JP2018510143A5 - - Google Patents

Download PDF

Info

Publication number
JP2018510143A5
JP2018510143A5 JP2017544930A JP2017544930A JP2018510143A5 JP 2018510143 A5 JP2018510143 A5 JP 2018510143A5 JP 2017544930 A JP2017544930 A JP 2017544930A JP 2017544930 A JP2017544930 A JP 2017544930A JP 2018510143 A5 JP2018510143 A5 JP 2018510143A5
Authority
JP
Japan
Prior art keywords
tumor
pharmaceutical composition
mva
composition according
inactivated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017544930A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018510143A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/019663 external-priority patent/WO2016144564A2/en
Publication of JP2018510143A publication Critical patent/JP2018510143A/ja
Publication of JP2018510143A5 publication Critical patent/JP2018510143A5/ja
Pending legal-status Critical Current

Links

JP2017544930A 2015-02-25 2016-02-25 不活化非複製改変ワクシニアウイルスアンカラ（ｍｖａ）の固形腫瘍のための単独療法又は免疫チェックポイント遮断剤併用における使用 Pending JP2018510143A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562120862P 2015-02-25 2015-02-25
US62/120,862 2015-02-25
PCT/US2016/019663 WO2016144564A2 (en) 2015-02-25 2016-02-25 Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors

Publications (2)

Publication Number Publication Date
JP2018510143A JP2018510143A (ja) 2018-04-12
JP2018510143A5 true JP2018510143A5 (https=) 2019-04-04

Family

ID=56879727

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017544930A Pending JP2018510143A (ja) 2015-02-25 2016-02-25 不活化非複製改変ワクシニアウイルスアンカラ（ｍｖａ）の固形腫瘍のための単独療法又は免疫チェックポイント遮断剤併用における使用

Country Status (9)

Country Link
US (2) US10639366B2 (https=)
EP (2) EP3261669B1 (https=)
JP (1) JP2018510143A (https=)
KR (1) KR20170138996A (https=)
CN (2) CN115300622A (https=)
AU (1) AU2016229408A1 (https=)
BR (1) BR112017018160A2 (https=)
CA (1) CA2977660A1 (https=)
WO (1) WO2016144564A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115300622A (zh) 2015-02-25 2022-11-08 纪念斯隆-凯特琳癌症中心 使用灭活的修饰的痘苗病毒安卡拉作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂组合
CN107847534B (zh) 2015-04-17 2022-10-04 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
IL261321B2 (en) 2016-02-25 2023-12-01 Memorial Sloan Kettering Cancer Center Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors
KR20180133395A (ko) 2016-02-25 2018-12-14 메모리얼 슬로안 케터링 캔서 센터 암 면역요법을 위한, 인간 flt3l 또는 gm-csf의 발현이 있거나 없으며 티미딘 키나제가 결실된 복제 가능 약독화 백시니아 바이러스
EP4286009A3 (en) * 2017-04-21 2024-04-03 Sillajen, Inc. Oncolytic vaccinia virus and checkpoint inhibitor combination therapy
WO2018209315A1 (en) * 2017-05-12 2018-11-15 Memorial Sloan Kettering Cancer Center Vaccinia virus mutants useful for cancer immunotherapy
EP3703723A4 (en) 2017-10-31 2021-12-15 KaliVir Immunotherapeutics, Inc. ONCOLYTIC PLATFORM VECTOR FOR SYSTEMS ADMINISTRATION
US20210177964A1 (en) * 2017-11-06 2021-06-17 Memorial Sloan Kettering Cancer Center Heat-inactivated vaccinia virus as a vaccine immune adjuvant
CA3093696A1 (en) * 2018-03-13 2019-09-19 Memorial Sloan Kettering Cancer Center Oncolytic vaccinia virus expressing immune checkpoint blockade for cancer immunotherapy
WO2019202401A2 (en) * 2018-04-20 2019-10-24 The University Of Hong Kong Immuno-oncolytic modified vaccinia tian tan virus and methods of treating cancer
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
AU2019336940B2 (en) * 2018-09-06 2025-09-11 Bavarian Nordic A/S Storage improved poxvirus compositions
MX2021003013A (es) 2018-09-15 2021-08-11 Memorial Sloan Kettering Cancer Center Poxvirus recombinantes para inmunoterapia contra cáncer.
US20210196813A1 (en) * 2019-12-27 2021-07-01 Rush University Medical Center Utilizing Vaccines to Treat Cancer and Enhance the Success Rate of Cancer Immunotherapy
MX2022014110A (es) * 2020-05-15 2023-01-30 Immunesensor Therapeutics Inc Tratamientos combinados de agonistas de sting con inhibidores de puntos de control inmunitario.
US20240033342A1 (en) * 2020-08-17 2024-02-01 Nordic Science Group Aps Compositions for treating gastrointestinal adenocarcinomas by altering the tumor microenvironment
TW202227621A (zh) 2020-11-19 2022-07-16 美商凱立凡爾免疫治療股份有限公司 重塑腫瘤微環境的溶瘤免疫療法
JP2024505274A (ja) * 2021-02-02 2024-02-05 ゲオバックス インコーポレイテッド ワクチン接種中のｔ細胞プライミングの強化において使用されるウイルスコンストラクト

