)C)C LALVTGVFZZVMLK-UHFFFAOYSA-N 0.000 claims description 2
- JUGLNQNKEZDSTD-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-[(3-methylsulfonylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC(=CC=C1)S(=O)(=O)C)C)C JUGLNQNKEZDSTD-UHFFFAOYSA-N 0.000 claims description 2
- RVEJJJXIHUZYRR-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-[(4-methylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)C)C)C RVEJJJXIHUZYRR-UHFFFAOYSA-N 0.000 claims description 2
- QEENGCVMZHAIJZ-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-[(4-propan-2-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)C(C)C)C)C QEENGCVMZHAIJZ-UHFFFAOYSA-N 0.000 claims description 2
- SHFBYFWCOJWEDG-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-[(5-methylfuran-2-yl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC=1OC(=CC=1)C)C)C SHFBYFWCOJWEDG-UHFFFAOYSA-N 0.000 claims description 2
- LHWQEHXXOSSRJS-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-[[4-(trifluoromethyl)phenyl]methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical class COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)C(F)(F)F)C)C LHWQEHXXOSSRJS-UHFFFAOYSA-N 0.000 claims description 2
- XASLRXHABIHKDP-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-N-[(4-fluorophenyl)methyl]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)F)C)C XASLRXHABIHKDP-UHFFFAOYSA-N 0.000 claims description 2
- LYRKQTFOBNEDJK-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-N-[(4-methoxyphenyl)methyl]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)OC)C)C LYRKQTFOBNEDJK-UHFFFAOYSA-N 0.000 claims description 2
- XIUBDGVYFBEYCJ-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-N-[(6-methoxypyridin-3-yl)methyl]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical class COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC=1C=NC(=CC=1)OC)C)C XIUBDGVYFBEYCJ-UHFFFAOYSA-N 0.000 claims description 2
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims description 2
- 206010010741 Conjunctivitis Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 208000020061 Hand, Foot and Mouth Disease Diseases 0.000 claims description 2
- 208000025713 Hand-foot-and-mouth disease Diseases 0.000 claims description 2
- 201000006219 Herpangina Diseases 0.000 claims description 2
- 208000009525 Myocarditis Diseases 0.000 claims description 2
- 201000002481 Myositis Diseases 0.000 claims description 2
- QTJNNBRGPBTHMZ-UHFFFAOYSA-N N-(1,3-benzodioxol-5-ylmethyl)-8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound O1COC2=C1C=CC(=C2)CNC1=NC(=NC=2N1N=C(C=2C1=CC(=C(C=C1)OC)OC)C)C QTJNNBRGPBTHMZ-UHFFFAOYSA-N 0.000 claims description 2
- BAHNAAAFVIIMIT-UHFFFAOYSA-N N-[(4-chlorophenyl)methyl]-8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound ClC1=CC=C(C=C1)CNC1=NC(=NC=2N1N=C(C=2C1=CC(=C(C=C1)OC)OC)C)C BAHNAAAFVIIMIT-UHFFFAOYSA-N 0.000 claims description 2
- CSMYSRVFPOCHHT-UHFFFAOYSA-N N-[4-[[[8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-yl]amino]methyl]phenyl]acetamide Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)NC(C)=O)C)C CSMYSRVFPOCHHT-UHFFFAOYSA-N 0.000 claims description 2
- CATHMGQJNZCBHA-UHFFFAOYSA-N N-[4-[[[8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-yl]amino]methyl]phenyl]methanesulfonamide Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)NS(=O)(=O)C)C)C CATHMGQJNZCBHA-UHFFFAOYSA-N 0.000 claims description 2
- ZDTQMDUHXHDZJM-UHFFFAOYSA-N N-[4-[[[8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-yl]amino]methyl]phenyl]sulfonylpropanamide Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)S(=O)(=O)NC(CC)=O)C)C ZDTQMDUHXHDZJM-UHFFFAOYSA-N 0.000 claims description 2
- DXIWHVLCECHLAZ-UHFFFAOYSA-N N-benzyl-8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound C(C1=CC=CC=C1)NC1=NC(=NC=2N1N=C(C=2C1=CC(=C(C=C1)OC)OC)C)C DXIWHVLCECHLAZ-UHFFFAOYSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 206010033799 Paralysis Diseases 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 206010035623 Pleuritic pain Diseases 0.000 claims description 2
- 206010040047 Sepsis Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000004452 carbocyclyl group Chemical group 0.000 description 2
- 102000001556 1-Phosphatidylinositol 4-Kinase Human genes 0.000 description 1
- 108010029190 1-Phosphatidylinositol 4-Kinase Proteins 0.000 description 1
- CFWHYSOTKMDDJC-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(oxolan-2-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1OCCC1)C)C CFWHYSOTKMDDJC-UHFFFAOYSA-N 0.000 description 1
- YFDPPQUSEXMXPD-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-(piperidin-4-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1CCNCC1)C)C YFDPPQUSEXMXPD-UHFFFAOYSA-N 0.000 description 1
