JP2018511622A5

JP2018511622A5 -

Download PDF

Info

Publication number: JP2018511622A5
Authority: JP; Japan
Prior art keywords: tissue; poly; proteins; protein; peg
Prior art date: 2016-04-12
Legal status : Granted

Application number

JP2017553385A

Other languages

English (en)

Japanese (ja)

Other versions

JP6930733B2 (ja

JP2018511622A (ja

Filing date

2016-04-12

Publication date

2019-05-09

2015-04-17 Priority claimed from US14/689,625 external-priority patent/US20160303281A1/en

2016-04-12 Application filed filed Critical

2018-04-26 Publication of JP2018511622A publication Critical patent/JP2018511622A/ja

2019-05-09 Publication of JP2018511622A5 publication Critical patent/JP2018511622A5/ja

2021-09-01 Application granted granted Critical

2021-09-01 Publication of JP6930733B2 publication Critical patent/JP6930733B2/ja

Status Active legal-status Critical Current

2036-04-12 Anticipated expiration legal-status Critical

Links

239000002245 particle Substances 0.000 claims description 238
102000004169 proteins and genes Human genes 0.000 claims description 189
108090000623 proteins and genes Proteins 0.000 claims description 189
229920001223 polyethylene glycol Polymers 0.000 claims description 160
239000000203 mixture Substances 0.000 claims description 139
210000001519 tissue Anatomy 0.000 claims description 112
-1 storage proteins Proteins 0.000 claims description 108
229940012952 fibrinogen Drugs 0.000 claims description 89
229920000642 polymer Polymers 0.000 claims description 84
108010049003 Fibrinogen Proteins 0.000 claims description 70
102000008946 Fibrinogen Human genes 0.000 claims description 70
210000004027 cell Anatomy 0.000 claims description 67
239000000499 gel Substances 0.000 claims description 65
229950003499 fibrin Drugs 0.000 claims description 64
239000003795 chemical substances by application Substances 0.000 claims description 61
239000002105 nanoparticle Substances 0.000 claims description 58
210000000130 stem cell Anatomy 0.000 claims description 55
239000003814 drug Substances 0.000 claims description 50
VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 48
229940079593 drug Drugs 0.000 claims description 47
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
239000000243 solution Substances 0.000 claims description 43
108010073385 Fibrin Proteins 0.000 claims description 42
102000009123 Fibrin Human genes 0.000 claims description 42
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 40
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 36
238000000034 method Methods 0.000 claims description 36
239000000463 material Substances 0.000 claims description 34
239000000843 powder Substances 0.000 claims description 33
150000003839 salts Chemical class 0.000 claims description 28
210000003491 skin Anatomy 0.000 claims description 28
239000007787 solid Substances 0.000 claims description 28
230000006320 pegylation Effects 0.000 claims description 27
108010035532 Collagen Proteins 0.000 claims description 26
102000008186 Collagen Human genes 0.000 claims description 26
229920001436 collagen Polymers 0.000 claims description 26
108090000190 Thrombin Proteins 0.000 claims description 24
239000004599 antimicrobial Substances 0.000 claims description 24
229960004072 thrombin Drugs 0.000 claims description 24
102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 23
108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 23
210000002744 extracellular matrix Anatomy 0.000 claims description 23
102000004196 processed proteins & peptides Human genes 0.000 claims description 23
108090000765 processed proteins & peptides Proteins 0.000 claims description 23
238000003860 storage Methods 0.000 claims description 23
102000009027 Albumins Human genes 0.000 claims description 21
108010088751 Albumins Proteins 0.000 claims description 21
210000002381 plasma Anatomy 0.000 claims description 21
229920001282 polysaccharide Polymers 0.000 claims description 21
239000005017 polysaccharide Substances 0.000 claims description 21
239000012867 bioactive agent Substances 0.000 claims description 19
229920001222 biopolymer Polymers 0.000 claims description 19
150000004676 glycans Chemical class 0.000 claims description 19
210000002435 tendon Anatomy 0.000 claims description 18
238000004132 cross linking Methods 0.000 claims description 17
239000004005 microsphere Substances 0.000 claims description 17
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
239000002202 Polyethylene glycol Substances 0.000 claims description 14
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
229910052760 oxygen Inorganic materials 0.000 claims description 14
229920001184 polypeptide Polymers 0.000 claims description 14
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 13
239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 13
239000003242 anti bacterial agent Substances 0.000 claims description 13
230000003115 biocidal effect Effects 0.000 claims description 13
239000003102 growth factor Substances 0.000 claims description 13
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 13
210000003205 muscle Anatomy 0.000 claims description 13
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 13
229920003169 water-soluble polymer Polymers 0.000 claims description 13
210000000845 cartilage Anatomy 0.000 claims description 12
108700042778 Antimicrobial Peptides Proteins 0.000 claims description 11
102000044503 Antimicrobial Peptides Human genes 0.000 claims description 11
229920002683 Glycosaminoglycan Polymers 0.000 claims description 11
229920002907 Guar gum Polymers 0.000 claims description 11
229920002125 Sokalan® Polymers 0.000 claims description 11
239000002246 antineoplastic agent Substances 0.000 claims description 11
239000012736 aqueous medium Substances 0.000 claims description 11
125000002091 cationic group Chemical group 0.000 claims description 11
238000000227 grinding Methods 0.000 claims description 11
235000010417 guar gum Nutrition 0.000 claims description 11
239000000665 guar gum Substances 0.000 claims description 11
229960002154 guar gum Drugs 0.000 claims description 11
229920002674 hyaluronan Polymers 0.000 claims description 11
108020004414 DNA Proteins 0.000 claims description 10
108090000288 Glycoproteins Proteins 0.000 claims description 10
102000003886 Glycoproteins Human genes 0.000 claims description 10
229940088710 antibiotic agent Drugs 0.000 claims description 10
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
230000036571 hydration Effects 0.000 claims description 10
238000006703 hydration reaction Methods 0.000 claims description 10
239000011859 microparticle Substances 0.000 claims description 10
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 10
229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
229920001661 Chitosan Polymers 0.000 claims description 9
229920002307 Dextran Polymers 0.000 claims description 9
102000016942 Elastin Human genes 0.000 claims description 9
108010014258 Elastin Proteins 0.000 claims description 9
102000004190 Enzymes Human genes 0.000 claims description 9
108090000790 Enzymes Proteins 0.000 claims description 9
108010010803 Gelatin Proteins 0.000 claims description 9
108010085895 Laminin Proteins 0.000 claims description 9
102000007547 Laminin Human genes 0.000 claims description 9
229920001218 Pullulan Polymers 0.000 claims description 9
239000004373 Pullulan Substances 0.000 claims description 9
239000006143 cell culture medium Substances 0.000 claims description 9
229960002086 dextran Drugs 0.000 claims description 9
229920002549 elastin Polymers 0.000 claims description 9
229940088598 enzyme Drugs 0.000 claims description 9
239000008273 gelatin Substances 0.000 claims description 9
229920000159 gelatin Polymers 0.000 claims description 9
235000019322 gelatine Nutrition 0.000 claims description 9
235000011852 gelatine desserts Nutrition 0.000 claims description 9
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 9
235000019423 pullulan Nutrition 0.000 claims description 9
239000000341 volatile oil Substances 0.000 claims description 9
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 8
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
229940123208 Biguanide Drugs 0.000 claims description 8
229920001287 Chondroitin sulfate Polymers 0.000 claims description 8
102000015636 Oligopeptides Human genes 0.000 claims description 8
108010038807 Oligopeptides Proteins 0.000 claims description 8
230000000844 anti-bacterial effect Effects 0.000 claims description 8
229940041181 antineoplastic drug Drugs 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 8
229940059329 chondroitin sulfate Drugs 0.000 claims description 8
229920001577 copolymer Polymers 0.000 claims description 8
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 8
239000002243 precursor Substances 0.000 claims description 8
230000002829 reductive effect Effects 0.000 claims description 8
239000007858 starting material Substances 0.000 claims description 8
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 7
241000283690 Bos taurus Species 0.000 claims description 7
108010076876 Keratins Proteins 0.000 claims description 7
102000011782 Keratins Human genes 0.000 claims description 7
239000003096 antiparasitic agent Substances 0.000 claims description 7
210000004204 blood vessel Anatomy 0.000 claims description 7
230000021164 cell adhesion Effects 0.000 claims description 7
210000005228 liver tissue Anatomy 0.000 claims description 7
239000002609 medium Substances 0.000 claims description 7
229920001285 xanthan gum Polymers 0.000 claims description 7