Family Cites Families (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
DE69233158T2 (de) 1991-03-07 2004-05-13 Connaught Technology Corp., Greenville Gentechnologisch hergestellter stamm für impfstoffe
ATE298370T1 (de) 1994-04-29 2005-07-15 Baxter Healthcare Sa Rekombinante poxviren mit fremdenpolynukleotiden in wichtigen regionen
US6093700A (en) 1995-05-11 2000-07-25 Thomas Jefferson University Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF
DE69519521T2 (de) 1994-10-03 2001-06-28 The Government Of The United States Of America, As Represented By The Secretary National Institute Of Health Zusammensetzung enthaltend ein antigen exprimierendes rekombinantes virus und ein immunstimulierendes molekül exprimierendes rekombinantes virus
US6004777A (en) 1997-03-12 1999-12-21 Virogenetics Corporation Vectors having enhanced expression, and methods of making and uses thereof
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
WO2000073487A1 (en) 1999-05-27 2000-12-07 Arizona Board Of Regents Novel viral vectors having enhanced effectiveness with dramatically reduced virulence
WO2000073479A1 (en) 1999-05-28 2000-12-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
BR0015491A (pt) 1999-11-12 2002-10-15 Oncolytics Biotech Inc Métodos para tratar um distúrbio proliferativo celular mediado por ras em um mamìfero, para tratar um neoplasma tendo uma via-ras ativada em um humano, para inibir metástase de um neoplasma tendo uma via-ras ativada em um mamìfero, e para tratar um neoplasma suspeito de ter uma via-ras ativada em um mamìfero, composição farmacêutica, kit, e, método para tratar uma população de células compreendendo um neoplasma suspeito de ter uma via-ras ativada in vitro
DK1263936T3 (da) * 2000-03-14 2006-02-13 Bavarian Nordic As andret stamme af den modificerede Vacciniavirus Ankara (MVA)
US7306902B2 (en) 2002-06-28 2007-12-11 Oncolyties Biotech Inc. Oncolytic viruses as phenotyping agents for neoplasms
MXPA03004298A (es) 2000-11-20 2004-02-12 Oncolytics Biotech Inc Metodo para transmitir optimamente virus a masa de tumor solido.
UA76731C2 (uk) 2000-11-23 2006-09-15 Баваріан Нордік А/С Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації
US6372455B1 (en) 2001-04-19 2002-04-16 Arizona Board Of Regents Recombinant vaccinia viral vectors
US6750043B2 (en) 2001-04-19 2004-06-15 Arizona Board Of Regents Viral vectors having reduced virulence
US20040091995A1 (en) 2001-06-15 2004-05-13 Jeffrey Schlom Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
US20030113919A1 (en) 2001-08-17 2003-06-19 Aventis Pasteur, Ltd. Immunogenic targets for melanoma
DE10144664B4 (de) 2001-09-11 2005-06-09 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Vacciniavirus MVA-E3L-Knock-Out-Mutanten und Verwendung hiervon
US7001718B2 (en) 2001-12-20 2006-02-21 Massachusetts Institute Of Technology Method of inhibiting pathogenicity of infectious agents
CN100540051C (zh) * 2002-04-19 2009-09-16 巴法里安诺迪克有限公司 用于接种新生儿的改良的安卡拉痘苗病毒
US20070178065A1 (en) 2002-05-03 2007-08-02 Lattime Edmund C Neutralizing factors as vaccine adjuvants
DE10221411B4 (de) 2002-05-14 2004-07-08 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Rekombinantes Fowlpox-Virus
ATE315660T1 (de) 2002-05-16 2006-02-15 Bavarian Nordic As Intergene regionen als insertionsstellen im genom von modifiziertem vaccinia virus ankara (mva)
WO2004042001A2 (en) 2002-05-17 2004-05-21 Emory University Virus-like particles, methods of preparation, and immonogenic compositions
JP2004031674A (ja) 2002-06-26 2004-01-29 Disco Abrasive Syst Ltd コンタミネーション除去装置
AU2003249059A1 (en) 2002-07-24 2004-02-09 Arizona Board Of Regents Use of vaccinia virus deleted for the e3l gene as a vaccine vector
