JP2018509143A5 - - Google Patents

Info

Publication number

JP2018509143A5

JP2018509143A5 JP2017545273A JP2017545273A JP2018509143A5 JP 2018509143 A5 JP2018509143 A5 JP 2018509143A5 JP 2017545273 A JP2017545273 A JP 2017545273A JP 2017545273 A JP2017545273 A JP 2017545273A JP 2018509143 A5 JP2018509143 A5 JP 2018509143A5

Authority

JP

Japan

Prior art keywords

seq

formula

alkyl

compound

pharmaceutically acceptable

Prior art date

2016-02-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 19
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 18
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 18
• 150000003839 salts Chemical class 0.000 claims 10
• 229940113082 thymine Drugs 0.000 claims 9
• 229940035893 uracil Drugs 0.000 claims 9
• 230000008685 targeting Effects 0.000 claims 6
• -1 4-methoxytrityl Chemical group 0.000 claims 5
• 125000002252 acyl group Chemical group 0.000 claims 5
• 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 5
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 4
• 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 208000007345 glycogen storage disease Diseases 0.000 claims 2
• 125000005647 linker group Chemical group 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 1
• 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 1
• 125000003710 aryl alkyl group Chemical group 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1