LTMQZVLXCLQPCT-UHFFFAOYSA-N 1,1,6-trimethyltetralin Chemical compound C1CCC(C)(C)C=2C1=CC(C)=CC=2 LTMQZVLXCLQPCT-UHFFFAOYSA-N 0.000 claims description 6
XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 6
102000004506 Blood Proteins Human genes 0.000 claims description 6
108010017384 Blood Proteins Proteins 0.000 claims description 6
229920000045 Dermatan sulfate Polymers 0.000 claims description 6
229920002148 Gellan gum Polymers 0.000 claims description 6
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 6
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 6
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 6
210000004381 amniotic fluid Anatomy 0.000 claims description 6
229940121375 antifungal agent Drugs 0.000 claims description 6
239000002220 antihypertensive agent Substances 0.000 claims description 6
229960005475 antiinfective agent Drugs 0.000 claims description 6
229940125687 antiparasitic agent Drugs 0.000 claims description 6
230000001588 bifunctional effect Effects 0.000 claims description 6
230000000975 bioactive effect Effects 0.000 claims description 6
229920002988 biodegradable polymer Polymers 0.000 claims description 6
239000004621 biodegradable polymer Substances 0.000 claims description 6
210000005068 bladder tissue Anatomy 0.000 claims description 6
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 6
210000001612 chondrocyte Anatomy 0.000 claims description 6
229960005188 collagen Drugs 0.000 claims description 6
239000003431 cross linking reagent Substances 0.000 claims description 6
AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims description 6
229940051593 dermatan sulfate Drugs 0.000 claims description 6
AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims description 6
235000010492 gellan gum Nutrition 0.000 claims description 6
239000000216 gellan gum Substances 0.000 claims description 6
210000005003 heart tissue Anatomy 0.000 claims description 6
235000012907 honey Nutrition 0.000 claims description 6
229940099552 hyaluronan Drugs 0.000 claims description 6
KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims description 6
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
230000000968 intestinal effect Effects 0.000 claims description 6
210000004072 lung Anatomy 0.000 claims description 6
239000002073 nanorod Substances 0.000 claims description 6
239000002078 nanoshell Substances 0.000 claims description 6
210000000944 nerve tissue Anatomy 0.000 claims description 6
210000004923 pancreatic tissue Anatomy 0.000 claims description 6
229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 claims description 6
210000005084 renal tissue Anatomy 0.000 claims description 6
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
210000001260 vocal cord Anatomy 0.000 claims description 6
235000010493 xanthan gum Nutrition 0.000 claims description 6
239000000230 xanthan gum Substances 0.000 claims description 6
229940082509 xanthan gum Drugs 0.000 claims description 6
108010078791 Carrier Proteins Proteins 0.000 claims description 5
102000014914 Carrier Proteins Human genes 0.000 claims description 5
108010067306 Fibronectins Proteins 0.000 claims description 5
102000016359 Fibronectins Human genes 0.000 claims description 5
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 5
229930182566 Gentamicin Natural products 0.000 claims description 5
108010089792 Hemeproteins Proteins 0.000 claims description 5
102000008015 Hemeproteins Human genes 0.000 claims description 5
108090000862 Ion Channels Proteins 0.000 claims description 5
102000004310 Ion Channels Human genes 0.000 claims description 5
108010052285 Membrane Proteins Proteins 0.000 claims description 5
108010063312 Metalloproteins Proteins 0.000 claims description 5
102000010750 Metalloproteins Human genes 0.000 claims description 5
102000005431 Molecular Chaperones Human genes 0.000 claims description 5
108010006519 Molecular Chaperones Proteins 0.000 claims description 5
108010089610 Nuclear Proteins Proteins 0.000 claims description 5
102000007999 Nuclear Proteins Human genes 0.000 claims description 5
102000016611 Proteoglycans Human genes 0.000 claims description 5
108010067787 Proteoglycans Proteins 0.000 claims description 5
108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 5
102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 5
108020004459 Small interfering RNA Proteins 0.000 claims description 5
101710172711 Structural protein Proteins 0.000 claims description 5
108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 5
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 5
241000700605 Viruses Species 0.000 claims description 5
LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims description 5
229950010221 alexidine Drugs 0.000 claims description 5
230000002421 anti-septic effect Effects 0.000 claims description 5
239000003429 antifungal agent Substances 0.000 claims description 5
210000004369 blood Anatomy 0.000 claims description 5
239000008280 blood Substances 0.000 claims description 5
230000015271 coagulation Effects 0.000 claims description 5
238000005345 coagulation Methods 0.000 claims description 5
230000007123 defense Effects 0.000 claims description 5
125000004386 diacrylate group Chemical group 0.000 claims description 5
102000034240 fibrous proteins Human genes 0.000 claims description 5
108091005899 fibrous proteins Proteins 0.000 claims description 5
239000012634 fragment Substances 0.000 claims description 5
102000034238 globular proteins Human genes 0.000 claims description 5
108091005896 globular proteins Proteins 0.000 claims description 5
239000000122 growth hormone Substances 0.000 claims description 5
229940088597 hormone Drugs 0.000 claims description 5
239000005556 hormone Substances 0.000 claims description 5
229960003160 hyaluronic acid Drugs 0.000 claims description 5
210000000987 immune system Anatomy 0.000 claims description 5
235000015110 jellies Nutrition 0.000 claims description 5
239000008274 jelly Substances 0.000 claims description 5
KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims description 5
150000002632 lipids Chemical class 0.000 claims description 5
230000031787 nutrient reservoir activity Effects 0.000 claims description 5
235000015097 nutrients Nutrition 0.000 claims description 5
239000000813 peptide hormone Substances 0.000 claims description 5
102000005962 receptors Human genes 0.000 claims description 5
108020003175 receptors Proteins 0.000 claims description 5
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 4
102000002585 Contractile Proteins Human genes 0.000 claims description 4
108010068426 Contractile Proteins Proteins 0.000 claims description 4
102000004127 Cytokines Human genes 0.000 claims description 4
108090000695 Cytokines Proteins 0.000 claims description 4
229920002971 Heparan sulfate Polymers 0.000 claims description 4
229920000288 Keratan sulfate Polymers 0.000 claims description 4
240000003553 Leptospermum scoparium Species 0.000 claims description 4
108010093825 Mucoproteins Proteins 0.000 claims description 4
102000001621 Mucoproteins Human genes 0.000 claims description 4
206010028980 Neoplasm Diseases 0.000 claims description 4
108090000189 Neuropeptides Proteins 0.000 claims description 4
229920000954 Polyglycolide Polymers 0.000 claims description 4
229920002305 Schizophyllan Polymers 0.000 claims description 4
208000007536 Thrombosis Diseases 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
239000000739 antihistaminic agent Substances 0.000 claims description 4
239000003904 antiprotozoal agent Substances 0.000 claims description 4
239000003443 antiviral agent Substances 0.000 claims description 4
229960000686 benzalkonium chloride Drugs 0.000 claims description 4
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 4
229960001950 benzethonium chloride Drugs 0.000 claims description 4
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
239000007853 buffer solution Substances 0.000 claims description 4
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
235000010418 carrageenan Nutrition 0.000 claims description 4
229920001525 carrageenan Polymers 0.000 claims description 4
239000000679 carrageenan Substances 0.000 claims description 4
229940113118 carrageenan Drugs 0.000 claims description 4
239000000919 ceramic Substances 0.000 claims description 4
229960003260 chlorhexidine Drugs 0.000 claims description 4
239000011557 critical solution Substances 0.000 claims description 4
230000004069 differentiation Effects 0.000 claims description 4
GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 claims description 4
210000001671 embryonic stem cell Anatomy 0.000 claims description 4
239000003193 general anesthetic agent Substances 0.000 claims description 4
230000028993 immune response Effects 0.000 claims description 4
102000006495 integrins Human genes 0.000 claims description 4
108010044426 integrins Proteins 0.000 claims description 4
239000002502 liposome Substances 0.000 claims description 4
229920000609 methyl cellulose Polymers 0.000 claims description 4
235000010981 methylcellulose Nutrition 0.000 claims description 4
239000001923 methylcellulose Substances 0.000 claims description 4
230000007935 neutral effect Effects 0.000 claims description 4
108020004707 nucleic acids Proteins 0.000 claims description 4
102000039446 nucleic acids Human genes 0.000 claims description 4
150000007523 nucleic acids Chemical class 0.000 claims description 4
208000033808 peripheral neuropathy Diseases 0.000 claims description 4
150000003904 phospholipids Chemical class 0.000 claims description 4