AU2003267361A1 (en) 2002-09-12 2004-04-30 Gsf-Forschungszentrum Fur Umwelt Und Gesundheit Gmbh Orthopoxvirus antigens and use thereof
CA2511625A1 (en) * 2002-12-23 2004-07-15 City Of Hope Modified vaccinia ankara expressing p53 in cancer immunotherapy
WO2004087047A2 (en) 2003-02-07 2004-10-14 Arizona Board Of Regents Mutants of replication competent vaccinia virus
ATE420160T1 (de) 2003-06-18 2009-01-15 Genelux Corp Modifizierte rekombinante vacciniaviren, verwendungen davon
WO2005007824A2 (en) 2003-07-08 2005-01-27 Arizona Board Of Regents Mutants of vaccinia virus as oncolytic agents
CA2435967A1 (en) 2003-07-25 2005-01-25 Oncolytics Biotech, Inc. Reovirus for the treatment of lymphoid malignancies
CA2436196A1 (en) 2003-07-25 2005-01-25 Oncolytics Biotech Inc. Oncolytic virus for purging cellular compositions of cells of lymphoid malignancies
WO2005028634A2 (en) 2003-09-18 2005-03-31 Emory University Improved mva vaccines
EP1518932A1 (en) 2003-09-29 2005-03-30 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Modified vaccinia virus Ankara (MVA) mutant and use thereof
EP1786474B1 (en) 2004-08-12 2011-06-01 Cedars-Sinai Medical Center Combined gene therapy for the treatment of macroscopic gliomas
EP1683870A1 (en) 2005-01-24 2006-07-26 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Vaccines based on the use of MVA
WO2006120474A2 (en) 2005-05-13 2006-11-16 Oxxon Therapeutics Ltd Compositions for inducing an immune response against tumor antigens
ES2281252B1 (es) 2005-07-27 2009-02-16 Consejo Superior De Investigaciones Cientificas Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida.
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
US20070077231A1 (en) 2005-09-30 2007-04-05 Contag Christopher H Immune effector cells pre-infected with oncolytic virus
EP1989224B1 (en) 2006-02-24 2010-10-20 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Immunogenic peptides and methods of use
KR100788930B1 (ko) 2006-04-18 2007-12-27 포항공과대학교 산학협력단 항암 조성물
DK2596801T3 (en) 2006-10-06 2018-08-13 Bavarian Nordic As RECOMBINANT MODIFIED VACCINIA ANKARA VIRUS CODING A HER-2 ANTIGEN FOR USING CANCER TREATMENT
EP2097517B1 (en) 2006-10-16 2014-06-04 Genelux Corporation Recombinant Lister strain vaccinia virus encoding an anti-VEGF single chain antibody
WO2008108890A2 (en) 2006-10-18 2008-09-12 University Of Rochester Conditionally replicating viruses for cancer therapy
KR20080084528A (ko) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
CA2690627C (en) 2007-06-15 2014-12-02 Genelux Corporation Microorganisms for imaging and/or treatment of tumors
JP2010533718A (ja) 2007-07-18 2010-10-28 ジェネラックス・コーポレイション 腫瘍溶解性ウイルス治療に付随する副作用の処置もしくは改善用医薬の製造における化学治療剤の使用
AU2008312444B2 (en) 2007-10-18 2014-02-06 Bavarian Nordic A/S Use of MVA to treat prostate cancer
JP2011500608A (ja) 2007-10-22 2011-01-06 オンコリティクス バイオテク，インコーポレーテッド 増殖性障害の治療レジメン
RU2503717C2 (ru) 2007-11-19 2014-01-10 Трансжене Са Поксвирусные онколитические векторы
HRP20150360T1 (hr) 2007-11-19 2015-05-08 Transgene Sa Poksvirusni onkolitiäśki vektori
US20120052003A9 (en) 2008-05-16 2012-03-01 Szalay Aladar A Microorganisms for preventing and treating neoplasms accompanying cellular therapy
WO2009152179A1 (en) 2008-06-09 2009-12-17 Arizona Board Of Regents Compositions, methods, and kits for eliciting an immune response
EP2349296B1 (en) 2008-08-21 2017-04-05 Ottawa Hospital Research Institute Engineered synergistic oncolytic viral symbiosis
EP2424999A1 (en) 2009-04-30 2012-03-07 Centre Hospitalier Universitaire Vaudois Lausanne (CHUV) Modified immunization vectors
