JP2018529656A5 - - Google Patents
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- Publication number
- JP2018529656A5 JP2018529656A5 JP2018509504A JP2018509504A JP2018529656A5 JP 2018529656 A5 JP2018529656 A5 JP 2018529656A5 JP 2018509504 A JP2018509504 A JP 2018509504A JP 2018509504 A JP2018509504 A JP 2018509504A JP 2018529656 A5 JP2018529656 A5 JP 2018529656A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cancer
- dll3
- cancer cells
- ihc assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562207830P | 2015-08-20 | 2015-08-20 | |
| US62/207,830 | 2015-08-20 | ||
| US201662323998P | 2016-04-18 | 2016-04-18 | |
| US62/323,998 | 2016-04-18 | ||
| US201662373906P | 2016-08-11 | 2016-08-11 | |
| US62/373,906 | 2016-08-11 | ||
| PCT/US2016/047870 WO2017031458A2 (en) | 2015-08-20 | 2016-08-19 | Anti-dll3 antibody drug conjugates and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529656A JP2018529656A (ja) | 2018-10-11 |
| JP2018529656A5 true JP2018529656A5 (enExample) | 2019-09-26 |
Family
ID=58052015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509504A Ceased JP2018529656A (ja) | 2015-08-20 | 2016-08-19 | 抗ｄｌｌ３抗体薬物コンジュゲートおよび使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20180243435A1 (enExample) |
| EP (1) | EP3337517A4 (enExample) |
| JP (1) | JP2018529656A (enExample) |
| KR (1) | KR20180041717A (enExample) |
| CN (1) | CN108136015A (enExample) |
| AU (1) | AU2016308365A1 (enExample) |
| BR (1) | BR112018003269A2 (enExample) |
| CA (1) | CA2996165A1 (enExample) |
| CL (2) | CL2018000458A1 (enExample) |
| CO (1) | CO2018001624A2 (enExample) |
| EA (1) | EA201890530A1 (enExample) |
| HK (1) | HK1257056A1 (enExample) |
| IL (1) | IL257645A (enExample) |
| MX (1) | MX2018002166A (enExample) |
| PE (1) | PE20181292A1 (enExample) |
| PH (1) | PH12018500380A1 (enExample) |
| TW (1) | TW201718026A (enExample) |
| UY (1) | UY36862A (enExample) |
| WO (1) | WO2017031458A2 (enExample) |
| ZA (1) | ZA201801401B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| KR102530742B1 (ko) | 2016-05-20 | 2023-05-09 | 하푼 테라퓨틱스, 인크. | 단일 도메인 혈청 알부민 결합 단백질 |
| CN109862919A (zh) * | 2016-10-11 | 2019-06-07 | 免疫医疗有限公司 | 抗体-药物缀合物联合免疫介导的治疗剂 |
| CA3078969A1 (en) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| JP7316284B2 (ja) * | 2018-01-15 | 2023-07-27 | ナンジン レジェンド バイオテック カンパニー，リミテッド | Ｔｉｇｉｔに対する抗体及びその多様体 |
| MX2020012217A (es) | 2018-05-14 | 2021-03-02 | Harpoon Therapeutics Inc | Porción de unión para activación condicional de moléculas de inmunoglobulina. |
| CN111655295B (zh) | 2018-08-29 | 2024-05-28 | 荣昌生物制药(烟台)股份有限公司 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| US12703762B2 (en) | 2018-12-18 | 2026-08-11 | Novartis Ag | Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof |
| MX2021010441A (es) | 2019-03-01 | 2021-09-21 | Allogene Therapeutics Inc | Receptores antigenicos quimericos y agentes de union dirigidos a dll3. |
| US20220145397A1 (en) * | 2019-03-08 | 2022-05-12 | Oncolab Diagnostics Gmbh | Cancer diagnosis and prognosis |
| US12678067B1 (en) | 2019-03-20 | 2026-07-14 | Biological Art Group, Inc. | Telemetry implants |
| WO2020232303A1 (en) | 2019-05-14 | 2020-11-19 | Harpoon Therapeutics, Inc. | EpCAM BINDING PROTEINS AND METHODS OF USE |
| EP3980129A1 (en) * | 2019-06-07 | 2022-04-13 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| CN115038718B (zh) * | 2019-11-08 | 2024-07-02 | 山东先声生物制药有限公司 | 抗人程序性死亡配体-1（pd-l1）的抗体及其用途 |
| EP3819312A1 (en) * | 2019-11-10 | 2021-05-12 | Amgen, Inc | Dosing regimen for anti-dll3 agents |
| JP2023507795A (ja) * | 2019-12-20 | 2023-02-27 | アントス セラピューティクス， インコーポレイテッド | 第ＸＩ／ＸＩａ因子抗体の医薬製剤および投薬レジメン |
| US12686725B2 (en) | 2020-05-05 | 2026-07-21 | Mythic Therapeutics, Inc. | Anti-DLL3 antibodies and methods of use |
| US20220119824A1 (en) * | 2020-08-12 | 2022-04-21 | Actym Therapeutics, Inc. | Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms |
| EP4277665A1 (en) | 2021-01-13 | 2023-11-22 | Memorial Sloan Kettering Cancer Center | Anti-dll3 antibody-drug conjugate |
| CN117425501A (zh) | 2021-01-13 | 2024-01-19 | 纪念斯隆凯特琳癌症中心 | 抗体-吡咯并苯二氮䓬衍生物缀合物 |
| WO2022240688A1 (en) * | 2021-05-10 | 2022-11-17 | Amgen Inc. | Dosing regimen for combination therapy targeting dll3 and pd-1 |
| CN116271079B (zh) * | 2021-07-30 | 2025-11-14 | 上海复旦张江生物医药股份有限公司 | 一种抗dll3抗体及其制备方法、其药物偶联物和应用 |
| JP7892050B2 (ja) * | 2021-07-30 | 2026-07-17 | シャンハイ フダン－チャンジャン バイオ－ファーマシューティカル カンパニー リミテッド | 抗ｄｌｌ３抗体とその製造方法、その薬物複合体及び使用 |
| JP2024534892A (ja) * | 2021-09-02 | 2024-09-26 | メモリアル スローン ケタリング キャンサー センター | 抗ｄｌｌ３抗体及びその使用 |
| AU2022345323A1 (en) * | 2021-09-17 | 2024-03-28 | WuXi Biologics Ireland Limited | D3-binding molecules and uses thereof |
| CN114230666B (zh) * | 2021-12-20 | 2022-09-02 | 南京诺唯赞生物科技股份有限公司 | 一种t7 rna聚合酶的单克隆抗体及其制备方法 |
| TW202346346A (zh) * | 2021-12-23 | 2023-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ｄｌｌ３抗體、其抗體－藥物偶聯物及其醫藥用途 |
| CN114369162B (zh) * | 2021-12-28 | 2023-05-30 | 合肥天港免疫药物有限公司 | 抗体及其应用 |
| EP4482586A1 (en) * | 2022-02-23 | 2025-01-01 | Amgen Inc. | Cancer treatment targeting dll3 |
| CN114573698B (zh) * | 2022-03-16 | 2023-01-06 | 沈阳三生制药有限责任公司 | 一种FcRn抗原结合蛋白及其制备方法和应用 |
| CN121293357A (zh) | 2022-08-22 | 2026-01-09 | 雅博得乐医疗公司 | Dll3结合分子及其用途 |
| CN116253798B (zh) * | 2022-12-15 | 2023-10-27 | 华中农业大学 | 一株针对猪δ冠状病毒S1蛋白构象表位的中和性单克隆抗体 |
| CN116217715B (zh) * | 2023-01-17 | 2023-08-15 | 山东农业大学 | 基于识别不同抗原决定簇的马铃薯y病毒单克隆抗体的组合及其应用 |
| IL322887A (en) * | 2023-02-27 | 2025-10-01 | Suzhou Suncadia Biopharmaceuticals Co Ltd | Anti-DLL3 antibody, antibody-drug conjugate and pharmaceutical use thereof |
| TW202600599A (zh) * | 2024-03-11 | 2026-01-01 | 大陸商樂普生物科技股份有限公司 | 抗ｄｌｌ３抗體及其用途 |
