JP6643350B2 - Ｃｄ４７に結合する抗体医薬 - Google Patents

Ｃｄ４７に結合する抗体医薬 Download PDF

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JP6643350B2
JP6643350B2 JP2017546200A JP2017546200A JP6643350B2 JP 6643350 B2 JP6643350 B2 JP 6643350B2 JP 2017546200 A JP2017546200 A JP 2017546200A JP 2017546200 A JP2017546200 A JP 2017546200A JP 6643350 B2 JP6643350 B2 JP 6643350B2
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antibody
chain variable
antigen
variable domain
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JP2018510147A5 (enExample
JP2018510147A (ja
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スワンソン，バーバラ・エイ
グレイ，ジョン・ディクソン
チョウ，ホーユエ
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Sorrento Therapeutics Inc
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Sorrento Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017546200A 2015-03-04 2016-03-04 Ｃｄ４７に結合する抗体医薬 Active JP6643350B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562128462P 2015-03-04 2015-03-04
US62/128,462 2015-03-04
PCT/US2016/020980 WO2016141328A2 (en) 2015-03-04 2016-03-04 Antibody therapeutics that bind cd47

Related Child Applications (1)

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JP2019186564A Division JP2020023532A (ja) 2015-03-04 2019-10-10 Ｃｄ４７に結合する抗体医薬

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JP2018510147A JP2018510147A (ja) 2018-04-12
JP2018510147A5 JP2018510147A5 (enExample) 2019-04-04
JP6643350B2 true JP6643350B2 (ja) 2020-02-12

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JP2017546200A Active JP6643350B2 (ja) 2015-03-04 2016-03-04 Ｃｄ４７に結合する抗体医薬
JP2019186564A Withdrawn JP2020023532A (ja) 2015-03-04 2019-10-10 Ｃｄ４７に結合する抗体医薬
JP2021000870A Active JP7137646B2 (ja) 2015-03-04 2021-01-06 Ｃｄ４７に結合する抗体医薬
JP2021000869A Active JP7105938B2 (ja) 2015-03-04 2021-01-06 Ｃｄ４７に結合する抗体医薬
JP2021089081A Withdrawn JP2021121635A (ja) 2015-03-04 2021-05-27 Ｃｄ４７に結合する抗体医薬

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JP2021000870A Active JP7137646B2 (ja) 2015-03-04 2021-01-06 Ｃｄ４７に結合する抗体医薬
JP2021000869A Active JP7105938B2 (ja) 2015-03-04 2021-01-06 Ｃｄ４７に結合する抗体医薬
JP2021089081A Withdrawn JP2021121635A (ja) 2015-03-04 2021-05-27 Ｃｄ４７に結合する抗体医薬

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US (1) US10035855B2 (enExample)
EP (1) EP3265125A4 (enExample)
JP (5) JP6643350B2 (enExample)
KR (2) KR102850868B1 (enExample)
CN (2) CN107921121B (enExample)
AR (1) AR103868A1 (enExample)
AU (2) AU2016225993B2 (enExample)
IL (2) IL287958B2 (enExample)
MX (1) MX385673B (enExample)
TW (3) TWI843184B (enExample)
WO (1) WO2016141328A2 (enExample)

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CN114380912A (zh) 2022-04-22
CN107921121B (zh) 2022-02-08
TWI719966B (zh) 2021-03-01
JP2020023532A (ja) 2020-02-13
CN114380912B (zh) 2024-07-23
IL254321B (en) 2021-12-01
AU2016225993B2 (en) 2020-09-24
MX2017011329A (es) 2018-06-06
JP7137646B2 (ja) 2022-09-14
TW202248215A (zh) 2022-12-16
US10035855B2 (en) 2018-07-31
KR102850868B1 (ko) 2025-08-28
MX385673B (es) 2025-03-04
KR20180006369A (ko) 2018-01-17
TW201639889A (zh) 2016-11-16
CN107921121A (zh) 2018-04-17
IL287958A (en) 2022-01-01
AU2020294159A1 (en) 2021-01-28
EP3265125A2 (en) 2018-01-10
KR102625835B1 (ko) 2024-01-17
IL287958B1 (en) 2025-08-01
TWI843184B (zh) 2024-05-21
WO2016141328A2 (en) 2016-09-09
KR20240007967A (ko) 2024-01-17
JP7105938B2 (ja) 2022-07-25
IL287958B2 (en) 2025-12-01
IL254321A0 (en) 2017-11-30
TW202120555A (zh) 2021-06-01
TWI778518B (zh) 2022-09-21
AU2016225993A1 (en) 2017-09-28
JP2021121635A (ja) 2021-08-26
CA2978594A1 (en) 2016-09-09
AU2020294159B2 (en) 2024-05-02
AR103868A1 (es) 2017-06-07
US20160257751A1 (en) 2016-09-08
JP2021054858A (ja) 2021-04-08
JP2021054859A (ja) 2021-04-08
WO2016141328A3 (en) 2016-10-27
JP2018510147A (ja) 2018-04-12
EP3265125A4 (en) 2018-11-07

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