JP2014518544A5 - - Google Patents
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- Publication number
- JP2014518544A5 JP2014518544A5 JP2013556664A JP2013556664A JP2014518544A5 JP 2014518544 A5 JP2014518544 A5 JP 2014518544A5 JP 2013556664 A JP2013556664 A JP 2013556664A JP 2013556664 A JP2013556664 A JP 2013556664A JP 2014518544 A5 JP2014518544 A5 JP 2014518544A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- solvate
- salt
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 44
- 150000003839 salts Chemical class 0.000 claims description 23
- 239000012453 solvate Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 19
- -1 3-chloro-4-fluorophenyl Chemical group 0.000 claims description 18
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 15
- 125000000623 heterocyclic group Chemical group 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 10
- 230000003463 hyperproliferative effect Effects 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 5
- 229960001433 erlotinib Drugs 0.000 claims description 5
- 125000001072 heteroaryl group Chemical group 0.000 claims description 5
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- TZOYRHZJCBKRRO-MUJOQTPCSA-N (e)-n-[4-(3-chloro-4-fluoroanilino)-7-[2-[(1r,5s)-3-oxabicyclo[3.1.0]hexan-1-yl]ethynyl]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound N1=CN=C2C=C(C#C[C@]34[C@H](C3)COC4)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 TZOYRHZJCBKRRO-MUJOQTPCSA-N 0.000 claims description 2
- YDPCJZLPVMOMEC-MTGFJVSHSA-N (e)-n-[4-(3-chloro-4-fluoroanilino)-7-[2-[(2r)-oxolan-2-yl]ethynyl]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound N1=CN=C2C=C(C#C[C@@H]3OCCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 YDPCJZLPVMOMEC-MTGFJVSHSA-N 0.000 claims description 2
- YDPCJZLPVMOMEC-NAASZUNDSA-N (e)-n-[4-(3-chloro-4-fluoroanilino)-7-[2-[(2s)-oxolan-2-yl]ethynyl]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound N1=CN=C2C=C(C#C[C@H]3OCCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 YDPCJZLPVMOMEC-NAASZUNDSA-N 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 208000032612 Glial tumor Diseases 0.000 claims description 2
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims description 2
- 206010018338 Glioma Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 230000001394 metastastic effect Effects 0.000 claims description 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 208000030266 primary brain neoplasm Diseases 0.000 claims description 2
- 125000004547 quinazolin-6-yl group Chemical group N1=CN=CC2=CC(=CC=C12)* 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 5
- 206010059282 Metastases to central nervous system Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- TZOYRHZJCBKRRO-FGGACMJJSA-N (e)-n-[4-(3-chloro-4-fluoroanilino)-7-[2-[(1s,5r)-3-oxabicyclo[3.1.0]hexan-1-yl]ethynyl]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound N1=CN=C2C=C(C#C[C@@]34[C@@H](C3)COC4)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 TZOYRHZJCBKRRO-FGGACMJJSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449088P | 2011-03-04 | 2011-03-04 | |
| US61/449,088 | 2011-03-04 | ||
| PCT/US2012/027614 WO2012122058A2 (en) | 2011-03-04 | 2012-03-02 | Alkyne substituted quinazoline compound and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518544A JP2014518544A (ja) | 2014-07-31 |
| JP2014518544A5 true JP2014518544A5 (OSRAM) | 2015-04-16 |
| JP6006242B2 JP6006242B2 (ja) | 2016-10-12 |
Family
ID=46798728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013556664A Active JP6006242B2 (ja) | 2011-03-04 | 2012-03-02 | アルキン置換キナゾリン化合物および使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9090588B2 (OSRAM) |
| EP (1) | EP2680850B1 (OSRAM) |
| JP (1) | JP6006242B2 (OSRAM) |
| KR (4) | KR20220031732A (OSRAM) |
| CN (1) | CN103998040B (OSRAM) |
| AU (3) | AU2012225693A1 (OSRAM) |
| BR (1) | BR112013022552B1 (OSRAM) |
| CA (1) | CA2828713C (OSRAM) |
| IL (1) | IL228072A (OSRAM) |
| MX (1) | MX344302B (OSRAM) |
| RU (1) | RU2013144571A (OSRAM) |
| SG (3) | SG10201913982WA (OSRAM) |
| TW (1) | TWI617556B (OSRAM) |
| WO (1) | WO2012122058A2 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220031732A (ko) | 2011-03-04 | 2022-03-11 | 뉴젠 세러퓨틱스 인코포레이티드 | 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 |
