JP2018510147A5 - - Google Patents

Download PDF

Info

Publication number
JP2018510147A5
JP2018510147A5 JP2017546200A JP2017546200A JP2018510147A5 JP 2018510147 A5 JP2018510147 A5 JP 2018510147A5 JP 2017546200 A JP2017546200 A JP 2017546200A JP 2017546200 A JP2017546200 A JP 2017546200A JP 2018510147 A5 JP2018510147 A5 JP 2018510147A5
Authority
JP
Japan
Prior art keywords
antibody
fully human
seq
cancer
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017546200A
Other languages
English (en)
Japanese (ja)
Other versions
JP6643350B2 (ja
JP2018510147A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/020980 external-priority patent/WO2016141328A2/en
Publication of JP2018510147A publication Critical patent/JP2018510147A/ja
Publication of JP2018510147A5 publication Critical patent/JP2018510147A5/ja
Application granted granted Critical
Publication of JP6643350B2 publication Critical patent/JP6643350B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017546200A 2015-03-04 2016-03-04 Cd47に結合する抗体医薬 Active JP6643350B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562128462P 2015-03-04 2015-03-04
US62/128,462 2015-03-04
PCT/US2016/020980 WO2016141328A2 (en) 2015-03-04 2016-03-04 Antibody therapeutics that bind cd47

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019186564A Division JP2020023532A (ja) 2015-03-04 2019-10-10 Cd47に結合する抗体医薬

Publications (3)

Publication Number Publication Date
JP2018510147A JP2018510147A (ja) 2018-04-12
JP2018510147A5 true JP2018510147A5 (enExample) 2019-04-04
JP6643350B2 JP6643350B2 (ja) 2020-02-12

Family

ID=56848772

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2017546200A Active JP6643350B2 (ja) 2015-03-04 2016-03-04 Cd47に結合する抗体医薬
JP2019186564A Withdrawn JP2020023532A (ja) 2015-03-04 2019-10-10 Cd47に結合する抗体医薬
JP2021000870A Active JP7137646B2 (ja) 2015-03-04 2021-01-06 Cd47に結合する抗体医薬
JP2021000869A Active JP7105938B2 (ja) 2015-03-04 2021-01-06 Cd47に結合する抗体医薬
JP2021089081A Withdrawn JP2021121635A (ja) 2015-03-04 2021-05-27 Cd47に結合する抗体医薬

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019186564A Withdrawn JP2020023532A (ja) 2015-03-04 2019-10-10 Cd47に結合する抗体医薬
JP2021000870A Active JP7137646B2 (ja) 2015-03-04 2021-01-06 Cd47に結合する抗体医薬
JP2021000869A Active JP7105938B2 (ja) 2015-03-04 2021-01-06 Cd47に結合する抗体医薬
JP2021089081A Withdrawn JP2021121635A (ja) 2015-03-04 2021-05-27 Cd47に結合する抗体医薬

Country Status (11)

