JP2018510343A5 - - Google Patents
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- JP2018510343A5 JP2018510343A5 JP2017549301A JP2017549301A JP2018510343A5 JP 2018510343 A5 JP2018510343 A5 JP 2018510343A5 JP 2017549301 A JP2017549301 A JP 2017549301A JP 2017549301 A JP2017549301 A JP 2017549301A JP 2018510343 A5 JP2018510343 A5 JP 2018510343A5
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- biomarker panel
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- 239000000090 biomarker Substances 0.000 claims description 134
- 238000000034 method Methods 0.000 claims description 53
- 208000024827 Alzheimer disease Diseases 0.000 claims description 17
- -1 peroxyredoxin-1 Proteins 0.000 claims description 17
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 16
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 13
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 12
- 230000006735 deficit Effects 0.000 claims description 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 9
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 8
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 210000002381 plasma Anatomy 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 7
- 208000027626 Neurocognitive disease Diseases 0.000 claims description 6
- 102000001708 Protein Isoforms Human genes 0.000 claims description 6
- 108010029485 Protein Isoforms Proteins 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 210000005013 brain tissue Anatomy 0.000 claims description 5
- 208000010877 cognitive disease Diseases 0.000 claims description 5
- 238000004949 mass spectrometry Methods 0.000 claims description 5
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 5
- 210000003296 saliva Anatomy 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 5
- 210000002700 urine Anatomy 0.000 claims description 5
- 108010085238 Actins Proteins 0.000 claims description 4
- 102000007469 Actins Human genes 0.000 claims description 4
- 239000005557 antagonist Substances 0.000 claims description 4
- 229940039856 aricept Drugs 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 229960003530 donepezil Drugs 0.000 claims description 4
- 229940108366 exelon Drugs 0.000 claims description 4
- 229960003980 galantamine Drugs 0.000 claims description 4
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 4
- 229960004640 memantine Drugs 0.000 claims description 4
- 229940033872 namenda Drugs 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 229940051845 razadyne Drugs 0.000 claims description 4
- 229960004136 rivastigmine Drugs 0.000 claims description 4
- 206010012289 Dementia Diseases 0.000 claims description 3
- 238000011156 evaluation Methods 0.000 claims description 3
- 238000001502 gel electrophoresis Methods 0.000 claims description 3
- 238000002372 labelling Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 102000009027 Albumins Human genes 0.000 claims description 2
- 108010088751 Albumins Proteins 0.000 claims description 2
- 102000013918 Apolipoproteins E Human genes 0.000 claims description 2
- 108010025628 Apolipoproteins E Proteins 0.000 claims description 2
- 102000007345 Chromogranins Human genes 0.000 claims description 2
- 108010007718 Chromogranins Proteins 0.000 claims description 2
- 108090000996 Cofilin 1 Proteins 0.000 claims description 2
- 102000004360 Cofilin 1 Human genes 0.000 claims description 2
- 102000000989 Complement System Proteins Human genes 0.000 claims description 2
- 108010069112 Complement System Proteins Proteins 0.000 claims description 2
- 102000019205 Dynactin Complex Human genes 0.000 claims description 2
- 108010012830 Dynactin Complex Proteins 0.000 claims description 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 2
- 102000004878 Gelsolin Human genes 0.000 claims description 2
- 108090001064 Gelsolin Proteins 0.000 claims description 2
- 229920002527 Glycogen Polymers 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 2
- 201000002832 Lewy body dementia Diseases 0.000 claims description 2
- 102100032514 MARCKS-related protein Human genes 0.000 claims description 2