| CN102918029B (zh) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
| JP6437820B2 (ja) * | 2011-07-27 | 2018-12-12 | シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド | キナゾリン誘導体、その製造方法、中間体、組成物及びその適用 |
| CN104119350B (zh) | 2013-04-28 | 2017-04-12 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
| CN103254183B (zh) * | 2013-05-10 | 2015-11-11 | 苏州明锐医药科技有限公司 | 阿法替尼的制备方法 |
| CN103254156B (zh) * | 2013-05-10 | 2015-08-26 | 苏州明锐医药科技有限公司 | 阿法替尼中间体的制备方法 |
| MY196809A (en) * | 2015-12-24 | 2023-05-03 | Kyowa Kirin Co Ltd | (),()-unsaturated amide compound |
| DE102016224889B4 (de) * | 2016-12-14 | 2019-11-07 | Airbus Defence and Space GmbH | Verfahren zur Vorbeugung einer Ablösung einer Fluidströmung, Strömungskörpersystem und Luftfahrzeug |
| US11083492B2 (en) * | 2018-06-06 | 2021-08-10 | Lifetech Scientific (Shenzhen) Co., Ltd | Method for implanting an interventional medical device |
| US10973321B2 (en) | 2018-09-04 | 2021-04-13 | Steelcase Inc. | Workspace system and components and method for the use thereof |
| CA3113241A1 (en) | 2018-09-25 | 2020-04-02 | Black Diamond Therapeutics, Inc. | Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use |
| KR20220047810A (ko) * | 2019-08-15 | 2022-04-19 | 블랙 다이아몬드 테라퓨틱스, 인코포레이티드 | 알키닐 퀴나졸린 화합물 |
| CN113527215B (zh) * | 2020-04-17 | 2023-12-05 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、制备方法及其应用 |
| TWI820414B (zh) * | 2020-04-17 | 2023-11-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、製備方法及其應用 |
| JP2023548055A (ja) * | 2020-11-02 | 2023-11-15 | ブラック ダイアモンド セラピューティクス，インコーポレイティド | 癌をアルキン置換キナゾリン誘導体で治療する方法 |
| WO2024179451A1 (zh) * | 2023-03-02 | 2024-09-06 | 江苏康缘药业股份有限公司 | 一种炔基取代的喹唑啉化合物的晶型、其制备方法和应用 |
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| CN102382106A (zh) | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| KR20220031732A (ko) | 2011-03-04 | 2022-03-11 | 뉴젠 세러퓨틱스 인코포레이티드 | 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 |
| CN102918029B (zh) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
-
2012
- 2012-03-02 KR KR1020227006071A patent/KR20220031732A/ko not_active Ceased
- 2012-03-02 CA CA2828713A patent/CA2828713C/en active Active
- 2012-03-02 KR KR1020137026199A patent/KR102061743B1/ko active Active
- 2012-03-02 CN CN201280011384.6A patent/CN103998040B/zh active Active
- 2012-03-02 KR KR1020197038395A patent/KR20200003933A/ko not_active Ceased
- 2012-03-02 US US14/002,983 patent/US9090588B2/en active Active
- 2012-03-02 KR KR1020217010767A patent/KR20210043016A/ko not_active Ceased
- 2012-03-02 SG SG10201913982WA patent/SG10201913982WA/en unknown
- 2012-03-02 SG SG10201601711SA patent/SG10201601711SA/en unknown
- 2012-03-02 BR BR112013022552-1A patent/BR112013022552B1/pt active IP Right Grant
- 2012-03-02 AU AU2012225693A patent/AU2012225693A1/en not_active Abandoned
- 2012-03-02 WO PCT/US2012/027614 patent/WO2012122058A2/en not_active Ceased
- 2012-03-02 MX MX2013010016A patent/MX344302B/es active IP Right Grant
- 2012-03-02 RU RU2013144571/04A patent/RU2013144571A/ru not_active Application Discontinuation
- 2012-03-02 EP EP12754325.4A patent/EP2680850B1/en active Active
- 2012-03-02 JP JP2013556664A patent/JP6006242B2/ja active Active
- 2012-03-02 SG SG2013066352A patent/SG193291A1/en unknown
- 2012-03-03 TW TW101107247A patent/TWI617556B/zh active
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2013
- 2013-08-22 IL IL228072A patent/IL228072A/en active IP Right Grant
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2015
- 2015-06-19 US US14/745,308 patent/US20160031860A1/en not_active Abandoned
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2017
- 2017-02-14 AU AU2017200984A patent/AU2017200984A1/en not_active Abandoned
- 2017-08-11 US US15/675,438 patent/US20180093975A1/en not_active Abandoned
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2018
- 2018-11-22 AU AU2018267622A patent/AU2018267622B2/en active Active
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2019
- 2019-01-18 US US16/252,458 patent/US20190382382A1/en not_active Abandoned
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2020
- 2020-03-27 US US16/833,020 patent/US11524956B2/en active Active
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