210000005059 placental tissue Anatomy 0.000 claims description 4
229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 claims description 4
229920000747 poly(lactic acid) Polymers 0.000 claims description 4
229920001610 polycaprolactone Polymers 0.000 claims description 4
239000004632 polycaprolactone Substances 0.000 claims description 4
229920000728 polyester Polymers 0.000 claims description 4
210000002966 serum Anatomy 0.000 claims description 4
238000010008 shearing Methods 0.000 claims description 4
108091006024 signal transducing proteins Proteins 0.000 claims description 4
102000034285 signal transducing proteins Human genes 0.000 claims description 4
230000003330 sporicidal effect Effects 0.000 claims description 4
210000002536 stromal cell Anatomy 0.000 claims description 4
230000000699 topical effect Effects 0.000 claims description 4
239000011782 vitamin Substances 0.000 claims description 4
229940088594 vitamin Drugs 0.000 claims description 4
235000013343 vitamin Nutrition 0.000 claims description 4
229930003231 vitamin Natural products 0.000 claims description 4
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 3
XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 3
WDQLRUYAYXDIFW-RWKIJVEZSA-N (2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-4-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 WDQLRUYAYXDIFW-RWKIJVEZSA-N 0.000 claims description 3
MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims description 3
LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 3
JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical compound C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 claims description 3
CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims description 3
ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 claims description 3
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 3
QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims description 3
XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims description 3
SPHKINBTXPIQTH-UHFFFAOYSA-N 2H-benzotriazol-4-yl hydrogen carbonate Chemical compound OC(=O)OC1=CC=CC2=NNN=C12 SPHKINBTXPIQTH-UHFFFAOYSA-N 0.000 claims description 3
229930000680 A04AD01 - Scopolamine Natural products 0.000 claims description 3
244000215068 Acacia senegal Species 0.000 claims description 3
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
241001430066 Anulocaulis Species 0.000 claims description 3
108010001478 Bacitracin Proteins 0.000 claims description 3
239000004342 Benzoyl peroxide Substances 0.000 claims description 3
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 3
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 3
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims description 3
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 3
229910052688 Gadolinium Inorganic materials 0.000 claims description 3
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 3
229930186217 Glycolipid Natural products 0.000 claims description 3
229920000084 Gum arabic Polymers 0.000 claims description 3
102000002812 Heat-Shock Proteins Human genes 0.000 claims description 3
108010004889 Heat-Shock Proteins Proteins 0.000 claims description 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims description 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 claims description 3
102000004877 Insulin Human genes 0.000 claims description 3
108090001061 Insulin Proteins 0.000 claims description 3
ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 3
235000016887 Leptospermum scoparium Nutrition 0.000 claims description 3
229920000161 Locust bean gum Polymers 0.000 claims description 3
229930192392 Mitomycin Natural products 0.000 claims description 3
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 3
STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims description 3
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 3
239000000006 Nitroglycerin Substances 0.000 claims description 3
229920001145 Poly(N-vinylacetamide) Polymers 0.000 claims description 3
229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 3
229920002732 Polyanhydride Polymers 0.000 claims description 3
108010093965 Polymyxin B Proteins 0.000 claims description 3
229920000153 Povidone-iodine Polymers 0.000 claims description 3
108091008103 RNA aptamers Proteins 0.000 claims description 3
240000004584 Tamarindus indica Species 0.000 claims description 3
235000004298 Tamarindus indica Nutrition 0.000 claims description 3
239000004098 Tetracycline Substances 0.000 claims description 3
235000010489 acacia gum Nutrition 0.000 claims description 3
239000000205 acacia gum Substances 0.000 claims description 3
125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims description 3
210000001789 adipocyte Anatomy 0.000 claims description 3
210000004504 adult stem cell Anatomy 0.000 claims description 3
229940061720 alpha hydroxy acid Drugs 0.000 claims description 3
150000001280 alpha hydroxy acids Chemical class 0.000 claims description 3
230000000954 anitussive effect Effects 0.000 claims description 3
239000000730 antalgic agent Substances 0.000 claims description 3
229940045799 anthracyclines and related substance Drugs 0.000 claims description 3
230000003712 anti-aging effect Effects 0.000 claims description 3
230000002280 anti-androgenic effect Effects 0.000 claims description 3
239000004004 anti-anginal agent Substances 0.000 claims description 3
230000001166 anti-perspirative effect Effects 0.000 claims description 3
239000000043 antiallergic agent Substances 0.000 claims description 3
239000000051 antiandrogen Substances 0.000 claims description 3
239000003416 antiarrhythmic agent Substances 0.000 claims description 3
239000003146 anticoagulant agent Substances 0.000 claims description 3
229940127219 anticoagulant drug Drugs 0.000 claims description 3
239000001961 anticonvulsive agent Substances 0.000 claims description 3
239000000935 antidepressant agent Substances 0.000 claims description 3
229940005513 antidepressants Drugs 0.000 claims description 3
239000002111 antiemetic agent Substances 0.000 claims description 3
229940030600 antihypertensive agent Drugs 0.000 claims description 3
229940127088 antihypertensive drug Drugs 0.000 claims description 3
239000003430 antimalarial agent Substances 0.000 claims description 3
239000003213 antiperspirant Substances 0.000 claims description 3
239000003435 antirheumatic agent Substances 0.000 claims description 3
239000000074 antisense oligonucleotide Substances 0.000 claims description 3
238000012230 antisense oligonucleotides Methods 0.000 claims description 3
229940124584 antitussives Drugs 0.000 claims description 3
230000006907 apoptotic process Effects 0.000 claims description 3
210000001130 astrocyte Anatomy 0.000 claims description 3
229960003071 bacitracin Drugs 0.000 claims description 3
229930184125 bacitracin Natural products 0.000 claims description 3
CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 claims description 3
230000001580 bacterial effect Effects 0.000 claims description 3
239000003855 balanced salt solution Substances 0.000 claims description 3
229960003328 benzoyl peroxide Drugs 0.000 claims description 3
235000019400 benzoyl peroxide Nutrition 0.000 claims description 3
ACBQROXDOHKANW-UHFFFAOYSA-N bis(4-nitrophenyl) carbonate Chemical compound C1=CC([N+](=O)[O-])=CC=C1OC(=O)OC1=CC=C([N+]([O-])=O)C=C1 ACBQROXDOHKANW-UHFFFAOYSA-N 0.000 claims description 3
229910052797 bismuth Inorganic materials 0.000 claims description 3
JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims description 3
238000012661 block copolymerization Methods 0.000 claims description 3
210000001772 blood platelet Anatomy 0.000 claims description 3
210000001185 bone marrow Anatomy 0.000 claims description 3
210000002798 bone marrow cell Anatomy 0.000 claims description 3
229960003150 bupivacaine Drugs 0.000 claims description 3
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 3
229960001736 buprenorphine Drugs 0.000 claims description 3
229930003827 cannabinoid Natural products 0.000 claims description 3
239000003557 cannabinoid Substances 0.000 claims description 3
229960001631 carbomer Drugs 0.000 claims description 3
230000000747 cardiac effect Effects 0.000 claims description 3
239000002327 cardiovascular agent Substances 0.000 claims description 3
239000003518 caustics Substances 0.000 claims description 3
239000002738 chelating agent Substances 0.000 claims description 3
230000003399 chemotactic effect Effects 0.000 claims description 3
229960002896 clonidine Drugs 0.000 claims description 3
229960004022 clotrimazole Drugs 0.000 claims description 3
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 3
239000003433 contraceptive agent Substances 0.000 claims description 3
239000003246 corticosteroid Substances 0.000 claims description 3
229960001334 corticosteroids Drugs 0.000 claims description 3
125000000753 cycloalkyl group Chemical group 0.000 claims description 3
239000000412 dendrimer Substances 0.000 claims description 3
229920000736 dendritic polymer Polymers 0.000 claims description 3
229960000633 dextran sulfate Drugs 0.000 claims description 3
229960001259 diclofenac Drugs 0.000 claims description 3
DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 3
YIOJGTBNHQAVBO-UHFFFAOYSA-N dimethyl-bis(prop-2-enyl)azanium Chemical compound C=CC[N+](C)(C)CC=C YIOJGTBNHQAVBO-UHFFFAOYSA-N 0.000 claims description 3
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims description 3
230000002526 effect on cardiovascular system Effects 0.000 claims description 3