CA2709292A1 (en) 2009-07-10 2011-01-10 The Governors Of The University Of Alberta Oncolytic viruses and methods for treating neoplastic disorders
ES2848650T3 (es) 2009-09-14 2021-08-11 Sillajen Biotherapeutics Inc Terapia combinada contra el cáncer con virus vaccinia oncolítico
GB201006405D0 (en) 2010-04-16 2010-06-02 Isis Innovation Poxvirus expression system
WO2011156470A1 (en) 2010-06-08 2011-12-15 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University A method for inserting genetic material into genomic dna
US20130230884A1 (en) 2010-07-16 2013-09-05 John Chaput Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation
JP2013538577A (ja) 2010-09-23 2013-10-17 バクスター・インターナショナル・インコーポレイテッド 組み換えウイルスベクターおよび黄熱病ウイルスに対する免疫反応を惹起するための方法
AU2012204467B2 (en) 2011-01-04 2016-08-18 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
ES2733211T3 (es) 2011-04-15 2019-11-28 Genelux Corp Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas
FI20115914L (fi) 2011-09-16 2013-03-17 Oncos Therapeutics Ltd Muunnettu onkolyyttinen virus
WO2013052915A2 (en) 2011-10-05 2013-04-11 Genelux Corporation Method for detecting replication or colonization of a biological therapeutic
WO2013063348A1 (en) 2011-10-28 2013-05-02 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Genetic element that enhances protein translation
US20140087362A1 (en) 2012-03-16 2014-03-27 Aladar A. Szalay Methods for assessing effectiveness and monitoring oncolytic virus treatment
WO2014031693A1 (en) 2012-08-20 2014-02-27 Genelux Corporation Compositions containing protein polymers and vaccinia virus, and methods of use thereof
KR20210008155A (ko) 2012-08-30 2021-01-20 암젠 인크 단순 헤르페스 바이러스 및 면역 체크포인트 억제제를 사용한 흑색종의 치료방법
WO2014037124A1 (en) 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
US20150250837A1 (en) 2012-09-20 2015-09-10 Morningside Technology Ventures Ltd. Oncolytic virus encoding pd-1 binding agents and uses of the same
TWI690322B (zh) 2012-10-02 2020-04-11 法商傳斯堅公司 含病毒的調配物及其使用
EP2908851A1 (en) 2012-10-19 2015-08-26 Bavarian Nordic Inc. Methods and compositions for the treatment of cancer
US20180200320A1 (en) 2012-11-21 2018-07-19 Aviratek Biomedical Solutions, Llc Method and compositions for the use of botanical extracts in the treatment of viral infections, cancer, pain, itch, and inflammation
US20140193859A1 (en) 2013-01-08 2014-07-10 Bertram Jacobs Temperature-dependent insertion of genetic material into genomic DNA
US20140271549A1 (en) 2013-03-15 2014-09-18 Aladar A. Szalay Use of Antibiotics to Enhance Treatment With Therapeutic Viruses
WO2014193973A2 (en) 2013-05-28 2014-12-04 Dcb-Usa Llc Antibody locker for the inactivation of protein drug
GB201310917D0 (en) 2013-06-19 2013-07-31 Cancer Res Inst Royal Vaccinia virus for gene-directed enzyme prodrug therapy
RS65104B1 (sr) 2013-08-22 2024-02-29 Univ Pittsburgh Commonwealth Sys Higher Education Onkolitičke imunoterapije
WO2015066715A1 (en) 2013-11-04 2015-05-07 Viracell Advanced Products, Llc Virus-like particles and methods related thereto
AU2014347004B2 (en) 2013-11-05 2019-08-08 Bavarian Nordic A/S Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor
CN106061488B (zh) 2013-12-02 2021-04-09 菲奥医药公司 癌症的免疫治疗
KR20230076867A (ko) 2013-12-20 2023-05-31 더 브로드 인스티튜트, 인코퍼레이티드 신생항원 백신과의 병용 요법
US20170106065A1 (en) 2013-12-31 2017-04-20 Bavarian Nordic A/S Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist of TIM-3
WO2015138471A1 (en) 2014-03-10 2015-09-17 Arizona Board Of Regents On Behalf Of Arizona State University Heat inactivated poxvirus improves vaccination results
WO2015138741A1 (en) 2014-03-12 2015-09-17 Cars-N-Kids Llc Systems and methods for determining if a child safety seat is in a moving vehicle