| TW202608926A (zh) * | 2024-04-29 | 2026-03-01 | 新加坡商福佑泰生物製藥（新加坡）公司 | 靶向ｄｌｌ３的抗體以及抗體—藥物偶聯物及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104520324A (zh) * | 2012-02-24 | 2015-04-15 | 施特姆森特Rx股份有限公司 | Dll3调节剂及其使用方法 |
| RU2691698C2 (ru) * | 2012-02-24 | 2019-06-17 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Антитела против sez6 и способы их применения |
| DK2839860T3 (da) * | 2012-10-12 | 2019-06-17 | Medimmune Ltd | Pyrrolobenzodiazepiner og konjugater deraf |
| ES2731681T3 (es) * | 2013-02-22 | 2019-11-18 | Abbvie Stemcentrx Llc | Conjugados de anticuerpo anti-DLL3 y PBD y usos de los mismos |
| US20160106861A1 (en) * | 2013-04-26 | 2016-04-21 | Spirogen Sarl | Axl antibody-drug conjugate and its use for the treatment of cancer |
| CA2922544A1 (en) * | 2013-08-28 | 2015-03-05 | Stemcentrx, Inc. | Engineered anti-dll3 conjugates and methods of use |
| JP2016531915A (ja) * | 2013-08-28 | 2016-10-13 | ステムセントリックス， インコーポレイテッド | 部位特異的抗体コンジュゲーション方法および組成物 |
| US10010624B2 (en) * | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052535A1 (en) * | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052533A1 (en) * | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052534A1 (en) * | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
-
2016
- 2016-08-19 EP EP16837930.3A patent/EP3337517A4/en not_active Withdrawn
- 2016-08-19 UY UY0001036862A patent/UY36862A/es not_active Application Discontinuation
- 2016-08-19 PE PE2018000271A patent/PE20181292A1/es unknown
- 2016-08-19 AU AU2016308365A patent/AU2016308365A1/en not_active Abandoned
- 2016-08-19 CN CN201680061029.8A patent/CN108136015A/zh active Pending
- 2016-08-19 JP JP2018509504A patent/JP2018529656A/ja not_active Ceased
- 2016-08-19 KR KR1020187007525A patent/KR20180041717A/ko not_active Withdrawn
- 2016-08-19 BR BR112018003269A patent/BR112018003269A2/pt not_active Application Discontinuation
- 2016-08-19 HK HK18116192.2A patent/HK1257056A1/zh unknown
- 2016-08-19 US US15/753,509 patent/US20180243435A1/en not_active Abandoned
- 2016-08-19 TW TW105126609A patent/TW201718026A/zh unknown
- 2016-08-19 WO PCT/US2016/047870 patent/WO2017031458A2/en not_active Ceased
- 2016-08-19 MX MX2018002166A patent/MX2018002166A/es unknown
- 2016-08-19 CA CA2996165A patent/CA2996165A1/en not_active Abandoned
- 2016-08-19 EA EA201890530A patent/EA201890530A1/ru unknown
-
2018
- 2018-02-20 IL IL257645A patent/IL257645A/en unknown
- 2018-02-20 CL CL2018000458A patent/CL2018000458A1/es unknown
- 2018-02-20 PH PH12018500380A patent/PH12018500380A1/en unknown
- 2018-02-20 CO CONC2018/0001624A patent/CO2018001624A2/es unknown
- 2018-02-28 ZA ZA2018/01401A patent/ZA201801401B/en unknown
- 2018-12-21 CL CL2018003758A patent/CL2018003758A1/es unknown
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