RU2712196C2 - Производные пиразоло[1,5-a]триазин-4-амина, применимые в терапии - Google Patents
Производные пиразоло[1,5-a]триазин-4-амина, применимые в терапии Download PDFInfo
- Publication number
- RU2712196C2 RU2712196C2 RU2018102449A RU2018102449A RU2712196C2 RU 2712196 C2 RU2712196 C2 RU 2712196C2 RU 2018102449 A RU2018102449 A RU 2018102449A RU 2018102449 A RU2018102449 A RU 2018102449A RU 2712196 C2 RU2712196 C2 RU 2712196C2
- Authority
- RU
- Russia
- Prior art keywords
- dimethoxyphenyl
- triazin
- methyl
- amine
- pyrazolo
- Prior art date
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- QQOWHRYOXYEMTL-UHFFFAOYSA-N triazin-4-amine Chemical class N=C1C=CN=NN1 QQOWHRYOXYEMTL-UHFFFAOYSA-N 0.000 title description 5
- 238000002560 therapeutic procedure Methods 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 97
- 150000003839 salts Chemical class 0.000 claims abstract description 47
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 32
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 31
- 125000004429 atom Chemical group 0.000 claims abstract description 26
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 25
- 125000005843 halogen group Chemical group 0.000 claims abstract description 20
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 16
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 16
- 150000002367 halogens Chemical class 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 11
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 8
- 102000001556 1-Phosphatidylinositol 4-Kinase Human genes 0.000 claims abstract description 7
- 108010029190 1-Phosphatidylinositol 4-Kinase Proteins 0.000 claims abstract description 7
- 239000003112 inhibitor Substances 0.000 claims abstract description 7
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000001301 oxygen Substances 0.000 claims abstract description 3
- -1 1-oxidopyridin-1-yl-4-yl Chemical group 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 13
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
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- HDHREEXDABMYCS-UHFFFAOYSA-N 4-[[[8-(3,4-dimethoxyphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-yl]amino]methyl]phenol Chemical compound COC=1C=C(C=CC=1OC)C=1C(=NN2C=1N=C(N=C2NCC1=CC=C(C=C1)O)C)C HDHREEXDABMYCS-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15173687.3 | 2015-06-24 | ||
| EP15173687 | 2015-06-24 | ||
| PCT/EP2016/063383 WO2016206999A1 (en) | 2015-06-24 | 2016-06-10 | Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018102449A RU2018102449A (ru) | 2019-07-24 |
| RU2018102449A3 RU2018102449A3 (OSRAM) | 2019-08-20 |
| RU2712196C2 true RU2712196C2 (ru) | 2020-01-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2018102449A RU2712196C2 (ru) | 2015-06-24 | 2016-06-10 | Производные пиразоло[1,5-a]триазин-4-амина, применимые в терапии |
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| Country | Link |
|---|---|
| US (1) | US10407429B2 (OSRAM) |
| EP (1) | EP3313842B1 (OSRAM) |
| JP (1) | JP6689299B2 (OSRAM) |
| CN (1) | CN107949563B (OSRAM) |
| AU (1) | AU2016284638B2 (OSRAM) |
| BR (1) | BR112017026061B1 (OSRAM) |
| CA (1) | CA2989722C (OSRAM) |
| RU (1) | RU2712196C2 (OSRAM) |
| WO (1) | WO2016206999A1 (OSRAM) |
| ZA (1) | ZA201800485B (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3419980B1 (en) | 2016-02-26 | 2025-01-01 | The Board of Trustees of the Leland Stanford Junior University | Pi-kinase inhibitors with anti-infective activity |
| RU2770363C2 (ru) * | 2017-04-05 | 2022-04-15 | Куровир Аб | Гетероароматические соединения, пригодные в терапии |
| TWI795510B (zh) * | 2018-01-17 | 2023-03-11 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | PI4KIIIβ抑制劑 |
| MY200452A (en) | 2018-08-21 | 2023-12-27 | Kyorin Seiyaku Kk | Bicyclic heteroaromatic ring derivative |
| AU2019359166B2 (en) | 2018-10-10 | 2024-07-11 | Curovir Ab | 2,6-dimethyl-N-((pyridin-4-yl)methyl)imidazo(1,2-b)pyridazin-8-amine and 2,5-dimethyl-N-((pyridin-4-yl)methyl)pyrazolo(1,5-a)pyrimidin-7-amine derivatives for treating viral infections |
