JP2019525899A5 - - Google Patents
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- JP2019525899A5 JP2019525899A5 JP2018564979A JP2018564979A JP2019525899A5 JP 2019525899 A5 JP2019525899 A5 JP 2019525899A5 JP 2018564979 A JP2018564979 A JP 2018564979A JP 2018564979 A JP2018564979 A JP 2018564979A JP 2019525899 A5 JP2019525899 A5 JP 2019525899A5
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- 150000001875 compounds Chemical class 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000005911 diet Nutrition 0.000 claims 3
- 230000037213 diet Effects 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000010577 Niemann-Pick disease type C Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000033626 Renal failure acute Diseases 0.000 claims 1
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 1
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000001037 epileptic effect Effects 0.000 claims 1
- 238000002637 fluid replacement therapy Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 235000020887 ketogenic diet Nutrition 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021174538A JP7479337B2 (ja) | 2016-06-07 | 2021-10-26 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
| JP2023215845A JP2024028287A (ja) | 2016-06-07 | 2023-12-21 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662346975P | 2016-06-07 | 2016-06-07 | |
| US62/346,975 | 2016-06-07 | ||
| PCT/US2017/035826 WO2017213999A1 (en) | 2016-06-07 | 2017-06-02 | Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021174538A Division JP7479337B2 (ja) | 2016-06-07 | 2021-10-26 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525899A JP2019525899A (ja) | 2019-09-12 |
| JP2019525899A5 true JP2019525899A5 (enExample) | 2020-07-09 |
| JP7058610B2 JP7058610B2 (ja) | 2022-04-22 |
Family
ID=60578899
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564979A Active JP7058610B2 (ja) | 2016-06-07 | 2017-06-02 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
| JP2021174538A Active JP7479337B2 (ja) | 2016-06-07 | 2021-10-26 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
| JP2023215845A Withdrawn JP2024028287A (ja) | 2016-06-07 | 2023-12-21 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021174538A Active JP7479337B2 (ja) | 2016-06-07 | 2021-10-26 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
| JP2023215845A Withdrawn JP2024028287A (ja) | 2016-06-07 | 2023-12-21 | ベータ－ヒドロキシブチレート及びブタンジオールの中鎖脂肪酸エステル並びに組成物、並びにそれを使用するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10889538B2 (enExample) |
| EP (2) | EP4585270A3 (enExample) |
| JP (3) | JP7058610B2 (enExample) |
| KR (2) | KR102519244B1 (enExample) |
| CN (2) | CN109477993B (enExample) |
| AU (2) | AU2017278099B2 (enExample) |
| CA (1) | CA3026621A1 (enExample) |
| CO (1) | CO2018014167A2 (enExample) |
| IL (2) | IL263561B (enExample) |
| MX (2) | MX2021009806A (enExample) |
| RU (1) | RU2761829C2 (enExample) |
| SG (1) | SG11201810765PA (enExample) |
| WO (1) | WO2017213999A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2761829C2 (ru) | 2016-06-07 | 2021-12-13 | Зе Дж. Дэвид Глэдстоун Инститьютс | Образуемые среднецепочечными жирными кислотами сложные эфиры бета-гидроксибутирата и бутандиола и композиции и способы на их основе |
| WO2019018683A1 (en) | 2017-07-21 | 2019-01-24 | Buck Institute For Research On Aging | BETA-HYDROXYBUTYRATE AND BUTANEDIOL ENANTIOMERS AND METHODS OF USE THEREOF |
| US12037317B2 (en) | 2018-01-25 | 2024-07-16 | Buck Institute For Research On Aging | Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds |
| US20190248733A1 (en) * | 2018-02-14 | 2019-08-15 | Benjamin Bikman | Oral supplements of fatty acid and amino acid ketone esters to improve metabolic, physical and cognitive health |
| WO2020147981A1 (de) * | 2019-01-17 | 2020-07-23 | Ioi Oleo Gmbh | Verfahren zur herstellung von verkappten 3-hydroxycarbonsäuren sowie deren salzen und estern |
| EP3880642A1 (de) * | 2019-01-17 | 2021-09-22 | IOI Oleo GmbH | Verfahren zur herstellung von fettalkoholestern von hydroxycarbonsäuren |
| CN113574048B (zh) * | 2019-01-17 | 2024-06-18 | 凯托利皮克斯治疗有限责任公司 | 生产任选的酰化羟基羧酸的多元醇基酯的方法 |
| CN110372502A (zh) * | 2019-07-25 | 2019-10-25 | 润泰化学（泰兴）有限公司 | 一种1,3-二醇的双酯化合成方法 |