Country Link
US (1) US10035855B2 (enExample)
EP (1) EP3265125A4 (enExample)
JP (5) JP6643350B2 (enExample)
KR (2) KR102850868B1 (enExample)
CN (2) CN107921121B (enExample)
AR (1) AR103868A1 (enExample)
AU (2) AU2016225993B2 (enExample)
IL (2) IL287958B2 (enExample)
MX (1) MX385673B (enExample)
TW (3) TWI843184B (enExample)
WO (1) WO2016141328A2 (enExample)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3411071A4 (en) 2016-10-20 2019-08-28 I-Mab NOVEL MONOCLONAL CD47 ANTIBODY AND USES THEREOF
US11352425B2 (en) 2016-11-08 2022-06-07 Absos, Llc Anti-CD47 antibodies
KR102607101B1 (ko) 2017-01-26 2023-11-29 제트엘아이피 홀딩 리미티드 Cd47 항원 결합 유닛 및 그것의 사용
US11286301B2 (en) * 2017-02-28 2022-03-29 The Board Of Trustees Of The Leland Stanford Junior University Antifibrotic activity of CD47 blockade
US11401329B2 (en) 2017-08-02 2022-08-02 Phanes Therapeutics, Inc. Anti-CD47 antibodies and uses thereof
AU2017439776B2 (en) * 2017-11-20 2025-03-27 Taizhou Mabtech Pharmaceutical Co., Ltd Bifunctional fusion protein targeting CD47 and PD-l1
TWI831759B (zh) 2017-12-01 2024-02-11 美商思進公司 Cd47抗體及其用於治療癌症之用途
CN110577597B (zh) * 2018-06-11 2021-10-22 康诺亚生物医药科技(成都)有限公司 一种阻断CD47和SIRPα相互作用的抗体
WO2020009725A1 (en) * 2018-07-05 2020-01-09 Trican Biotechnology Co., Ltd Human anti-cd47 antibodies and uses thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
EP3826676A4 (en) * 2018-10-31 2022-05-04 I-Mab Biopharma US Limited NOVEL CD47 ANTIBODIES AND METHODS OF USE THEREOF
AU2020315598B2 (en) 2019-07-16 2024-12-12 Gilead Sciences, Inc. HIV vaccines and methods of making and using
KR102902719B1 (ko) 2019-10-18 2025-12-24 포티 세븐, 엘엘씨 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료
CA3153636A1 (en) 2019-10-31 2021-05-06 Forty Seven, Inc. Anti-cd47 and anti-cd20 based treatment of blood cancer
MX2022006787A (es) * 2019-12-05 2022-07-19 Sorrento Therapeutics Inc Composiciones y metodos que comprenden un anticuerpo anti-cd47 en combinacion con un anticuerpo dirigido al tumor.
GB201918230D0 (en) 2019-12-11 2020-01-22 Prec Therapeutics Ltd Antibodies and their uses
CN113004406B (zh) * 2019-12-20 2022-04-26 广东菲鹏制药股份有限公司 抗cd47抗体及其应用
EP4445902A3 (en) 2019-12-24 2024-12-18 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
CN117964757A (zh) 2020-02-14 2024-05-03 吉利德科学公司 与ccr8结合的抗体和融合蛋白及其用途
WO2021191870A1 (en) 2020-03-27 2021-09-30 Dcprime B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
KR20230033647A (ko) 2020-06-30 2023-03-08 멘두스 비.브이. 난소암 백신에서 백혈병 유래 세포의 용도
EP4190813A4 (en) * 2020-07-31 2025-02-12 Bio-Thera Solutions, Ltd. CD47 ANTIBODIES AND THEIR APPLICATION
WO2022109227A1 (en) * 2020-11-19 2022-05-27 Icahn School Of Medicine At Mount Sinai Combined cancer therapy of b7-h3 and cd47 immune checkpoint inhbitior and methods of use
KR102757518B1 (ko) * 2020-12-07 2025-01-21 (주)이노베이션바이오 Cd47에 특이적인 항체 및 이의 용도
US20240076412A1 (en) * 2021-01-05 2024-03-07 National Institute Of Biological Sciences, Beijing A bispecific antibody targeting gpc3 and cd47
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
CA3219221A1 (en) * 2021-05-07 2022-11-10 Immuneoncia Therapeutics, Inc. Bispecific antibody specifically binding to cd47 and pd-l1
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
EP4359415A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271650A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
US11932634B2 (en) 2021-06-23 2024-03-19 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
CN117881698A (zh) * 2021-06-30 2024-04-12 创新生物有限公司 对cd47具有特异性的人源化抗体及包含其的用于预防或治疗cd47相关疾病的药物组合物
AU2022375782B2 (en) 2021-10-28 2026-02-26 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