- 101710136868 MARCKS-related protein Proteins 0.000 claims description 2
- 102100027869 Moesin Human genes 0.000 claims description 2
- 101710105361 Phosphoglucomutase 1 Proteins 0.000 claims description 2
- 102100030999 Phosphoglucomutase-1 Human genes 0.000 claims description 2
- 208000024777 Prion disease Diseases 0.000 claims description 2
- UGPMCIBIHRSCBV-XNBOLLIBSA-N Thymosin beta 4 Chemical compound N([C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O UGPMCIBIHRSCBV-XNBOLLIBSA-N 0.000 claims description 2
- 102100035000 Thymosin beta-4 Human genes 0.000 claims description 2
- 102000005918 Ubiquitin Thiolesterase Human genes 0.000 claims description 2
- 108010005656 Ubiquitin Thiolesterase Proteins 0.000 claims description 2
- 201000004810 Vascular dementia Diseases 0.000 claims description 2
- 102000050760 Vitamin D-binding protein Human genes 0.000 claims description 2
- 101710179590 Vitamin D-binding protein Proteins 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 230000030741 antigen processing and presentation Effects 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000015271 coagulation Effects 0.000 claims description 2
- 238000005345 coagulation Methods 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- 210000004292 cytoskeleton Anatomy 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 108010036236 extracellular matrix receptor Proteins 0.000 claims description 2
- 210000001650 focal adhesion Anatomy 0.000 claims description 2
- 229940096919 glycogen Drugs 0.000 claims description 2
- 230000034659 glycolysis Effects 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 230000004060 metabolic process Effects 0.000 claims description 2
- 210000000274 microglia Anatomy 0.000 claims description 2
- 230000006724 microglial activation Effects 0.000 claims description 2
- 230000002025 microglial effect Effects 0.000 claims description 2
- 108010071525 moesin Proteins 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 108010079996 thymosin beta(4) Proteins 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000000203 mixture Substances 0.000 description 5
- 210000001642 activated microglia Anatomy 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229950007874 solanezumab Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021102858A JP2021177180A (ja) | 2015-03-17 | 2021-06-22 | アルツハイマー病の診断及び治療のための材料及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201504432A GB201504432D0 (en) | 2015-03-17 | 2015-03-17 | Materials and methods for diagnosis and treatment of alzheimers disease |
| GB1504432.4 | 2015-03-17 | ||
| PCT/EP2016/055883 WO2016146783A1 (en) | 2015-03-17 | 2016-03-17 | Materials and methods for diagnosis and treatment of alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021102858A Division JP2021177180A (ja) | 2015-03-17 | 2021-06-22 | アルツハイマー病の診断及び治療のための材料及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510343A JP2018510343A (ja) | 2018-04-12 |
| JP2018510343A5 true JP2018510343A5 (enExample) | 2019-05-09 |
| JP6954839B2 JP6954839B2 (ja) | 2021-10-27 |
Family
ID=53016214
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549301A Active JP6954839B2 (ja) | 2015-03-17 | 2016-03-17 | アルツハイマー病の診断及び治療のための材料及び方法 |
| JP2021102858A Pending JP2021177180A (ja) | 2015-03-17 | 2021-06-22 | アルツハイマー病の診断及び治療のための材料及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021102858A Pending JP2021177180A (ja) | 2015-03-17 | 2021-06-22 | アルツハイマー病の診断及び治療のための材料及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10718785B2 (enExample) |
| EP (1) | EP3271728B1 (enExample) |
| JP (2) | JP6954839B2 (enExample) |
| CA (1) | CA2979773A1 (enExample) |
| GB (1) | GB201504432D0 (enExample) |
| WO (1) | WO2016146783A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201509134D0 (en) | 2015-05-28 | 2015-07-15 | Electrophoretics Ltd | Biomolecules involved in Alzheimer's disease |
| CA3070446A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | Treating cancer by blocking the interaction of tim-3 and its ligand |
| KR102034929B1 (ko) * | 2017-09-27 | 2019-10-22 | 한양대학교 산학협력단 | Nckap1 단백질 또는 상기 단백질을 암호화하는 유전자를 포함하는 신경계 퇴행성질환의 예방 또는 치료용 약학적 조성물 |