| WO2020074160A1 (en) | 2018-10-10 | 2020-04-16 | Curovir Ab | Condensed pyrimidine or pyridazine derivatives as antiviral agents |
| WO2020146657A1 (en) * | 2019-01-11 | 2020-07-16 | The Board Of Trustees Of The Leland Stanford Junior University | Pi4-kinase inhibitors with anti-cancer activity |
| AU2020241869B2 (en) | 2019-03-21 | 2025-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | PI4-kinase inhibitors and methods of using the same |
| EP4028131B1 (en) | 2019-08-20 | 2023-11-22 | Curovir Ab | Heteroaromatic compounds useful in therapy |
| CN113801119B (zh) * | 2021-08-30 | 2022-09-30 | 新乡医学院 | 一种吡唑并[1,3,5]三嗪类化合物的合成方法 |
| WO2024184442A1 (en) | 2023-03-09 | 2024-09-12 | Curovir Ab | Compound and formulation for systemic therapy by oral transmucosal administration |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6191131B1 (en) * | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6313124B1 (en) * | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| EA200200422A1 (ru) * | 1999-09-30 | 2002-10-31 | Ньюроджен Корпорейшн | НЕКОТОРЫЕ АЛКИЛЕНДИАМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-а]-1,3,5-ТРИАЗИНЫ |
| WO2013128028A1 (en) * | 2012-03-01 | 2013-09-06 | Lead Discovery Center Gmbh | Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors |
| WO2014075168A1 (en) * | 2012-11-16 | 2014-05-22 | University Health Network | Pyrazolopyrimidine compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1344779T1 (sl) * | 1998-01-28 | 2006-02-28 | Bristol Myers Squibb Pharma Co | Azolo-pirimidini |
| GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| FR2943058B1 (fr) | 2009-03-11 | 2011-06-03 | Centre Nat Rech Scient | Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique. |
| US8633198B1 (en) * | 2011-09-20 | 2014-01-21 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza A RNA-dependent RNA polymerase |
| EP2634189A1 (en) | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors |
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2016
- 2016-06-10 RU RU2018102449A patent/RU2712196C2/ru active
- 2016-06-10 EP EP16731540.7A patent/EP3313842B1/en active Active
- 2016-06-10 BR BR112017026061-1A patent/BR112017026061B1/pt active IP Right Grant
- 2016-06-10 AU AU2016284638A patent/AU2016284638B2/en active Active
- 2016-06-10 CA CA2989722A patent/CA2989722C/en active Active
- 2016-06-10 JP JP2017566742A patent/JP6689299B2/ja active Active
- 2016-06-10 WO PCT/EP2016/063383 patent/WO2016206999A1/en not_active Ceased
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- 2016-06-10 US US15/737,907 patent/US10407429B2/en active Active
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2018
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| US6191131B1 (en) * | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6313124B1 (en) * | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| EA200200422A1 (ru) * | 1999-09-30 | 2002-10-31 | Ньюроджен Корпорейшн | НЕКОТОРЫЕ АЛКИЛЕНДИАМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-а]-1,3,5-ТРИАЗИНЫ |
| WO2013128028A1 (en) * | 2012-03-01 | 2013-09-06 | Lead Discovery Center Gmbh | Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors |
| WO2014075168A1 (en) * | 2012-11-16 | 2014-05-22 | University Health Network | Pyrazolopyrimidine compounds |
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| BR112017026061A2 (pt) | 2018-08-14 |
| HK1254809A1 (en) | 2019-07-26 |
| CA2989722C (en) | 2023-09-19 |
| ZA201800485B (en) | 2020-05-27 |
| BR112017026061B1 (pt) | 2023-03-28 |
| NZ738280A (en) | 2024-10-25 |
| EP3313842A1 (en) | 2018-05-02 |
| US10407429B2 (en) | 2019-09-10 |
| WO2016206999A1 (en) | 2016-12-29 |
| JP2018522861A (ja) | 2018-08-16 |
| EP3313842B1 (en) | 2020-04-15 |
| RU2018102449A (ru) | 2019-07-24 |
| CN107949563B (zh) | 2020-06-05 |
| CA2989722A1 (en) | 2016-12-29 |
| US20180298007A1 (en) | 2018-10-18 |
| JP6689299B2 (ja) | 2020-04-28 |
| AU2016284638A1 (en) | 2018-01-18 |
| RU2018102449A3 (OSRAM) | 2019-08-20 |
| CN107949563A (zh) | 2018-04-20 |
| AU2016284638B2 (en) | 2020-01-23 |
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