- VYQSIZVVCQZJQU-UHFFFAOYSA-N 8-(3,4-dimethoxyphenyl)-2,7-dimethyl-N-[(2-methylpyrimidin-5-yl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical class COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC=1C=NC(=NC=1)C)C)C VYQSIZVVCQZJQU-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- YJDVHPJGGNUSBC-UHFFFAOYSA-N N-(cyclohexylmethyl)-8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound C1(CCCCC1)CNC1=NC(=NC=2N1N=C(C=2C1=CC(=C(C=C1)OC)OC)C)C YJDVHPJGGNUSBC-UHFFFAOYSA-N 0.000 description 1
- GWOLGEAYNCVYSY-UHFFFAOYSA-N N-[2-(4-chlorophenyl)ethyl]-8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound ClC1=CC=C(C=C1)CCNC1=NC(=NC=2N1N=C(C=2C1=CC(=C(C=C1)OC)OC)C)C GWOLGEAYNCVYSY-UHFFFAOYSA-N 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15173687 | 2015-06-24 | ||
| EP15173687.3 | 2015-06-24 | ||
| PCT/EP2016/063383 WO2016206999A1 (en) | 2015-06-24 | 2016-06-10 | Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522861A JP2018522861A (ja) | 2018-08-16 |
| JP2018522861A5 true JP2018522861A5 (OSRAM) | 2019-07-11 |
| JP6689299B2 JP6689299B2 (ja) | 2020-04-28 |
Family
ID=53483747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566742A Active JP6689299B2 (ja) | 2015-06-24 | 2016-06-10 | 療法に有用なピラゾロ［１，５−ａ］トリアジン−４−アミン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10407429B2 (OSRAM) |
| EP (1) | EP3313842B1 (OSRAM) |
| JP (1) | JP6689299B2 (OSRAM) |
| CN (1) | CN107949563B (OSRAM) |
| AU (1) | AU2016284638B2 (OSRAM) |
| BR (1) | BR112017026061B1 (OSRAM) |
| CA (1) | CA2989722C (OSRAM) |
| RU (1) | RU2712196C2 (OSRAM) |
| WO (1) | WO2016206999A1 (OSRAM) |
| ZA (1) | ZA201800485B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11091472B2 (en) | 2016-02-26 | 2021-08-17 | The Regents Of The University Of California | PI-kinase inhibitors with anti-infective activity |
| JP7200126B2 (ja) * | 2017-04-05 | 2023-01-06 | キュロヴィル・アクチボラグ | 療法において有用なヘテロ芳香族化合物 |
| MA51611A (fr) * | 2018-01-17 | 2021-04-21 | Glaxosmithkline Ip Dev Ltd | Inhibiteurs de pi4kiiibêta |
| CN118084937A (zh) | 2018-08-21 | 2024-05-28 | 杏林制药株式会社 | 双环杂芳族环衍生物 |
| WO2020074160A1 (en) | 2018-10-10 | 2020-04-16 | Curovir Ab | Condensed pyrimidine or pyridazine derivatives as antiviral agents |
| AU2019359166B2 (en) * | 2018-10-10 | 2024-07-11 | Curovir Ab | 2,6-dimethyl-N-((pyridin-4-yl)methyl)imidazo(1,2-b)pyridazin-8-amine and 2,5-dimethyl-N-((pyridin-4-yl)methyl)pyrazolo(1,5-a)pyrimidin-7-amine derivatives for treating viral infections |
| WO2020146657A1 (en) * | 2019-01-11 | 2020-07-16 | The Board Of Trustees Of The Leland Stanford Junior University | Pi4-kinase inhibitors with anti-cancer activity |
| JP7701051B2 (ja) | 2019-03-21 | 2025-07-01 | ザ ボード オブ トラスティス オブ ザ リーランド スタンフォード ジュニア ユニヴァーシティー | Ｐｉ４－キナーゼ阻害剤及びその使用方法 |
| EP4028131B1 (en) | 2019-08-20 | 2023-11-22 | Curovir Ab | Heteroaromatic compounds useful in therapy |
| CN113801119B (zh) * | 2021-08-30 | 2022-09-30 | 新乡医学院 | 一种吡唑并[1,3,5]三嗪类化合物的合成方法 |
| WO2024184442A1 (en) | 2023-03-09 | 2024-09-12 | Curovir Ab | Compound and formulation for systemic therapy by oral transmucosal administration |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6191131B1 (en) * | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6313124B1 (en) * | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| CA2614603C (en) * | 1998-01-28 | 2011-08-16 | Bristol-Myers Squibb Pharma Company | Azolo triazines and pyrimidines |
| PL354675A1 (en) * | 1999-09-30 | 2004-02-09 | Neurogen Corporation | Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines |
| GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| FR2943058B1 (fr) | 2009-03-11 | 2011-06-03 | Centre Nat Rech Scient | Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique. |
| US8633198B1 (en) * | 2011-09-20 | 2014-01-21 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza A RNA-dependent RNA polymerase |
| EP2634190A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| EP2634189A1 (en) | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors |
| AU2013344716B2 (en) * | 2012-11-16 | 2018-03-01 | University Health Network | Pyrazolopyrimidine compounds |
-
2016
- 2016-06-10 RU RU2018102449A patent/RU2712196C2/ru active
- 2016-06-10 EP EP16731540.7A patent/EP3313842B1/en active Active
- 2016-06-10 AU AU2016284638A patent/AU2016284638B2/en active Active
- 2016-06-10 CA CA2989722A patent/CA2989722C/en active Active
- 2016-06-10 JP JP2017566742A patent/JP6689299B2/ja active Active
- 2016-06-10 BR BR112017026061-1A patent/BR112017026061B1/pt active IP Right Grant
- 2016-06-10 WO PCT/EP2016/063383 patent/WO2016206999A1/en not_active Ceased
- 2016-06-10 US US15/737,907 patent/US10407429B2/en active Active
- 2016-06-10 CN CN201680036895.1A patent/CN107949563B/zh active Active
-
2018
- 2018-01-23 ZA ZA2018/00485A patent/ZA201800485B/en unknown
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