| GB201918657D0 (en) | 2019-12-17 | 2020-01-29 | Tdeltas Ltd | Compounds for new use |
| CN116113617A (zh) * | 2020-07-13 | 2023-05-12 | Ioi油脂化学品有限责任公司 | 氧代丁醇酯化的多元羧酸聚甘油酯的制备方法 |
| CN116917264A (zh) * | 2020-07-13 | 2023-10-20 | 凯托利皮克斯治疗有限责任公司 | 羟基丁酸羧酸酯的制备方法 |
| WO2022012766A1 (de) * | 2020-07-13 | 2022-01-20 | Ioi Oleo Gmbh | Verfahren zur herstellung von oxobutanol-estern von polymeren carbonsäuren |
| CN112341542B (zh) * | 2021-01-08 | 2021-05-14 | 清华大学 | 一种3-羟基丁酰化修饰蛋白质药物及其制备方法和应用 |
| BR112023014818A2 (pt) * | 2021-01-26 | 2023-10-03 | Buck Inst Res Aging | Uso de ésteres de cetona exógena para induzir perda de peso em mamíferos |
| US12059398B2 (en) * | 2022-08-26 | 2024-08-13 | Health Via Modern Nutrition Inc. | Compositions of 1,3-butanediol and beta-hydroxybutyric acid to provide optimal therapeutic ketosis |
| US20250009707A1 (en) | 2023-06-29 | 2025-01-09 | BOPZ Nutrition Ltd. | Methods of inducing ketosis in non-human mammals |
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| US4263216A (en) | 1978-10-20 | 1981-04-21 | The Procter & Gamble Company | Diglyceride manufacture |
| IL59407A (en) * | 1979-03-06 | 1983-12-30 | Sanofi Sa | Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them |
| US4436726A (en) | 1980-12-15 | 1984-03-13 | Fujisawa Pharmaceutical Co., Ltd. | N-Acylpeptide compound, processes for the preparation thereof and the pharmaceutical compositions |
| BE1001209A3 (fr) | 1987-11-19 | 1989-08-22 | Solvay | Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol. |
| US5126373A (en) | 1987-11-19 | 1992-06-30 | Henri Brunengraber | Composition for parenteral and oral nutrition |
| EP0556387B1 (en) | 1988-04-27 | 1995-08-09 | Daicel Chemical Industries, Ltd. | Process for preparing optically active 1,3-butanediol |
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| WO2019018683A1 (en) | 2017-07-21 | 2019-01-24 | Buck Institute For Research On Aging | BETA-HYDROXYBUTYRATE AND BUTANEDIOL ENANTIOMERS AND METHODS OF USE THEREOF |
| US12037317B2 (en) | 2018-01-25 | 2024-07-16 | Buck Institute For Research On Aging | Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds |
| US20190262415A1 (en) | 2018-02-26 | 2019-08-29 | Ketologie LLC | Supplement for inducing and sustaining nutritional ketosis |
-
2017
- 2017-06-02 RU RU2018143895A patent/RU2761829C2/ru active
- 2017-06-02 MX MX2021009806A patent/MX2021009806A/es unknown
- 2017-06-02 US US16/306,524 patent/US10889538B2/en active Active
- 2017-06-02 CN CN201780041428.2A patent/CN109477993B/zh active Active
- 2017-06-02 KR KR1020197000530A patent/KR102519244B1/ko active Active
- 2017-06-02 EP EP25179114.1A patent/EP4585270A3/en active Pending
- 2017-06-02 WO PCT/US2017/035826 patent/WO2017213999A1/en not_active Ceased
- 2017-06-02 AU AU2017278099A patent/AU2017278099B2/en active Active
- 2017-06-02 JP JP2018564979A patent/JP7058610B2/ja active Active
- 2017-06-02 CN CN202111675586.8A patent/CN114292190B/zh active Active
- 2017-06-02 KR KR1020227044586A patent/KR102638807B1/ko active Active
- 2017-06-02 MX MX2018015302A patent/MX385367B/es unknown
- 2017-06-02 EP EP17810768.6A patent/EP3465335A4/en active Pending
- 2017-06-02 CA CA3026621A patent/CA3026621A1/en active Pending
- 2017-06-02 SG SG11201810765PA patent/SG11201810765PA/en unknown
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2018
- 2018-12-06 IL IL263561A patent/IL263561B/en unknown
- 2018-12-26 CO CONC2018/0014167A patent/CO2018014167A2/es unknown
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2019
- 2019-07-29 US US16/525,437 patent/US10562839B2/en active Active
- 2019-07-31 US US16/528,524 patent/US10647658B2/en active Active
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2020
- 2020-12-02 US US17/110,236 patent/US11608308B2/en active Active
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2021
- 2021-06-07 AU AU2021203726A patent/AU2021203726C1/en active Active
- 2021-10-26 JP JP2021174538A patent/JP7479337B2/ja active Active
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2022
- 2022-03-24 IL IL291694A patent/IL291694A/en unknown
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2023
- 2023-12-21 JP JP2023215845A patent/JP2024028287A/ja not_active Withdrawn