230000002124 endocrine Effects 0.000 claims description 3
210000002889 endothelial cell Anatomy 0.000 claims description 3
230000003511 endothelial effect Effects 0.000 claims description 3
239000002532 enzyme inhibitor Substances 0.000 claims description 3
210000002514 epidermal stem cell Anatomy 0.000 claims description 3
210000002919 epithelial cell Anatomy 0.000 claims description 3
229960005309 estradiol Drugs 0.000 claims description 3
229930182833 estradiol Natural products 0.000 claims description 3
BNKAXGCRDYRABM-UHFFFAOYSA-N ethenyl dihydrogen phosphate Chemical class OP(O)(=O)OC=C BNKAXGCRDYRABM-UHFFFAOYSA-N 0.000 claims description 3
210000004700 fetal blood Anatomy 0.000 claims description 3
210000002950 fibroblast Anatomy 0.000 claims description 3
229960002949 fluorouracil Drugs 0.000 claims description 3
PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 claims description 3
UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 3
210000001654 germ layer Anatomy 0.000 claims description 3
229960003711 glyceryl trinitrate Drugs 0.000 claims description 3
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
239000010931 gold Substances 0.000 claims description 3
229910052737 gold Inorganic materials 0.000 claims description 3
239000003163 gonadal steroid hormone Substances 0.000 claims description 3
239000007952 growth promoter Substances 0.000 claims description 3
230000003779 hair growth Effects 0.000 claims description 3
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 3
229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
239000002955 immunomodulating agent Substances 0.000 claims description 3
229940121354 immunomodulator Drugs 0.000 claims description 3
210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 3
239000000411 inducer Substances 0.000 claims description 3
229940125396 insulin Drugs 0.000 claims description 3
210000002490 intestinal epithelial cell Anatomy 0.000 claims description 3
125000002346 iodo group Chemical group I* 0.000 claims description 3
CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims description 3
235000008696 isoflavones Nutrition 0.000 claims description 3
210000002510 keratinocyte Anatomy 0.000 claims description 3
229960004125 ketoconazole Drugs 0.000 claims description 3
DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 3
229960000991 ketoprofen Drugs 0.000 claims description 3
239000003446 ligand Substances 0.000 claims description 3
235000010420 locust bean gum Nutrition 0.000 claims description 3
239000000711 locust bean gum Substances 0.000 claims description 3
210000004698 lymphocyte Anatomy 0.000 claims description 3
206010025482 malaise Diseases 0.000 claims description 3
210000002901 mesenchymal stem cell Anatomy 0.000 claims description 3
239000002082 metal nanoparticle Substances 0.000 claims description 3
239000000693 micelle Substances 0.000 claims description 3
229960005040 miconazole nitrate Drugs 0.000 claims description 3
229960004857 mitomycin Drugs 0.000 claims description 3
239000003607 modifier Substances 0.000 claims description 3
150000002772 monosaccharides Chemical class 0.000 claims description 3
210000003098 myoblast Anatomy 0.000 claims description 3
210000000107 myocyte Anatomy 0.000 claims description 3
HOHCIWOKFBMYLM-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enamide Chemical compound CN(C)C.CC(=C)C(N)=O HOHCIWOKFBMYLM-UHFFFAOYSA-N 0.000 claims description 3
ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims description 3
229940031182 nanoparticles iron oxide Drugs 0.000 claims description 3
239000003887 narcotic antagonist Substances 0.000 claims description 3
229940053050 neomycin sulfate Drugs 0.000 claims description 3
210000001178 neural stem cell Anatomy 0.000 claims description 3
210000004498 neuroglial cell Anatomy 0.000 claims description 3
210000002569 neuron Anatomy 0.000 claims description 3
210000000440 neutrophil Anatomy 0.000 claims description 3
229960002715 nicotine Drugs 0.000 claims description 3
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 3
229960003512 nicotinic acid Drugs 0.000 claims description 3
235000001968 nicotinic acid Nutrition 0.000 claims description 3
239000011664 nicotinic acid Substances 0.000 claims description 3
IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims description 3
229960001907 nitrofurazone Drugs 0.000 claims description 3
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 3
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 3
RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 claims description 3
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 3
230000009984 peri-natal effect Effects 0.000 claims description 3
210000003668 pericyte Anatomy 0.000 claims description 3
239000013612 plasmid Substances 0.000 claims description 3
210000001778 pluripotent stem cell Anatomy 0.000 claims description 3
229920002939 poly(N,N-dimethylacrylamides) Polymers 0.000 claims description 3
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 3
229920001308 poly(aminoacid) Polymers 0.000 claims description 3
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 3
229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 3
229920002627 poly(phosphazenes) Polymers 0.000 claims description 3
229920002401 polyacrylamide Polymers 0.000 claims description 3
239000000622 polydioxanone Substances 0.000 claims description 3
150000004291 polyenes Chemical class 0.000 claims description 3
229920000024 polymyxin B Polymers 0.000 claims description 3
229960005266 polymyxin b Drugs 0.000 claims description 3
239000003910 polypeptide antibiotic agent Substances 0.000 claims description 3
229920001299 polypropylene fumarate Polymers 0.000 claims description 3
229920000166 polytrimethylene carbonate Polymers 0.000 claims description 3
229920002635 polyurethane Polymers 0.000 claims description 3
239000004814 polyurethane Substances 0.000 claims description 3
229960001621 povidone-iodine Drugs 0.000 claims description 3
229940002612 prodrug Drugs 0.000 claims description 3
239000000651 prodrug Substances 0.000 claims description 3
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims description 3
239000002096 quantum dot Substances 0.000 claims description 3
239000010453 quartz Substances 0.000 claims description 3
229960004889 salicylic acid Drugs 0.000 claims description 3
210000004116 schwann cell Anatomy 0.000 claims description 3
229960002646 scopolamine Drugs 0.000 claims description 3
STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims description 3
210000001646 side-population cell Anatomy 0.000 claims description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
150000003378 silver Chemical class 0.000 claims description 3
229960003600 silver sulfadiazine Drugs 0.000 claims description 3
UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 claims description 3
210000001057 smooth muscle myoblast Anatomy 0.000 claims description 3
210000000329 smooth muscle myocyte Anatomy 0.000 claims description 3
239000011734 sodium Substances 0.000 claims description 3
229910052708 sodium Inorganic materials 0.000 claims description 3
210000003594 spinal ganglia Anatomy 0.000 claims description 3
150000003431 steroids Chemical class 0.000 claims description 3
229960003604 testosterone Drugs 0.000 claims description 3
229960002180 tetracycline Drugs 0.000 claims description 3
229930101283 tetracycline Natural products 0.000 claims description 3
235000019364 tetracycline Nutrition 0.000 claims description 3
150000003522 tetracyclines Chemical class 0.000 claims description 3
210000003014 totipotent stem cell Anatomy 0.000 claims description 3
238000001890 transfection Methods 0.000 claims description 3
210000002444 unipotent stem cell Anatomy 0.000 claims description 3
239000005526 vasoconstrictor agent Substances 0.000 claims description 3
229940124549 vasodilator Drugs 0.000 claims description 3
239000003071 vasodilator agent Substances 0.000 claims description 3
NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical class OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 claims description 3
150000003722 vitamin derivatives Chemical class 0.000 claims description 3
150000003751 zinc Chemical class 0.000 claims description 3
108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
BRJJFBHTDVWTCJ-UHFFFAOYSA-N 1-[n'-[6-[[amino-[[n'-(2-ethylhexyl)carbamimidoyl]amino]methylidene]amino]hexyl]carbamimidoyl]-2-(2-ethylhexyl)guanidine;dihydrochloride Chemical compound Cl.Cl.CCCCC(CC)CN=C(N)NC(N)=NCCCCCCN=C(N)NC(N)=NCC(CC)CCCC BRJJFBHTDVWTCJ-UHFFFAOYSA-N 0.000 claims description 2
VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 2
DMKKMGYBLFUGTO-UHFFFAOYSA-N 2-methyloxirane;oxirane Chemical compound C1CO1.C1CO1.CC1CO1 DMKKMGYBLFUGTO-UHFFFAOYSA-N 0.000 claims description 2
235000002961 Aloe barbadensis Nutrition 0.000 claims description 2
244000144927 Aloe barbadensis Species 0.000 claims description 2
108010085220 Multiprotein Complexes Proteins 0.000 claims description 2
102000007474 Multiprotein Complexes Human genes 0.000 claims description 2
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
229920000289 Polyquaternium Polymers 0.000 claims description 2
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
150000007513 acids Chemical class 0.000 claims description 2
235000011399 aloe vera Nutrition 0.000 claims description 2
210000003663 amniotic stem cell Anatomy 0.000 claims description 2
229940035676 analgesics Drugs 0.000 claims description 2
230000003255 anti-acne Effects 0.000 claims description 2
230000003474 anti-emetic effect Effects 0.000 claims description 2
