JP2018510865A5 - - Google Patents
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- Publication number
- JP2018510865A5 JP2018510865A5 JP2017547497A JP2017547497A JP2018510865A5 JP 2018510865 A5 JP2018510865 A5 JP 2018510865A5 JP 2017547497 A JP2017547497 A JP 2017547497A JP 2017547497 A JP2017547497 A JP 2017547497A JP 2018510865 A5 JP2018510865 A5 JP 2018510865A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cancer
- fully human
- seq
- psma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010024305 Leukaemia monocytic Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000006894 monocytic leukemia Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000003757 neuroblast Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131227P | 2015-03-10 | 2015-03-10 | |
| US62/131,227 | 2015-03-10 | ||
| PCT/US2016/021672 WO2016145139A1 (en) | 2015-03-10 | 2016-03-10 | Antibody therapeutics that bind psma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510865A JP2018510865A (ja) | 2018-04-19 |
| JP2018510865A5 true JP2018510865A5 (enExample) | 2019-04-11 |
Family
ID=56879307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547497A Pending JP2018510865A (ja) | 2015-03-10 | 2016-03-10 | Ｐｓｍａに結合する抗体医薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10100126B2 (enExample) |
| EP (1) | EP3268039B1 (enExample) |
| JP (1) | JP2018510865A (enExample) |
| KR (1) | KR20180012740A (enExample) |
| CN (1) | CN108025063A (enExample) |
| AR (1) | AR104484A1 (enExample) |
| AU (1) | AU2016229087A1 (enExample) |
| CA (1) | CA2979219A1 (enExample) |
| IL (1) | IL254310A0 (enExample) |
| MX (1) | MX2017011600A (enExample) |
| TW (1) | TW201639891A (enExample) |
| WO (1) | WO2016145139A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019008538A (es) | 2017-01-20 | 2019-11-05 | Juno Therapeutics Gmbh | Conjugados de superficie celular y composiciones y métodos celulares relacionados. |
| US11614448B2 (en) | 2017-03-30 | 2023-03-28 | Ecs-Progastrin Sa | Compositions and methods for detecting prostate cancer |
| JP7284707B2 (ja) | 2017-04-07 | 2023-05-31 | ジュノー セラピューティクス インコーポレイテッド | 前立腺特異的膜抗原（ｐｓｍａ）またはその改変型を発現する操作された細胞および関連方法 |
| KR20210046725A (ko) | 2018-08-20 | 2021-04-28 | 1글로브 바이오메디칼 씨오., 엘티디. | 신규 암 면역요법 항체 조성물 |
| MX2022008381A (es) * | 2020-01-06 | 2022-08-08 | Cytomx Therapeutics Inc | Compuestos relacionados con auristatina, compuestos conjugados de auristatina y metodos de uso de ellos. |
| CN111303288B (zh) * | 2020-03-04 | 2020-12-25 | 和铂医药(苏州)有限公司 | 一种分离的结合抗原psma的蛋白及其用途 |
| JP2023532807A (ja) | 2020-07-08 | 2023-07-31 | ラヴァ・セラピューティクス・エヌ・ヴイ | Ｐｓｍａ及びガンマ－デルタｔ細胞受容体に結合する抗体 |
| CN112480260B (zh) * | 2020-12-09 | 2022-03-08 | 福州迈新生物技术开发有限公司 | 抗psma蛋白单克隆抗体、细胞系及其制备方法和应用 |
| AU2024233625A1 (en) | 2023-03-03 | 2025-09-18 | Arsenal Biosciences, Inc. | Systems targeting psma and ca9 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6010902A (en) | 1988-04-04 | 2000-01-04 | Bristol-Meyers Squibb Company | Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity |
| US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
| DE4118120A1 (de) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| DE19728697C1 (de) * | 1997-07-04 | 1999-03-25 | Deutsches Krebsforsch | Humaner Antikörper gegen ein Fusions(poly)peptid bzw. -protein, das einen Anteil von mindestens sechs Histidinen aufweist |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
| US6938003B2 (en) | 2000-06-30 | 2005-08-30 | Mahesh Harpale | Method and apparatus for a credibility reporting system to augment an online exchange |
| GB0025144D0 (en) | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
| CA2474616A1 (en) * | 2002-01-28 | 2003-08-07 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (psma) |
| US20040202995A1 (en) | 2003-04-09 | 2004-10-14 | Domantis | Nucleic acids, proteins, and screening methods |
| DK1851250T3 (da) * | 2005-02-18 | 2012-07-09 | Medarex Inc | Humant monoklonalt antistof mod prostataspecifikt membranantigen (psma) |
| JP5249587B2 (ja) * | 2005-02-18 | 2013-07-31 | メダレックス， インク． | フコシル残基を欠く前立腺特異的膜抗原（ｐｓｍａ）に対するモノクローナル抗体 |
| TW200813091A (en) * | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
| JOP20080381B1 (ar) * | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| WO2009127046A1 (en) * | 2008-04-14 | 2009-10-22 | Proscan Rx Pharma Inc. | Prostate specific membrane antigen antibodies and antigen binding fragments |
| CA2742968C (en) * | 2008-11-07 | 2020-06-09 | Fabrus Llc | Combinatorial antibody libraries and uses thereof |
| WO2010118522A1 (en) * | 2009-04-14 | 2010-10-21 | Proscan Rx Pharma Inc. | Antibodies against prostate specific membrane antigen |
| CA2780221A1 (en) * | 2009-11-04 | 2011-05-12 | Fabrus Llc | Methods for affinity maturation-based antibody optimization |
| CN103333249A (zh) * | 2013-06-14 | 2013-10-02 | 广州康合生物科技有限公司 | 一种抗前列腺特异性膜抗原（psma）的单克隆抗体及其应用 |
| RU2577228C2 (ru) * | 2014-03-14 | 2016-03-10 | Закрытое Акционерное Общество "Биокад" | Анти-il-17-антитела, способ их получения и способ применения |
-
2016
- 2016-03-10 US US15/066,806 patent/US10100126B2/en active Active
- 2016-03-10 JP JP2017547497A patent/JP2018510865A/ja active Pending
- 2016-03-10 AR ARP160100637A patent/AR104484A1/es unknown
- 2016-03-10 CN CN201680025173.6A patent/CN108025063A/zh active Pending
- 2016-03-10 KR KR1020177028573A patent/KR20180012740A/ko not_active Withdrawn
- 2016-03-10 AU AU2016229087A patent/AU2016229087A1/en not_active Abandoned
- 2016-03-10 CA CA2979219A patent/CA2979219A1/en not_active Abandoned
- 2016-03-10 TW TW105107403A patent/TW201639891A/zh unknown
- 2016-03-10 EP EP16762476.6A patent/EP3268039B1/en active Active
- 2016-03-10 MX MX2017011600A patent/MX2017011600A/es unknown
- 2016-03-10 WO PCT/US2016/021672 patent/WO2016145139A1/en not_active Ceased
-
2017
- 2017-09-04 IL IL254310A patent/IL254310A0/en unknown
-
2018
- 2018-09-21 US US16/138,944 patent/US20190010250A1/en not_active Abandoned
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