CA2979773A1 - Materials and methods for diagnosis and treatment of alzheimer's disease - Google Patents

Materials and methods for diagnosis and treatment of alzheimer's disease Download PDF

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Publication number
CA2979773A1
CA2979773A1 CA2979773A CA2979773A CA2979773A1 CA 2979773 A1 CA2979773 A1 CA 2979773A1 CA 2979773 A CA2979773 A CA 2979773A CA 2979773 A CA2979773 A CA 2979773A CA 2979773 A1 CA2979773 A1 CA 2979773A1
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Prior art keywords
protein
biomarkers
sample
subunit
subject
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Pending
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CA2979773A
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English (en)
French (fr)
Inventor
Ian Hugo Pike
Claire Louise RUSSELL
Malcolm Ward
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Proteome Sciences PLC
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Electrophoretics Ltd
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Publication of CA2979773A1 publication Critical patent/CA2979773A1/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57581Thymosin; Related peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y504/00Intramolecular transferases (5.4)
    • C12Y504/02Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02002Phosphoglucomutase (5.4.2.2)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CA2979773A 2015-03-17 2016-03-17 Materials and methods for diagnosis and treatment of alzheimer's disease Pending CA2979773A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201504432A GB201504432D0 (en) 2015-03-17 2015-03-17 Materials and methods for diagnosis and treatment of alzheimers disease
GB1504432.4 2015-03-17
PCT/EP2016/055883 WO2016146783A1 (en) 2015-03-17 2016-03-17 Materials and methods for diagnosis and treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
CA2979773A1 true CA2979773A1 (en) 2016-09-22

Family

ID=53016214

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2979773A Pending CA2979773A1 (en) 2015-03-17 2016-03-17 Materials and methods for diagnosis and treatment of alzheimer's disease

Country Status (6)

Country Link
US (1) US10718785B2 (enExample)
EP (1) EP3271728B1 (enExample)
JP (2) JP6954839B2 (enExample)
CA (1) CA2979773A1 (enExample)
GB (1) GB201504432D0 (enExample)
WO (1) WO2016146783A1 (enExample)

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GB201509134D0 (en) 2015-05-28 2015-07-15 Electrophoretics Ltd Biomolecules involved in Alzheimer's disease
CA3070446A1 (en) 2017-07-25 2019-01-31 Immutics, Inc. Treating cancer by blocking the interaction of tim-3 and its ligand
KR102034929B1 (ko) * 2017-09-27 2019-10-22 한양대학교 산학협력단 Nckap1 단백질 또는 상기 단백질을 암호화하는 유전자를 포함하는 신경계 퇴행성질환의 예방 또는 치료용 약학적 조성물
KR102063610B1 (ko) * 2018-05-23 2020-01-08 충북대학교 산학협력단 퇴행성 신경질환 진단용 신규한 바이오마커 및 이의 용도
KR102232200B1 (ko) * 2019-03-13 2021-03-25 아주대학교산학협력단 알츠하이머치매 진단 바이오마커
US20220003787A1 (en) * 2018-10-30 2022-01-06 Ajou University Industry-Academic Cooperation Foundation Biomarker proteins for diagnosing alzheimer's dementia and use thereof
KR101992060B1 (ko) * 2018-10-30 2019-06-21 아주대학교산학협력단 알츠하이머치매 진단 체액 바이오마커 후보 단백4종
CN109738653B (zh) * 2019-01-11 2022-04-12 湖南诺琪生物科技有限公司 用于阿尔茨海默症的检测、诊断或风险预测的抗原蛋白组合以及包含其的试剂盒
CN120058944A (zh) 2019-01-30 2025-05-30 真和制药有限公司 抗gal3抗体及其用途
CN110261272B (zh) * 2019-07-05 2020-08-18 西南交通大学 基于地理探测和pca对pm2.5浓度分布的关键影响因子筛选方法
CN112336859A (zh) * 2019-08-06 2021-02-09 上海绿谷制药有限公司 通过抑制t细胞摄取氨基酸治疗阿尔茨海默病的方法
KR20220104706A (ko) * 2019-10-28 2022-07-26 에전 알츠하이머병의 침묵 단계를 진단하기 위한 바이오마커 및 이의 용도
KR102313455B1 (ko) * 2020-02-27 2021-10-15 이화여자대학교 산학협력단 알츠하이머병 경도인지장애의 진단 또는 알츠하이머병 치매로의 진행 위험성 예측 방법
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
CN112695084A (zh) * 2021-02-08 2021-04-23 山东大学第二医院 诊断阿尔茨海默病和阿尔茨海默病进展的生物标志物及应用
GB202102399D0 (en) * 2021-02-19 2021-04-07 Univ Manchester Methods of determining alzheimer's disease
US20250270618A1 (en) * 2021-03-08 2025-08-28 The Children's Medical Center Corporation Methods for diagnosis and treatment of alzheimer's disease
US20230144446A1 (en) * 2021-07-23 2023-05-11 Cassava Sciences, Inc. Blood-based diagnostic assays for alzheimer's disease
WO2023235871A2 (en) * 2022-06-03 2023-12-07 Seer, Inc. Systems, compositions, and methods relating to neurodegenerative diseases
WO2024073067A2 (en) * 2022-09-30 2024-04-04 Mayo Foundation For Medical Education And Research Assessing and treating tremor

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US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JPWO2004001865A1 (ja) 2002-06-19 2005-10-27 株式会社東芝 熱電素子とそれを用いた電子部品モジュールおよび携帯用電子機器
WO2005020784A2 (en) 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
WO2005019825A2 (en) * 2003-08-20 2005-03-03 Genova Ltd. Secreted polypeptide species and use thereof
US7794948B2 (en) * 2003-11-07 2010-09-14 Vermilllion, Inc. Biomarkers for alzheimer's disease
WO2006110621A2 (en) * 2005-04-11 2006-10-19 Cornell Research Foundation, Inc. Multiplexed biomarkers for monitoring the alzheimer's disease state of a subject
ES2453106T3 (es) * 2009-01-26 2014-04-04 Electrophoretics Limited Métodos de diagnóstico y pronóstico en relación con la enfermedad de Alzheimer
WO2010111587A1 (en) 2009-03-26 2010-09-30 Trustees Of The University Of Pennsylvania Modulators of tdp-43 mediated toxicity
WO2011005893A2 (en) * 2009-07-07 2011-01-13 Abbott Laboratories Biomarkers and methods for detecting alzheimer's disease
EP2553466A4 (en) 2010-04-01 2013-10-16 Banyan Biomarkers Inc MARKERS AND ASSAYS FOR DETECTING NEUROTOXICITY
WO2013086429A2 (en) * 2011-12-09 2013-06-13 Veracyte, Inc. Methods and compositions for classification of samples
GB2511525A (en) * 2013-03-05 2014-09-10 Randox Teoranta Methods and Compositions for the Diagnosis of Alzheimer's Disease
GB201310203D0 (en) * 2013-06-07 2013-07-24 Electrophoretics Ltd Materials and methods relating to Alzheimer's disease
GB201322094D0 (en) * 2013-12-13 2014-01-29 Electrophoretics Ltd Methods and compositions relating to alzheimers disease

Also Published As

Publication number Publication date
US10718785B2 (en) 2020-07-21
WO2016146783A1 (en) 2016-09-22
JP2018510343A (ja) 2018-04-12
US20180067133A1 (en) 2018-03-08
JP2021177180A (ja) 2021-11-11
GB201504432D0 (en) 2015-04-29
JP6954839B2 (ja) 2021-10-27
EP3271728B1 (en) 2024-02-28
EP3271728A1 (en) 2018-01-24

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