230000002682 anti-psoriatic effect Effects 0.000 claims description 2
229940125681 anticonvulsant agent Drugs 0.000 claims description 2
229940125683 antiemetic agent Drugs 0.000 claims description 2
229940030225 antihemorrhagics Drugs 0.000 claims description 2
229940030999 antipsoriatics Drugs 0.000 claims description 2
239000003576 central nervous system agent Substances 0.000 claims description 2
WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 claims description 2
229960001884 chlorhexidine diacetate Drugs 0.000 claims description 2
229940124558 contraceptive agent Drugs 0.000 claims description 2
230000018044 dehydration Effects 0.000 claims description 2
238000006297 dehydration reaction Methods 0.000 claims description 2
239000000645 desinfectant Substances 0.000 claims description 2
PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 claims description 2
239000003974 emollient agent Substances 0.000 claims description 2
SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims description 2
229960002428 fentanyl Drugs 0.000 claims description 2
IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 claims description 2
210000000604 fetal stem cell Anatomy 0.000 claims description 2
239000002874 hemostatic agent Substances 0.000 claims description 2
210000003494 hepatocyte Anatomy 0.000 claims description 2
210000000936 intestine Anatomy 0.000 claims description 2
229960004130 itraconazole Drugs 0.000 claims description 2
210000001074 muscle attachment cell Anatomy 0.000 claims description 2
210000004165 myocardium Anatomy 0.000 claims description 2
201000001119 neuropathy Diseases 0.000 claims description 2
230000007823 neuropathy Effects 0.000 claims description 2
230000001734 parasympathetic effect Effects 0.000 claims description 2
229910052698 phosphorus Inorganic materials 0.000 claims description 2
239000011574 phosphorus Substances 0.000 claims description 2
229910052709 silver Inorganic materials 0.000 claims description 2
239000004332 silver Substances 0.000 claims description 2
GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 2
DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims description 2
229960000699 terbinafine hydrochloride Drugs 0.000 claims description 2
244000303965 Cyamopsis psoralioides Species 0.000 claims 6
230000001139 anti-pruritic effect Effects 0.000 claims 2
229940124623 antihistamine drug Drugs 0.000 claims 2
239000003908 antipruritic agent Substances 0.000 claims 2
RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 claims 1
108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
102000018997 Growth Hormone Human genes 0.000 claims 1
108010051696 Growth Hormone Proteins 0.000 claims 1
TYMRLRRVMHJFTF-UHFFFAOYSA-N Mafenide Chemical compound NCC1=CC=C(S(N)(=O)=O)C=C1 TYMRLRRVMHJFTF-UHFFFAOYSA-N 0.000 claims 1
HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 claims 1
229920001710 Polyorthoester Polymers 0.000 claims 1
229940035674 anesthetics Drugs 0.000 claims 1
230000003288 anthiarrhythmic effect Effects 0.000 claims 1
230000001430 anti-depressive effect Effects 0.000 claims 1
230000003178 anti-diabetic effect Effects 0.000 claims 1
230000000843 anti-fungal effect Effects 0.000 claims 1
229940124599 anti-inflammatory drug Drugs 0.000 claims 1
230000000118 anti-neoplastic effect Effects 0.000 claims 1
229940033495 antimalarials Drugs 0.000 claims 1
229940034982 antineoplastic agent Drugs 0.000 claims 1
229960001231 choline Drugs 0.000 claims 1
231100001010 corrosive Toxicity 0.000 claims 1
229940000033 dermatological agent Drugs 0.000 claims 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
230000002584 immunomodulator Effects 0.000 claims 1
GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims 1
229960003640 mafenide Drugs 0.000 claims 1
150000002759 monoacylglycerols Chemical class 0.000 claims 1
239000002745 poly(ortho ester) Substances 0.000 claims 1
230000000391 smoking effect Effects 0.000 claims 1
235000018102 proteins Nutrition 0.000 description 168
239000000017 hydrogel Substances 0.000 description 56
208000027418 Wounds and injury Diseases 0.000 description 39
206010052428 Wound Diseases 0.000 description 37
239000012530 fluid Substances 0.000 description 26
239000011159 matrix material Substances 0.000 description 25
238000002347 injection Methods 0.000 description 24
239000007924 injection Substances 0.000 description 24
239000002953 phosphate buffered saline Substances 0.000 description 20
210000004872 soft tissue Anatomy 0.000 description 18
238000002360 preparation method Methods 0.000 description 16
230000033115 angiogenesis Effects 0.000 description 14
230000008439 repair process Effects 0.000 description 13
239000000126 substance Substances 0.000 description 13
239000011800 void material Substances 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
230000015572 biosynthetic process Effects 0.000 description 12
230000012010 growth Effects 0.000 description 12
229940071826 hydroxyethyl cellulose Drugs 0.000 description 12
239000007788 liquid Substances 0.000 description 12
244000007835 Cyamopsis tetragonoloba Species 0.000 description 11
238000000576 coating method Methods 0.000 description 11
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 11
125000000524 functional group Chemical group 0.000 description 11
238000011065 in-situ storage Methods 0.000 description 11
241000700159 Rattus Species 0.000 description 10
230000000845 anti-microbial effect Effects 0.000 description 10
238000001802 infusion Methods 0.000 description 10
239000004570 mortar (masonry) Substances 0.000 description 10
239000011148 porous material Substances 0.000 description 10
238000006243 chemical reaction Methods 0.000 description 9
239000011248 coating agent Substances 0.000 description 9
239000000839 emulsion Substances 0.000 description 9
210000000056 organ Anatomy 0.000 description 9
239000011780 sodium chloride Substances 0.000 description 9
239000000725 suspension Substances 0.000 description 9
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 8
239000011575 calcium Substances 0.000 description 8
229910052791 calcium Inorganic materials 0.000 description 8
244000005700 microbiome Species 0.000 description 8
230000008569 process Effects 0.000 description 8
238000007920 subcutaneous administration Methods 0.000 description 8
229920001059 synthetic polymer Polymers 0.000 description 8
230000017423 tissue regeneration Effects 0.000 description 8
239000003981 vehicle Substances 0.000 description 8
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 7
241001662443 Phemeranthus parviflorus Species 0.000 description 7
229920002413 Polyhexanide Polymers 0.000 description 7
210000001691 amnion Anatomy 0.000 description 7
230000007547 defect Effects 0.000 description 7
230000006870 function Effects 0.000 description 7
230000001965 increasing effect Effects 0.000 description 7
238000007912 intraperitoneal administration Methods 0.000 description 7
239000011777 magnesium Substances 0.000 description 7
229910052749 magnesium Inorganic materials 0.000 description 7
235000004252 protein component Nutrition 0.000 description 7
230000009467 reduction Effects 0.000 description 7
239000004094 surface-active agent Substances 0.000 description 7
238000011282 treatment Methods 0.000 description 7
102000012422 Collagen Type I Human genes 0.000 description 6
108010022452 Collagen Type I Proteins 0.000 description 6
230000000735 allogeneic effect Effects 0.000 description 6
239000003124 biologic agent Substances 0.000 description 6
230000004071 biological effect Effects 0.000 description 6
238000001727 in vivo Methods 0.000 description 6
208000015181 infectious disease Diseases 0.000 description 6
238000010186 staining Methods 0.000 description 6
238000001356 surgical procedure Methods 0.000 description 6
125000003396 thiol group Chemical group [H]S* 0.000 description 6
102000007469 Actins Human genes 0.000 description 5
108010085238 Actins Proteins 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
230000003833 cell viability Effects 0.000 description 5
239000002131 composite material Substances 0.000 description 5
150000001875 compounds Chemical class 0.000 description 5
239000006071 cream Substances 0.000 description 5
230000007423 decrease Effects 0.000 description 5
239000000975 dye Substances 0.000 description 5
238000009472 formulation Methods 0.000 description 5
229920001477 hydrophilic polymer Polymers 0.000 description 5
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 5
208000014674 injury Diseases 0.000 description 5
239000006210 lotion Substances 0.000 description 5
210000005036 nerve Anatomy 0.000 description 5
239000012071 phase Substances 0.000 description 5
239000000047 product Substances 0.000 description 5
125000001424 substituent group Chemical group 0.000 description 5
238000012360 testing method Methods 0.000 description 5
230000029663 wound healing Effects 0.000 description 5
108091003079 Bovine Serum Albumin Proteins 0.000 description 4
102000018233 Fibroblast Growth Factor Human genes 0.000 description 4
108050007372 Fibroblast Growth Factor Proteins 0.000 description 4
241001465754 Metazoa Species 0.000 description 4
108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 4
102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 4
208000003251 Pruritus Diseases 0.000 description 4
102000004887 Transforming Growth Factor beta Human genes 0.000 description 4
108090001012 Transforming Growth Factor beta Proteins 0.000 description 4
108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 4
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 4
