JP2018508219A5 - - Google Patents
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- JP2018508219A5 JP2018508219A5 JP2017546715A JP2017546715A JP2018508219A5 JP 2018508219 A5 JP2018508219 A5 JP 2018508219A5 JP 2017546715 A JP2017546715 A JP 2017546715A JP 2017546715 A JP2017546715 A JP 2017546715A JP 2018508219 A5 JP2018508219 A5 JP 2018508219A5
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- Prior art keywords
- fusion protein
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- seq
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- 102000037865 fusion proteins Human genes 0.000 claims description 175
- 108020001507 fusion proteins Proteins 0.000 claims description 175
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 121
- 108020004707 nucleic acids Proteins 0.000 claims description 79
- 102000039446 nucleic acids Human genes 0.000 claims description 79
- 150000007523 nucleic acids Chemical class 0.000 claims description 79
- 230000003834 intracellular effect Effects 0.000 claims description 62
- 230000002209 hydrophobic effect Effects 0.000 claims description 55
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 52
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 52
- 230000004068 intracellular signaling Effects 0.000 claims description 39
- 230000027455 binding Effects 0.000 claims description 38
- 101000969553 Homo sapiens Cell surface glycoprotein CD200 receptor 1 Proteins 0.000 claims description 37
- 102100021396 Cell surface glycoprotein CD200 receptor 1 Human genes 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 34
- 235000001014 amino acid Nutrition 0.000 claims description 27
- 150000001413 amino acids Chemical class 0.000 claims description 27
- 239000013598 vector Substances 0.000 claims description 25
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 23
- 102000017578 LAG3 Human genes 0.000 claims description 23
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims description 22
- 108091008874 T cell receptors Proteins 0.000 claims description 22
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 22
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims description 22
- 239000000427 antigen Substances 0.000 claims description 22
- 108091007433 antigens Proteins 0.000 claims description 22
- 102000036639 antigens Human genes 0.000 claims description 22
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims description 19
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims description 19
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 16
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims description 16
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 16
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 16
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 12
- 230000000139 costimulatory effect Effects 0.000 claims description 11
- -1 CD300 Proteins 0.000 claims description 10
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 10
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 10
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 8
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 8
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 8
- 101001038037 Homo sapiens Lysophosphatidic acid receptor 5 Proteins 0.000 claims description 8
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 8
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 8
- 102100040404 Lysophosphatidic acid receptor 5 Human genes 0.000 claims description 8
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 8
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 8
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 8
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 7
- 230000009149 molecular binding Effects 0.000 claims description 7
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 6
- 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 claims description 6
- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims description 6
- 230000004083 survival effect Effects 0.000 claims description 6
- 102100027207 CD27 antigen Human genes 0.000 claims description 5
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 5
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims description 5
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 5
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims description 4
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims description 4
- 101150013553 CD40 gene Proteins 0.000 claims description 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
- 102000015212 Fas Ligand Protein Human genes 0.000 claims description 4
- 108010039471 Fas Ligand Protein Proteins 0.000 claims description 4
- 102100031351 Galectin-9 Human genes 0.000 claims description 4
- 101100229077 Gallus gallus GAL9 gene Proteins 0.000 claims description 4
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 4
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims description 4
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims description 4
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 4