GB201405834D0 (en) 2014-04-01 2014-05-14 Univ London Queen Mary Oncolytic virus
KR102499737B1 (ko) 2014-05-13 2023-02-13 버베리안 노딕 에이/에스 종양 항원을 발현하는 재조합 폭스바이러스 및 면역 체크포인트 분자 길항제 또는 효현제로 암을 치료하기 위한 복합 요법
ES2833425T3 (es) 2014-07-16 2021-06-15 Roussy Inst Gustave Combinación de virus oncolítico con moduladores de punto de control inmunitario
RU2696312C2 (ru) 2014-07-16 2019-08-01 Трансген Са Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек
EP3188752A2 (en) * 2014-09-03 2017-07-12 Bavarian Nordic A/S Recombinant modified vaccinia virus ankara (mva) filovirus vaccine
JP2017530114A (ja) 2014-09-26 2017-10-12 バヴァリアン・ノルディック・アクティーゼルスカブ フラジェリンをコードする組み換えｍｖａによる鼻腔内免疫のための方法と組成物
KR101645642B1 (ko) 2014-10-16 2016-08-11 대한민국 Kvac１０３ 유래의 재조합 백시니아 바이러스
EP4523756A3 (en) 2015-02-13 2025-05-28 Transgene Immunotherapeutic vaccine and antibody combination therapy
CN115300622A (zh) 2015-02-25 2022-11-08 纪念斯隆-凯特琳癌症中心 使用灭活的修饰的痘苗病毒安卡拉作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂组合
CN107847534B (zh) 2015-04-17 2022-10-04 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
US10967015B2 (en) 2015-06-15 2021-04-06 New York University Method of treatment using oncolytic viruses
JP6827467B2 (ja) 2015-06-19 2021-02-10 シルラジェン，インコーポレイテッド ウイルス塞栓術のための組成物および方法
CN105039269A (zh) 2015-07-24 2015-11-11 北京鼎成肽源生物技术有限公司 一种用于治疗非小细胞肺癌的新型病毒疫苗及其制备方法
EP4137150A1 (en) 2015-08-03 2023-02-22 The United States of America, as represented by the Secretary, Department of Health and Human Services Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use
WO2017043815A1 (en) 2015-09-08 2017-03-16 Sillajen, Inc. Modified oncolytic vaccinia viruses expressing a cytokine and a car- boxylesterase and methods of use thereof
EP3347473A4 (en) 2015-09-09 2019-04-10 Tvax Biomedical I, LLC METHOD FOR COMBINING ADOPTIVE T CELL THERAPY WITH ONCOLYTIC VIRUS ATTACHMENT THERAPY
US11266726B2 (en) 2015-10-30 2022-03-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for the treatment of HER2-expressing solid tumors
BR112018012180A2 (pt) 2015-12-17 2018-12-04 Psioxus Therapeutics Ltd vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr
ES2921605T3 (es) 2016-01-29 2022-08-30 Bavarian Nordic As Vacuna contra el virus de la encefalitis equina basada en el virus de la variolovacuna modificado Ankara (VMA) recombinante
IL261321B2 (en) 2016-02-25 2023-12-01 Memorial Sloan Kettering Cancer Center Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors
KR20180133395A (ko) 2016-02-25 2018-12-14 메모리얼 슬로안 케터링 캔서 센터 암 면역요법을 위한, 인간 flt3l 또는 gm-csf의 발현이 있거나 없으며 티미딘 키나제가 결실된 복제 가능 약독화 백시니아 바이러스
WO2017156349A1 (en) 2016-03-10 2017-09-14 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
WO2017205674A1 (en) 2016-05-25 2017-11-30 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic vaccinia virus mutants and using same for cancer treatment
WO2017209053A1 (ja) 2016-05-30 2017-12-07 アステラス製薬株式会社 新規な遺伝子組換えワクシニアウイルス
CA3070146A1 (en) 2016-07-19 2018-01-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic viruses targeting stat3
AU2017299983B2 (en) 2016-07-21 2021-01-07 Kolon Life Science, Inc. Recombinant vaccinia virus and use thereof
KR20230113832A (ko) 2016-08-09 2023-08-01 시티 오브 호프 키메라 폭스바이러스 조성물 및 이의 용도
WO2018049248A1 (en) 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus equipped with bispecific engager molecules
AU2017332367B2 (en) 2016-09-21 2021-12-23 Stephen H. Thorne High mobility group box i mutant
WO2018058258A1 (en) 2016-09-30 2018-04-05 University Health Network Recombinant oncolytic viruses for cancer therapy
MX2021003013A (es) 2018-09-15 2021-08-11 Memorial Sloan Kettering Cancer Center Poxvirus recombinantes para inmunoterapia contra cáncer.

