JP2018508512A5 - - Google Patents
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- JP2018508512A5 JP2018508512A5 JP2017545299A JP2017545299A JP2018508512A5 JP 2018508512 A5 JP2018508512 A5 JP 2018508512A5 JP 2017545299 A JP2017545299 A JP 2017545299A JP 2017545299 A JP2017545299 A JP 2017545299A JP 2018508512 A5 JP2018508512 A5 JP 2018508512A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- composition
- composition according
- metastatic
- chemotherapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 33
- 206010028980 Neoplasm Diseases 0.000 claims 18
- 201000011510 cancer Diseases 0.000 claims 18
- 230000001394 metastastic effect Effects 0.000 claims 8
- 206010061289 metastatic neoplasm Diseases 0.000 claims 8
- 238000002512 chemotherapy Methods 0.000 claims 7
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 5
- 206010017758 gastric cancer Diseases 0.000 claims 5
- 201000011549 stomach cancer Diseases 0.000 claims 5
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 4
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 4
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 4
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 4
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010027406 Mesothelioma Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 claims 2
- 230000001919 adrenal effect Effects 0.000 claims 2
- 230000001054 cortical effect Effects 0.000 claims 2
- 208000007276 esophageal squamous cell carcinoma Diseases 0.000 claims 2
- 230000000306 recurrent effect Effects 0.000 claims 2
- 208000008732 thymoma Diseases 0.000 claims 2
- 208000006468 Adrenal Cortex Neoplasms Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 201000005179 adrenal carcinoma Diseases 0.000 claims 1
- 208000020990 adrenal cortex carcinoma Diseases 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000007128 adrenocortical carcinoma Diseases 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 210000003236 esophagogastric junction Anatomy 0.000 claims 1
- 238000011354 first-line chemotherapy Methods 0.000 claims 1
- 201000006585 gastric adenocarcinoma Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 201000007492 gastroesophageal junction adenocarcinoma Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 102000048776 human CD274 Human genes 0.000 claims 1
- 102000048362 human PDCD1 Human genes 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000011518 platinum-based chemotherapy Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562121025P | 2015-02-26 | 2015-02-26 | |
| US62/121,025 | 2015-02-26 | ||
| US201562133721P | 2015-03-16 | 2015-03-16 | |
| US62/133,721 | 2015-03-16 | ||
| US201562160291P | 2015-05-12 | 2015-05-12 | |
| US62/160,291 | 2015-05-12 | ||
| US201562215394P | 2015-09-08 | 2015-09-08 | |
| US62/215,394 | 2015-09-08 | ||
| US201562254424P | 2015-11-12 | 2015-11-12 | |
| US62/254,424 | 2015-11-12 | ||
| PCT/US2016/019120 WO2016137985A1 (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020050850A Division JP7116113B2 (ja) | 2015-02-26 | 2020-03-23 | がんを治療するためのｐｄ－１／ｐｄ－ｌ１阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508512A JP2018508512A (ja) | 2018-03-29 |
| JP2018508512A5 true JP2018508512A5 (cg-RX-API-DMAC10.html) | 2019-03-14 |
| JP6885869B2 JP6885869B2 (ja) | 2021-06-16 |
Family
ID=55588542
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017545299A Active JP6885869B2 (ja) | 2015-02-26 | 2016-02-23 | がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤 |
| JP2020050850A Active JP7116113B2 (ja) | 2015-02-26 | 2020-03-23 | がんを治療するためのｐｄ－１／ｐｄ－ｌ１阻害剤 |
| JP2021107909A Pending JP2021178822A (ja) | 2015-02-26 | 2021-06-29 | がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020050850A Active JP7116113B2 (ja) | 2015-02-26 | 2020-03-23 | がんを治療するためのｐｄ－１／ｐｄ－ｌ１阻害剤 |
| JP2021107909A Pending JP2021178822A (ja) | 2015-02-26 | 2021-06-29 | がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤 |
Country Status (15)
Families Citing this family (34)
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| RU2714233C2 (ru) | 2015-02-26 | 2020-02-13 | Мерк Патент Гмбх | Ингибиторы pd-1 / pd-l1 для лечения рака |
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| MX390878B (es) | 2015-06-16 | 2025-03-21 | Merck Patent Gmbh | Usos medicos de antagonista de ligando 1 de muerte programada (pd-l1). |
| PT3334763T (pt) | 2015-08-11 | 2024-10-28 | Wuxi Biologics Ireland Ltd | Novos anticorpos anti-pd-1 |
| WO2017040790A1 (en) | 2015-09-01 | 2017-03-09 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
| UA123270C2 (uk) | 2015-12-07 | 2021-03-10 | Мерк Патент Гмбх | Водний фармацевтичний препарат, який містить антитіло до pd-l1 авелумаб |
| CA3025391A1 (en) * | 2016-05-26 | 2017-11-30 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for cancer treatment |
| WO2017218191A1 (en) | 2016-06-17 | 2017-12-21 | The Trustees Of The University Of Pennsylvania | Compounds, compositions and methods for prevention and/or treatment of cancer |
| JP7164528B2 (ja) * | 2016-09-14 | 2022-11-01 | ベイジン・ハンミ・ファーマシューティカル・カンパニー・リミテッド | Ｐｄ－１に特異的に結合する可能な抗体及びその機能的断片 |
| IL265762B2 (en) * | 2016-10-06 | 2024-04-01 | Merck Patent Gmbh | Dosing regimen of avelumab for the treatment of cancer |
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| KR102603681B1 (ko) | 2016-12-07 | 2023-11-17 | 아게누스 인코포레이티드 | 항체 및 이의 사용방법 |
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| CN111741978A (zh) | 2018-02-21 | 2020-10-02 | 戊瑞治疗有限公司 | B7-h4抗体制剂 |
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| AU2019361923A1 (en) * | 2018-10-15 | 2021-06-03 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| JP7621943B2 (ja) * | 2018-11-14 | 2025-01-27 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | がんを治療するための、抗ｃｅａｃａｍ６および抗ｐｄ－１抗体または抗ｐｄ－ｌ１抗体のいずれかの医薬組み合わせ |
| US11851490B2 (en) | 2019-08-15 | 2023-12-26 | Northwestern University | Methods and compositions for treating, inhibiting, and/or preventing heterotopic ossification |
| US20210169979A1 (en) * | 2019-12-05 | 2021-06-10 | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | System and method for sonosensitized cancer immunotherapy with nanoparticles |
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| KR20230061434A (ko) * | 2020-09-04 | 2023-05-08 | 파르마 마르, 에스.에이. | 루비넥테딘 및 면역 체크포인트 억제제의 조합 |
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2016
- 2016-02-23 RU RU2017133273A patent/RU2714233C2/ru active
- 2016-02-23 SG SG10201810615VA patent/SG10201810615VA/en unknown
- 2016-02-23 BR BR112017018234A patent/BR112017018234A2/pt not_active Application Discontinuation
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- 2016-02-23 KR KR1020177026975A patent/KR20170132171A/ko not_active Ceased
- 2016-02-23 EP EP23193773.1A patent/EP4279087A3/en not_active Withdrawn
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2017
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2020
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- 2020-08-05 US US16/985,805 patent/US20200362040A1/en not_active Abandoned
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