- 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 claims description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 4
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 4
- 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 claims description 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 4
- 102000007497 Patched-2 Receptor Human genes 0.000 claims description 4
- 108010071083 Patched-2 Receptor Proteins 0.000 claims description 4
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 4
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 4
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 102000004127 Cytokines Human genes 0.000 claims description 3
- 108090000695 Cytokines Proteins 0.000 claims description 3
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims description 2
- 108090000288 Glycoproteins Proteins 0.000 claims description 2
- 102000003886 Glycoproteins Human genes 0.000 claims description 2
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims description 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims description 2
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims description 2
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 2
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 claims description 2
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 2
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims description 2
- 102000011408 Tripartite Motif Proteins Human genes 0.000 claims description 2
- 108010023649 Tripartite Motif Proteins Proteins 0.000 claims description 2
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims description 2
- 210000000170 cell membrane Anatomy 0.000 claims description 2
- 230000003013 cytotoxicity Effects 0.000 claims description 2
- 231100000135 cytotoxicity Toxicity 0.000 claims description 2
- 210000000428 immunological synapse Anatomy 0.000 claims description 2
- 230000006872 improvement Effects 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims description 2
- 230000009870 specific binding Effects 0.000 claims description 2
- 230000000638 stimulation Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 239000003446 ligand Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 230000011664 signaling Effects 0.000 description 3
- 102000006306 Antigen Receptors Human genes 0.000 description 2
- 108010083359 Antigen Receptors Proteins 0.000 description 2
- 102000008160 Cyclin A1 Human genes 0.000 description 2
- 108010060267 Cyclin A1 Proteins 0.000 description 2
- 101000621309 Homo sapiens Wilms tumor protein Proteins 0.000 description 2
- 102000003735 Mesothelin Human genes 0.000 description 2
- 108090000015 Mesothelin Proteins 0.000 description 2
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 102100022748 Wilms tumor protein Human genes 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 102000057542 human CD200R1 Human genes 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562128979P | 2015-03-05 | 2015-03-05 | |
| US62/128,979 | 2015-03-05 | ||
| PCT/US2016/021064 WO2016141357A1 (en) | 2015-03-05 | 2016-03-04 | Immunomodulatory fusion proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081118A Division JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508219A JP2018508219A (ja) | 2018-03-29 |
| JP2018508219A5 true JP2018508219A5 (OSRAM) | 2019-04-11 |
| JP6917896B2 JP6917896B2 (ja) | 2021-08-18 |
Family
ID=55587371
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546715A Active JP6917896B2 (ja) | 2015-03-05 | 2016-03-04 | 免疫調節性融合タンパク質およびその使用 |
| JP2020081118A Expired - Fee Related JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
| JP2021150184A Active JP7441201B2 (ja) | 2015-03-05 | 2021-09-15 | 免疫調節性融合タンパク質およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081118A Expired - Fee Related JP7026161B2 (ja) | 2015-03-05 | 2020-05-01 | 免疫調節性融合タンパク質およびその使用 |
| JP2021150184A Active JP7441201B2 (ja) | 2015-03-05 | 2021-09-15 | 免疫調節性融合タンパク質およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20180044404A1 (OSRAM) |
| EP (2) | EP3265481B1 (OSRAM) |
| JP (3) | JP6917896B2 (OSRAM) |
| KR (1) | KR20170120701A (OSRAM) |
| CN (1) | CN107531805A (OSRAM) |
| AU (3) | AU2016226022B2 (OSRAM) |
| BR (1) | BR112017018919A8 (OSRAM) |
| CA (2) | CA2978186A1 (OSRAM) |
| ES (1) | ES2979088T3 (OSRAM) |
| HK (1) | HK1246317A1 (OSRAM) |
| IL (1) | IL254165B (OSRAM) |
| MX (4) | MX2017011201A (OSRAM) |
| MY (2) | MY189195A (OSRAM) |
| RU (1) | RU2755227C2 (OSRAM) |
| SA (1) | SA517382216B1 (OSRAM) |
| SG (2) | SG10201908203SA (OSRAM) |
| WO (1) | WO2016141357A1 (OSRAM) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9511092B2 (en) | 2013-01-28 | 2016-12-06 | St. Jude Children's Research Hospital, Inc. | Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| AU2015339743C1 (en) | 2014-10-31 | 2021-04-22 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified T cells and uses thereof |
| US20180044404A1 (en) | 2015-03-05 | 2018-02-15 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| EP3466967A1 (en) | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| EP3394092A1 (en) | 2015-12-23 | 2018-10-31 | Fred Hutchinson Cancer Research Center | High affinity t cell receptors and uses thereof |