AU2022376954B2 (en) 2021-10-29 2026-04-23 Gilead Sciences, Inc. Cd73 compounds
KR102438419B1 (ko) * 2021-12-01 2022-09-01 메디포스트(주) Cd47 과발현 중간엽 줄기세포를 포함하는 폐 질환 예방 또는 치료용 조성물
CA3237577A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
AU2022419982B2 (en) 2021-12-22 2026-04-16 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
EP4493554A1 (en) 2022-03-17 2025-01-22 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023183817A1 (en) 2022-03-24 2023-09-28 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
CR20240451A (es) 2022-04-21 2024-12-04 Gilead Sciences Inc Compuestos de modulación de kras g12d
PE20250758A1 (es) 2022-07-01 2025-03-13 Gilead Sciences Inc Compuestos de cd73
KR20250036855A (ko) 2022-07-12 2025-03-14 길리애드 사이언시즈, 인코포레이티드 Hiv 면역원성 폴리펩타이드 및 백신, 및 이들의 용도
WO2024064668A1 (en) 2022-09-21 2024-03-28 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY
CN120225509A (zh) 2022-12-22 2025-06-27 吉利德科学公司 Prmt5抑制剂及其用途
AU2024252725A1 (en) 2023-04-11 2025-11-06 Gilead Sciences, Inc. Kras modulating compounds
PE20260121A1 (es) 2023-04-21 2026-01-16 Gilead Sciences Inc Inhibidores de prmt5 y usos de los mismos
AU2024306338A1 (en) 2023-06-30 2026-01-08 Gilead Sciences, Inc. Kras modulating compounds
WO2025024811A1 (en) 2023-07-26 2025-01-30 Gilead Sciences, Inc. Parp7 inhibitors
KR20260046403A (ko) 2023-07-26 2026-04-07 길리애드 사이언시즈, 인코포레이티드 Parp7 저해제
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025245003A1 (en) 2024-05-21 2025-11-27 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025244201A1 (ko) * 2024-05-22 2025-11-27 주식회사 이뮨온시아 항-cd47 항체를 이용한 진행성 또는 전이성 고형암의 치료 방법
WO2026039365A1 (en) 2024-08-12 2026-02-19 Gilead Sciences, Inc. Kras modulating compounds
WO2026089992A1 (en) 2024-10-21 2026-04-30 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138496B2 (en) * 2002-02-08 2006-11-21 Genetastix Corporation Human monoclonal antibodies against human CXCR4
EP2111869A1 (en) * 2008-04-23 2009-10-28 Stichting Sanquin Bloedvoorziening Compositions and methods to enhance the immune system
EP4349868A3 (en) * 2010-05-14 2024-08-28 The Board of Trustees of the Leland Stanford Junior University Humanized and chimeric monoclonal antibodies to cd47
EA034778B1 (ru) * 2012-02-06 2020-03-19 Инхибркс, Инк. Антитела к cd47 и способы их применения
PL2900694T3 (pl) * 2012-09-27 2018-12-31 Merus N.V. Dwuswoiste przeciwciała igg jako aktywatory komórek t
EP4706769A2 (en) * 2012-12-03 2026-03-11 NovImmune SA Anti-cd47 antibodies and methods of use thereof
RU2015122228A (ru) * 2012-12-12 2017-01-19 Васкулокс Инк. Терапевтические антитела к CD47
JP2016507555A (ja) * 2013-02-06 2016-03-10 インヒブルクス エルピー 血小板非減少性かつ赤血球非減少性cd47抗体及びその使用方法

Similar Documents

Publication Publication Date Title
JP2021054859A5 (enExample)
JP2018510865A5 (enExample)
JP2018510151A5 (enExample)
JP2018508509A5 (enExample)
JP2017176174A5 (enExample)
JP2012116856A5 (enExample)
JP2014509837A5 (enExample)
JP2018193386A5 (enExample)
CN113316591A (zh) Cd73抗体及其制备方法和应用
JP2019513118A5 (enExample)
JP2014205674A5 (enExample)
WO2016207304A8 (en) Monoclonal anti-il-1racp antibodies
JP2022553324A5 (enExample)
JP2012176953A5 (enExample)
JP2017114866A5 (enExample)
FI3683235T3 (fi) Anti-IL-33-vasta-aineita ja niiden käyttöjä
RU2017132160A (ru) Антитела к pd-l1 и их применение для усиления функции t-клеток
JP2012254092A5 (enExample)
JP2009521474A5 (enExample)
JP2017048240A5 (enExample)
JP2011511773A5 (enExample)
JP2018504105A5 (enExample)
JP2013235610A5 (enExample)
JP2010506596A5 (enExample)
JP2016512223A5 (enExample)