Similar Documents

Publication Publication Date Title
JP2018510143A5 (https=)
Taefehshokr et al. Promising approaches in cancer immunotherapy
JP2018513165A5 (https=)
Capece et al. Targeting costimulatory molecules to improve antitumor immunity
JP6858558B2 (ja) 新生物疾患の処置、減少、阻害、又は制御において使用するための、免疫調節薬
Van der Jeught et al. Targeting the tumor microenvironment to enhance antitumor immune responses
JP2019506428A5 (https=)
FI3932951T3 (fi) Menetelmiä ihosyövän hoitamiseksi antamalla PD-1-inhibiittoria
Nelson et al. The “Trojan Horse” approach to tumor immunotherapy: targeting the tumor microenvironment
US20140271687A1 (en) Methods of Targeting T-Cells to Tumors
JP2019515008A5 (https=)
JP2016528195A5 (https=)
JP6892443B2 (ja) がん治療で使用するためのチェックポイント阻害剤及び全細胞マイコバクテリウム
KR20210149870A (ko) 비-소세포 폐암을 치료하기 위한 항-ｂ7-ｈ1 및 항-ｃｔｌａ-4 항체
JP2021518408A5 (https=)
JP7321489B2 (ja) がん免疫アジュバント
JP2022189827A (ja) 癌を治療するための免疫調節剤と組み合わせた低酸素活性化型プロドラッグの投与
Kotteas et al. Immunotherapy for pancreatic cancer
KR20240038991A (ko) 암을 치료하기 위한 체크포인트 저해제 및 종양용해 바이러스의 조합
Villarreal et al. Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity
Ray et al. Cancer immunology and CAR-T cells: A turning point therapeutic approach in colorectal carcinoma with clinical insight
Esin Clinical applications of immunotherapy combination methods and new opportunities for the future
Salkeni et al. Resistance to immunotherapy: mechanisms and means for overcoming
Hoesli et al. Immunotherapy for head and neck squamous cell carcinoma
Vishwakarma et al. Novel Immunotherapeutic Approaches for Cancer Therapy