| KR102063610B1 (ko) * | 2018-05-23 | 2020-01-08 | 충북대학교 산학협력단 | 퇴행성 신경질환 진단용 신규한 바이오마커 및 이의 용도 |
| KR102232200B1 (ko) * | 2019-03-13 | 2021-03-25 | 아주대학교산학협력단 | 알츠하이머치매 진단 바이오마커 |
| US20220003787A1 (en) * | 2018-10-30 | 2022-01-06 | Ajou University Industry-Academic Cooperation Foundation | Biomarker proteins for diagnosing alzheimer's dementia and use thereof |
| KR101992060B1 (ko) * | 2018-10-30 | 2019-06-21 | 아주대학교산학협력단 | 알츠하이머치매 진단 체액 바이오마커 후보 단백4종 |
| CN109738653B (zh) * | 2019-01-11 | 2022-04-12 | 湖南诺琪生物科技有限公司 | 用于阿尔茨海默症的检测、诊断或风险预测的抗原蛋白组合以及包含其的试剂盒 |
| CN120058944A (zh) | 2019-01-30 | 2025-05-30 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CN110261272B (zh) * | 2019-07-05 | 2020-08-18 | 西南交通大学 | 基于地理探测和pca对pm2.5浓度分布的关键影响因子筛选方法 |
| CN112336859A (zh) * | 2019-08-06 | 2021-02-09 | 上海绿谷制药有限公司 | 通过抑制t细胞摄取氨基酸治疗阿尔茨海默病的方法 |
| KR20220104706A (ko) * | 2019-10-28 | 2022-07-26 | 에전 | 알츠하이머병의 침묵 단계를 진단하기 위한 바이오마커 및 이의 용도 |
| KR102313455B1 (ko) * | 2020-02-27 | 2021-10-15 | 이화여자대학교 산학협력단 | 알츠하이머병 경도인지장애의 진단 또는 알츠하이머병 치매로의 진행 위험성 예측 방법 |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| CN112695084A (zh) * | 2021-02-08 | 2021-04-23 | 山东大学第二医院 | 诊断阿尔茨海默病和阿尔茨海默病进展的生物标志物及应用 |
| GB202102399D0 (en) * | 2021-02-19 | 2021-04-07 | Univ Manchester | Methods of determining alzheimer's disease |
| US20250270618A1 (en) * | 2021-03-08 | 2025-08-28 | The Children's Medical Center Corporation | Methods for diagnosis and treatment of alzheimer's disease |
| US20230144446A1 (en) * | 2021-07-23 | 2023-05-11 | Cassava Sciences, Inc. | Blood-based diagnostic assays for alzheimer's disease |
| WO2023235871A2 (en) * | 2022-06-03 | 2023-12-07 | Seer, Inc. | Systems, compositions, and methods relating to neurodegenerative diseases |
| WO2024073067A2 (en) * | 2022-09-30 | 2024-04-04 | Mayo Foundation For Medical Education And Research | Assessing and treating tremor |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| JPWO2004001865A1 (ja) | 2002-06-19 | 2005-10-27 | 株式会社東芝 | 熱電素子とそれを用いた電子部品モジュールおよび携帯用電子機器 |
| WO2005020784A2 (en) | 2003-05-23 | 2005-03-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| WO2005019825A2 (en) * | 2003-08-20 | 2005-03-03 | Genova Ltd. | Secreted polypeptide species and use thereof |
| US7794948B2 (en) * | 2003-11-07 | 2010-09-14 | Vermilllion, Inc. | Biomarkers for alzheimer's disease |
| WO2006110621A2 (en) * | 2005-04-11 | 2006-10-19 | Cornell Research Foundation, Inc. | Multiplexed biomarkers for monitoring the alzheimer's disease state of a subject |
| ES2453106T3 (es) * | 2009-01-26 | 2014-04-04 | Electrophoretics Limited | Métodos de diagnóstico y pronóstico en relación con la enfermedad de Alzheimer |
| WO2010111587A1 (en) | 2009-03-26 | 2010-09-30 | Trustees Of The University Of Pennsylvania | Modulators of tdp-43 mediated toxicity |
| WO2011005893A2 (en) * | 2009-07-07 | 2011-01-13 | Abbott Laboratories | Biomarkers and methods for detecting alzheimer's disease |
| EP2553466A4 (en) | 2010-04-01 | 2013-10-16 | Banyan Biomarkers Inc | MARKERS AND ASSAYS FOR DETECTING NEUROTOXICITY |
| WO2013086429A2 (en) * | 2011-12-09 | 2013-06-13 | Veracyte, Inc. | Methods and compositions for classification of samples |
| GB2511525A (en) * | 2013-03-05 | 2014-09-10 | Randox Teoranta | Methods and Compositions for the Diagnosis of Alzheimer's Disease |
| GB201310203D0 (en) * | 2013-06-07 | 2013-07-24 | Electrophoretics Ltd | Materials and methods relating to Alzheimer's disease |
| GB201322094D0 (en) * | 2013-12-13 | 2014-01-29 | Electrophoretics Ltd | Methods and compositions relating to alzheimers disease |
-
2015
- 2015-03-17 GB GB201504432A patent/GB201504432D0/en not_active Ceased
-
2016
- 2016-03-17 WO PCT/EP2016/055883 patent/WO2016146783A1/en not_active Ceased
- 2016-03-17 EP EP16714282.7A patent/EP3271728B1/en active Active
- 2016-03-17 CA CA2979773A patent/CA2979773A1/en active Pending
- 2016-03-17 US US15/559,371 patent/US10718785B2/en active Active
- 2016-03-17 JP JP2017549301A patent/JP6954839B2/ja active Active
-
2021
- 2021-06-22 JP JP2021102858A patent/JP2021177180A/ja active Pending
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