| WO2017162797A1 (en) * | 2016-03-23 | 2017-09-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| CA3019005A1 (en) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018009972A1 (en) * | 2016-07-14 | 2018-01-18 | Peter Maccallum Cancer Institute | Chimeric antigen receptor modified t cells |
| EP4512829A3 (en) | 2016-07-14 | 2025-06-11 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| US20200095547A1 (en) * | 2016-12-02 | 2020-03-26 | Darya ALIZADEH | Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors |
| JP7250677B2 (ja) | 2016-12-22 | 2023-04-03 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| AU2017382243A1 (en) * | 2016-12-22 | 2019-05-02 | Windmil Therapeutics, Inc. | Compositions and methods for modulating the immune system |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR102619015B1 (ko) | 2017-03-15 | 2023-12-28 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| AU2018236461B2 (en) * | 2017-03-17 | 2025-03-27 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| EP3661965A4 (en) | 2017-08-02 | 2022-07-13 | Phanes Therapeutics, Inc. | ANTI-CD47 ANTIBODIES AND USES THEREOF |
| EP3664830A4 (en) | 2017-08-07 | 2020-07-01 | The Regents of the University of California | RISK-FREE CELL THERAPEUTIC GENERATION PLATFORM |
| US10960071B2 (en) | 2017-08-07 | 2021-03-30 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| CN111278864A (zh) * | 2017-09-07 | 2020-06-12 | 库尔生物制药有限公司 | 抗原呈递多肽及其使用方法 |
| WO2019055862A1 (en) | 2017-09-14 | 2019-03-21 | Fred Hutchinson Cancer Research Center | HIGH AFFINITY T CELL RECEPTORS AND USES THEREOF |
| WO2019090355A1 (en) * | 2017-11-06 | 2019-05-09 | Children's National Medical Center | Cells expressing antibodies and methods of treatment using the same |
| CN118256563A (zh) * | 2017-11-10 | 2024-06-28 | 北京卡替医疗技术有限公司 | 一种扩增免疫细胞的方法 |
| EP3737689A4 (en) | 2018-01-09 | 2021-12-01 | Cue Biopharma, Inc. | MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| JP7439372B2 (ja) * | 2018-06-21 | 2024-02-28 | シャタック ラボ，インコーポレイテッド | ヘテロ二量体タンパク質及びその使用 |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| KR102261407B1 (ko) * | 2018-10-10 | 2021-06-08 | 한국화학연구원 | Hvem을 표적으로 하는 키메라 항원 수용체 |
| WO2020102240A1 (en) * | 2018-11-13 | 2020-05-22 | Memorial Sloan Kettering Cancer Center | Compositions and methods for adoptive cell therapy for cancer |
| TWI856047B (zh) | 2018-12-19 | 2024-09-21 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| GB201900858D0 (en) * | 2019-01-22 | 2019-03-13 | Price Nicola Kaye | Receptors providing targeted costimulation for adoptive cell therapy |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| WO2020185796A1 (en) | 2019-03-11 | 2020-09-17 | Fred Hutchinson Cancer Research Center | High avidity wt1 t cell receptors and uses thereof |
| CN113710697A (zh) * | 2019-03-15 | 2021-11-26 | 美国政府(由卫生和人类服务部的部长所代表) | 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途 |
| BR112021018600B1 (pt) * | 2019-03-21 | 2023-10-17 | Onk Therapeutics Limited | Uso de uma célula nk e seu método de produção |
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| MX2022000769A (es) * | 2019-07-19 | 2022-05-18 | Memorial Sloan Kettering Cancer Center | Polipéptido de fusión para inmunoterapia. |
| CN114929751B (zh) * | 2019-09-27 | 2024-11-05 | 南京艾美斐生物医药科技有限公司 | Ror1特异性嵌合抗原受体及其治疗应用 |
| BR112022010225A2 (pt) * | 2019-11-27 | 2022-09-06 | Univ Texas | Transdução de car combinado em grande escala e edição de gene crispr de células nk |
| EP4066842A4 (en) * | 2019-11-29 | 2023-01-25 | Suzhou Nova Therapeutics Co. Ltd | APPLICATION OF CAR-T CELLS IN MANUFACTURE OF DRUG FOR TREATMENT OF CANCER |
| IL293718A (en) * | 2019-12-11 | 2022-08-01 | Myeloid Therapeutics Inc | Therapeutic cell compositions and methods for manufacture and uses thereof |
| JP7727326B6 (ja) * | 2020-01-19 | 2025-09-08 | 北京▲峠▼替医療技術有限公司 | 免疫細胞の機能を向上させる強化受容体 |
| CA3174812A1 (en) * | 2020-04-09 | 2021-10-14 | Autolus Limited | Cell |
| GB202101491D0 (en) * | 2021-02-03 | 2021-03-17 | Autolus Ltd | Molecule |
| US20230133554A1 (en) * | 2020-04-09 | 2023-05-04 | Autolus Limited | Molecule |
| CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| EP4151660A4 (en) * | 2020-05-22 | 2024-01-17 | Chongqing Precision Biotech Company Limited | Fusion protein for reversing tumor microenvironment and use thereof |
| KR20230088333A (ko) | 2020-07-17 | 2023-06-19 | 인스틸 바이오 유케이 리미티드 | 입양 세포 요법을 위한 표적화된 공동자극을 제공하는 수용체 |
| WO2022020745A1 (en) * | 2020-07-23 | 2022-01-27 | Emory University | Galectin-9 specific binding agents for use in treating cancer |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| IL305795A (en) * | 2021-03-10 | 2023-11-01 | B G Negev Technologies & Applications Ltd At Ben Gurion Univ | Reporter cells expressing chimeric proteins for use in determining the presence and or activity of immune barrier molecules |
| EP4340862A4 (en) * | 2021-05-20 | 2025-05-21 | Achelois Biopharma, Inc. | Immune checkpoint multivalent particles compositions and methods of use |
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