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 4
238000010521 absorption reaction Methods 0.000 description 4
239000000560 biocompatible material Substances 0.000 description 4
239000012620 biological material Substances 0.000 description 4
230000036760 body temperature Effects 0.000 description 4
229940098773 bovine serum albumin Drugs 0.000 description 4
230000009087 cell motility Effects 0.000 description 4
230000006378 damage Effects 0.000 description 4
229940126864 fibroblast growth factor Drugs 0.000 description 4
238000011049 filling Methods 0.000 description 4
230000009969 flowable effect Effects 0.000 description 4
239000006260 foam Substances 0.000 description 4
102000034356 gene-regulatory proteins Human genes 0.000 description 4
108091006104 gene-regulatory proteins Proteins 0.000 description 4
238000002513 implantation Methods 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
238000002156 mixing Methods 0.000 description 4
239000000178 monomer Substances 0.000 description 4
231100000252 nontoxic Toxicity 0.000 description 4
230000003000 nontoxic effect Effects 0.000 description 4
239000004055 small Interfering RNA Substances 0.000 description 4
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 4
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
241000124008 Mammalia Species 0.000 description 3
108010089430 Phosphoproteins Proteins 0.000 description 3
102000007982 Phosphoproteins Human genes 0.000 description 3
239000000654 additive Substances 0.000 description 3
235000010443 alginic acid Nutrition 0.000 description 3
229920000615 alginic acid Polymers 0.000 description 3
125000003277 amino group Chemical group 0.000 description 3
206010003246 arthritis Diseases 0.000 description 3
230000003416 augmentation Effects 0.000 description 3
210000000481 breast Anatomy 0.000 description 3
239000001110 calcium chloride Substances 0.000 description 3
229910001628 calcium chloride Inorganic materials 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
238000004113 cell culture Methods 0.000 description 3
229940099898 chlorophyllin Drugs 0.000 description 3
235000019805 chlorophyllin Nutrition 0.000 description 3
238000001212 derivatisation Methods 0.000 description 3
201000010099 disease Diseases 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000003995 emulsifying agent Substances 0.000 description 3
239000003205 fragrance Substances 0.000 description 3
238000001879 gelation Methods 0.000 description 3
230000035876 healing Effects 0.000 description 3
210000002216 heart Anatomy 0.000 description 3
229940106780 human fibrinogen Drugs 0.000 description 3
230000002209 hydrophobic effect Effects 0.000 description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
238000007917 intracranial administration Methods 0.000 description 3
238000007918 intramuscular administration Methods 0.000 description 3
238000007913 intrathecal administration Methods 0.000 description 3
230000002601 intratumoral effect Effects 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
230000001788 irregular Effects 0.000 description 3
210000004379 membrane Anatomy 0.000 description 3
239000012528 membrane Substances 0.000 description 3
229920005615 natural polymer Polymers 0.000 description 3
239000003921 oil Substances 0.000 description 3
235000019198 oils Nutrition 0.000 description 3
239000006072 paste Substances 0.000 description 3
210000002826 placenta Anatomy 0.000 description 3
229920000671 polyethylene glycol diacrylate Polymers 0.000 description 3
238000006116 polymerization reaction Methods 0.000 description 3
238000011069 regeneration method Methods 0.000 description 3
210000002460 smooth muscle Anatomy 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
210000004876 tela submucosa Anatomy 0.000 description 3
239000002562 thickening agent Substances 0.000 description 3
230000002792 vascular Effects 0.000 description 3
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 description 2
102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 2
108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 2
102000015225 Connective Tissue Growth Factor Human genes 0.000 description 2
108010039419 Connective Tissue Growth Factor Proteins 0.000 description 2
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
108010071289 Factor XIII Proteins 0.000 description 2
102000003972 Fibroblast growth factor 7 Human genes 0.000 description 2
108090000385 Fibroblast growth factor 7 Proteins 0.000 description 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical group NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
102100031000 Hepatoma-derived growth factor Human genes 0.000 description 2
241000282412 Homo Species 0.000 description 2
101001083798 Homo sapiens Hepatoma-derived growth factor Proteins 0.000 description 2
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
102000015696 Interleukins Human genes 0.000 description 2
108010063738 Interleukins Proteins 0.000 description 2
UILOTUUZKGTYFQ-UHFFFAOYSA-N Mafenide acetate Chemical compound CC(O)=O.NCC1=CC=C(S(N)(=O)=O)C=C1 UILOTUUZKGTYFQ-UHFFFAOYSA-N 0.000 description 2
241001529936 Murinae Species 0.000 description 2
NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 2
108010025020 Nerve Growth Factor Proteins 0.000 description 2
102000015336 Nerve Growth Factor Human genes 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
108010022999 Serine Proteases Proteins 0.000 description 2
102000012479 Serine Proteases Human genes 0.000 description 2
FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 2
208000026137 Soft tissue injury Diseases 0.000 description 2
102000013275 Somatomedins Human genes 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
239000005844 Thymol Substances 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
238000013019 agitation Methods 0.000 description 2
150000001299 aldehydes Chemical class 0.000 description 2
229940072056 alginate Drugs 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
230000002924 anti-infective effect Effects 0.000 description 2
239000002260 anti-inflammatory agent Substances 0.000 description 2
229940121363 anti-inflammatory agent Drugs 0.000 description 2
229940064004 antiseptic throat preparations Drugs 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
230000008901 benefit Effects 0.000 description 2
150000004283 biguanides Chemical class 0.000 description 2
239000000227 bioadhesive Substances 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
229940077737 brain-derived neurotrophic factor Drugs 0.000 description 2
239000000872 buffer Substances 0.000 description 2
210000004413 cardiac myocyte Anatomy 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
230000004663 cell proliferation Effects 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
239000000812 cholinergic antagonist Substances 0.000 description 2
229960002227 clindamycin Drugs 0.000 description 2
KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 2
230000035602 clotting Effects 0.000 description 2
238000013270 controlled release Methods 0.000 description 2
239000013256 coordination polymer Substances 0.000 description 2
238000002316 cosmetic surgery Methods 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
239000008367 deionised water Substances 0.000 description 2
229910021641 deionized water Inorganic materials 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
210000004207 dermis Anatomy 0.000 description 2
230000005489 elastic deformation Effects 0.000 description 2
230000001747 exhibiting effect Effects 0.000 description 2
229940012444 factor xiii Drugs 0.000 description 2
210000003195 fascia Anatomy 0.000 description 2
239000007863 gel particle Substances 0.000 description 2
239000003349 gelling agent Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
210000003958 hematopoietic stem cell Anatomy 0.000 description 2
230000000887 hydrating effect Effects 0.000 description 2
239000012678 infectious agent Substances 0.000 description 2
230000008595 infiltration Effects 0.000 description 2
238000001764 infiltration Methods 0.000 description 2
239000007972 injectable composition Substances 0.000 description 2
230000003993 interaction Effects 0.000 description 2
150000002515 isoflavone derivatives Chemical class 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
238000011068 loading method Methods 0.000 description 2
229960002721 mafenide acetate Drugs 0.000 description 2
229940041616 menthol Drugs 0.000 description 2
229960000282 metronidazole Drugs 0.000 description 2
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
230000000813 microbial effect Effects 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
201000003152 motion sickness Diseases 0.000 description 2
229940053128 nerve growth factor Drugs 0.000 description 2
230000002981 neuropathic effect Effects 0.000 description 2
AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 2
150000002905 orthoesters Chemical class 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
210000000496 pancreas Anatomy 0.000 description 2
108010049224 perlecan Proteins 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
230000035755 proliferation Effects 0.000 description 2
238000010526 radical polymerization reaction Methods 0.000 description 2
230000001603 reducing effect Effects 0.000 description 2
230000008929 regeneration Effects 0.000 description 2
230000010076 replication Effects 0.000 description 2
239000000565 sealant Substances 0.000 description 2
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
210000002027 skeletal muscle Anatomy 0.000 description 2
