JP2018529656A5 - - Google Patents
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- Publication number
- JP2018529656A5 JP2018529656A5 JP2018509504A JP2018509504A JP2018529656A5 JP 2018529656 A5 JP2018529656 A5 JP 2018529656A5 JP 2018509504 A JP2018509504 A JP 2018509504A JP 2018509504 A JP2018509504 A JP 2018509504A JP 2018529656 A5 JP2018529656 A5 JP 2018529656A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cancer
- dll3
- cancer cells
- ihc assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 102100036466 Delta-like protein 3 Human genes 0.000 claims 8
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 8
- 238000003556 assay Methods 0.000 claims 8
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 238000011518 platinum-based chemotherapy Methods 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562207830P | 2015-08-20 | 2015-08-20 | |
| US62/207,830 | 2015-08-20 | ||
| US201662323998P | 2016-04-18 | 2016-04-18 | |
| US62/323,998 | 2016-04-18 | ||
| US201662373906P | 2016-08-11 | 2016-08-11 | |
| US62/373,906 | 2016-08-11 | ||
| PCT/US2016/047870 WO2017031458A2 (en) | 2015-08-20 | 2016-08-19 | Anti-dll3 antibody drug conjugates and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529656A JP2018529656A (ja) | 2018-10-11 |
| JP2018529656A5 true JP2018529656A5 (enExample) | 2019-09-26 |
Family
ID=58052015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509504A Ceased JP2018529656A (ja) | 2015-08-20 | 2016-08-19 | 抗ｄｌｌ３抗体薬物コンジュゲートおよび使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20180243435A1 (enExample) |
| EP (1) | EP3337517A4 (enExample) |
| JP (1) | JP2018529656A (enExample) |
| KR (1) | KR20180041717A (enExample) |
| CN (1) | CN108136015A (enExample) |
| AU (1) | AU2016308365A1 (enExample) |
| BR (1) | BR112018003269A2 (enExample) |
| CA (1) | CA2996165A1 (enExample) |
| CL (2) | CL2018000458A1 (enExample) |
| CO (1) | CO2018001624A2 (enExample) |
| EA (1) | EA201890530A1 (enExample) |
| HK (1) | HK1257056A1 (enExample) |
| IL (1) | IL257645A (enExample) |
| MX (1) | MX2018002166A (enExample) |
| PE (1) | PE20181292A1 (enExample) |
| PH (1) | PH12018500380A1 (enExample) |
| TW (1) | TW201718026A (enExample) |
| UY (1) | UY36862A (enExample) |
| WO (1) | WO2017031458A2 (enExample) |
| ZA (1) | ZA201801401B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111234027A (zh) | 2015-05-21 | 2020-06-05 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| JP2019534882A (ja) * | 2016-10-11 | 2019-12-05 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | 免疫介在性療法薬を有する抗体−薬物コンジュゲート |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| UA129446C2 (uk) | 2017-10-13 | 2025-04-30 | Гарпун Терап'Ютікс, Інк. | Триспецифічні білки і способи їх застосування |
| CN111601826B (zh) * | 2018-01-15 | 2023-12-15 | 南京传奇生物科技有限公司 | 针对tigit的抗体及其变体 |
| WO2019222283A1 (en) | 2018-05-14 | 2019-11-21 | Harpoon Therapeutics, Inc. | Binding moiety for conditional activation of immunoglobulin molecules |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN113874526A (zh) * | 2019-03-08 | 2021-12-31 | 肿瘤实验室诊断有限公司 | 癌症的诊断和预后 |
| JP2022535452A (ja) * | 2019-06-07 | 2022-08-08 | ミシック セラピューティクス インコーポレイテッド | 抗原結合タンパク質構築物およびその使用 |
| US20230002492A1 (en) * | 2019-11-08 | 2023-01-05 | Simcere (Shanghai) Pharmaceutical Co., Ltd. | Anti-human programmed cell death ligand-1 (pd-l1) antibody and use thereof |
| EP3819312A1 (en) * | 2019-11-10 | 2021-05-12 | Amgen, Inc | Dosing regimen for anti-dll3 agents |
| BR112022012064A2 (pt) * | 2019-12-20 | 2022-08-30 | Anthos Therapeutics Inc | Formulação de distribuição de fármaco intravenosa, frasco compreendendo a mesma e método de tratamento de um sujeito acometido por ou em risco de desenvolver um distúrbio tromboembólico |
| US20230227577A1 (en) * | 2020-05-05 | 2023-07-20 | Oncorus, Inc. | Anti-dll3 antibodies and methods of use |
| CA3204628A1 (en) | 2021-01-13 | 2022-07-21 | John T. POIRIER | Antibody-pyrrolobenzodiazepine derivative conjugate |
| US20240115721A1 (en) | 2021-01-13 | 2024-04-11 | Memorial Sloan Kettering Cancer Center | Anti-dll3 antibody-drug conjugate |
| AU2022273509A1 (en) * | 2021-05-10 | 2023-10-19 | Amgen Inc. | Dosing regimen for combination therapy targeting dll3 and pd-1 |
| CN116271079B (zh) * | 2021-07-30 | 2025-11-14 | 上海复旦张江生物医药股份有限公司 | 一种抗dll3抗体及其制备方法、其药物偶联物和应用 |
