CN114292190B - 丁二醇的中链脂肪酸酯，其组合物、口服制剂及其应用方法 - Google Patents

丁二醇的中链脂肪酸酯，其组合物、口服制剂及其应用方法 Download PDF

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CN114292190B
CN114292190B CN202111675586.8A CN202111675586A CN114292190B CN 114292190 B CN114292190 B CN 114292190B CN 202111675586 A CN202111675586 A CN 202111675586A CN 114292190 B CN114292190 B CN 114292190B
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oral formulation
composition
mice
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CN114292190A (zh
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E·维丁
S·乌尔里希
J·纽曼
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J David Gladstone Institutes
University of California San Diego UCSD
Ithaca College
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J David Gladstone Institutes
University of California San Diego UCSD
Ithaca College
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CN202111675586.8A 2016-06-07 2017-06-02 丁二醇的中链脂肪酸酯，其组合物、口服制剂及其应用方法 Active CN114292190B (zh)

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Application Number Priority Date Filing Date Title
US201662346975P 2016-06-07 2016-06-07
US62/346,975 2016-06-07
CN201780041428.2A CN109477993B (zh) 2016-06-07 2017-06-02 β-羟基丁酸酯和丁二醇的中链脂肪酸酯和组合物及其使用方法
PCT/US2017/035826 WO2017213999A1 (en) 2016-06-07 2017-06-02 Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same

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CN201780041428.2A Active CN109477993B (zh) 2016-06-07 2017-06-02 β-羟基丁酸酯和丁二醇的中链脂肪酸酯和组合物及其使用方法

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US (4) US10889538B2 (enExample)
EP (2) EP4585270A3 (enExample)
JP (3) JP7058610B2 (enExample)
KR (2) KR102638807B1 (enExample)
CN (2) CN114292190B (enExample)
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EP3654963A4 (en) 2017-07-21 2021-04-14 Buck Institute for Research on Aging BETA-HYDROXYBUTYRATE AND BUTANEDIOL S ENANTIOMERS AND THEIR METHODS OF USE
WO2019147503A1 (en) 2018-01-25 2019-08-01 Buck Institute For Research On Aging Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds
WO2019161047A1 (en) * 2018-02-14 2019-08-22 Bickman Benjamin Oral supplements of fatty acid and amino acid ketone esters to improve metabolic, physical and cognitive health
CN113329991A (zh) * 2019-01-17 2021-08-31 Ioi油脂化学品有限责任公司 封端的3-羟基羧酸及其盐和酯的生产方法
BR112021014015A2 (pt) 2019-01-17 2021-09-21 Ioi Oleo Gmbh Método para a produção de ésteres de álcool graxo de ácidos hidroxicarboxílicos
US11919851B2 (en) * 2019-01-17 2024-03-05 Ketolipix Therapeutics Gmbh Method for producing polyol-based esters of optionally acylated hydroxycarboxylic acids
CN110372502A (zh) * 2019-07-25 2019-10-25 润泰化学（泰兴）有限公司 一种1,3-二醇的双酯化合成方法
GB201918657D0 (en) 2019-12-17 2020-01-29 Tdeltas Ltd Compounds for new use
US20230303478A1 (en) * 2020-07-13 2023-09-28 Ioi Oleo Gmbh Process for preparing carboxylic acid esters of hydroxybutanoates
WO2022012766A1 (de) * 2020-07-13 2022-01-20 Ioi Oleo Gmbh Verfahren zur herstellung von oxobutanol-estern von polymeren carbonsäuren
JP2023543110A (ja) * 2020-07-13 2023-10-13 ケトリピックス セラポーティクス ゲーエムベーハー オキソブタノールでエステル化されたポリグリセロールエステルを製造する方法
CN112341542B (zh) * 2021-01-08 2021-05-14 清华大学 一种3-羟基丁酰化修饰蛋白质药物及其制备方法和应用
KR20230136627A (ko) * 2021-01-26 2023-09-26 버크 인스티튜트 포 리서치 온 에이징 포유 동물에서 체중 감소를 유도하기 위한 외인성 케톤 에스테르의 용도
US12059398B2 (en) * 2022-08-26 2024-08-13 Health Via Modern Nutrition Inc. Compositions of 1,3-butanediol and beta-hydroxybutyric acid to provide optimal therapeutic ketosis
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