239000002904 solvent Substances 0.000 description 2
241000894007 species Species 0.000 description 2
210000000278 spinal cord Anatomy 0.000 description 2
239000007921 spray Substances 0.000 description 2
230000003068 static effect Effects 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
230000008961 swelling Effects 0.000 description 2
239000011206 ternary composite Substances 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
229960000790 thymol Drugs 0.000 description 2
230000007838 tissue remodeling Effects 0.000 description 2
238000002054 transplantation Methods 0.000 description 2
230000008733 trauma Effects 0.000 description 2
210000003954 umbilical cord Anatomy 0.000 description 2
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
235000013311 vegetables Nutrition 0.000 description 2
ZJIFDEVVTPEXDL-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) hydrogen carbonate Chemical compound OC(=O)ON1C(=O)CCC1=O ZJIFDEVVTPEXDL-UHFFFAOYSA-N 0.000 description 1
239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 description 1
SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 1
IHDBZCJYSHDCKF-UHFFFAOYSA-N 4,6-dichlorotriazine Chemical compound ClC1=CC(Cl)=NN=N1 IHDBZCJYSHDCKF-UHFFFAOYSA-N 0.000 description 1
QXZGLTYKKZKGLN-UHFFFAOYSA-N 4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)ON1C(=O)CCC1=O QXZGLTYKKZKGLN-UHFFFAOYSA-N 0.000 description 1
OFNXOACBUMGOPC-HZYVHMACSA-N 5'-hydroxystreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](CO)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O OFNXOACBUMGOPC-HZYVHMACSA-N 0.000 description 1
NWAGXLBTAPTCPR-UHFFFAOYSA-N 5-(2,5-dioxopyrrolidin-1-yl)oxy-5-oxopentanoic acid Chemical compound OC(=O)CCCC(=O)ON1C(=O)CCC1=O NWAGXLBTAPTCPR-UHFFFAOYSA-N 0.000 description 1
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
101150079978 AGRN gene Proteins 0.000 description 1
HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 1
229920000936 Agarose Polymers 0.000 description 1
102100036601 Aggrecan core protein Human genes 0.000 description 1
108010067219 Aggrecans Proteins 0.000 description 1
102100040026 Agrin Human genes 0.000 description 1
108700019743 Agrin Proteins 0.000 description 1
241000972773 Aulopiformes Species 0.000 description 1
102000004954 Biglycan Human genes 0.000 description 1
108090001138 Biglycan Proteins 0.000 description 1
102000015081 Blood Coagulation Factors Human genes 0.000 description 1
108010039209 Blood Coagulation Factors Proteins 0.000 description 1
206010006803 Burns third degree Diseases 0.000 description 1
102000000905 Cadherin Human genes 0.000 description 1
108050007957 Cadherin Proteins 0.000 description 1
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
241000723346 Cinnamomum camphora Species 0.000 description 1
244000223760 Cinnamomum zeylanicum Species 0.000 description 1
235000005979 Citrus limon Nutrition 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
235000005956 Cosmos caudatus Nutrition 0.000 description 1
239000004971 Cross linker Substances 0.000 description 1
244000301850 Cupressus sempervirens Species 0.000 description 1
240000004784 Cymbopogon citratus Species 0.000 description 1
235000017897 Cymbopogon citratus Nutrition 0.000 description 1
244000166675 Cymbopogon nardus Species 0.000 description 1
235000018791 Cymbopogon nardus Nutrition 0.000 description 1
102000004237 Decorin Human genes 0.000 description 1
108090000738 Decorin Proteins 0.000 description 1
208000008960 Diabetic foot Diseases 0.000 description 1
BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
229940123907 Disease modifying antirheumatic drug Drugs 0.000 description 1
206010013530 Diverticula Diseases 0.000 description 1
206010013554 Diverticulum Diseases 0.000 description 1
240000002943 Elettaria cardamomum Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
108091013881 Epiphycan Proteins 0.000 description 1
102000027313 Epiphycan Human genes 0.000 description 1
239000004593 Epoxy Substances 0.000 description 1
241000283073 Equus caballus Species 0.000 description 1
208000010228 Erectile Dysfunction Diseases 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
244000004281 Eucalyptus maculata Species 0.000 description 1
241000282324 Felis Species 0.000 description 1
206010049290 Feminisation acquired Diseases 0.000 description 1
208000034793 Feminization Diseases 0.000 description 1
102000017177 Fibromodulin Human genes 0.000 description 1
108010013996 Fibromodulin Proteins 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
206010016717 Fistula Diseases 0.000 description 1
241000233866 Fungi Species 0.000 description 1
240000001238 Gaultheria procumbens Species 0.000 description 1
235000007297 Gaultheria procumbens Nutrition 0.000 description 1
241000208152 Geranium Species 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
208000031220 Hemophilia Diseases 0.000 description 1
208000009292 Hemophilia A Diseases 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
206010019909 Hernia Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
241000721662 Juniperus Species 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
235000013628 Lantana involucrata Nutrition 0.000 description 1
240000005183 Lantana involucrata Species 0.000 description 1
244000165082 Lavanda vera Species 0.000 description 1
235000010663 Lavandula angustifolia Nutrition 0.000 description 1
102100032114 Lumican Human genes 0.000 description 1
108010076371 Lumican Proteins 0.000 description 1
235000015459 Lycium barbarum Nutrition 0.000 description 1
PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000014749 Mentha crispa Nutrition 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
244000078639 Mentha spicata Species 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
229920003095 Methocel™ K15M Polymers 0.000 description 1
235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 description 1
244000179970 Monarda didyma Species 0.000 description 1
235000010672 Monarda didyma Nutrition 0.000 description 1
235000009421 Myristica fragrans Nutrition 0.000 description 1
244000270834 Myristica fragrans Species 0.000 description 1
102100037369 Nidogen-1 Human genes 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
108091006006 PEGylated Proteins Proteins 0.000 description 1
241001504519 Papio ursinus Species 0.000 description 1
108010066305 Parkinson Disease Associated Proteins Proteins 0.000 description 1
102000018315 Parkinson Disease Associated Proteins Human genes 0.000 description 1
206010034133 Pathogen resistance Diseases 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
241000218657 Picea Species 0.000 description 1
235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
241000018646 Pinus brutia Species 0.000 description 1
235000011613 Pinus brutia Nutrition 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 1
239000004365 Protease Substances 0.000 description 1
108010081750 Reticulin Proteins 0.000 description 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
241000220317 Rosa Species 0.000 description 1
240000000513 Santalum album Species 0.000 description 1
235000008632 Santalum album Nutrition 0.000 description 1
206010039491 Sarcoma Diseases 0.000 description 1
229920002385 Sodium hyaluronate Polymers 0.000 description 1
102000005890 Spectrin Human genes 0.000 description 1
108010019965 Spectrin Proteins 0.000 description 1
206010041541 Spinal compression fracture Diseases 0.000 description 1
206010041925 Staphylococcal infections Diseases 0.000 description 1
241000191967 Staphylococcus aureus Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
244000223014 Syzygium aromaticum Species 0.000 description 1
235000016639 Syzygium aromaticum Nutrition 0.000 description 1
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
208000031737 Tissue Adhesions Diseases 0.000 description 1
235000009499 Vanilla fragrans Nutrition 0.000 description 1
244000263375 Vanilla tahitensis Species 0.000 description 1
235000012036 Vanilla tahitensis Nutrition 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
108010031318 Vitronectin Proteins 0.000 description 1
102100035140 Vitronectin Human genes 0.000 description 1
206010053692 Wound complication Diseases 0.000 description 1
206010048038 Wound infection Diseases 0.000 description 1
210000001015 abdomen Anatomy 0.000 description 1
210000000579 abdominal fat Anatomy 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
239000012190 activator Substances 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
229940050528 albumin Drugs 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 1
150000001336 alkenes Chemical class 0.000 description 1
239000000921 anthelmintic agent Substances 0.000 description 1
229940124339 anthelmintic agent Drugs 0.000 description 1
239000000058 anti acne agent Substances 0.000 description 1
230000001078 anti-cholinergic effect Effects 0.000 description 1
229940127003 anti-diabetic drug Drugs 0.000 description 1
230000001387 anti-histamine Effects 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000002141 anti-parasite Effects 0.000 description 1
230000003356 anti-rheumatic effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
229940124340 antiacne agent Drugs 0.000 description 1
229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
229940124345 antianginal agent Drugs 0.000 description 1
229940124347 antiarthritic drug Drugs 0.000 description 1
229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
239000003472 antidiabetic agent Substances 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000003434 antitussive agent Substances 0.000 description 1