| US20250114467A1 (en) * | 2021-07-30 | 2025-04-10 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Anti-dll3 antibody and preparation method therefor, drug conjugate and application thereof |
| CN118159558A (zh) * | 2021-09-02 | 2024-06-07 | 纪念斯隆-凯特琳癌症中心 | 抗dll3抗体和其用途 |
| IL311510A (en) * | 2021-09-17 | 2024-05-01 | Wuxi Biologics Ireland Ltd | D3 binding molecules and uses thereof |
| CN114230666B (zh) * | 2021-12-20 | 2022-09-02 | 南京诺唯赞生物科技股份有限公司 | 一种t7 rna聚合酶的单克隆抗体及其制备方法 |
| US20250057968A1 (en) * | 2021-12-23 | 2025-02-20 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-dll3 antibody and pharmaceutical use thereof, and antibody-drug conjugate containing anti-dll3 antibody |
| CN114369162B (zh) * | 2021-12-28 | 2023-05-30 | 合肥天港免疫药物有限公司 | 抗体及其应用 |
| MX2024010330A (es) * | 2022-02-23 | 2024-08-30 | Amgen Inc | Tratamiento del cancer dirigido a dll3. |
| CN114573698B (zh) * | 2022-03-16 | 2023-01-06 | 沈阳三生制药有限责任公司 | 一种FcRn抗原结合蛋白及其制备方法和应用 |
| EP4577578A1 (en) | 2022-08-22 | 2025-07-02 | Abdera Therapeutics Inc. | Dll3 binding molecules and uses thereof |
| CN116253798B (zh) * | 2022-12-15 | 2023-10-27 | 华中农业大学 | 一株针对猪δ冠状病毒S1蛋白构象表位的中和性单克隆抗体 |
| CN116217715B (zh) | 2023-01-17 | 2023-08-15 | 山东农业大学 | 基于识别不同抗原决定簇的马铃薯y病毒单克隆抗体的组合及其应用 |
| KR20250153805A (ko) * | 2023-02-27 | 2025-10-27 | 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드 | 항-dll3 항체, 이의 항체-약물 접합체 및 이의 의약적 용도 |
| WO2025190281A1 (en) * | 2024-03-11 | 2025-09-18 | Lepu Biopharma Co., Ltd. | Anti-dll3 antibodies and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2812849T3 (es) * | 2012-02-24 | 2021-03-18 | Abbvie Stemcentrx Llc | Anticuerpos anti-DLL3 y procedimientos de utilización de los mismos |
| ES2741936T3 (es) * | 2012-02-24 | 2020-02-12 | Abbvie Stemcentrx Llc | Anticuerpos anti-SEZ6 y procedimientos de uso |
| HUE045435T2 (hu) * | 2012-10-12 | 2019-12-30 | Medimmune Ltd | Pirrolobenzodiazepinek és konjugátumaik |
| WO2014130879A2 (en) * | 2013-02-22 | 2014-08-28 | Stem Centrx, Inc. | Novel antibody conjugates and uses thereof |
| JP2016518382A (ja) * | 2013-04-26 | 2016-06-23 | ピエール、ファーブル、メディカマン | Ａｘｌ抗体薬物複合体および癌の治療のためのその使用 |
| PE20160674A1 (es) * | 2013-08-28 | 2016-07-21 | Stemcentrx Inc | Metodos de conjugacion de anticuerpos especificos de sitio y composiciones |
| AU2014312210A1 (en) * | 2013-08-28 | 2016-04-07 | Abbvie Stemcentrx Llc | Engineered anti-DLL3 conjugates and methods of use |
| EP3054984A1 (en) * | 2013-10-11 | 2016-08-17 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US9956299B2 (en) * | 2013-10-11 | 2018-05-01 | Medimmune Limited | Pyrrolobenzodiazepine—antibody conjugates |
| US9950078B2 (en) * | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052532A1 (en) * | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
-
2016
- 2016-08-19 EA EA201890530A patent/EA201890530A1/ru unknown
- 2016-08-19 PE PE2018000271A patent/PE20181292A1/es unknown
- 2016-08-19 US US15/753,509 patent/US20180243435A1/en not_active Abandoned
- 2016-08-19 JP JP2018509504A patent/JP2018529656A/ja not_active Ceased
- 2016-08-19 EP EP16837930.3A patent/EP3337517A4/en not_active Withdrawn
- 2016-08-19 AU AU2016308365A patent/AU2016308365A1/en not_active Abandoned
- 2016-08-19 CA CA2996165A patent/CA2996165A1/en not_active Abandoned
- 2016-08-19 KR KR1020187007525A patent/KR20180041717A/ko not_active Withdrawn
- 2016-08-19 BR BR112018003269A patent/BR112018003269A2/pt not_active Application Discontinuation
- 2016-08-19 UY UY0001036862A patent/UY36862A/es not_active Application Discontinuation
- 2016-08-19 HK HK18116192.2A patent/HK1257056A1/zh unknown
- 2016-08-19 TW TW105126609A patent/TW201718026A/zh unknown
- 2016-08-19 WO PCT/US2016/047870 patent/WO2017031458A2/en not_active Ceased
- 2016-08-19 CN CN201680061029.8A patent/CN108136015A/zh active Pending
- 2016-08-19 MX MX2018002166A patent/MX2018002166A/es unknown
-
2018
- 2018-02-20 CL CL2018000458A patent/CL2018000458A1/es unknown
- 2018-02-20 PH PH12018500380A patent/PH12018500380A1/en unknown
- 2018-02-20 CO CONC2018/0001624A patent/CO2018001624A2/es unknown
- 2018-02-20 IL IL257645A patent/IL257645A/en unknown
- 2018-02-28 ZA ZA2018/01401A patent/ZA201801401B/en unknown
- 2018-12-21 CL CL2018003758A patent/CL2018003758A1/es unknown
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