MX385673B - Productos terapeuticos de anticuerpos que se enlazan a cd47. - Google Patents

Productos terapeuticos de anticuerpos que se enlazan a cd47.

Info

Publication number
MX385673B
MX385673B MX2017011329A MX2017011329A MX385673B MX 385673 B MX385673 B MX 385673B MX 2017011329 A MX2017011329 A MX 2017011329A MX 2017011329 A MX2017011329 A MX 2017011329A MX 385673 B MX385673 B MX 385673B
Authority
MX
Mexico
Prior art keywords
antibodies
derivatives
polypeptides
methods
fragments
Prior art date
Application number
MX2017011329A
Other languages
English (en)
Other versions
MX2017011329A (es
Inventor
Barbara A Swanson
Heyue Zhou
John Dixon Gray
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of MX2017011329A publication Critical patent/MX2017011329A/es
Publication of MX385673B publication Critical patent/MX385673B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a composiciones y métodos en relación con, o derivados a partir de, los anticuerpos anti-CD47. De una manera más específica, se dan a conocer anticuerpos completamente humanos que se enlazan a CD47, fragmentos que se enlazan a los anticuerpos de CD47 y los derivados de estos anticuerpos, y polipéptidos que se enlazan a CD47 que comprenden estos fragmentos. Todavía además, se dan a conocer ácidos nucleicos que codifican estos anticuerpos, fragmentos de anticuerpos, y los derivados y polipéptidos, las células que comprenden esos polinucleótidos, los métodos para la elaboración de estos anticuerpos, fragmentos de anticuerpos, y los derivados y polipéptidos, y los métodos para utilizar estos anticuerpos, fragmentos de anticuerpos, y los derivados y polipéptidos, incluyendo los métodos para el tratamiento de una enfermedad.
MX2017011329A 2015-03-04 2016-03-04 Productos terapeuticos de anticuerpos que se enlazan a cd47. MX385673B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562128462P 2015-03-04 2015-03-04
PCT/US2016/020980 WO2016141328A2 (en) 2015-03-04 2016-03-04 Antibody therapeutics that bind cd47

Publications (2)

Publication Number Publication Date
MX2017011329A MX2017011329A (es) 2018-06-06
MX385673B true MX385673B (es) 2025-03-04

Family

ID=56848772

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017011329A MX385673B (es) 2015-03-04 2016-03-04 Productos terapeuticos de anticuerpos que se enlazan a cd47.

Country Status (11)

Country Link
US (1) US10035855B2 (es)
EP (1) EP3265125A4 (es)
JP (5) JP6643350B2 (es)
KR (2) KR102625835B1 (es)
CN (2) CN107921121B (es)
AR (1) AR103868A1 (es)
AU (2) AU2016225993B2 (es)
IL (2) IL287958B2 (es)
MX (1) MX385673B (es)
TW (3) TWI843184B (es)
WO (1) WO2016141328A2 (es)

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Also Published As

Publication number Publication date
TW202248215A (zh) 2022-12-16
EP3265125A4 (en) 2018-11-07
IL287958B1 (en) 2025-08-01
JP2021054859A (ja) 2021-04-08
US10035855B2 (en) 2018-07-31
AR103868A1 (es) 2017-06-07
IL254321B (en) 2021-12-01
TWI778518B (zh) 2022-09-21
JP2020023532A (ja) 2020-02-13
TWI719966B (zh) 2021-03-01
CA2978594A1 (en) 2016-09-09
IL287958B2 (en) 2025-12-01
CN114380912B (zh) 2024-07-23
TWI843184B (zh) 2024-05-21
CN107921121A (zh) 2018-04-17
MX2017011329A (es) 2018-06-06
KR102850868B1 (ko) 2025-08-28
AU2016225993B2 (en) 2020-09-24
EP3265125A2 (en) 2018-01-10
IL287958A (en) 2022-01-01
CN107921121B (zh) 2022-02-08
JP6643350B2 (ja) 2020-02-12
JP2018510147A (ja) 2018-04-12
IL254321A0 (en) 2017-11-30
JP2021121635A (ja) 2021-08-26
WO2016141328A3 (en) 2016-10-27
AU2020294159A1 (en) 2021-01-28
KR20180006369A (ko) 2018-01-17
TW201639889A (zh) 2016-11-16
US20160257751A1 (en) 2016-09-08
TW202120555A (zh) 2021-06-01
KR102625835B1 (ko) 2024-01-17
JP2021054858A (ja) 2021-04-08
AU2016225993A1 (en) 2017-09-28
CN114380912A (zh) 2022-04-22
WO2016141328A2 (en) 2016-09-09
KR20240007967A (ko) 2024-01-17
JP7105938B2 (ja) 2022-07-25
JP7137646B2 (ja) 2022-09-14
AU2020294159B2 (en) 2024-05-02

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