229940121357 antivirals Drugs 0.000 description 1
229920006187 aquazol Polymers 0.000 description 1
239000012861 aquazol Substances 0.000 description 1
239000008365 aqueous carrier Substances 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
235000019568 aromas Nutrition 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
150000001540 azides Chemical class 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
230000003796 beauty Effects 0.000 description 1
239000003139 biocide Substances 0.000 description 1
229920000249 biocompatible polymer Polymers 0.000 description 1
230000032770 biofilm formation Effects 0.000 description 1
239000003114 blood coagulation factor Substances 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
BQRGNLJZBFXNCZ-UHFFFAOYSA-N calcein am Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)=C(OC(C)=O)C=C1OC1=C2C=C(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(=O)C)C(OC(C)=O)=C1 BQRGNLJZBFXNCZ-UHFFFAOYSA-N 0.000 description 1
229960000846 camphor Drugs 0.000 description 1
229930008380 camphor Natural products 0.000 description 1
150000001718 carbodiimides Chemical class 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
235000005300 cardamomo Nutrition 0.000 description 1
229940125692 cardiovascular agent Drugs 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
210000003855 cell nucleus Anatomy 0.000 description 1
238000001516 cell proliferation assay Methods 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
230000008859 change Effects 0.000 description 1
238000010382 chemical cross-linking Methods 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
229940045110 chitosan Drugs 0.000 description 1
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
210000001136 chorion Anatomy 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
229960005233 cineole Drugs 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
230000037369 collagen remodeling Effects 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000002254 contraceptive effect Effects 0.000 description 1
230000008602 contraction Effects 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
238000012937 correction Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
208000031513 cyst Diseases 0.000 description 1
231100000433 cytotoxic Toxicity 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
229920006237 degradable polymer Polymers 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
150000002009 diols Chemical group 0.000 description 1
238000009826 distribution Methods 0.000 description 1
150000002027 dodecanoic acid esters Chemical class 0.000 description 1
UWLPCYBIJSLGQO-UHFFFAOYSA-N dodecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCC(O)=O UWLPCYBIJSLGQO-UHFFFAOYSA-N 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
150000002118 epoxides Chemical class 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000000605 extraction Methods 0.000 description 1
210000003754 fetus Anatomy 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000002350 fibrinopeptide Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
230000003890 fistula Effects 0.000 description 1
238000002073 fluorescence micrograph Methods 0.000 description 1
230000004927 fusion Effects 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
230000036541 health Effects 0.000 description 1
230000004217 heart function Effects 0.000 description 1
210000003709 heart valve Anatomy 0.000 description 1
230000002008 hemorrhagic effect Effects 0.000 description 1
230000002439 hemostatic effect Effects 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
150000002433 hydrophilic molecules Chemical class 0.000 description 1
OFNXOACBUMGOPC-UHFFFAOYSA-N hydroxystreptomycin Natural products CNC1C(O)C(O)C(CO)OC1OC1C(C=O)(O)C(CO)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O OFNXOACBUMGOPC-UHFFFAOYSA-N 0.000 description 1
125000002883 imidazolyl group Chemical group 0.000 description 1
125000001841 imino group Chemical group [H]N=* 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
201000001881 impotence Diseases 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000010952 in-situ formation Methods 0.000 description 1
125000001041 indolyl group Chemical group 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000003999 initiator Substances 0.000 description 1
238000009434 installation Methods 0.000 description 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000012948 isocyanate Substances 0.000 description 1
150000002513 isocyanates Chemical class 0.000 description 1
OKPOKMCPHKVCPP-UHFFFAOYSA-N isoorientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(OC)=C(O)C=C3CCN2C)=C1 OKPOKMCPHKVCPP-UHFFFAOYSA-N 0.000 description 1
150000002540 isothiocyanates Chemical class 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
210000002429 large intestine Anatomy 0.000 description 1
239000001102 lavandula vera Substances 0.000 description 1
235000018219 lavender Nutrition 0.000 description 1
210000003041 ligament Anatomy 0.000 description 1
229930007744 linalool Natural products 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
210000005229 liver cell Anatomy 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
238000002803 maceration Methods 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
108010082117 matrigel Proteins 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
239000011325 microbead Substances 0.000 description 1
238000002406 microsurgery Methods 0.000 description 1
210000004088 microvessel Anatomy 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
230000001002 morphogenetic effect Effects 0.000 description 1
210000000214 mouth Anatomy 0.000 description 1
230000002107 myocardial effect Effects 0.000 description 1
UUIQMZJEGPQKFD-UHFFFAOYSA-N n-butyric acid methyl ester Natural products CCCC(=O)OC UUIQMZJEGPQKFD-UHFFFAOYSA-N 0.000 description 1
QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 description 1
229940000041 nervous system drug Drugs 0.000 description 1
108010008217 nidogen Proteins 0.000 description 1
150000004767 nitrides Chemical class 0.000 description 1
OKXGHXHZNCJMSV-UHFFFAOYSA-N nitro phenyl carbonate Chemical compound [O-][N+](=O)OC(=O)OC1=CC=CC=C1 OKXGHXHZNCJMSV-UHFFFAOYSA-N 0.000 description 1
238000012758 nuclear staining Methods 0.000 description 1
239000001702 nutmeg Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
YTSACTNRGUJEGO-UHFFFAOYSA-N oxirane prop-1-ene Chemical group CC=C.C1CO1 YTSACTNRGUJEGO-UHFFFAOYSA-N 0.000 description 1
150000002942 palmitic acid derivatives Chemical class 0.000 description 1
230000002445 parasympatholytic effect Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
239000002304 perfume Substances 0.000 description 1
210000003516 pericardium Anatomy 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000010399 physical interaction Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000010665 pine oil Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000233 poly(alkylene oxides) Polymers 0.000 description 1
239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
239000004633 polyglycolic acid Substances 0.000 description 1
229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
239000000955 prescription drug Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
230000004853 protein function Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000007348 radical reaction Methods 0.000 description 1
239000012857 radioactive material Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000002278 reconstructive surgery Methods 0.000 description 1
230000001172 regenerating effect Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000003014 reinforcing effect Effects 0.000 description 1
230000003716 rejuvenation Effects 0.000 description 1
230000002940 repellent Effects 0.000 description 1
239000005871 repellent Substances 0.000 description 1
JTQHYPFKHZLTSH-UHFFFAOYSA-N reticulin Natural products COC1CC(OC2C(CO)OC(OC3C(O)CC(OC4C(C)OC(CC4OC)OC5CCC6(C)C7CCC8(C)C(CCC8(O)C7CC=C6C5)C(C)O)OC3C)C(O)C2OC)OC(C)C1O JTQHYPFKHZLTSH-UHFFFAOYSA-N 0.000 description 1
150000004492 retinoid derivatives Chemical class 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
239000010671 sandalwood oil Substances 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
238000007789 sealing Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000007873 sieving Methods 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
229940010747 sodium hyaluronate Drugs 0.000 description 1
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
239000012128 staining reagent Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000005728 strengthening Methods 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000002522 swelling effect Effects 0.000 description 1
210000001258 synovial membrane Anatomy 0.000 description 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
229960003766 thrombin (human) Drugs 0.000 description 1
230000009772 tissue formation Effects 0.000 description 1
230000008467 tissue growth Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
229940124543 ultraviolet light absorber Drugs 0.000 description 1
210000003932 urinary bladder Anatomy 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
108010047303 von Willebrand Factor Proteins 0.000 description 1
102100036537 von Willebrand factor Human genes 0.000 description 1
229960001134 von willebrand factor Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1
230000037303 wrinkles Effects 0.000 description 1

JP2017553385A 2015-04-17 2016-04-12 擬塑性ミクロゲルマトリクスの組成物およびキット Active JP6930733B2 (ja)